• Title/Summary/Keyword: Multiple objective model

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Development and Validation of MRI-Based Radiomics Models for Diagnosing Juvenile Myoclonic Epilepsy

  • Kyung Min Kim;Heewon Hwang;Beomseok Sohn;Kisung Park;Kyunghwa Han;Sung Soo Ahn;Wonwoo Lee;Min Kyung Chu;Kyoung Heo;Seung-Koo Lee
    • Korean Journal of Radiology
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    • v.23 no.12
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    • pp.1281-1289
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    • 2022
  • Objective: Radiomic modeling using multiple regions of interest in MRI of the brain to diagnose juvenile myoclonic epilepsy (JME) has not yet been investigated. This study aimed to develop and validate radiomics prediction models to distinguish patients with JME from healthy controls (HCs), and to evaluate the feasibility of a radiomics approach using MRI for diagnosing JME. Materials and Methods: A total of 97 JME patients (25.6 ± 8.5 years; female, 45.5%) and 32 HCs (28.9 ± 11.4 years; female, 50.0%) were randomly split (7:3 ratio) into a training (n = 90) and a test set (n = 39) group. Radiomic features were extracted from 22 regions of interest in the brain using the T1-weighted MRI based on clinical evidence. Predictive models were trained using seven modeling methods, including a light gradient boosting machine, support vector classifier, random forest, logistic regression, extreme gradient boosting, gradient boosting machine, and decision tree, with radiomics features in the training set. The performance of the models was validated and compared to the test set. The model with the highest area under the receiver operating curve (AUROC) was chosen, and important features in the model were identified. Results: The seven tested radiomics models, including light gradient boosting machine, support vector classifier, random forest, logistic regression, extreme gradient boosting, gradient boosting machine, and decision tree, showed AUROC values of 0.817, 0.807, 0.783, 0.779, 0.767, 0.762, and 0.672, respectively. The light gradient boosting machine with the highest AUROC, albeit without statistically significant differences from the other models in pairwise comparisons, had accuracy, precision, recall, and F1 scores of 0.795, 0.818, 0.931, and 0.871, respectively. Radiomic features, including the putamen and ventral diencephalon, were ranked as the most important for suggesting JME. Conclusion: Radiomic models using MRI were able to differentiate JME from HCs.

The relationships among professional self-concept, self-esteem and job satisfaction in the clinical dental hygienists (임상치과위생사의 전문직 자아개념, 자아존중감 및 직무만족도와의 관련성)

  • Min, Hee-Hong
    • Journal of Korean society of Dental Hygiene
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    • v.18 no.1
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    • pp.55-63
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    • 2018
  • Objectives: The objective of this study is to investigate the relationship among professional self-concept, self-esteem and job satisfaction in the clinical dental hygienists and provide the basic data for the effective management of clinical dental hygienists. Methods: A self-reported questionnaire was filled out by 250 clinical dental hygienists in Seoul, Gyeonggi, Chungcheong, Jeolla, and Gyeongsang Provinces from February 1 to March 30, 2017. Data were analyzed using IMB SPSS/WIN 22.0 program. Professional self-concept, self-esteem and job satisfaction according to the general characteristics and job characteristics were analzyed by independent t-test, one way ANOVA and Tukey. The relationship among professional self-concept, self-esteem and job satisfaction was found by Pearson's correlation. Multiple regression analysis was used to find out the relationship among professional self-concept, self-esteem and job satisfaction in the clinical dental hygienist. The significance level was a=0.05. Results: Clinical dental hygienist's professional self-concept was 3.76 points, self-esteem was 3.08 points and job satisfaction was 3.35 points. In general characteristics, professional self-concept showed the significant differences by age (p=0.043), marital status (p=0.005), level of education (p=0.001), duration of clinical career (p=0.003) and economic level (p=0.001). Job satisfaction showed the significant differences by age (p=0.019) and level of education (p=0.024). In job related characteristic, professional self-concept showed the significant differences by working area (p=0.001), working intensity (p=0.011) and position (p=0.001), while job satisfaction showed the significant differences by working area (p=0.014) and working intensity (p=0.001). Influencing factors in the job satisfaction in the clinical dental hygienists were age, working intensity, self-esteem, and professional self-concept. The explanatory of the model was 29.0%. Conclusions: Professional self-concept, self-esteem and job satisfaction in the clinical dental hygienists are related. To improve job satisfaction of the clinical dental hygienists, program development and institutional support to improve self-esteem and professional self-concept are needed.

Do High Ratings Signal a Good Movie? An Empirical Investigation of Signaling Effectiveness (좋은 평점이 항상 영화의 성공을 가져오는 것일까? 잠재 성장 모형을 응용한 Signaling 효과성에 관한 연구)

  • Kim, Juhee;Nam, Dae-il
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.13 no.3
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    • pp.113-124
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    • 2018
  • The objective of this study is to examine the effectiveness of signals and advancing our understanding of the relationship between ratings and audience decisions based on the signaling theory. Though many studies argue that information asymmetry affects decision making, few studies have examined two key signaling factors: its potential to have multiple sources and the effect of time on its effectiveness. This study examined how experts' and the general audience's ratings affect decision making. We also considered change patterns in ratings to explore how time effect on ratings affect selection behavior. We tested our hypotheses using the latent growth model based on signaling theory and behavior approaches. The results show that a general audience's ratings is perceived as more credible than are those of experts and that audience members are significantly affected by upward patterns in ratings. The findings suggest that general audiences play a critical role as signal providers. Thus, market participants such as producers should pay more attention to the general audience's ratings in order to increase revenues. They should also consider the time effect of signaling, such as upward trends in ratings.

Effects of Milk Consumption on Calcaneal Quantitative Ultrasound and Bone Turnover Markers of Women Living in Asan (아산시 거주 여성에서 우유섭취가 골초음파 상태와 골대사지표에 미치는 영향)

  • Kim, Hee-Seon;Kim, Min-Kyoung;Jang, Dong-Min;Kim, Nam-Soo;Kim, Jin-Ho;Lee, Byung-Kook
    • Korean Journal of Community Nutrition
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    • v.12 no.4
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    • pp.440-448
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    • 2007
  • The objective of this study is to determine the effectiveness of 16-month milk consumption as a part of the health promotion community program for women in Asan. Subjects included 313 women belonging to the milk group (mean age = 69.1, range $47{\sim}89 y$) and 66 women to the control (mean age=43.6, range $20{\sim}69 y$) group. For those in the milk group, one cup (200 ml) of partially lactose-digested low-fat milk was provided everyday for 16 months. Each subject was interviewed to assess calcium intake by a 24-h recall after fasting blood was obtained for analyzing bone turnover markers, and calcaneus broadband ultrasound attenuation (BUA) was measured by quantitative ultrasound (QUS) on the left heel before and after the milk supplementation. After 16 months, the calcium intake levels changed from 55% of recommended dietary allowance (RDA) to 85% RDA in the milk group and from 73% RDA to 84% RDA in the control group. BUA were reduced from $67.9{\pm}8.1$ to $64.7{\pm}17.5$ dB/MHz for milk and from $90.4{\pm}13.0$ to $87.2{\pm}15.2$ dB/MHz for control groups. Paired t-test showed the changes of BUA for both groups (-3.24 and -3.15 dB/MHz for milk and control groups, respectively) were significant, but the two groups did not show any differences in absolute changes. When post-BUA was analyzed after age, initial BUA and menopausal status were controlled as covariates in ANCOVA model, the milk group showed significantly (p < 0.05) smaller changes than the control group (-3.50 vs -6.71 dB/MHz, respectively). According to a multiple regression analysis, milk consumption and initial BUA showed significant interaction meaning that those with lower initial BUA showed higher milk effects. We conclude that one-cup a day milk consumption for 16 month can prevent further bone loss and significantly improve calcium intake.

Clinical and Symptomatic Correlates of Alexithymia in Schizophrenia (정신분열병의 감정표현 불능증과 관련된 임상 및 증상 요인)

  • Lee, Kyung-Ha;Kim, Dae-Ho;Roh, Sung-Won;Nam, Jeong-Hyun
    • Korean Journal of Psychosomatic Medicine
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    • v.13 no.1
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    • pp.32-40
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    • 2005
  • Objectives : This study looked at the symptoms of alexithymia in schizophrenia and their association with clinical variables and schizophrenic symptomatology. Methods Consecutive fifty eight inpatients with DSM-IV diagnoses of schizophrenia completed 26item version of Toronto Alexithymia Scale (TAS), Symptom Checklist-90-Revised(SCL-90-R), and Positive and Negative Syndrome Scale(PANSS). Results : Authors did not find any correlation between scores of PANSS and TAS. However, all the subscale scores of SCL-90-R were significantly correlated with total score of TAS. Also, 'difficulty identifying and deistinguishing between feelings and bodily sensations' and 'difficulty describing feelings' significantly correlated with SCL-90-R subscale scores. 'Reduced daydreaming' had mixed findings and 'externally oriented thinking' did not correlate. Multiple regression model included Global Severity Index of SCL-90-R accounting 28.2% of variance for TAS scores. Conclusion : These findings together with discrepancy in results between objective and subjective tests suggest that alexithymia in schizophrenia may have two constructs, 'difficulty to describe and communicate feelings(state)' and 'externally oriented thinking(trait)' Authors suggest further study needs to confirm construct validity of TAS in this population.

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Effect of Flipped Learning Education in Physical Examination and Practicum (플립러닝을 활용한 건강사정 및 실습 교육 효과)

  • Cho, Mi-Kyoung;Kim, Mi Young
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.17 no.12
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    • pp.81-90
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    • 2016
  • The objective of this study was to investigate the effect of an education method applying the flipped learning technique for college students. Both self-directed learning readiness and educational performance before and after applying the flipped learning were examined. After applying the flipped learning technique, teacher-student interaction, learning satisfaction, and learning motivation were identified. The correlation of each variable was examined after applying the flipped learning technique to investigate its influence on learning motivation. A total of 68 second-year nursing students enrolled in E University were analyzed. A difference between before and after applying the flipped learning was analyzed by the paired t-test; a correlation between the variables was analyzed via Pearson's correlation coefficient; and an influence on the dependent variable learning motivation was analyzed using the stepwise multiple regression analysis. The results showed that self-directed learning readiness increased before and after applying the flipped learning technique with statistical significance, and the difference of educational performance was not significant. After an education session applying the flipped learning technique, a learning motivation demonstrated a significantly positive correlation with self-directed learning readiness (r=0.33, p=.006), college student educational performance (r=0.51, p<.001), teacher-student interaction (r=0.72, p<.001), and learning satisfaction (r=0.79, p<.001). A significantly positive correlation was also observed between the other variables. Factors influencing learning motivation were learning satisfaction and teacher-student interaction. The explanatory power for learning motivation in the regression model considering these two variables was 71.3% (F=80.66, p<.001). Therefore, to enhance learning motivation in applying the flipped learning technique, it is necessary to increase learning satisfaction and to establish a strategy that further vitalizes the teacher-student interaction.

Exploration on the Affecting Factors in Goal Planning (목표계획과정의 영향요인 탐색연구)

  • Yoo, Jae-Wook;Huh, Keun
    • Management & Information Systems Review
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    • v.32 no.2
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    • pp.1-19
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    • 2013
  • The purpose of this study is to provide the model for goal planning system and explore the affecting factors in suitability of goal planning system and possibility of goal attainment. The findings in a factor analysis of the sample of Korean firms indicate that the factors suggested by theories and previous studies can be summarized to 40 implications and then 7 groups including attachment of top managers, systemicity, participation system, motivation, alignment of top-down & bottom-up. adjustment for environmental changes, goal content. In addition, the findings in multiple regression analyses show that goal content, alignment of top-down & bottom-up, and adjustment for environmental changes are positively, significantly influence the recognition level of employees on the suitability of goal planning system. On the other hand, goal content, attachment of top managers, and motivation are significantly influence the recognition level of employees on the possibility of goal attainment. This study provides the checklist for the suitability of goal planning system and various implications for practitioners.

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Estimation of genetic parameter for carcass traits of commercial steers in Pyeongchang (평창지역 거세출하우 자료를 이용한 유전모수 추정)

  • Dang, Chang-Gwon;Kim, Hyeong-Cheol;Jang, Sun-Sik;Lee, Jeong-Mook;Hong, Yeong-Hun;Jeon, Gi-Jun;Yeon, Seong-Heum;Kang, Hee-Seol;Yang, Bo-Suk;Hong, Seong-Koo;Lee, Jun-Heon;Lee, Seung-Hwan
    • Korean Journal of Agricultural Science
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    • v.40 no.4
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    • pp.339-345
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    • 2013
  • The objective of this study was to establish genetic evaluation systems with carcass data collected by 68 individual farms from 2007 to 2011 in Pyeongchang area of Kangwon province. All the possible of environment effects were corrected by analysis of variance (ANOVA) to estimate more accurate genetic parameters. Heritabilities and genetic correlations were estimated from carcass data collected from Hanwoo steers(n=10,441) born in Pyeongchang region from 2005 to 2008. Traits evaluated included carcass weight (CWT), eye muscle area (EMA), back fat thickness (BF) and marbling score (MS). As for the mean value and standard deviation for carcass traits, CWT, EMA, BF and MS were 424.5, 92, 13.7 and 5.7. Parameters were estimated using a multiple trait animal model and derivative-free restricted maximum likelihood procedures. Estimated heritabilities for CWT, EMA, BF and MS were 0.30, 0.21, 0.42 and 0.42, respectively. Genetic correlation of CWT with EMA, BF and MS were estimated to 0.24, 0.36 and 0.07, respectively. Genetic correlation of EMA with BF and MS was -0.27 and 0.61, respectively.

A Study on Self-Leadership and Job Involvement of Multicultural Family Home-Visit Instructors (다문화가족 방문교육지도사의 셀프리더십과 직무몰입에 관한 연구)

  • Chae, Jin-Young;Kim, Hera;Hwang, Hae Shin;Kwon, Ki Nam;Kang, Bogjeong;Suh, Joo Hyun
    • Korean Journal of Child Studies
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    • v.37 no.6
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    • pp.83-94
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    • 2016
  • Objective: The purpose of this study was to investigate differences in self-leadership and job involvement based on the education levels, majors, and teaching experiences of multicultural family home-visit instructors and the influence of self-leadership on job involvement. Methods: 668 home-visit instructors participated in the online survey from 140 multicultural family support centers in Seoul, 6 metropolitan cities, 9 provinces, and other cities and counties. Data were analyzed through frequency, percentages, Pearson's correlations, one-way ANOVA, $Scheff{\acute{e}}$ post-hoc test, and stepwise multi-regression using SPSS 21.0. Results: The main findings are as follows. First, instructors who were high school graduates had significantly higher scores in self-leadership than the other groups. There was only a significant difference in self-reward of self-leadership based on their majors. There were no significant differences in job involvement based on the education level and major. The greater their home-visit teaching experiences, the higher their scores in self-leadership and job involvement. Second, the stepwise multiple regression model showed that self-expectation, self-goal setting, constructive thinking, and rehearsal of self-leadership explained 49% of the total variance in job involvement. Conclusion: Even though the high school graduates had significantly higher scores in self-expectation, rehearsal, and constructive thinking of self-leadership than the other groups, over-generalization should be avoided because the sample size was relatively small. Based on the finding that greater home-visit teaching experiences was associated with higher self-leadership and job involvement, it would be necessary to improve working condition to prevent instructors from changing jobs. These findings stress the importance of providing opportunities for home-visit instructors to develop leadership, thus improving job involvement.

Diagnostic Significance of Combined Detection of Epstein-Barr Virus Antibodies, VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA for Nasopharyngeal Carcinoma

  • Cai, Yong-Lin;Li, Jun;Lu, Ai-Ying;Zheng, Yu-Ming;Zhong, Wei-Ming;Wang, Wei;Gao, Jian-Quan;Zeng, Hong;Cheng, Ji-Ru;Tang, Min-Zhong
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.5
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    • pp.2001-2006
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    • 2014
  • The objective of this study was to investigate the diagnostic significance of EBV antibody combined detection for nasopharyngeal carcinoma (NPC) in a high incidence region of southern China. Two hundred and eleven untreated NPC patients, 203 non-NPC ENT patients, and 210 healthy controls were recruited for the study. The titers of VCA/IgA and EA/IgA were assessed by immunoenzyme assay, and the levels of Rta/IgG and EBNA1/IgA were determined by enzyme-linked immunosorbent assay. The levels of VCA/IgA, EA/IgA, Rta/IgG and EBNA1/IgA demonstrated no association with gender or age (p>0.05). The receiver operating characteristic curve and the area under the curve were used to evaluate the diagnostic value. The sensitivity of VCA/IgA (98.1%) and the specificity of EA/IgA (98.5%) were the highest. When a logistic regression model was used to combine the results from multiple antibodies to increase the accuracy, the combination of VCA/IgA+Rta/IgG, whose area under the curve was 0.99, had the highest diagnostic efficiency, and its sensitivity, specificity and Youden index were 94.8%, 98.0% and 0.93 respectively. The data suggest that the combination of VCA/IgA+Rta/IgG may be most suitable for NPC serodiagnosis.