• Mass Spectrometry Letters
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• v.2 no.4
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• pp.92-95
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• 2011

Pyrophosphates are the key intermediates in the biosynthesis of isoprenoids, and their concentrations could reveal the benefits of statins in cardiovascular diseases. Quantitative analysis of five pyrophosphates, including isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), geranyl pyrophosphate (GPP), farnesyl pyrophosphate (FPP), and geranylgeranyl pyrophosphate (GGPP), was performed using liquid chromatography-tandem mass spectrometry (LC-MS/MS) in negative ionization mode. After dilution with methanol, samples were separated on a 3 ${\mu}m$ particle multi-modal $C_{18}$ column ($50{\times}2$ mm) and quantified within 10 min. The gradient elution consists of 10 mM ammonium bicarbonate and 0.5% triethylamine (TEA) in water and 0.1% TEA in 80% acetonitrile was used at the flow rate of 0.4 mL/min. Overall recoveries were 51.4-106.6%, while the limit of quantification was 0.05 ${\mu}g$/mL for GPP and FPP and 0.1 ${\mu}g$/mL for IPP, DMAPP, and GGPP. The precision (% CV) and accuracy (% bias) of the assay were 1.9-12.3% and 89.6-111.8%, respectively, in 0.05-10 ${\mu}g$/mL calibration ranges ($R^2$ > 0.993). The devised LC-MS/MS technique with the multi-modal $C_{18}$ column can be used to estimate the biological activity of pyrophosphates in plasma and may be applicable to cardiovascular events with cholesterol metabolism as well as the drug efficacy of statins.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2002.03a
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• pp.211-219
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• 2002

This study is performed to investigate the behavior of multi-column piers and to evaluate the seismic performance. In this study, 3 types of scale model piers with 2-column are designed and tested by quasi-static load in both longitudinal and transverse directions. Each type of model consisting of 2 specimens has different reinforcement details in the lap splice of longitudinal bars and amount of transverse reinforcements. This paper reports that the ductility of the model in transverse direction is rather higher than in longitudinal direction because of formation of several plastic hinges and that the ultimate displacement and the energy absorbtion capacity are enhanced by using continuous longitudinal bars instead of lap-splice ones. And it is confirmed that relatively large amount of ductility can be achieved by providing sufficient lap-splice length and transverse reinforcements with end hook even if longitudinal bars are lap spliced in the base of pier.

• Journal of the Semiconductor & Display Technology
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• v.8 no.4
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• pp.43-48
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• 2009

The aim of this paper is to describe the development of the electron-beam optic analysis algorithm for simulating the e-beam behavior concerned with electrostatic lenses and their focal properties in the micro-column of the multi-beam lithography system. The electrostatic lens consists of an array of electrodes held at different potentials. The electrostatic lens, the so-called einzel lens, which is composed of three electrodes, is used to focus the electron beam by adjusting the voltages of the electrodes. The optics of an electron beam penetrating a region of an electric field is similar to the situation in light optics. The electron is accelerated or decelerated, and the trajectory depends on the angle of incidence with respect to the equi-potential surfaces of the field. The performance parameters, such as the working distances and the beam diameters are obtained by the computational simulations as a function of the focusing voltages of the einzel lens electrodes. Based on the developed simulation algorithm, the high performance of the micro-column can be achieved through optimized control of the einzel lens.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2011.05b
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• pp.85-88
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• 2011

MRS(Multi Ribbed Slab) method was developed to accomodate Korean construction practice and needs of Korean customer. By means of 4story-1piece column and MRS method, we achieved construction cost cut down and reduction of construction period.

• Journal of the Earthquake Engineering Society of Korea
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• v.9 no.5 s.45
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• pp.53-61
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• 2005

In order to evaluate the limit earthquake resistance of multi-story steel frames influenced by the strength and stiffness ratios of members, a series inelastic response analysis were carried out. From the analysis results, the damage distribution rules of multi-story steel frames were proposed. Conclusions are summarized as follows; 1)As the stiffness ratios of beam and column becomes small, the damage concentrates on the lower end of columns of the first story. 2) Considering the strength and stiffness ratios of the beam and column with weak beam type mechanism, the equations predicting the damage distribution of multi-story steel flames were proposed. 3) Through the equation which was supposed in this study, it is speculated that the damage distribution of the rigid or semirigid beam collapse type multi-story steel structure building can be predicted.

• Journal of KIBIM
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• v.3 no.3
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• pp.19-28
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• 2013

In Korea highway bridges, most piers are the type of one-column or multi-column ones. So, in this study, under an environment applying BIM so fast, to activate researches on two-column piers subjected to bidirectional seismic loading, a 3D parametric modeling method was selected when the model of two-column piers and one-column piers were formed. Also, interface module between input data in structural analysis and 3D model of RC pier was developed. The module can create the input data for non-linear structural analysis like material, geometric properties and additional coefficients.

• International Journal of Safety
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• v.3 no.1
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• pp.15-19
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• 2004

A new tower internal, which is called CSE, is presented. The CSE is composed of a nozzle perforated in its bottom along the entire periphery and equipped with a multi vane axial swirler at the inlet and hollow cylindrical separator at the outlet of the nozzle. According to the experimental work for obtaining the necessary hydraulic information of the CSE, which is used for preliminary design of a separation column, the CSE showed a stable operation over the wide rage of gas/liquid ratio. However, it caused large pressure drop due to the high gas velocity which should carry liquid droplets through the element. The high pressure drop may cause problems in energy recovery and the application of the CSE can be limited to the high pressure columns. Assuming that the tray efficiency of the CSE is the same with the existing separation columns, the results of the column design showed the size reduction of the column diameters by 30 to $40\%$ and investment cost saving, depending on operating conditions. The application of the CSE to separation column may also contribute to the de-bottlenecking the existing column.

• Journal of the Korean Institute of Intelligent Systems
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• v.18 no.5
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• pp.611-616
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• 2008

Error correcting codes (ECCs) are commonly used to protect against the soft errors. Single error correcting and double error detecting (SEC-DED) codes are generally used for this purpose. The proposed approach in this paper selectively reduced power consumption, delay, and area in single-error correcting, double error-detecting checker circuits that perform memory error correction. The multi-objective genetic algorithm is employed to solve the non -linear optimization problem. The proposed method allows that user can choose one of different non-dominated solutions depending on which consideration is important among them. Because we use multi-objective genetic algorithm, we can find various dominated solutions. Therefore, we can choose the ECC according to the important factor of the power, delay and area. The method is applied to odd-column weight Hsiao code which is well- known ECC code and experiments were performed to show the performance of the proposed method.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.1243-1249
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• 2010

Ground anchors can be good solution in large and deep excavation. Anchored supports generally provide larger workspace than strut supports and good performances. The major benefit provided by these anchored systems was the open excavation area created by eliminating horizontal or raked struts, which generally inhibit rapid construction within the site area. In loose soils, however, anchors are sometimes hard to get high pullout anchor capacity, so that the spacing of anchor both horizontally and vertically is frequently controlled, in which the construction costs of anchors are increased. In order to increase anchor capacity, therefore, conceptual introduction of the multi-strand anchor is presented in this paper. Also, this study shows an numerical study of predicting the load transfer of the multi-strand anchor and a beam-column analysis was performed by a Elastic-Plastic beam theory.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.11a
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• pp.261-264
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• 2008

Recently, as necessity for urban recycling has increased, the research on integrated multi-purpose space has been required. Development of the system for integrated multi-purpose space is needed to form the efficient and higher value-added space. In this research, the notion of integrated multi-purpose space is defined and two proposed structural system, which are space truss and mega structure system, are compared. Mega structure system has been found as more proper system and proposed for analysis. As verified by the number of mega beam and shape of mega column, the analysis has been carried out. The results show that mega structure system offers proper performance for integrated multi-purpose space.