• Genomics & Informatics
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• v.6 no.1
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• pp.54-58
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• 2008

Genotyping Tool for Viral SEQuences (GTVseq) provides scientists with the genotype information on the viral genome sequences including HIV-1, HIV-2, HBV, HCV, HTLV-1, HTLV-2, poliovirus, enterovirus, flavivirus, Hantavirus, and rotavirus. GTVseq produces alternative and additive genotype information for the query viral sequences based on two different, but related, scoring methods. The genotype information produced is reported in a graphical manner for the reference genotype matches and each graphical output is linked to the detailed sequence alignments between the query and the matched reference sequences. GTVseq also reports the potential 'repeats' and/or 'recombination' sequence region in a separated window. GTVseq does not replace completely other well-known genotyping tools such as NCBI's virus sequence genotyping tool (http://www.ncbi. nlm.nih.gov/projects/genotyping/formpage.cgi), but provides additional information useful in the confirmation or for further investigation of the genotype(s) for the newly isolated viral sequences.

• Proceedings of the Korean Society of Broadcast Engineers Conference
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• 2015.07a
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• pp.75-77
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• 2015

디스플레이 해상도가 지속적으로 고해상화가 되면서, 기존 저해상도 영상을 고해상도 디스플레이 크기에 맞춰 해상도를 키우는 기법인 초해상화(super-resolution, SR) 기법에 많은 관심이 쏟아지고 있으며 이에 대한 많은 초해상화 논문들이 게재되었다. 이 중 현재 최상 품질의 고해상도 영상을 복원하는 한 초해상화 기법은, 입력 받은 저해상도 영상을 자가 예제(self-examples)로 사용하여 선형 매핑(linear mapping)을 통해 점진적으로 여러 레벨(level)를 거쳐 조금씩 키우는 방법이다. 이때 각 레벨마다 기존 저해상도 영상 크기로 반복적으로 줄여 오차를 줄이는 역투영법(back-projection)을 사용하는데, 이 방법은 처리된 영상에 시각적 품질을 낮추는 링 아티팩트(ringing artifacts)를 생산하며, 이는 매 레벨마다 계속 누적이 되어 고해상도 결과 이미지 품질에 악영향을 미치는 단점이 있다. 이를 보완하기 위해, 본 논문에서는 저해상도 정지 영상을 고해상도 정지 영상으로 점진적으로 키울 때 일반적인 역투영법 대신 비국소적 평균법(non-local means, NLM) 기반 역투영법을 사용하는 초해상화 기법을 제안한다. 제안하는 기법은 매 레벨마다 생기는 링 아티팩트를 효과적으로 제거하여 높은 시각적 품질의 고해상도 영상을 복원할 수 있게 한다. 실험을 통해 제안된 초해상화 기법을 사용 시 기존 초해상화 기법보다 향상된 고품질 고해상도 영상 복원이 가능한 것을 확인하였다.

• Journal of the Korean Society for Library and Information Science
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• v.32 no.1
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• pp.27-43
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• 1998

This article examines the current status and future trends in library and information services in USA, with particular emphasis on the library automation system, library cooperation, Internet andinformation services, activities of information services organizations. Client/server computing and integrated Web-based technology make it possible for libraries to build a new generation of automated library systems, and digital libraries project is the highest priority. As a cooperative effort among libraries, they formed consortia such as ARL/AAU on the national level. and CIC on the regional level, and GALILEO, LLN, OhioLink, Texshare, VIVA, ILLINET on the state level information netwok. The Internet and the World Wide Web have a huge impact, so American libraries are developing new skills to provide value-added information services using Internet resources. Lastly, recent information activities of the LC, NAL, NLM, ERIC, NTIS are described.

• The Journal of Korean Medicine
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• v.38 no.3
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• pp.170-184
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• 2017

Objectives: The objective of this study was to summarize randomized clinical trials (RCTs) that have assessed efficacy and safety of mahuang and ephedrine on treatment of obesity and to propose better process of study. Methods: NLM Medline (pubmed), the Cochrane library, Scopus, Science Direct, RISS, KISS were systemically searched for clinical trials investigating the efficacy, safety of mahuang and ephedrine on treatment of obesity from 2000 to 2017. Results: 16 RCTs met all the inclusion criteria. In most reports, mahuang and ephedrine significantly reduced body weight, body fat mass. There were no serious adverse events associated with mahuang and ephedrine in all studies. Conclusions: In appropriate dose of mahuang and ephedrine for healthy adult was safe, and weight loss effect of mahuang and ephedrine was better than control group. Improved clinical practice guidelines should be developed for safe use of mahuang and ephedrine.

• Proceedings of the Korea Society of Poultry Science Conference
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• 2003.11a
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• pp.67-68
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• 2003

한국 재래 닭의 유전적 특성 규명 및 기능 유전체 연구의 기초재료를 확보하고자 대량 EST 염기서열 결정 및 생물정보학 분석을 실시하였다. 대량 EST 염기서열 분석을 위한 첫 번째 단계로 재래 닭의 뇌, 비장, 정소, 배아 생식기를 이용하여 cDNA library를 구축하였다. 각각의 library로부터 총 15,121개의 클론을 선정하여 염기서열을 결정하였다. 생물정보학 분석결과 15,121개의 염기서열은 총 10,353개의 contig로 정리되었다. 이들 염기서열을 기존 데이터베이스를 대상으로 tBlastX(http://www.ncbi.nlm.nih.gov/BLAST) 분석을 실시한 결과, 염기서열 중 56 ％가 기존 데이터베이스에 존재하는 유전자와의 상동성을 보였다. 상동성을 보이는 유전자들은 유전자의 구조 및 기능 분석에 이용될 것이고, 상동성을 보이지 않는 유전자들은 microarray와 같은 대량 유전자 발현분석 시스템을 이용하여 선별한 후 기능분석이 실시될 것이다.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.556-564
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• 2021

Numerous spatial and transform-domain-based conventional denoising algorithms struggle to keep critical and minute structural features of the image, especially at high noise levels. Although neural network approaches are effective, they are not always reliable since they demand a large quantity of training data, are computationally complicated, and take a long time to construct the model. A new framework of enhanced hybrid filtering is developed for denoising color images tainted by additive white Gaussian Noise with the goal of reducing algorithmic complexity and improving performance. In the first stage of the proposed approach, the noisy image is refined using a high-dimensional non-local means filter based on Principal Component Analysis, followed by the extraction of the method noise. The wavelet transform and SURE Shrink techniques are used to further culture this method noise. The final denoised image is created by combining the results of these two steps. Experiments were carried out on a set of standard color images corrupted by Gaussian noise with multiple standard deviations. Comparative analysis of empirical outcome indicates that the proposed method outperforms leading-edge denoising strategies in terms of consistency and performance while maintaining the visual quality. This algorithm ensures homogeneous noise reduction, which is almost independent of noise variations. The power of both the spatial and transform domains is harnessed in this multi realm consolidation technique. Rather than processing individual colors, it works directly on the multispectral image. Uses minimal resources and produces superior quality output in the optimal execution time.

• Journal of Sasang Constitutional Medicine
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• v.25 no.4
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• pp.277-288
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• 2013

Objectives This study was aimed to propose the guideline of the diarrhea in Sasang Constitutional Medicine. Methods 1) Literature search It was investigated that the prescriptions stated the diarrhea as a main and accessory symptoms to be treated in "Donguisasangshinpyun", "Donguisusebowon Sasang Chobongwon", "Donguisusebowon Gabobon", "Donguisusebowon Sinchukbon", "Dongmuyugo" 2) Clinial paper search (1) The foreign papers were searched by using the search word with 'Sasang AND Diarrhea' in pubmed (http://www.ncbi.nlm.nih.gov/pubmed/) and The Cochrane Library(http://www.thecochranelibrary.com) (2) The domestic papers were searched by using the search word with 'Soeumin AND Diarrhea', 'Soyangin AND Diarrhea', 'Taeeumin AND Diarrhea', 'Taeyangin AND Diarrhea', 'Sasang AND Diarrhea' in NDSL (http://www.ndsl.kr), KISS(http://kiss.kstudy.com), Oasis(http://oasis.kiom.re.kr), RISS(http://www.riss.kr) (3) The extracted factors were the evaluations on the mainly complained symptom, adopted four constitutional therapy and efficacy. Results & Conclusions The guidelines for treating the diarrhea in the Four Constitutional Medicine are as follows. 1) It is to categorize the constitution. 2) The diarrhea of taeeumin is prescribed with 'A Series of Taeeumjowi-tang, Galgeunhaegi-tang, Cheongsimyeonja-tang, Sahyang-san, etc'. by classifying into cold, fever, consumption and addiction. 3) The diarrhea of soyangin is regarded as an internal disease and it is prescribed with 'Baekhaobuja-tang, Baekhaobujaijung-tang, etc'. by classifying taeeum symptom and so-yin symptom. 4) The diarrhea of soeumin is Mangeum-disease and 'Jeoryeongchajeonja-tang, Hyeongbangsabaek-san, Hwalseokgosam-tang, Hyeongbanggihwang-tang, etc'. is prescribed depending on the complication.

• Journal of Acupuncture Research
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• v.26 no.6
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• pp.21-30
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• 2009

Objectives : Being introduced in the 1980s, laser acupuncture studies have been steadily carried on such as its thermal effects on human body. However, the mechanisms of effect are not yet clearly explained. Generally, laser acupuncture could be favorable for pediatric patients or people under special conditions (hemophilia, needle-phobia, pathogen-carriers, etc.) because of lower risk of infection, bleeding, pain or fainting. But there are still problems for using laser acupuncture equivalently as the traditional metal needle. The goal of this study is to review the fundamentals, history and present trend of laser acupuncture study, and to suggest how to develop laser acupuncture as an oriental medical device. Method : We performed literature search using PubMed(http://www.ncbi.nlm.nih.gov/pubmed) and Scopus(http://www.scopus.com). Search conditions are laser acupuncture, laser needle, LLLT(as title or abstract) or Litscher G(as author). Main target studies are physical fundamentals, clinical trials, physiological results and device proposals. Results : Many research have shown the similarities of laser acupuncture and traditional metal acupuncture and have reported clinical and physiological effects of laser acupuncture. But, still laser acupuncture is not widely used in Korea due to high-cost of equipments and the lack of clear understanding of laser devices. Additionally, there are still challenges in standardization and device development. Conclusions : Frequencies, laser modes, waveguides, adaptor types, polarization and signal modulations are suggested as future study subjects on laser acupuncture. More various studies and efforts for device development have to be performed to provide oriental medical doctors with evidence based confidence about usage of laser acupuncture.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.15 no.2
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• pp.102-110
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• 2015

The main source of noise in computed tomography (CT) images is a quantum noise, which results from statistical fluctuations of X-ray quanta reaching the detector. This paper proposes a neural network (NN) based hybrid filter for removing quantum noise. The proposed filter consists of bilateral filters (BFs), a single or multiple neural edge enhancer(s) (NEE), and a neural filter (NF) to combine them. The BFs take into account the difference in value from the neighbors, to preserve edges while smoothing. The NEE is used to clearly enhance the desired edges from noisy images. The NF acts like a fusion operator, and attempts to construct an enhanced output image. Several measurements are used to evaluate the image quality, like the root mean square error (RMSE), the improvement in signal to noise ratio (ISNR), the standard deviation ratio (MSR), and the contrast to noise ratio (CNR). Also, the modulation transfer function (MTF) is used as a means of determining how well the edge structure is preserved. In terms of all those measurements and means, the proposed filter shows better performance than the guided filter, and the nonlocal means (NLM) filter. In addition, there is no severe restriction to select the number of inputs for the fusion operator differently from the neuro-fuzzy system. Therefore, without concerning too much about the filter selection for fusion, one could apply the proposed hybrid filter to various images with different modalities, once the corresponding noise characteristics are explored.

• Journal of Life Science
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• v.26 no.11
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• pp.1341-1344
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• 2016

Dendropanax morbifera is an endemic tree species of Korea, it is restricted to the southern parts of Korea. The internal transcribed spacer (ITS) region of nuclear ribosomal DNA (nrDNA) for Dendropanax morbifera grown at Bogil-do, Korea was determined. We investigated the sequence-based phylogenetic relationships of plants related and clarified its taxonomical position. The determined sequences consisted of 689 residues. ITS1 was 222 bp long while ITS2 was 233 bp long. The 5.8S rDNA was 160 bp long. The ITS region sequences of the Dendropanax species included in this study were obtained from GenBank. Oreopanax polycephalus was used as the outgroup. A pairwise alignment was calculated using the Clustal X program. A phylogenetic tree was constructed by the neighbor-joining method using the Tree view program. Sequence similarities among species including D. morbifera Bogil-do isolate showed the range 92.6 to 99.7% in sequence-based phylogenetic analysis using total 615 base pairs of ITS1, 5.8S rDNA and ITS2. D. morbifera Bogil-do isolate exhibited the highest degree of relatedness to D. chevalieri, sharing 99.7% ITS region similarity. D. morbifera Bogil-do isolate also showed to D. trifidus, sharing 99.4% ITS region similarity.