• BMB Reports
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• 제48권4호
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• pp.217-222
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• 2015

Colorectal cancer (CRC) is the third most common cancer and the fourth most common cause of cancer-related death worldwide. Distant metastasis is a major cause of mortality in CRC. MicroRNAs (miRNAs) are small non-coding RNA molecules involved in the post-transcriptional and translational regulation of gene expression. Many miRNAs are aberrantly expressed in cancer and influence tumor progression. Accumulating studies suggest that multiple miRNAs are actively involved in the CRC metastasis process. Thus, we aim to introduce the role of miRNAs in multi-steps of CRC metastasis, including cancer cell invasion, intravasation, circulation, extravasation, colonization, angiogenesis, and epithelial-mesenchymal transition (EMT). Moreover, we suggest the potential application of miRNAs as biomarkers for CRC patients with metastasis. [BMB Reports 2015; 48(4): 217-222]

• BMB Reports
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• 제45권11호
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• pp.595-603
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• 2012

Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy.

• 셀메드
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• 제3권2호
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• pp.12.1-12.4
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• 2013

Identification of target protein is an important procedure in the course of drug discovery. Because of complexity, action mechanisms of herbal medicine are rather obscure, unlike small-molecular drugs. Inverse docking simulation is a reverse use of molecular docking involving multiple target searches for known chemical structure. This methodology can be applied in the field of target fishing and toxicity prediction for herbal compounds as well as known drug molecules. The aim of this review is to introduce a series of in silico works for predicting potential drug targets and side-effects based on inverse docking simulations.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 D
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• pp.2870-2872
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• 2005

본 논문에서는 시각기반 센서 네트워크에 의해 다중물체의 위치를 인식 및 추적하여 목표물들의 위치를 결정할 수 있는 분산형 시각 시스템을 제시한다. 각 시각 센서는 칼라와 동작 정보에 의한 대상물체의 정확한 분할 및 다중물체에 대한 실시간 추적 그리고 간단한 원근법에 의한 포즈 추정을 수행한다. 각 시각 센서를 하나의 에이전트 - 시각 에이전트 -로 정의하고, 전체 시각기반 센서 네트워크를 복수 에이전트 시스템(multiagent system)으로 구성한다. 이로써 대상물체의 핸드오버시 그 대상물체의 신분에 대한 매칭 문제를 Identified Contract Net (ICN) 프로토콜을 제안하여 해결한다. ICN 프로토콜은 시각 에이전트의 개수에 독립적이고 그것을 사용할 경우 시각 에이전트들 간의 캘리브레이션도 필요로 하지 않기 때문에 시각기반 센서 네트워크의 속도, 확장성 및 모듈성을 높여준다. 실험을 통해 구성한 시각기반 센서 네트워크에서 ICN 프로토콜이 적용됨을 성공적으로 검증하였다.

• 천문학회보
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• 제39권2호
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• pp.66.2-66.2
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• 2014

The size evolution of galaxies is one of the fascinating issues in these days. It is known that the size of a galaxy is closely related to other galactic properties, such as the central surface brightness, stellar mass, and redshift. However, we need to measure the sizes of galaxies precisely to understand those relations. We determine the sizes of early-type galaxies in the nearby clusters (z<0.2) using the GALAPAGOS. The GALAPAGOS is a tool which provides surface photometry for multiple sources, which make it fast and convenient to deal with huge image data. We run the GALAPAGOS individually to the Subaru/Suprime-Cam and the HST/ACS images for the same targets. We present and discuss the result of our size measurements for further applications.

• Genomics & Informatics
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• 제11권1호
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• pp.55-57
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• 2013

Growing numbers of studies employ cell line-based systematic short interfering RNA (siRNA) screens to study gene functions and to identify drug targets. As multiple sources of variations that are unique to siRNA screens exist, there is a growing demand for a computational tool that generates normalized values and standardized scores. However, only a few tools have been available so far with limited usability. Here, we present siMacro, a fast and easy-to-use Microsoft Office Excel-based tool with a graphic user interface, designed to process single-condition or two-condition synthetic screen datasets. siMacro normalizes position and batch effects, censors outlier samples, and calculates Z-scores and robust Z-scores, with a spreadsheet output of >120,000 samples in under 1 minute.

• 한국통신학회논문지
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• 제21권12호
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• pp.3165-3173
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• 1996

기존의 적외선 레티클 탐색기에 대한 모델링은 주로 정적인 상황에서 이루어졌다. 본 논문에서는 레티클 탐색기의 동적 시뮬레이션 틀을 개발하고 다중 표적, 특히 섬광탄이 존재하는 상황에서 효율적인 신호처리 기법을 제안한다. 개발된 시뮬레이션 틀은 다양한 상황에서 적외서 레티클 탐색기의 성능을 분석하고 효율적인 신호처리 기법을 연구하는데 필수적인 틀이다. 섬광탄이 존재하는 환경에서 제안한 반대응 알고리즘은 간단하면서 효율적인 기법임을 실험결과로 부터 알 수 있었다.

• Journal of Forest and Environmental Science
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• 제34권5호
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• pp.405-411
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• 2018

Implementation of mitigation options on land is important for realisation of the goals of the Paris Agreement to stabilize temperature at $2^{\circ}C$. In India, the Intended Nationally Determined Contribution (INDC) targets include a forestry goal of creation of carbon sinks of 2.5 to 3 billion tonnes by 2030. There are however, multiple barriers to implementation of forestry mitigation options in India. They include environmental, social, financial, technological and institutional barriers. The barriers are varied not just across land categories but also for a land category depending on its regional location and distribution. In addition to these barriers is the impeding climate change that places at risk realisation of the mitigation potential as rising temperatures, drought, and fires associated with projected climate change may lead to forests becoming a weaker sink or a net carbon source before the end of the century.

• Journal of the Korean Statistical Society
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• 제6권1호
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• pp.65-76
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• 1977

The relative importance of single-shot kill probabilities, rates of fire, weapon allocation strategies, and the size of initial force in warfare between two force with heterogeneous multiple weapon systems are considered by examining their effect on a natural measure of effectiveness, the expected number of survivors. Attrition equations are derived via stochastic formulation to represent the mean course of battle having an underlying probability distribution. It is assumed that each side uses indirect area fires. Level of intelligence activities are reflected in the availability of spontaneous information on the current enemy status. Depending on the availability of the information on the current enemy status, each participatory unit may follow 1) a prescribed attack pattern (fraction of the available units assigned to various enemy targets) or 2) an adaptive attack pattern depending on the enemy status at that time. Conditions for possible stalemate are discussed.

• BMB Reports
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• 제34권5호
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• pp.391-394
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• 2001

The balance between life and death of a cell regulates essential developmental processes in multicellular organisms. Apoptotic cell death is a complex, stepwise program involving multiple protein components that trigger and execute the demise of the cell. Of the many triggers of apoptosis, most are not well understood, but some key components have been identified, such as those of the Bcl-2 family, which function as anti-apoptotic or proapoptotic factors. Bax, a pro-apoptotic member of this family, has been shown to serve as a component of many apoptotic triggering cascades and its mechanism of action is the focus of intense study. Herein we discuss current, differing ideas on the function of Bax and its structure, and suggest novel mechanisms for how this death protein targets mitochondria, triggering apoptosis.