Pulmonary Toxicity Assessment of Aluminum Oxide Nanoparticles via Nasal Instillation Exposure
![]() |
Kwon, Jung-Taek
(Environmental Health Research Department, National Institute of Environmental Research)
Seo, Gyun-Baek (Environmental Health Research Department, National Institute of Environmental Research) Lee, Mimi (Environmental Health Research Department, National Institute of Environmental Research) Kim, Hyun-Mi (Environmental Health Research Department, National Institute of Environmental Research) Shim, Ilseob (Environmental Health Research Department, National Institute of Environmental Research) Jo, Eunhye (Environmental Health Research Department, National Institute of Environmental Research) Kim, Pilje (Environmental Health Research Department, National Institute of Environmental Research) Choi, Kyunghee (Environmental Health Research Department, National Institute of Environmental Research) |
1 | Kwon JT, Minai-Tehrani A, Hwang SK, Kim JE, Shin JY, Yu KN, et al. Acute Pulmonary Toxicity and Body Distribution of Inhaled Metallic Silver Nanoparticles. Toxicol Res. 2012; 28(1): 25-31. DOI ScienceOn |
2 | Sung JH, Ji JH, Park JD, Yoon JU, Kim DS, Jeon KS, et al. Subchronic inhalation toxicity of silver nanoparticles. Toxicol Sci. 2009; 108(2): 452-461. DOI ScienceOn |
3 | Sung JH, Ji JH, Yoon JU, Kim DS, Song MY, Jeong J, et al. Lung function changes in Sprague- Dawley rats after prolonged inhalation exposure to silver nanoparticles. Inhal Toxicol. 2008; 20(6): 567-574. DOI ScienceOn |
4 | Thorne PS, McCray PB, Howe TS, O'Neill MA. Early-onset inflammatory responses in vivo to adenoviral vectors in the presence or absence of lipopolysaccharide-induced inflammation. Am J Respir Cell Mol Biol. 1999; 20(6): 1155-1164. DOI ScienceOn |
5 | Oberdorster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005; 113(7): 823-839. DOI ScienceOn |
6 | Arora A. Ceramics in nanotech revolution. Adv Eng Mater. 2004; 6(4): 244-247. DOI ScienceOn |
7 | Uner M, Wissing S, Yener G, Muller R. Influence of surfactants on the physical stability of solid lipid nanoparticle (SLN) formulations. Die Pharmazie-An International J. Pharm Sci. 2004; 59(4): 331-332. |
8 | Roco MC. Broader societal issues of nanotechnology. J Nanopart Res. 2003; 5(3-4): 181-189. DOI ScienceOn |
9 | OECD WPMN, "List of manufactured nanomaterials and list of endpoints for pahse one of the OECD testing programme", 2008, Paris, France |
10 | Kim Y, Park J, Kim H, Lee J, Bae E, Lee S, et al. Investigation on the Main Exposure Sources of Nanomaterials for Nanohazards Assessment. J Environ Toxicol. 2008; 23(4): 257-265. 과학기술학회마을 |
11 | Kwon JT, Kim DS, Minai-Tehrani A, Hwang SK, Chang SH, Lee ES, et al. Inhaled fluorescent magnetic nanoparticles induced extramedullary hematopoiesis in the spleen of mice. J Occup Health. 2009; 51(5): 423-431. DOI ScienceOn |
12 |
Warheit DB, Hoke RA, Finlay C, Donner EM, Reed KL, Sayes CM. Development of a base set of toxicity tests using ultrafine |
13 | Dreher KL. Health and environmental impact of nanotechnology: toxicological assessment of manufactured nanoparticles. Toxicol Sci. 2004; 77(1): 3-5. |
14 |
Kim IS, Baek M, Choi SJ. Comparative cytotoxicity of |
15 | Wagner AJ, Bleckmann CA, Murdock RC, Schrand AM, Schlager JJ, Hussain SM. Cellular interaction of different forms of aluminum nanoparticles in rat alveolar macrophages. J Phys Chem B. 2007; 111(25): 7353-7359. DOI ScienceOn |
16 | Green G. Pulmonary clearance of infectious agents. Annu Rev Med. 1968; 19: 315-336. DOI ScienceOn |
17 | Hussain S, Hess K, Gearhart J, Geiss K, Schlager J. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. In Vitro Toxicol. 2005; 19(7): 975-984. DOI ScienceOn |
18 | Chen L, Yokel RA, Hennig B, Toborek M. Manufactured aluminum oxide nanoparticles decrease expression of tight junction proteins in brain vasculature. J Neuroimmune Pharmacol. 2008; 3(4): 286-295. DOI |
19 | J Pauluhn. Pulmonary toxicity and fate of agglomerated 10 and 40 nm aluminum oxyhydroxides following 4-week inhalation exposure of rats: toxic effects are determined by agglomerated, not primary particle size. Toxicol Sci. 2009; 109(1): 152-167. DOI ScienceOn |
20 | Kwon JT, Hwang SK, Jin H, Kim DS, Minai- Tehrani A, Yoon HJ, et al. Body distribution of inhaled fluorescent magnetic nanoparticles in the mice. J Occup Health. 2008; 50(1): 1-6. DOI ScienceOn |
21 | Warheit DB, Carakostas MC, Hartsky MA, Hansen JF. Development of a short-term inhalation bioassay to assess pulmonary toxicity of inhaled particles: comparisons of pulmonary responses to carbonyl iron and silica. Toxicol Appl. Pharmacol. 1991; 107(2): 350-368. DOI ScienceOn |
22 | Warheit DB, Webb TR, Colvin VL, Reed KL, Sayes CM. Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci. 2007; 95(1): 270-280. DOI |
23 | Braydich-Stolle LK, Speshock JL, Castle A, Smith M, Murdock RC, Hussain SM. Nanosized aluminum altered immune function. ACS nano. 2010; 4(7): 3661-3670. DOI ScienceOn |
![]() |