• The Journal of the Korea Contents Association
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• v.21 no.12
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• pp.559-572
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• 2021

The purpose of this study is to examine whether multicultural youth's participation in activities affects academic performance, verify whether achievement motivation and social relations have multiple mediating effects, and analyze whether there are differences between male and female groups. To this end, a total of 1,635 high school sophomores were analyzed in the 8th year (2018) of the Multicultural Youth Panel Survey. As a result of the analysis, first, it was confirmed that the influence of multicultural youth's participation in youth activities on academic performance was partially mediated by achievement motivation and social relations. Second, for all multicultural adolescents, 'achievement motivation' was found to have a significant effect on academic performance, and this route was found to be male students is a female student. It was found to be more positive than 001), and the difference between groups was statistically significant. Therefore, it is necessary to expand opportunities to participate in youth activities for multicultural youth and to prepare creative activity spaces and content support policies.

• Journal of Veterinary Science
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• v.24 no.1
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• pp.2.1-2.14
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• 2023

Background: Hypothermia is a crucial environmental factor that elevates the risk of cardiovascular disease, but the underlying effect is unclear. Objectives: This study examined the role of cold stress (CS) in cardiac injury and its underlying mechanisms. Methods: In this study, a chronic CS-induced myocardial injury model was used; mice were subjected to chronic CS (4℃) for three hours per day for three weeks. Results: CS could result in myocardial injury by inducing the levels of heat shock proteins 70 (HSP70), enhancing the generation of creatine phosphokinase-isoenzyme (CKMB) and malondialdehyde (MDA), increasing the contents of tumor necrosis factor-α (TNF-α), high mobility group box 1 (HMGB1) interleukin1b (IL-1β), IL-18, IL-6, and triggering the depletion of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Multiple signaling pathways were activated by cold exposure, including pyroptosis-associated NOD-like receptor 3 (NLRP3)-regulated caspase-1-dependent/Gasdermin D (GSDMD), inflammation-related toll-like receptor 4 (TLR4)/myeloid differentiation factor 88 (MyD88)-mediated nuclear factor kappa B (NF-κB), and mitogen-activated protein kinase (MAPK), as well as oxidative stressinvolved thioredoxin-1/thioredoxin-interacting protein (Txnip) signaling pathways, which play a pivotal role in myocardial injury resulting from hypothermia. Conclusions: These findings provide new insights into the increased risk of cardiovascular disease at extremely low temperatures.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.1
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• pp.55-65
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• 2017

This study was conducted to investigate the mediating effects of coping on the impact of life stress on depression, subjective well-being and psychological well-being in nursing students. Self-report questionnaires were used to collect data from 147 nursing students. Data were analyzed using descriptive statistics, Pearson's correlation coefficient and hierarchical multiple regression. Nursing students who had a higher level of depression had a higher level of life stress, as well as a higher frequency of avoidance coping. Conversely, those who had a higher level of subjective well-being and psychological well-being had a lower level of life stress, as well as a lower frequency of avoidance coping. There were also significant positive correlations between psychological well-being and problem solving coping. The results showed that avoidance coping partially mediated the effects of life stress on depression, subjective well-being and psychological well-being. The results suggest that it is necessary to offer stress management programs to reduce avoidance coping, with additional consideration of life stress and coping strategies, to prevent depression and improve well-being among nursing students.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.5
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• pp.1106-1115
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• 2009

Mori Ramulus has multiple applications in Korean traditional medicine prescription because it has antioxidant and anti-inflammatory effects by reducing macrophage activities. Yet, no studies on the anti-arthritic activity of EMR (extract of Mori Ramulus) have been reported in vitro and in vivo. Rheumatoid arthritis (RA) is a systemic autoimmune disease with chronic inflammation characterized by hyperplasia of synovial cells in affected joints, which ultimately leads to the destruction of cartilage and bone. Because collagen-induced arthritis (CIA) is similar to RA in pathological symptoms and immune reactions, there have been several reports concerning RA using CIA mouse model. Here, we investigated the effects of Mori Ramulus on RA using CIA mice. The importance of CD4+ Th1 cells in RA progress was previously indicated and studies further showed that Th17 cells play a prime role in severity of disease. Accordingly, the present study was focused on CIA associated with CD4+ Th1 cells and Th1 7 cells. DBA/1OlaHsd mice were immunized with bovine type II collagen (CII). After a second collagen immunization, mice were treated with EMR once a day for 4 weeks. The severity of arthritis within the paw joints was evaluated by histological assessment of cartilage destruction and pannus formation. Immune cells in peripheral blood mononuclear cells (PBMC), draining lymph node (DLN) and paw joints, cytokine production and gene expression were assessed from CIA mouse using ELISA, FACS and real-time PCR analysis. Administration of EMR significantly suppressed the progression of CIA and inhibited the production of TNF-$\alpha$, IL-6 and IL-17 in the serum. The erosion of cartilage was dramatically reduced in mouse knees after treatment with EMR. In conclusion, our results demonstrate that EMR significantly suppressed the progression of CIA and that this action was mediated by the decreased production of TNF-$\alpha$, IL-6, IL-17 and collagen II-specific antibody in the serum. EMR suppressed Th17 cells and reduced level of IL-6 via B cell suppression, and thus, the levels of autoantibodies produced from B cells were decreased. Furthermore, EMR suppressed NKT cells which directly stimulate B cells and develop imbalance of Th1/Th2 cell. Oral administration of EMR (100 mg/kg or 200 mg/kg) significantly suppressed the progression of CIA, which is comparable to that of methotrexate (MTX, 0.3 mg/kg) used as a positive control. We are currently studying the mechanism underlying the therapeutic role for EMR in CIA mice.

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.14 no.4
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• pp.91-100
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• 2019

Many university students try to start up a lot because of career uncertainty, and this study reflected this environmental situation. The subject of the study is the degree to which subjective norms of university students affect the start-up intention. In addition, we looked at the mediated effects of self-efficiency and the moderated effects of security competence. To verify the hypothesis of the study, 201 university students in Seoul were asked about the relevant variables. And based on prior theory, hypotheses and questionnaires were made. In addition, the validity, reliability and correlation analysis of each variable were conducted. Multiple regression analysis was used for hypothesis analysis. As a result, subjective norms have a positive effect on the start-up intention. Next, self-efficiency was found to be mediating the relationship between subjective norms and start-up intentions. Finally, when subjective norms affect the start-up intention, security competence showed negative moderate effect. The implications of this study are as follows: First, a positive perception of start-up by those around them is needed when it comes to raising the intention of starting a business. This positive perception also affects the confidence and sense of challenge in start-up and affects their start-up intention. However, if career anchor prefer stable employment for the organization, it can be seen that they negatively affect the start-up intention.

• Management & Information Systems Review
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• v.38 no.3
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• pp.171-186
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• 2019

The purpose of this study is to identify the effects of entrepreneurship on entrepreneurial efficacy and entrepreneurial intention, and to provide implications for analyzing mediating effects of career decision self-efficacy in bilateral relations. The data were collected from entrepreneurship, entrepreneurship students, and, and 220 students were surveyed. For the empirical analysis, frequency analysis, factor analysis, reliability verification, correlation analysis, and multiple regression analysis were performed using SPSSWIN 21.0. The specific analysis results are as follows. First, in the relationship between entrepreneurship and career decision-making self-efficacy, entrepreneurship has a significant effect on career decision-making self-efficacy. Second, in the relationship between entrepreneurship, entrepreneurship efficacy, and intention of entrepreneurship, entrepreneurship has significant influence on entrepreneurship efficacy and entrepreneurship intention. Third, the mediating effect analysis of career decision self-efficacy in the relationship between entrepreneurship, entrepreneurial efficacy, and entrepreneurship intention showed that all mediated effects were significant. The results of this study should be achieved through a convergence curriculum in which entrepreneurship education and career education can be considered at the entrepreneurial education stage in order to enhance entrepreneurship and intention to influence entrepreneurship and career choice. Practical implications were suggested for more effective education.

• Journal of Convergence for Information Technology
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• v.11 no.2
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• pp.138-145
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• 2021

The purpose of this study was to investigate the mediating effects of academic procrastination behavior on the relationship between academic stress and dropout intention. The research questions are First, does the academic stress of college students influence the intention to drop out? Second, does academic procrastination behavior the relationship between academic stress and dropout intention? A survey was conducted on 218 college students about academic stress, dropout intention, and academic procrastination behavior. Correlation analysis was conducted to find out the relationship between academic stress, dropout, and academic procrastination behavior, and Multiple regression analysis was performed to determine the moderating effect of academic procrastination behavior. The mediating effect was verified using Baron and Kenny's procedure, and the significance was verified by Sobel verification. The results are as follows: First, academic stress, dropout intention, and academic delay behavior showed significant positive correlations.. Second, Academic stress showed 15% of explanatory power as an influential factor on dropout intention, and 5% of explanatory power was an influential factor on academic procrastination behavior. Third, the through mediation analysis, there was partial mediated effects of academic procrastination behavior between academic stress and dropout intention. Our findings suggest that to improve the dropout intention among college students, educators should carefully design and develop an education program

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.454-460
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• 2021

This study focused on the sex culture and the sexual rights of women, examining the gender-role stereotype that is related to the protection of the sexual rights of female college students and identifying the influence of self- esteem. The research was conducted on gender-role stereotypes, sexual assertiveness, and self-esteem among female university students attending four-year universities in Seoul and Gyeonggi. Four hundred eighty-two copies were used for analysis. The Pearson's correlation coefficient was used to identify the correlation between the variables. Multiple regression analysis was conducted to identify the mediated effects of self-esteem in the effects of gender-role stereotypes on sexual assertiveness. The Sobel test was conducted to confirm that the effects were statistically significant. The results of this study were as follows. First, the gender-role stereotype had negative correlations with self-esteem and sexual assertiveness. Self-esteem had positive correlations with sexual assertiveness. Second, self-esteem was found to be a partial mediating factor when the gender-role stereotype had a statistically significant effect on sexual assertiveness. Therefore, a coping strategy under the influence of the gender-role stereotype is necessary for improving the sexual assertiveness skill of female students. This study also suggests the need for sex role-related education programs or counseling on self-esteem.

• The Journal of the Korea Contents Association
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• v.17 no.10
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• pp.206-215
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• 2017

The Purpose of this study was to investigate of coping strategies(active and passive) between pain beliefs and depression, pain disability among chronic back pain patients. Data were analyzed by the SPSS-WIN 21.0 program. Indirect SPSS macro(Bootsrapping)was used to analyze the multiple-mediation model of this study. The result showed that the mean score for pain belief was $3.42{\pm}9.67$, and he passive coping strategies was $29.68{\pm}8.04$, active coping was $25.49{\pm}4.22$. The mean score of depression was $25.49{\pm}11.56$. The pain disability index was $46.94{\pm}12.65$. It found that there were significant correlations among the 5 variables. The multiple mediated effects of passive coping and active coping on pain beliefs and depression were (b=.453, 95% CI=.228, .703) and on pain beliefs and pain disability were (b = .285, 95% CI = .131, .519) in chronic low back pain patients. This study discovered that the active coping strategies had a positive mediating effect in the relationship between pain beliefs and depression, pain beliefs and pain disability. And passive coping strategies had a negative mediating effect. Based on findings of this study, improving the active coping strategy programs or management is highly recommended in chronic back pain patients.

• Biomolecules & Therapeutics
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• v.23 no.3
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• pp.218-224
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• 2015

Endocannabinoids can affect multiple cellular targets, such as cannabinoid (CB) receptors, transient receptor potential cation channel, subfamily V, member 1 (TRPV1) and peroxisome proliferator-activated receptor ${\gamma}$($PPAR{\gamma}$). The stimuli to induce adipocyte differentiation in hBM-MSCs increase the gene transcription of the $CB_1$ receptor, TRPV1 and $PPAR{\gamma}$. In this study, the effects of three endocannabinoids, N-arachidonoyl ethanolamine (AEA), N-arachidonoyl dopamine (NADA) and 2-arachidonoyl glycerol (2-AG), on adipogenesis in hBM-MSCs were evaluated. The adipocyte differentiation was promoted by AEA whereas inhibited by NADA. No change was observed by the treatment of non-cytotoxic concentrations of 2-AG. The difference between AEA and NADA in the regulation of adipogenesis is associated with their effects on $PPAR{\gamma}$ transactivation. AEA can directly activate $PPAR{\gamma}$. The effect of AEA on $PPAR{\gamma}$ in hBM-MSCs may prevail over that on the $CB_1$ receptor mediated signal transduction, giving rise to the AEA-induced promotion of adipogenesis. In contrast, NADA had no effect on the $PPAR{\gamma}$ activity in the $PPAR{\gamma}$ transactivation assay. The inhibitory effect of NADA on adipogenesis in hBM-MSCs was reversed not by capsazepine, a TRPV1 antagonist, but by rimonabant, a $CB_1$ antagonist/inverse agonist. Rimonabant by itself promoted adipogenesis in hBM-MSCs, which may be interpreted as the result of the inverse agonism of the $CB_1$ receptor. This result suggests that the constantly active $CB_1$ receptor may contribute to suppress the adipocyte differentiation of hBM-MSCs. Therefore, the selective $CB_1$ agonists that are unable to affect cellular $PPAR{\gamma}$ activity inhibit adipogenesis in hBM-MSCs.