• Genomics & Informatics
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• v.19 no.4
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• pp.48.1-48.10
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• 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encodes small envelope protein (E) that plays a major role in viral assembly, release, pathogenesis, and host inflammation. Previous studies demonstrated that pyrazine ring containing amiloride analogs inhibit this protein in different types of coronavirus including SARS-CoV-1 small envelope protein E (SARS-CoV-1 E). SARS-CoV-1 E has 93.42% sequence identity with SARS-CoV-2 E and shared a conserved domain NS3/small envelope protein (NS3_envE). Amiloride analog hexamethylene amiloride (HMA) can inhibit SARS-CoV-1 E. Therefore, we performed molecular docking and dynamics simulations to explore whether amiloride analogs are effective in inhibiting SARS-CoV-2 E. To do so, SARS-CoV-1 E and SARS-CoV-2 E proteins were taken as receptors while HMA and 3-amino-5-(azepan-1-yl)-N-(diaminomethylidene)-6-pyrimidin-5-ylpyrazine-2-carboxamide (3A5NP2C) were selected as ligands. Molecular docking simulation showed higher binding affinity scores of HMA and 3A5NP2C for SARS-CoV-2 E than SARS-CoV-1 E. Moreover, HMA and 3A5NP2C engaged more amino acids in SARS-CoV-2 E. Molecular dynamics simulation for 1 ㎲ (1,000 ns) revealed that these ligands could alter the native structure of the proteins and their flexibility. Our study suggests that suitable amiloride analogs might yield a prospective drug against coronavirus disease 2019.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7103-7110
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• 2015

The present study was conducted to investigate the effect of ${\gamma}$-radiation alone or combined with a cytotoxic drug, simvastatin, on viability and cell cycling of a myeloma cell line. P3NS1 myeloma cells were treated with the selected dose of simvastatin ($0.1{\mu}M/l$) 24 hours prior to ${\gamma}$-irradiation (0.25, 0.5 and 1Gy). The cell viability, induction of apoptosis, cell death, cell cycling, generation of ROS, and expression of P53, Bax, Bcl2, caspase3, PARP1 and Fas genes were estimated. The results indicated that simvastatin ($0.1{\mu}M/l$) treatment for 24 hours prior to ${\gamma}$-irradiation increased cell death to 37.5% as compared to 4.81% by radiation (0.5Gy) alone. It was found that simvastatin treatment before irradiation caused arrest of cells in G0/G1 and G2/M phases as assessed using flow cytometry. Interestingly, simvastatin treatment of P3NS1 cells increased the intracellular ROS production and decreased antioxidant enzyme activity with increased P53, Bax and Caspase3 gene expression while that of Bcl2 was decreased. Consequently, our results indicated that pre-treatment with simvastatin increased radio sensitivity of myeloma tumor cells in addition to apoptotic effects through an intrinsic mitochondrial pathway.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.7B
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• pp.760-770
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• 2011

The existing mobility management schemes do not fully support the next generation network, which is composed of IP-based core network and various access networks. Currently, ETRI has been developing the AIMS (Access Independent Mobility Service) system which satisfies the ITU-T requirements of mobility management in the next generation network. The AIMS system is designed to provide a mobile host with a fast and reliable mobility service among heterogeneous access networks. Recently, many user devices have multiple communication interfaces, e.g., 3G and WLAN, and thus they can make two or more network connections at the same time. In this paper, we design a scheme of flow mobility, i.e., the movement of selected data flows from one access technology to another, to be applied in the AIMS system, and verify the proposed scheme through the NS-3 simulation study. From the simulation results, we can know that the proposed flow mobility scheme can utilize the network resource efficiently in the heterogeneous mobile networks.

• Journal of Communications and Networks
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• v.15 no.3
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• pp.292-300
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• 2013

Nowadays, energy saving has become a hot topic and information and communication technology has become a major power consumer. In long term evolution advanced (LTE-A) networks, heterogeneous deployments of low-power nodes and conventional macrocells provide some new features, such as coverage extension, throughput enhancement, and load balancing. However, a large-scale deployment of low-power nodes brings substantial energy consumption and interference problems. In this paper, we propose a novel switching strategy (NS), which adaptively switches on or off some low-power nodes based on the instantaneous load of the system. It is compatible with the microcells' load balancing feature and can be easily implemented on the basis of existing LTE-A specifications. Moreover, we develop an analytical model for analyzing the performance of system energy consumption, block rate, throughput, and energy efficiency. The performance of NS is evaluated by comparison with existing strategies. Theoretical analysis and simulation results show that NS not only has a low block rate, but also achieves a high energy efficiency.

• Geophysics and Geophysical Exploration
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• v.2 no.4
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• pp.209-214
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• 1999

A field experiment generating shear waves by trench method was conducted at two places in Taejun area. We were able to separate the P- and S-waves by summing and subtracting the vertical and horizontal component of the data recorded at a three component downhole geophone in the borehole. The analysis of the records revealed that the shear waves were polarized to NS and EW directions. The faster shear waves were polarized to NS direction. The NS direction generally agrees with the dominant joints direction observed from the cores collected from the borehole.

• Physical Therapy Rehabilitation Science
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• v.10 no.2
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• pp.134-140
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• 2021

Objective: The purpose of this study was to investigate the alteration of upper cervical manipulation to autonomic nervous system (ANS) through the heart rate variability(HRV) analysis in young healthy individuals. Design: Two-group pretest-posttest design. Methods: Thirty four young healthy participants (17 males and 17 females) were randomized into the 2 groups, such as the upper cervical manipulation group (UCM group, n=17), neck stretching group (NS group, n=17). UCM group received a upper cervical manipulation, especially on the atlas, and NS group did stretch for both side of upper trapezius and levator scapular. For the UCM, Atlas mobility was checked by therapist and thrust was given once at the posterior arch of Atlas. HRV was measured before and after intervention to investigate ANS alteration. After the intervention, both groups were given 3 minutes break-time before measuring HRV. Results: The UCM group showed significant differences in ANS Activity, Stress Resistance, Stress index and Fatigue Index (p<0.05) while no differences in NS group with before and after intervention. There were significant differences in ANS Activity, Stress Resistance, and Fatigue Index between groups (p<0.05). Conclusions: This study suggected that upper cervical manipulationhas positive effects on the ANS activity, stress resistance, and fatigue index.

• The Journal of the Petrological Society of Korea
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• v.21 no.3
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• pp.287-307
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• 2012

The study area, which is located in the southeastern part of the Jirisan province of the Yeongnam massif, Korea, consists mainly of the Precambrian Hadong northern anorthosite complex (HNAC) and the Jirisan metamorphic rock complex (JMRC) and the Mesozoic granitoids which intrude them. Its tectonic frame is built into NS trend, unlike the general NE-trending tectonic frame of Korean Peninsula. This paper researched the structural characteristics at each deformation phase to clarify the geological structures associated with the NS-trending tectonic frame which was built in the HNAC and JMRC. The result indicates that the geological structures of this area were formed at least through three phases of deformation. (1) The $D_1$ deformation formed the $F_1$ sheath or "A"-type folds in the HNAC and JMRC, and the $S_{0-1}$ composite foliation and the $S_1$ foliation and the $D_1$ ductile shear zone which are (sub)parallel to the axial plane of $F_1$ fold, and the $L_1$ stretching lineation which is parallel to the $F_1$ fold axis owing to the large-scale top-to-the SE shearing on the $S_0$ foliation. (2) The $D_2$ deformation (re)folded the $D_1$ structural elements under the EW-trending tectonic compression environment, and formed the NS-trending $F_2$ open, tight, isoclinal, intrafolial folds with the $S_{0-1-2}$ composite foliation and the $S_2$ foliation and the $D_2$ ductile shear zone with S-C-C' structure and the $L_2$ stretching lineation which is (sub)parallel to the axial plane of $F_2$ fold. The extensive $D_2$ ductile shear zone (Hadong shear zone) of NS trend was persistently developed along the eastern boundary of HNAC and JMRC which would be to the limb of $F_2$ fold on a geological map scale. The Hadong shear zone is no less than 1.4 km width, and was formed in the mylonitization process which produced the mylonitic structure and the stretching lineation with the reduction of grain size during the $F_2$ passive folding. (3) The $D_3$ deformation formed the EW-trending $F_3$ kink or open fold under the NS-trending tectonic compression environment and partially rearranged the NS-trending pre-$D_3$ structural elements into (E)NE or (W)NW direction. The regional trend of $D_1$ tectonic frame before the $D_2$ deformation would be NE-SW unlike the present, and the NS-trending tectonic frame in the HNAC and JMRC like the present was formed by the rearrangement of the $D_1$ tectonic frame owing to the $F_2$ active and passive folding. Based on the main intrusion age of (N)NE-trending basic dyke in the study area, these three deformation events are interpreted to have occurred before the Late Paleozoic.

• The Journal of the Petrological Society of Korea
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• v.22 no.4
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• pp.251-261
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• 2013

Hwagae area, which is situated in the southeastern part of the Jirisan province, Yeongnam massif, Korea, is mainly composed of Precambrian Jirisan metamorphic rock complex (JMRC). Lithofacies distribution of the Precambrian constituent rocks mainly shows NS-trending tight fold and EW-trending open fold. This paper researched deformational phased structural characteristics of JMRC based on the geometric and kinematic features and the forming sequence of multi-deformed rock structures, and suggests that the geological structure of this area was formed through at least three phases of ductile deformation. (1) Most of structural elements related to the $D_1$ deformation were recognized as $S_{0-1-2}$ composite foliation which was transposed by the $D_2$ deformation. (2) The $D_2$ deformation occurred under the EW-directed tectonic compression, and formed the NS-trending $F_2$ fold and $D_2$ ductile shear zone which is (sub)parallel to the axial plane of $F_2$ fold. (3) The $D_3$ deformation occurred under the NS-directed tectonic compression, and partially reoriented the pre-$D_3$ structural elements into ENE or WNW direction. It indicates that the distribution of Precambrian lithofacies showing NS and EW-trending folds in the Hwagae area is closely associated with the $D_2$ and $D_3$ deformations, respectively.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.13 no.2
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• pp.492-497
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• 2012

In this paper, we determined the scintillation and thermoluminescence properties of $Cs_2NaCeBr_6$ elpasolite scintillation crystal. The emission spectrum of $Cs_2NaCeBr_6$ is located in the range of 300 ~ 450 nm, peaking at 377 nm and 400 nm. And, the fluorescence decay time of the crystal is composed two components. The fast component is 140 ns (94%), and the slow component is 880 ns (6%) of the crystal. The after-glow is caused by the electron and hole traps in the crystal lattices. We determined thermoluminescence parameters of the traps in the crystal. The determined activation energy(E), kinetic order and frequency factor of the traps are 0.67 eV, 1.71 and $2.51{\times}10^8s^{-1}$ respectively. In this crystal, re-combination rate is more dominant phenomenon than the re-trapping rate.

• Journal of the Institute of Electronics Engineers of Korea TE
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• v.39 no.3
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• pp.1-7
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• 2002

This paper presents a new PLL clock generator that can improve a jitter noise characteristics and acquisition process by designing a multi-PFD(Phase Frequency Detector) and an adaptive charge pump circuit. The conventional PLL has not only a jitter noise caused from such a demerit of the wide dead zone and duty cycle, but also a long delay interval that makes a high speed operation unable. An advanced multi-structured PFD circuit using the TSPC(True Single Phase Clocking) circuit is proposed, in which it shows an excellent functionalities in terms of the jitter noises by designing its circuit with the exact dead zone and duty cycle. Our new designed adaptive charge pump in the loop filter of a PLL can improve an acquisition characteristic by adaptively increasing of current. The Hspice simulation is done to evaluate the performance of the proposed circuit. Simulation result shows that our PLL has under 0.01ns in the dead zone, no influence from the duty cycle of input signals and under 50ns in the acquisition time. This circuit will be able to be used in develops of high-performance microprocessors and digital systems.