• Fisheries and Aquatic Sciences
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• v.3 no.3_4
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• pp.217-221
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• 2000

In previous study, marine actinomycetes producing the antibiotics were investigated to invent new antibiotics from east coast of Korea. The optimum growth conditions of Streptomyces sp. NS 13239 were $28^{\circ}C$, pH 7.0 and $3\%$ of NaCl concentration in various media. Streptomyces sp. NS 13239 showed strong antimicrobial activity against gram-positive bacteria, specially Methicillin resistant Staphylococcus aureus (MRSA), but just weak antimicrobial activity against yeasts and mold. On the other hand, it did not show antimicrobial activity against gram-negative bacteria. The optimum conditions for producing antibiotics were almost consistent with optimum growth conditions except carbon source and nitrogen source.

• Journal of Microbiology and Biotechnology
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• v.20 no.3
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• pp.510-512
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• 2010

A series of thiobarbituric acid derivatives were constructed and evaluated for inhibitory activity on hepatitis C virus NS5B polymerase. In biochemical assays using purified viral polymerase and RNA template, the $IC_{50}$ value was improved to 0.41 ${\mu}M$ from the original compound's 1.7 ${\mu}M$ value. In HCV sub genomic replicon assay, the $EC_{50}$ value was improved to 3.7 ${\mu}M$ from the original compound's 12.3 ${\mu}M$ value. $CC_{50}$ was higher than 77 ${\mu}M$ for all compounds tested, suggesting that they are useful candidates for anti-HCV therapy.

• Journal of Information Processing Systems
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• v.16 no.5
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• pp.1048-1063
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• 2020

In this study, we propose a reinforcement learning agent to control the data transmission rates of nodes in carrier sensing multiple access with collision avoidance (CSMA/CA)-based wireless networks. We design a reinforcement learning (RL) agent, based on Q-learning. The agent learns the environment using the timeout events of packets, which are locally available in data sending nodes. The agent selects actions to control the data transmission rates of nodes that adjust the modulation and coding scheme (MCS) levels of the data packets to utilize the available bandwidth in dynamically changing channel conditions effectively. We use the ns3-gym framework to simulate RL and investigate the effects of the parameters of Q-learning on the performance of the RL agent. The simulation results indicate that the proposed RL agent adequately adjusts the MCS levels according to the changes in the network, and achieves a high throughput comparable to those of the existing data transmission rate adaptation schemes such as Minstrel.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.04a
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• pp.215-217
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• 2014

본 논문에서는 ns-3 기반의 IEEE 802.15.4 모의 성능 평가에 대해 기술한다. IT 기술의 발달과 함께 차세대 전력망인 '스마트 그리드'가 대두되고 있다. 이에 따라 무선 센서들 간의 통신을 위해 IEEE 802.15.4 표준 기술이 채택되고 있다. IEEE 802.15.4 표준에는 beacon-enabled mode 와 non beacon-enabled mode 두 가지 채널 접근 기법이 존재하지만 특정 기법의 용도와 목적에 대해서는 구체적으로 명시되지 않는다. 따라서 본 논문에서는 스마트 그리드 환경에서 IEEE 802.15.4 의 두 채널 접근 기법의 성능을 시험하고 beacon-enabled mode 와 non beacon-enabled mode 간의 성능 분석을 통해 beacon-enabled mode 의 효용성에 대하여 연구한다.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2019.05a
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• pp.456-458
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• 2019

In this paper, transmission performance of streaming audio as a railway communication service based on LTE-R is analyzed. Performance analysis is perfomed with computer simulation based on NS(Network Simulation)-3, audio frame of MPEG(Moving Picture Experts Group)-4 is used as target application service for straming audio traffic. Results of this paper can be used to implement LTE-R networks and develope application services over LTE-R network.

• Journal of Conservation Science
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• v.26 no.3
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• pp.335-340
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• 2010

Urethane resin applicable for the first transcription of historical site and transcription of soil layer were synthesized in order to replace the imported urethane resin, NS-10. Comparing to the NS-10, the urethane polymers showed similar penetration to wet soil and formed a stable layer of polyurethane during progress working the peeling off the polyurethane pre-product from epoxy surface of final product. The urethane resins used for the first transcription of historical site improved tensile strength, which is consistent with that of NS-10. In addition the urethane resin for transcription of soil layer was supplied with hardness that have a also same strong point as like NS-10. This property is advantage due to simplifying the transcription work of soil layer in backward. When we tested to the real ground soil as well as experimentation compressed soil with use these synthesis urethane resin, we ca get the satisfying result in penetration property and stability and these properties evaluated the resins as an advanced product serving better convenience for worker.

• Genomics & Informatics
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• v.6 no.4
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• pp.173-180
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• 2008

The human genome has evolved as a consequence of evolutionary forces, such as natural selection. In this study, we investigated natural selection on the human genes by comparing the numbers of nonsynonymous (NS) and synonymous (S) mutations in individual genes. We initially collected all coding SNP data of all human genes from the public dbSNP. Among the human genes, we selected 3 different selection groups of genes: positively selected genes (NS/S${\geq}$3), negatively selected genes (NS/S${\leq}$1/3) and neutral selection genes (0.9

• Journal of The Korea Institute of Healthcare Architecture
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• v.21 no.2
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• pp.17-24
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• 2015

Purpose: This study examines distance from nurse station to bed according to composition of single bedroom. Methods: This study has two groups of target sample ward planes. The first group has diverse patients bedroom. The other group is 36 single bedrooms and 2 3-bedrooms. The guideline of distance measurement was instituted for consistency. This study has 3 main concepts of the guideline. 1) The distance is shortcut from NS to bed. 2) The traffic line is center line between walls and center of door. 3) The start point is center of NS and the end point is bed. Results: The result of this study can be summarized into two points. The first one is that single bedroom has good privacy and longer distance from NS to bed. The second one is that weak point of single bedroom was asked ward operating system and architectural planning like as patients room, bed per unit, location of NS and plan type. Implications: Consideration Should be taken into account for the effective bedroom composition and allocation in ward. This Stuy hopefully serve as a stepping stone for the standard design of space program in ward planning.

• Clinical and Experimental Pediatrics
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• v.62 no.7
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• pp.274-280
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• 2019

Purpose: To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods: Twenty-three patients with prepubertal NS treated at Pusan National University Children's Hospital between March 2009 and July 2017 were enrolled. According to the disease-causing genes identified, the patients with NS were divided into 4 groups. Three groups were positive for mutations of the PTPN11, RAF1, and SOS1 genes. The five genes undetected (FGU) group was negative for PTPN11, RAF1, SOS1, KRAS, and BRAF gene mutations. The influence of genotype was retrospectively analyzed by comparing the growth parameters after GH therapy. Results: The mean chronological age at the start of GH treatment was $5.85{\pm}2.67years$. At the beginning of the GH treatment, the height standard deviation score (SDS), growth velocity (GV), and lower levels of insulin-like growth factor-1 (IGF)-1 levels were not statistically different among the groups. All the 23 NS patients had significantly increased height SDS and serum IGF-1 level during the 3 years of treatment. GV was highest during the first year of treatment. During the 3 years of GH therapy, the PTPN11, RAF1, and SOS1 groups showed less improvement in height SDS, IGF-1 SDS, and GV, and less increase in bone age-to-chronological age ratio than the FGU group. Conclusion: The 3-year GH therapy in the 23 prepubertal patients with NS was effective in improving height SDS, GV, and serum IGF-1 levels. The FGU group showed a better response to recombinant human GH therapy than the PTPN11, RAF1, and SOS1 groups.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.5
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• pp.1073-1081
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• 2005

This paper describes a 3.3 V 10 bit CMOS digital-to-analog converter with a divided architecture of a 7 MSB and a 3 LSB, which uses an optimal Thermal-to-Binary Decoding method. Most of Dfh converters with hiか speed current drive are an architecture choosing current switch cell, column, row decoding method but this decoding circuit is complicated, occupies a large chip area. For these problems, this paper describes a D/A converter using an optimal Thermal-to-Binary Decoding method. The designed D/A converter with an active chip area of $0.953\;mm^2$ is fabricated by using a 0.35um process. The simulation data shows that the rise/fall time, settling time, and INL/DNL are 1.92/2.1 ns, 12.71 ns, and a less than ${\pm}2.3/{\pm}58$ LSB, respectively. The power dissipation of the D/A converter with a single power supply of 3.3 V is about 224 mW.