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Untold story of human cervical cancers: HPV-negative cervical cancer

  • Lee, Jae-Eun;Chung, Yein;Rhee, Siyeon;Kim, Tae-Hyung
    • BMB Reports
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    • v.55 no.9
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    • pp.429-438
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    • 2022
  • Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which also hinders the progress of research on HPV-negative cervical cancer. Since HPV-negative cervical cancer is associated with worse clinical features, greater attention is required to understand HPV-negative carcinoma. In this review, we provide a summary of knowledge gaps and current limitations of HPV-negative cervical cancer research based on current clinical statistics. We also discuss future directions for understanding the pathogenesis of HPV-independent cervical cancer.

Effect of Temperature on the Deterioration of Graphite-Based Negative Electrodes during the Prolonged Cycling of Li-ion Batteries

  • Yang, Jin Hyeok;Hwang, Seong Ju;Chun, Seung Kyu;Kim, Ki Jae
    • Journal of Electrochemical Science and Technology
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    • v.13 no.2
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    • pp.208-212
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    • 2022
  • In this paper, we report the effects of temperature on the deterioration of graphite-based negative electrodes during the longterm cycling of lithium-ion batteries (LIBs). After cycling 75 Ah pouch-type LIB full cells at temperatures of 45℃ (45-Cell) and 25℃ (25-Cell) until their end of life, we expected to observe changes in the negative electrode according to the temperature. The thickness of the negative electrode of the cell was greater after cycling; that of the electrode of 45-Cell (144 ㎛) was greater than that of the electrode of 25-Cell (109 ㎛). Cross-sectional scanning electron microscopy analysis confirmed that by-products caused this increase in the thickness of the negative electrode. The by-products that formed on the surface of the negative electrode during cycling increased the surface resistance and decreased the electrical conductivity. Voltage profiles showed that the negative electrode of 25-Cell exhibited an 84.7% retention of the initial capacity, whereas that of 45-Cell showed only a 70.3% retention. The results of this study are expected to be relevant to future analyses of the deterioration characteristics of the negative electrode and battery deterioration mechanisms, and are also expected to provide basic data for advanced battery design.

Consumer Aggression in Online Distribution of the Game; Motivation of Negative Consumer Behaviors

  • Eikjoe KIM;Jongwoo LEE
    • Journal of Distribution Science
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    • v.22 no.8
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    • pp.125-135
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    • 2024
  • Purpose: This paper aims to reveal similarities and differences in behaviors in negative consumer-brand relationships. Thus, we focused on consumer motivation which includes intensity and direction of behaviors. The motivation for negative customer behavior has been discussed in the context of brand hate, but there is only limited research that has tried to measure it using quantitative methods. We are trying to measure customers' motivation in negative consumer-brand relationships and reveal the relationship between in-field customers' negative behaviors. Research design, data, and methodology: We adopt Reactive-Proactive aggression to measure the motivation of customers' behaviors in a negative consumer-brand relationship. Also, to reveal the relationship between in-field behavior and customer aggression, we survey Korean game communities to reactive-proactive aggression and behaviors, whether they participate, in each observed behavior during the serial negative consumer movements that occurred in the Korean game industry. As a methodology, we run multinomial logistic regression. Results: We observed 9 behaviors in this case, and we found that reactive-proactive aggression is related to participation and motivation of these behaviors. Conclusions: We suggest the potential of reactive-proactive aggression as motivation for customers' complex negative behaviors. Based on this potential, we hope reactive-proactive aggression could be used to reveal similarities and differences in behaviors in negative consumer-brand relationships.

An Analysis of Influence Between the Power Feeding Line Insulation and Negative Rail Potential for the DC Ground Fault Protection in the Rubber Wheel System (고무차륜시스템에서의 지락보호를 위한 급전선로 절연과 부극전위와의 영향 분석)

  • Jung, Hosung;Shin, Seongkuen;Kim, Hyungchul;Park, Young;Cho, Sanghoon
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.62 no.4
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    • pp.577-583
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    • 2013
  • We have analyzed influence of potential rise in negative bus, which caused by decrease of power feeding line insulation, upon protecting method of DC ground protection device which detecting potential rise between negative bus and ground in order to detect ground fault in the rubber wheel system. For this purpose, we proposed negative potential equation between negative bus and ground and calculated negative potential according to system condition changes by estimating power feeding line insulation changes in steel wheel system and rubber wheel system, and equalizing DC power feeding system when ground fault occurred. Also, in order to estimate negative potential of real system, we modeled the rubber wheel system, and simulated normal status, grounding fault occurrence and power feeding line insulation changes. In normal status, negative potential did not rise significantly regardless of vehicle operation. When ground fault occurred, negative potential rose up over 300V regardless of fault resistance. However, we also observed that negative potential rose when power feeding line insulation dropped down under $1M{\Omega}$. In conclusion, our result shows that in case of rubber wheel system unlike steel wheel system, relay will be prevented maloperation and insulation status observation can be ensured when ground over voltage relay will be set 200V ~ 300V.

The Influences of Variables Related to Family and Employment on Work-Family Negative Spillover in Dual-Earner Couples (맞벌이 부부의 일-가족 부정적 전이에 영향을 미치는 가족 및 직업관련 변수)

  • Jang, Yoon Ok;Jeong, Seo Leen
    • Journal of Families and Better Life
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    • v.34 no.2
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    • pp.65-83
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    • 2016
  • The purpose of this study was to investigate the influences of variables related to family and employment on work-family negative spillover. The subjects of this study were 570 dual-earner with children. The research tool was questionnaires. For data analysis, factor analysis, Cronbach ${\alpha}$, and multiple regression were performed. The main results of this study were as following. First, among variables related to family, spouse support, parental satisfaction, marital satisfaction, perceived fairness in the division of household labor, daily housework hour and family strengths had an influence on $work{\rightarrow}family$ negative spillover in wives, and weekends housework hour, perceived fairness in the division of household labor, perception of the gender role, and satisfaction of the division in household labor had an influence on $work{\rightarrow}family$ negative spillover in husband. Second, among variables related to family, parental satisfaction, number of children influence on $family{\rightarrow}work$ negative spillover in wives, and spouse support, parental satisfaction, satisfaction of the division in household labor, marital satisfaction, and perception of the gender role had an influence on $family{\rightarrow}work$ negative spillover in husband. Third, among variables related to employment, support from workplace, weekly working hour, monthly income, and job satisfaction had an influence on $work{\rightarrow}family$ negative spillover in wives, and support from workplace, monthly income, household income, and weekly working hour had an influence on $work{\rightarrow}family$ negative spillover in husband. Forth, among variables related to employment, support from workplace in wives, and job satisfaction in husband had an influence on $family{\rightarrow}work$ negative spillover. To conclude, there was some difference in the variables influencing $work{\rightarrow}family$, $family{\rightarrow}work$ negative spillover between wife and husband. So, We have to take this difference into consideration in establishing work-family life balance policies.

Constructing Negative Links from Multi-facet of Social Media

  • Li, Lin;Yan, YunYi;Jia, LiBin;Ma, Jun
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.11 no.5
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    • pp.2484-2498
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    • 2017
  • Various types of social media make the people share their personal experience in different ways. In some social networking sites. Some users post their reviews, some users can support these reviews with comments, and some users just rate the reviews as kind of support or not. Unfortunately, there is rare explicit negative comments towards other reviews. This means if there is a link between two users, it must be positive link. Apparently, the negative link is invisible in these social network. Or in other word, the negative links are redundant to positive links. In this work, we first discuss the feature extraction from social media data and propose new method to compute the distance between each pair of comments or reviews on social media. Then we investigate whether we can predict negative links via regression analysis when only positive links are manifested from social media data. In particular, we provide a principled way to mathematically incorporate multi-facet data in a novel framework, Constructing Negative Links, CsNL to predict negative links for discovering the hidden information. Additionally, we investigate the ways of solution to general negative link predication problems with CsNL and its extension. Experiments are performed on real-world data and results show that negative links is predictable with multi-facet of social media data by the proposed framework CsNL. Essentially, high prediction accuracy suggests that negative links are redundant to positive links. Further experiments are performed to evaluate coefficients on different kernels. The results show that user generated content dominates the prediction performance of CsNL.

Effects of Diet Therapy Related to Constitution on Over Weight and Obese Human (체질에 따른 식사요법이 체중과다 및 비만에 미치는 영향)

  • 허봉수;백숙은
    • Journal of the East Asian Society of Dietary Life
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    • v.8 no.3
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    • pp.261-270
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    • 1998
  • This study was conducted in order to investigate the effect of diet therapy on over weight and obese humans in Korea Subseng Research Institute from January 1, 1994 to August 31, 1997. The constitutions of subjects were classified mild negative, strong negative, mild positive and strong positive respectively by ecology and O-ring test. These results were obtained from the subjects who practiced at least 75% diet therapy recommended for over weight and obese human for 14~400days. The constitutions of over weight and obese human by Relative Body Weight (RBW$\geq$110%) were 89 mild negative humans, 62 strong negative humans, 56 mild positive humans and 30 strong positive humans. The constitutions of over weight and obese human by Body Mass Index(BMI$\geq$25) were 77 mild negative humans, 50 strong negative humans 46 mild positive humans and 23 strong positive humans. The negative subjects were higher than the positive subjects on over weight and obese humans. The diet therapy related to constitiution on over weight and obese humans showed RBW reduction of 6.73$\pm$0.53 on mild negative human, 7.78$\pm$1.69 on strong negative human, 6.94$\pm$0.76 on mild positive human, and 7.80$\pm$1.15 on strong positive human at p<0.001 by student paired t-test. The diet therapy related to constitution on over weight and obese humans showed BMI reduction of 1.47$\pm$0.12 on mild negative humans, 1.24$\pm$0.11 on strong negative humans, 1.59$\pm$0.17 on mild positive humans, and 1.66$\pm$0.30 on strong positive humans at p<0.001 by student paired t-test.

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The Effects of Affectionate Relationship with Children's Mother on Loneliness -Negative Cognitive Regulation's Mediating Role- (어머니와의 애정적 유대가 아동의 외로움에 미치는 영향 -부정적 인지 조절 능력의 성별 매개효과를 중심으로 -)

  • Kim, Kwang Woong;Cho, You Jin;Chung, You Jin
    • Korean Journal of Child Studies
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    • v.26 no.5
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    • pp.379-389
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    • 2005
  • This study examined the negative cognitive regulation's mediating role between affectionate relationship with children's mother and loneliness. The subjects were 491 5th and 6th grade school children in Seoul and $Ky\breve{o}nggi$. Data were analyzed by Pearson's correlation and regression. Results showed that affectionate relationship with children's mother was positively related to negative cognitive regulation. Affectionate relationship with children's mother and negative cognitive regulation was negatively related to loneliness. The principal finding was that negative cognitive regulation had mediating role between affectionate relationship with children's mother and loneliness in boys. But negative cognitive regulation didn't have mediating role between affectionate relationship with children's mother and loneliness in girls.

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The Relation of Parents' Emotion Socialization to the Development of Emotion in Their Young Children (부모의 정서사회화와 유아의 정서성 발달의 관계)

  • Lee, Kang Yi;Choi, In Suk;Sung, Miyoung
    • Korean Journal of Child Studies
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    • v.28 no.3
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    • pp.187-199
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    • 2007
  • The relation of parents' emotion socialization to emotionality in their 5-year-old children was studied in 106 mothers and 105 fathers. They reported on their own family-related emotional expressiveness and on their children's negative emotions by questionnaires; mothers rated children on both positive and negative emotionality. Results showed that mothers expressed positive and negative emotions more frequently, and mothers showed more distress, expressive encouragement, and problem-focused reactions to children's negative emotions than fathers. Mothers' emotional expressiveness was related to children's emotionality, whereas only fathers' negative emotional expressiveness was related to children's negative emotionality. Mothers' distress and punitive reactions were associated with children's positive and negative emotionality. Mothers' problem-focused and emotion-focused and fathers' problem-focused reactions were associated with children's positive emotionality.

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CVT Power Transmitting Characteristics and Control Logics for Negative Torque (역방향 토크시 무단변속기 동력전달 특성과 제어로직)

  • 송한림;이희라;김현수
    • Transactions of the Korean Society of Automotive Engineers
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    • v.10 no.1
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    • pp.255-264
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    • 2002
  • In this paper, the power transmitting mechanism for negative torque of the metal V-belt (MVB) CVT were investigated by theoretically analyzing variation of band tension, block compression forces for each of the primary and secondary pulleys. An experimental study was performed to investigate the speed ratio - thrust characteristics for negative torque. The experimental results are in good acoordance with the theoretical results. CVT line pressure control logic was suggested for negative torque based the speed radio - negative torque - thrust characteristics and the thrust ratio curves. The results of this study can be used as basic design materials for developing the CVT control system for negative torque.