• Tuberculosis and Respiratory Diseases
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• v.69 no.2
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• pp.75-80
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• 2010

The year of 2009~2010 brought a number of concepts and new ideas were evaluated with promising results. However, some studies that challenged many beliefs. In acute respiratory distress syndrome (ARDS), recent clinical studies took into consideration of pathophysiologic changes of respiratory system compliance. Meta-analysis of positive end-expiratory pressure trials showed survival benefit of high positive end-expiratory pressure in ARDS. Until now, prone positioning did not show survival benefit in patients with ARDS. Extracorporeal membrane oxygenation (ECMO) based management improved survival in patients with severe ARDS. ECMO can be a management option in severe ARDS. Sedation is a standard practice in critically ill patients needing mechanical ventilation. However, Danish group reported less sedation of critically ill patients receiving mechanical ventilation was associated with an increase in days without ventilation. Although this single center study has some limitations, the overall results are promising. Use of maximal sterile barrier precautions (mask, sterile gown, sterile gloves, and large sterile drapes) with chlorhexidine-impregnated dressing reduced central venous catheter related infection. Selective oropharyngeal decontamination (application of topical antibiotics in the oropharynx) reduced the mortality rate of an intensive care unit (ICU) population. Normoglycemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation (NICE-SUGAR) trial reported intensive glucose control increased mortality among adults in the ICU. Some of the results of above papers are promising. However, some ideas may need for more frequent individual assessment and increase the workload of ICU staffs. Before implementation of new practice in ICU, we should take into consideration of individual hospital situation including human and material resources.

• Journal of the Korean Society of Food Science and Nutrition
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• v.21 no.2
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• pp.117-123
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• 1992

The present study was undertaken in order to elucidate the effects of pretreatment with nicotinamide on changes in serum glucose level, body weight, water consumption, serum insulin concentration, and the activity of pancreatic enzyme in rats treated with streptozotocin (STZ). Histological studies were also carried out to evaluate the effects on pancreatic tissues and Langerhans's islet cells. Nicotinamide pretreatment in STZ diabetic rats inhibited the rise of fasting serum glucose concentration and water consumption. Pretreatment with nicotinamide significantly increased the concentration of serum insulin and body weight changes compared to the STZ-treated group. Pancreatic lipase and trypsin activities were increased, but amylase activity was decreased and pancreatic $\beta$ -cell was destroyed by STZ. Pvetreatment with nicotinamide prevented these STZ-induced changes. These results suggest that nicotinamide pretreatment supresses STZ-induced changes in pancreatic enzymes by preventing $\beta$-cell destruction and therefore maintaining a normal serum insulin revel.

• Korean Institute of Interior Design Journal
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• v.21 no.3
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• pp.3-10
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• 2012

Vilhelm Wohlert is the Danish architect who designed Louisiana Museum of Modern Art near Copenhagen. Because of Louisiana Museum's popularity, Vilhelm Wohlert's name was started to be aware since 1990s. Although he is a well-known architect in Denmark, unfortunately his name is unknown in other countries. He designed various design projects from small scale furniture design to large scale museum and public projects. There are three programmatic categories in his architecture: exhibition programs including Louisiana Museum, residential program including private houses, and public programs including churches and schools. This thesis focuses on his residential design projects. Even though he designed a multi-family houses, Wohlert's house design consists of mainly one-off large private houses located in a nice natural environment. In chapter 3, the general history of his house projects was studied. Among them, the first exhibition house for Forum was explained more deeply to show Wohlert's early house design philosophy. In chapter 4, three built house projects were analyzed in detail. Analytical diagrams were used to show the key elements in the residential space. They are program composition, circulation, spatialization elements, final construction. His buildings have been compared with Alvar Aalto, Frank Lloyd Wright, and other Scandinavian architects. But there are some major differences that make Wohlert's design unique. In chapter 5, the case analysis results were summarized together to highlight the specific design characteristics found in Wohlert's residential design process. The universal spatial quality found in his residential projects can be applied in contemporary spatial designs.

• Journal of the Korean Society for Marine Environment & Energy
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• v.7 no.2
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• pp.70-74
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• 2004

There is a need to have a dredging index for decision of contaminated sediments dredging. Some differences from nation to nation were found in sediment quality guideline being applied by several nations because of economic level, environmental nature, and multiple uses. Therefore, it is not reasonable to adapt one guideline to be applied to sediments dredging. In this study, we developed dredging index by combining four numerical sets of sediment quality judgement into a quadrodiagram for prudential decisions. This newly developed dredging index was applied to the data obtained from Masan Bay before and after the dredging process. The quadrodiagrams of DI give us a nice graphical comparison and numerical values to explain the relative dredging effect under the circumstances of continuous input loadings. When the guideline value of DI is determined for the judgement of dredging considering social and economic impacts on local community, the DI value will be a scientific and reasonable tool in deciding dredging area and dredging depth.

• Proceedings of the KOSOMBE Conference
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• v.1996 no.05
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• pp.335-338
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• 1996

We attempted to reconstruct basement membrane (BM) in between the epidermal compartment and dermal compartment in the artificial skin preparation and examine its effect on the skin architecture as well as on the epidermal differentiation. Laminin, one of the component of BM, stimulate the migration of the basal cells but type IV collagen which is a major component of the mechanical network of BM did not stimulate epidermal migration. However laminin in the presence of type IV collagen at a 1:1 molar ratio did not stimulate epidermal migration but provide nice demarcation between epidermis and dermis. This mixture of laminin and type IV collagen enhanced epidermal differentiation in the artificial skin based on the morphological observation as well as biochemical criteria. The epidermal acquirement of migratory ability on the laminin-rich substrate suggest that this type of unbalance in the expression of the components of BM may prevail in the area of healing tissue and the invasive transition of the tumor. The result in this study provide the technical improvement in the artificial skin preparation and further application of this technique for the reconstruction of other bio-artificial organ.

• International Journal of Highway Engineering
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• v.9 no.4
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• pp.105-116
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• 2007

A ROUNDABOUT is more effective way to improve safety and prevent delays than signal intersection. ROUNDABOUT has been known highly safe treatment that could be used as a method to reduce conflicts between vehicles, to reduce travel speed in inner or approach of intersection, and to have no speed difference between drivers than intersection. In this study, the effective analysis on the installation of ROUNDABOUT was carried out using computer-based simulation tool VISSIM, in order to evaluate performance and safety of ROUNDABOUT and develope a warrant. In conclusion, the results indicated that there was remarkable increase of Y-intersection capacity and decrese of delay, and improvement of traffic safety. Finally, A nice feature of this study is to firstly attempt to use microscopic simulator to evaluate the effectiveness of ROUNDABOUT and suggest a passible operation boundary.

• Journal of Korean Society of Transportation
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• v.34 no.4
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• pp.354-372
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• 2016

This study identified factors affecting the crash severity at freeway work zones. A nice feature of this study was to take into account the characteristics of work zone traffic management in analyzing traffic safety concerns. In addition to crash records, vehicle detection systems (VDS) data and work zone historical data were used for establishing a dataset to be used for statistical analyses based on an ordered probit model. A total of six safety improvement strategies for freeway work zones, including traffic merging method, guidance information provision, speed management, warning information systems, traffic safety facility, and monitoring of effectiveness for countermeasures, were also proposed.

• Journal of Life Science
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• v.17 no.5 s.85
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• pp.694-698
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• 2007

Berberine, an alkaloid initially isolated from chinese herbal medicine, has antibiotic activities against a variety of organisms including bacteria, viruses, fungi, protozoans, and chlamydia. Furthermore, berberine has shown a number of beneficial effects, including anti-tumor, anti-inflammation, and vasodilatory effects. In this work we have investigated the effects of berberine on lymphocyte proliferation and GM-CSF production in mice. Mouse splenocytes were incubated with berberine and concanavalin A(Con A) to observe the effects on cell proliferation. The culture supernatants of splenocytes exposed to berberine, berberine plus LPS, and berberine plus Con A were harvested to assay GM-CSF. The cell proliferation of nice splenocytes exposed to berberine only($1{\mu}g/ml$) was increased significantly more than PBS(control) group. But the Con A-induced cell growth was inhibited by berberine. The GM-CSF production from mice splenocyte culture exposed to berberine only was increased in comparison with PBS(control) group, but the production of it with LPS or Con A was inhibited by berbeline. The present findings may explain lympocyte proliferating and regulating effects of berberine.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.109-114
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• 2004

This paper presents a theoretical and experimental study of a non-collocated pair of piezopolymer PVDF sensor and piezoceramic PZT actuator, which are bonded on a cantilever beam, in order to suppress unwanted vibration at the tip of the beam. The PZT actuator patch was bonded near the clamped part and the PVDF sensor, which was triangularly shaped, was bonded on the other part of the beam. This is because the triangular PVDF sensor is known that it can detect the tip velocity of a cantilever beam. Because the arrangement of the sensor and actuator pair is not collocated and overlapped each other, the pair can avoid so called 'the in-plane coupling'. The test beam is made of aluminum with the dimension of $200\times20\times2mm$, and the two PZT5H actuators are both $20\times20\times1mm$ and bonded on the beam out-of-phase, and the PVDF sensor is $178mm\times6mm\times52{\mu}m$. Before control, the sensor-actuator frequency response function is confirmed to have a nice phase response without accumulation in a reasonable frequency range of up to 5000 Hz. Both the DVFB and displacement feedback strategies made the error signal from the tip velocity (or displacement) sensor is transmitted to a power amplifier to operate the PZT actuator (secondary source). Both the control methods attenuate the magnitude of the first two resonances in the error spectrum of about 6-7 dB.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2000.11a
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• pp.731-736
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• 2000

The recently developed BEM-based NAH(nearfield acoustical holography) is a useful technique for identifying the sound source of vibrating objects. The acoustic parameters of a sound source can be reconstructed by using the vibro-acoustic transfer matrix, which is determined by means of BEM, and the sound pressure measured in the nearfield. Theoretically, one can come up with a very nice reconstructed result as the field plane gets near to the source surface. However, when a microphone is placed in the very close nearfield of the source surface, the scattering, reflection, or resonance in the gap between the source and the microphone can distort the acoustic field, and therefore, the measured field pressure would differ from the actual one in the absence of the microphone. In order to analyze this problem, the interference effect of the microphone is numerically calculated by using the nonsingular BEM that yields very small error in the nearfield. From this analysis, it is found that the prediction error of the field pressure decreases firstly and then increases as the microphone approaches the vibrating surface from the farfield to the close nearfield. It is noted that the microphone should be separated from the source surface by at least a diameter of the microphone for an error ratio less than 2% in the low frequency range less than about 2.7kHz. This means that if one wants to put a microphone in the very close nearfield. a microphone with small diameter should be used.