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The Effects of Pre-emptive Administration of Ketamine and norBNI on Pain Behavior, c-Fos, and Prodynorphin Protein Expression in the Rat Spinal Cord after Formalin-induced Pain Is Modulated by the DREAM Protein

  • Long, Idris;Suppian, Rapeah;Ismail, Zalina
    • The Korean Journal of Pain
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    • v.26 no.3
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    • pp.255-264
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    • 2013
  • Background: We investigated the effects of pre-emptive administration of ketamine and norBNI on pain behavior and the expression of DREAM, c-Fos, and prodynorphin proteins on the ipsilateral side of the rat spinal cord at 2 and 4 hours after formalin injection. Methods: Eighty-four male Sprague Dawley rats were divided into 4 major groups consisting of control rats (C) (n = 12), rats given only formalin injections (F) (n = 24), and rats treated with pre-emptive administration of either ketamine (K+F) (n = 24) or norBNI (N+F) (n = 24). The non-control groups were further divided into subgroups consisting of rats that were sacrificed at 2 and 4 hours (n = 12 for each group) after formalin injection. Pain behavior was recorded for 1 hour. After 2 and 4 hours, the rats were sacrificed and the spinal cords (L4-L5 sections) were removed for immunohistochemistry and Western blot analysis. Results: The pain behavior response was reduced in the K+F group compared to the other groups during the second phase of the formalin pain response. We detected an increase in the nuclear DREAM protein level in the K+F group at 2 and 4 hours and a transient decrease in the N+F group at 2 hours; however, it increased at 4 hours after injection. Fos-like immunoreactivity (FLI) and Prodynorphin-like immunoreactivity (PLI) neurons decreased in the K+F group but increased in the N+F group at 2 hours after injection. While FLI decreased, PLI increased in all groups at 4 hours after injection. Conclusions: We suggest that NMDA and kappa opioid receptors can modulate DREAM protein expression, which can affect pain behavior and protein transcriptional processes at 2 hours and bring about either harmful or protective effects at 4 hours after formalin injection.

SOME RESULTS ON MEROMORPHIC SOLUTIONS OF CERTAIN NONLINEAR DIFFERENTIAL EQUATIONS

  • Li, Nan;Yang, Lianzhong
    • Bulletin of the Korean Mathematical Society
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    • v.57 no.5
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    • pp.1095-1113
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    • 2020
  • In this paper, we investigate the transcendental meromorphic solutions for the nonlinear differential equations $f^nf^{(k)}+Q_{d_*}(z,f)=R(z)e^{{\alpha}(z)}$ and fnf(k) + Qd(z, f) = p1(z)eα1(z) + p2(z)eα2(z), where $Q_{d_*}(z,f)$ and Qd(z, f) are differential polynomials in f with small functions as coefficients, of degree d* (≤ n - 1) and d (≤ n - 2) respectively, R, p1, p2 are non-vanishing small functions of f, and α, α1, α2 are nonconstant entire functions. In particular, we give out the conditions for ensuring the existence of these kinds of meromorphic solutions and their possible forms of the above equations.

COMMUTATIVITY OF PRIME GAMMA NEAR RINGS WITH GENERALIZED DERIVATIONS

  • MARKOS, ADNEW;MIYAN, PHOOL;ALEMAYEHU, GETINET
    • Journal of applied mathematics & informatics
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    • v.40 no.5_6
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    • pp.915-923
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    • 2022
  • The purpose of the present paper is to obtain commutativity of prime Γ-near-ring N with generalized derivations F and G with associated derivations d and h respectively satisfying one of the following conditions:(i) G([x, y]α = ±f(y)α(xoy)βγg(y), (ii) F(x)βG(y) = G(y)βF(x), for all x, y ∈ N, β ∈ Γ (iii) F(u)βG(v) = G(v)βF(u), for all u ∈ U, v ∈ V, β ∈ Γ,(iv) if 0 ≠ F(a) ∈ Z(N) for some a ∈ V such that F(x)αG(y) = G(y)αF(x) for all x ∈ V and y ∈ U, α ∈ Γ.

PHOTOMOVEMENTS IN MICROORGANISMS

  • Lenci F.;Angelini N.;Checcucci G.;Ghetti F.;Gioffre D.;Sgarbossa A.
    • Proceedings of the Korean Society of Potoscience Conference
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    • spring
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    • pp.20-20
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    • 1996
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ON FUNCTIONAL EQUATIONS OF THE FERMAT-WARING TYPE FOR NON-ARCHIMEDEAN VECTORIAL ENTIRE FUNCTIONS

  • An, Vu Hoai;Ninh, Le Quang
    • Bulletin of the Korean Mathematical Society
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    • v.53 no.4
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    • pp.1185-1196
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    • 2016
  • We show a class of homogeneous polynomials of Fermat-Waring type such that for a polynomial P of this class, if $P(f_1,{\ldots},f_{N+1})=P(g_1,{\ldots},g_{N+1})$, where $f_1,{\ldots},f_{N+1}$; $g_1,{\ldots},g_{N+1}$ are two families of linearly independent entire functions, then $f_i=cg_i$, $i=1,2,{\ldots},N+1$, where c is a root of unity. As a consequence, we prove that if X is a hypersurface defined by a homogeneous polynomial in this class, then X is a unique range set for linearly non-degenerate non-Archimedean holomorphic curves.

COMPUTATION OF THE NIELSEN TYPE NUMBERS FOR MAPS ON THE KLEIN BOTTLE

  • Kim, Hyun-Jung;Lee, Jong-Bum;Yoo, Won-Sok
    • Journal of the Korean Mathematical Society
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    • v.45 no.5
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    • pp.1483-1503
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    • 2008
  • Let f : M ${\rightarrow}$ M be a self-map on the Klein bottle M. We compute the Lefschetz number and the Nielsen number of f by using the infra-nilmanifold structure of the Klein bottle and the averaging formulas for the Lefschetz numbers and the Nielsen numbers of maps on infra-nilmanifolds. For each positive integer n, we provide an explicit algorithm for a complete computation of the Nielsen type numbers $NP_n(f)$ and $N{\Phi}_{n}(f)\;of\;f^{n}$.

CERTAIN DIFFERENCE POLYNOMIALS AND SHARED VALUES

  • Li, Xiao-Min;Yu, Hui
    • Bulletin of the Korean Mathematical Society
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    • v.55 no.5
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    • pp.1529-1561
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    • 2018
  • Let f and g be nonconstant meromorphic (entire, respectively) functions in the complex plane such that f and g are of finite order, let a and b be nonzero complex numbers and let n be a positive integer satisfying $n{\geq}21$ ($n{\geq}12$, respectively). We show that if the difference polynomials $f^n(z)+af(z+{\eta})$ and $g^n(z)+ag(z+{\eta})$ share b CM, and if f and g share 0 and ${\infty}$ CM, where ${\eta}{\neq}0$ is a complex number, then f and g are either equal or at least closely related. The results in this paper are difference analogues of the corresponding results from.

SOME RECURRENCE RELATIONS FOR THE JACOBI POLYNOMIALS P(α,β)n(x)

  • Choi, Junesang;Shine, Raj S.N.;Rathie, Arjun K.
    • East Asian mathematical journal
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    • v.31 no.1
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    • pp.103-107
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    • 2015
  • We use some known contiguous function relations for $_2F_1$ to show how simply the following three recurrence relations for Jacobi polynomials $P_n^{({\alpha},{\beta)}(x)$: (i) $({\alpha}+{\beta}+n)P_n^{({\alpha},{\beta})}(x)=({\beta}+n)P_n^{({\alpha},{\beta}-1)}(x)+({\alpha}+n)P_n^{({\alpha}-1,{\beta})}(x);$ (ii) $2P_n^{({\alpha},{\beta})}(x)=(1+x)P_n^{({\alpha},{\beta}+1)}(x)+(1-x)P_n^{({\alpha}+1,{\beta})}(x);$ (iii) $P_{n-1}^{({\alpha},{\beta})}(x)=P_n^{({\alpha},{\beta}-1)}(x)+P_n^{({\alpha}-1,{\beta})}(x)$ can be established.

Inhibition Effect of Achyranthes japonica N. Root Extract on Cathepsin B (우슬뿌리 추출물의 Cathepsin B에 대한 저해효과)

  • Lee Ka-Soon;Lee Jin-Il;Lee Jong-Kuk;Lee Jeong;Kim Gi-Don;Oh Man-Jin
    • Food Science and Preservation
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    • v.12 no.3
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    • pp.275-281
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    • 2005
  • This study was carried out to investigate the cathepsin B inhibition effect by Achyranthes japonica N. root extract in vitro. The methanol/$H_{2}O$(4:1, v/v) extract was fractionated by ethyl acetate(F1), chloroform(F2), chloroform/methanol(3:1, v/v)(F3) and methanol(F4). The yield of F4 in Achyranthes japonica N. root was $8.27\%$. As an index material of Achyranthes japonica N. root, 20-hydroxy ecdysone was detected by TLC, and HPLC and it's content was $0.33\%$. Three isolates(F1, F3, F4) showed the cathepsin B inhibition activity, and F4 showed the highest inhibition activity among them. In the inhibition activity on cathepsin B, leupeptin, 20-hydroxy ecdysone and F4(at the same concentration of 20-hydroxy ecdysone.) were 92, 88 and $97\%$ on BANA($N{\alpha}$-benzoyl-DL-arginine ${\beta}$-naphthylamide) substrate, and 62, 36 and $67\%$ on CLN($N{\alpha}$-CBZ(carbobenzlyoxy)-L-lysine p-nitrophenyl ester HCI) substrate, respectively.

AN ENTIRE FUNCTION SHARING A POLYNOMIAL WITH LINEAR DIFFERENTIAL POLYNOMIALS

  • Ghosh, Goutam Kumar
    • Communications of the Korean Mathematical Society
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    • v.33 no.2
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    • pp.495-505
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    • 2018
  • The uniqueness problems on entire functions sharing at least two values with their derivatives or linear differential polynomials have been studied and many results on this topic have been obtained. In this paper, we study an entire function f(z) that shares a nonzero polynomial a(z) with $f^{(1)}(z)$, together with its linear differential polynomials of the form: $L=L(f)=a_1(z)f^{(1)}(z)+a_2(z)f^{(2)}(z)+{\cdots}+a_n(z)f^{(n)}(z)$, where the coefficients $a_k(z)(k=1,2,{\ldots},n)$ are rational functions and $a_n(z){\not{\equiv}}0$.