• Genomics & Informatics
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• v.20 no.1
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• pp.2.1-2.11
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• 2022

The method of single-cell RNA sequencing has been rapidly developed, and numerous experiments have been conducted over the past decade. Their results allow us to recognize various subpopulations and rare cell states in tissues, tumors, and immune systems that are previously unidentified, and guide us to understand fundamental biological processes that determine cell identity based on single-cell gene expression profiles. However, it is still challenging to understand the principle of comprehensive gene regulation that determines the cell fate only with transcriptome, a consequential output of the gene expression program. To elucidate the mechanisms related to the origin and maintenance of comprehensive single-cell transcriptome, we require a corresponding single-cell epigenome, which is a differentiated information of each cell with an identical genome. This review deals with the current development of single-cell epigenomic library construction methods, including multi-omics tools with crucial factors and additional requirements in the future focusing on DNA methylation, chromatin accessibility, and histone post-translational modifications. The study of cellular differentiation and the disease occurrence at a single-cell level has taken the first step with single-cell transcriptome and is now taking the next step with single-cell epigenome.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2004.11a
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• pp.53-56
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• 2004

This paper presents the improved burn-in method for the reliability of SRAM in MCP Semiconductor reliability is commonly improved through the burn-in process. Reliability problem is more significant in the Multi Chip Package, because of including over two devices in a package. In the SRAM-based Multi Chip Package, the failure of SRAM has a large effect on the yield and quality of the other chips - Flash Memory, DRAM, etc. So, the quality of SRAM must be guaranteed. To improve the quality of SRAM, we applied the improved wafer level burn-in process using multi cell selection method in addition to the current used methods. That method is effective in detecting special failure. Finally, with the composition of some kinds of methods, we could achieve the high qualify of SRAM in Multi Chip Package.

• 한국전산유체공학회:학술대회논문집
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• 2008.03a
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• pp.378-385
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• 2008

The present paper deals with the accurate and robust limiting procedure for the multi-dimensional flow analysis on unstructured meshes. The multi-dimensional limiting process (MLP) which was successfully proposed on structured grid system is extended to unstructured meshes. Based on MUSCL-type framework on unstructured meshes, the new slope limiter is devised to satisfy the MLP condition, which is quite effective to regulate the unwanted oscillations, especially on multiple dimensions. Considering the neighborhood based on the vertex of the cell, as well as the edge, this limiting strategy captures the multi-dimensional flow features very accurately with the proper stencils. From the various numerical results, these desirable characteristics of the proposed limiting strategy are clearly shown.

• 한국전산유체공학회:학술대회논문집
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• 2008.10a
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• pp.378-385
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• 2008

The present paper deals with the accurate and robust limiting procedure for the multi-dimensional flow analysis on unstructured meshes. The multi-dimensional limiting process (MLP) which was successfully proposed on structured grid system is extended to unstructured meshes. Based on MUSCL-type framework on unstructured meshes, the new slope limiter is devised to satisfy the MLP condition, which is quite effective to regulate the unwanted oscillations, especially on multiple dimensions. Considering the neighborhood based on the vertex of the cell, as well as the edge, this limiting strategy captures the multi-dimensional flow features very accurately with the proper stencils. From the various numerical results, these desirable characteristics of the proposed limiting strategy are clearly shown.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1997.10a
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• pp.1061-1064
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• 1997

Micro injection molding technology is very important fiw mass product of micro structures or micro parts. And, it is so difficult that the molding technology of micro pole or thin wall(barrier rib) structures with high aspect ratio. In this stud). \vc intend to research on the basic technology of micro wall structure part:< with high aspect ratio by the inject~on moldins method. The mold for esperimenrs with micro multi-square structures was made by L, I(;A process. One square polc's size is 157 157pm. height 50011111. And the distance of each poles is 5011n1. 7'hus. molding products will be for~nctl like as the net structure with thin wall of about 50pn thickness.(aspect ratio 10) Ihrough the e~lxriment. \be obtained the prociuctr of micro multi-square slructure with bout 37.000 cell per a piece. 'Ihe micro injection molding process technolog for thin wall by multi-square structure mold was analy~cd.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.18 no.6
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• pp.506-509
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• 2005

This paper presents the improved burn-in method for the reliability of SRAM in Multi Chip Package (MCP). Semiconductor reliability is commonly improved by the burn-in process. Reliability Problem is very significant in the MCP which includes over two chips in a package because the failure of one SRAM chip has a large influence on the yield and quality of the other chips such as Flash Memory, DRAM, etc. Therefore the quality of SRAM must be guaranteed. To improve the qualify of SRAM, we applied the improved wafer level burn-in process using multi cell selection method in addition to the previously used methods and it is found to be effective in detecting particular failures. Finally, with the composition of some kinds of methods, we achieved the high quality of SRAM in MCP.

• Journal of Korean Tunnelling and Underground Space Association
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• v.17 no.3
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• pp.295-303
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• 2015

This paper presents the study of leakage effect due to multi-cell inflater of rapid protection system to protect the possibilities of tunnel damages by flooding threats and unusual leakage to be occurred during and after subsea tunnel construction. Particularly, this protect system should be necessary in subsea tunnel. This research concentrates the physical model tests due to several multi-cell inflater to study protection capacity of leakage between the inflater and tunnel liner. A 27:1 small scale model are used in the model tests. The leakage rate, water pressure and axial displacement of inflater are measured during the model tests. According to the results, the minium leakage rate clearly shows in the case of two-cell inflater compared with in other cases. It is concluded that the results of this research will be very useful to understand the fundamental information of inflater structure design and development the technology of tunnel protection structures in the future.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.10
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• pp.2113-2120
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• 2011

In this paper, so as to improve spectral efficiency for cell-boundary users, we introduce a coordinated multi-point (CoMP) system, which is one of inter-cell cooperative transmission strategies studied in 3GPP long-term evolution-advanced (LTE-A) systems, and develop a system-level simulator to evaluate performance. To identify performance improvement of the system with inter-cell cooperative transmission, we select a 3GPP LTE system as a reference, which shows the highest performance among the existing mobile communication systems, and conduct a performance comparison. System-level simulation is performed based on widely-used OPNET tool. We implement modules including central unit (CU), CoMP eNodeB (CeNB), user equipment (UE), and multiple-input multiple-output (MIMO) channel model, while designing the inter-cell cooperative transmission system. Under WINNER wireless channel model and international telecommunication union (ITU) network model environments, we then evaluate the performance of edge users who belong to the lower 5% in terms of spectral efficiency. It is finally shown that throughput of the proposed CoMP system gets improved up to 2.5 times compared to that of the 3GPP LTE reference system.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.10
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• pp.4703-4723
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• 2018

In recent years, dense small cell network has been deployed to address the challenge that has resulted from the unprecendented growth of mobile data traffic and users. It has proven to be a cost efficeient solution to offload traffic from macro-cells. Software defined heterogeneous wireless network can decouple the control plane from the data plane. The control signal goes through the macro-cell while the data traffic can be offloaded by small cells. In this paper, we propose a framework for cell virtualization and user association in order to satisfy versatile requirements of multiple tenants. In the proposed framework, we propose an interference graph partioning based virtual-cell association and customized physical-cell association for multi-homed users in a software defined small cell network. The proposed user association scheme includes 3 steps: initialization, virtual-cell association and physical-cell association. Simulation results show that the proposed virtual-cell association outperforms the other schemes. For physical-cell association, the results on resource utilization and user fairness are examined for mobile users and infrastructure providers.

• Molecules and Cells
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• v.44 no.3
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• pp.127-135
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• 2021

Since the introduction of RNA sequencing (RNA-seq) as a high-throughput mRNA expression analysis tool, this procedure has been increasingly implemented to identify cell-level transcriptome changes in a myriad of model systems. However, early methods processed cell samples in bulk, and therefore the unique transcriptomic patterns of individual cells would be lost due to data averaging. Nonetheless, the recent and continuous development of new single-cell RNA sequencing (scRNA-seq) toolkits has enabled researchers to compare transcriptomes at a single-cell resolution, thus facilitating the analysis of individual cellular features and a deeper understanding of cellular functions. Nonetheless, the rapid evolution of high throughput single-cell "omics" tools has created the need for effective hypothesis verification strategies. Particularly, this issue could be addressed by coupling cell engineering techniques with single-cell sequencing. This approach has been successfully employed to gain further insights into disease pathogenesis and the dynamics of differentiation trajectories. Therefore, this review will discuss the current status of cell engineering toolkits and their contributions to single-cell and genome-wide data collection and analyses.