• Journal of Pharmacopuncture
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• v.18 no.3
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• pp.11-18
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• 2015

Objectives: Systems biology is a novel subject in the field of life science that aims at a systems' level understanding of biological systems. Because of the significant progress in high-throughput technologies and molecular biology, systems biology occupies an important place in research during the post-genome era. Methods: The characteristics of systems biology and its applicability to traditional medicine research have been discussed from three points of view: data and databases, network analysis and inference, and modeling and systems prediction. Results: The existing databases are mostly associated with medicinal herbs and their activities, but new databases reflecting clinical situations and platforms to extract, visualize and analyze data easily need to be constructed. Network pharmacology is a key element of systems biology, so addressing the multi-component, multi-target aspect of pharmacology is important. Studies of network pharmacology highlight the drug target network and network target. Mathematical modeling and simulation are just in their infancy, but mathematical modeling of dynamic biological processes is a central aspect of systems biology. Computational simulations allow structured systems and their functional properties to be understood and the effects of herbal medicines in clinical situations to be predicted. Conclusion: Systems biology based on a holistic approach is a pivotal research methodology for understanding the mechanisms of traditional medicine. If systems biology is to be incorporated into traditional medicine, computational technologies and holistic insights need to be integrated.

• Journal of the Institute of Electronics and Information Engineers
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• v.53 no.9
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• pp.12-17
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• 2016

In the holographic data storage system (HDSS), the data regarding the volume of a storage medium are recorded and read by the page, and the transmission rate and storage capacity can be increased because of two-dimensional, page-oriented data processing; furthermore, the multi-level HDSS can store more than one bit per pixel. For this same reason, however, and unlike conventional data-storage systems, the HDSS is hampered by two-dimensional (2D) intersymbol interference (ISI) and interpage interference (IPI). Progress regarding the published papers on 2D ISI, which is more severe in the multi-level HDSS, continues; however, mitigation of both 2D ISI and IPI in terms of the multi-level HDSS has not yet been studied. In this paper, we therefore propose a 4-level balanced-modulation code that simultaneously mitigates 2D ISI and IPI.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.4
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• pp.181-186
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• 2013

The construction costs for nonstructural systems such as mechanical/electrical equipment, ceiling system, and piping system occupy a significant proportion of the total cost. These nonstructural systems can also cause considerable economic losses and loss of life during and after an earthquake. Therefore, reduction of seismic risk of nonstructural components has been emerging as a key aspect of research in recent year. The primary objective of this study was to evaluate the seismic performance of a single-story and multi-story piping system installed in low-rise building and to identify the seismic vulnerability of the current piping systems. The seismic performance evaluation of the piping systems was conducted with 5 different earthquakes to account for the ground motion uncertainty and the preliminary results demonstrated that the maximum displacements of each floor in the multi-story piping system increased linearly with increasing floor level in the building system. This study revealed that the current design piping systems are significantly sensitive to the effect of floor height, which stress the necessity to improve the seismic performance of the current piping systems by, for example, strengthening with seismic sway bracing using transverse/longitudinal bracing cables or hangers.

• Journal of Korea Society of Industrial Information Systems
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• v.25 no.4
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• pp.39-47
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• 2020

We propose a multi-access points transmit power control algorithm in consideration of the channel estimation error and the multi-rate service. In the real communication systems, the channel estimation at the receiver side is imperfect due to limited number of pilot symbol usage. Furthermore, the multi-rate service is supported. We theoretically prove the uniqueness and the convergence of the proposed algorithm in multi-rate service environment. The proposed algorithm composes of one inner loop part and one outer loop part. Simulation results show that 1) the inner loop algorithm guarantees convergence of the transmit power level and the multi-rate service, 2) the outer loop algorithm compensates for the channel estimation error.

• Ocean Systems Engineering
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• v.2 no.1
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• pp.1-16
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• 2012

Offshore wind turbines are complex structural and mechanical systems located in a highly demanding environment. This paper proposes a multi-level system approach for studying the structural behavior of the support structure of an offshore wind turbine. In accordance with this approach, a proper numerical modeling requires the adoption of a suitable technique in order to organize the qualitative and quantitative assessment in various sub-problems, which can be solved by means of sub-models at different levels of detail, both for the structural behavior and for the simulation of loads. Consequently, in a first place, the effects on the structural response induced by the uncertainty of the parameters used to describe the environmental actions and the finite element model of the structure are inquired. After that, a meso-level FEM model of the blade is adopted in order to obtain the detailed load stress on the blade/hub connection.

• Journal of Korea Technology Innovation Society
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• v.16 no.1
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• pp.156-175
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• 2013

This study examines the approach of socio-technical systems and strategic niche management. It reviews the characteristics of that approach such as multi-level perspectives, the views on technology, and policy orientation. It applies the approach to the long-term vision making in science and technological innovation, socio-technical planning, participatory R&D, and science communication in Innovation policy areas and suggests some policy implications.

• International Journal of Fuzzy Logic and Intelligent Systems
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• v.5 no.2
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• pp.108-113
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• 2005

This paper suggests a control method for an efficient topology/parameter evolution in a bond graph-based GP design framework that automatically synthesizes designs for multi-domain, lumped parameter dynamic systems. We adopt a hierarchical breeding control mechanism with fitness-level-dependent differences to obtain better balancing of topology/parameter search - biased toward topological changes at low fitness levels, and toward parameter changes at high fitness levels. As a testbed for this approach in bond graph synthesis, an eigenvalue assignment problem, which is to find bond graph models exhibiting minimal distance errors from target sets of eigenvalues, was tested and showed improved performance for various sets of eigenvalues.

• Journal of Information Processing Systems
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• v.18 no.1
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• pp.159-172
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• 2022

The role of the interconnect network, which connects computing nodes to each other, is important in high-performance computing (HPC) systems. In recent years, the peripheral component interconnect express (PCIe) has become a promising interface as an interconnection network for high-performance and cost-effective HPC systems having the features of non-transparent bridge (NTB) technologies. OpenSHMEM is a programming model for distributed shared memory that supports a partitioned global address space (PGAS). Currently, little work has been done to develop the OpenSHMEM library for PCIe-interconnected HPC systems. This paper introduces a prototype implementation of the OpenSHMEM library through a switchless interconnect network using PCIe NTB to provide a PGAS programming model. In particular, multi-interrupt, multi-thread-based data transfer over the OpenSHMEM shared memory model is applied at the implementation level to reduce the latency and increase the throughput of the switchless ring network system. The implemented OpenSHMEM programming model over the PCIe NTB switchless interconnection network provides a feasible, cost-effective HPC system with a PGAS programming model.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.334-340
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• 2017

Reliability is considered a particularly important design factor for systems that have critical results once a failure occurs in a system, such as trains, airplanes, and passenger ships. The reliability of the system can be improved in several ways, but in a system that requires considerable reliability, the redundancy of parts is efficient in improving the system reliability. In the case of duplicating parts to improve reliability, the kind of parts and the number of duplicating parts should be determined under the system reliability, part costs, and resources. This study examined the redundancy allocation of multi-level systems with serial structures. This paper describes the definition of a multi-system and how to optimize the kind of parts and number of duplications to maximize the system reliability. To optimize the redundancy, the cuckoo search algorithm was applied. The search procedure, the solution representation and the development of the neighborhood solution were proposed to optimize the redundancy allocation of a multi-level system. The results of numerical experiments were compared with the genetic algorithm and cuckoo search algorithm.

• The Journal of Fisheries Business Administration
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• v.30 no.2
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• pp.25-37
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• 1999

Some multi echelon inventory systems carry perishable products. The value of these product reduces as the period of time they spend in the system. In this paper We derive the necessary condition to determine optimal quantity, service level for a perishable product. The systems considered consist of two echelons and carry single item. To determine the optimal order quantity, the demand is assumed to be constant, the holding costs may be different in the echelons, and it allows no shortages. I assumed the price of product decreases by negative exponential function. To determine service level, following assumptions used in the model ㆍlead time is constant. ㆍdemand is normal distribution. ㆍthe product starts to perish at the second echelon. Service level is computed for different levels of lead times and for different variance of demands and for different price functions. The experimental results indicate that the service level in cost is a function of service level in demand and perishability of product. Results of the models exhibit that perishability and the age of the product are critical to determine the lot sizing and service level.