• 한국반도체및디스플레이장비학회:학술대회논문집
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• 한국반도체및디스플레이장비학회 2004년도 International Symposium
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• pp.1-15
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• 2004

o Various microfluidic components including mixromixers and micropumps have been developed for disposable biochip applications. o Single cell capturing, positioning and nanoliter drug injection chip has been demostrated. o Multi-channel, two-dimensional micro-well array has been fabricated and cell capturing and specific reagent injection have been performed.

• 대한전자공학회논문지SD
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• 제47권12호
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• pp.8-16
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• 2010

NAND Multi-level cell Flash memory는 한 셀에 여러 bit의 정보를 저장하는 방법으로, 용량 집적도를 더욱 높일수 있는 기술로 각광 받고 있다. 하지만 한 셀당 레벨 수를 올릴 경우, 셀간 간섭 등 여러 물리적 이유들로 인해 오류가 발생하며, 이 주된 오류 방향은 unidirectional 함이 알려져 있다. 기존에는 오류 정정 부호(ECC)등을 이용하여 이를 해결하려 했지만, 우리는 셀간 간섭으로 인한 오류에 포커스를 맞추어, 이 영향을 예측하고 줄여서 오류를 보정하는 새로운 알고리즘들을 제안한다. 이 알고리즘은 기존 오류정정부호 기법들과 별도의 단계로 동시에 적용할 수 있기에 에러 정정능력 향상에 효과적이다. 제안된 알고리즘들을 시뮬레이션을 통하여 성능을 비교하고 효율적인 알고리즘이 무엇인지 알아본다.

• 대한전자공학회논문지TC
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• 제44권5호
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• pp.92-98
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• 2007

다중 셀 OFDMA 환경에서 OFDMA 무선망 제어 부를 사용 할 필요 없이 각 셀에서 독립적으로 자원 할당을 하기 위한 기법을 제안하였다. 셀 간 동일 채널 간섭을 최소화 하도록 설계 된 할당 가능한 부반송파 영역을 각 셀에 정해주고, 이 영역 안에서 동적 자원 할당을 하도록 하였다. 할당 가능 영역의 제한으로 발생하는 frequency selection diversity의 감소와 CCI가 집중되는 현상 사이의 Trade off 관계를 이용하기 위하여, frequency selectivity가 높은 채널을 위한 균등한 할당 영역 경계 (EB) 방식과 selectivity가 낮은 채널 환경을 위한 유연 적 할당 영역 경계 (FB) 방식을 제안하였다. 이러한 할당 영역 경계 방식들을 사용하여, Capacity와 Outage 측면에서 경계 방식을 사용하지 않고 동적 자원 할당을 한 경우에 비하여 우수한 성능을 얻을 수 있었다.

• Applied Microscopy
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• 제44권2호
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• pp.68-73
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• 2014

With wide use of nano-materials, it is increasingly important to address their potential toxicity to mammalian cells. However, toxic effects of these materials have been mainly assessed by the cell survival assays. Considering that mitochondrial morphology and quality are highly sensitive to the condition of the cells, and the impairment of mitochondrial function greatly affect the survival of cells, here we tested the impact of multi-walled carbon nanotubes (MWNT) on the survival, mitochondrial morphology, and their membrane potential in HeLa cells. Interestingly, although MWNT did not induce cell death until 24 hours as assessed by pyknotic cell assay, mitochondrial length was elongated and the mitochondrial membrane potential was significantly reduced by exposure of HeLa cells to MWNT. These results suggest that MWNT exposure is potentially harmful to the cell, and the mechanism how MWNT alters mitochondrial quality should be further explored to assess the safety of MWNT use.

• BMB Reports
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• 제36권1호
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• pp.43-48
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• 2003

Understanding the process of carcinogenesis will involve both the accumulation of many scientific facts derived from molecular, biochemical, cellular, physiological, whole animal experiments and epidemiological studies, as well as from conceptual understanding as to how to order and integrate those facts. From decades of cancer research, a number of the "hallmarks of cancer" have been identified, as well as their attendant concepts, including oncogenes, tumor suppressor genes, cell cycle biochemistry, hypotheses of metastasis, angiogenesis, etc. While all these "hallmarks" are well known, two important concepts, with their associated scientific observations, have been generally ignored by many in the cancer research field. The objective of the short review is to highlight the concept of the role of human adult pluri-potent stem cells as "target cells" for the carcinogenic process and the concept of the role of gap junctional intercellular communication in the multi-stage, multi-mechanism process of carcinogenesis. With these two concepts, an attempt has been made to integrate the other well-known concepts, such as the multi-stage, multi-mechanisn or the "initiation/promotion/progression" hypothesis; the stem cell theory of carcinogenesis; the oncogene/tumor suppression theory and the mutation/epigenetic theories of carcinogenesis. This new "integrative" theory tries to explain the well-known "hallmarks" of cancers, including the observation that cancer cells lack either heterologous or homologous gap junctional intercellular communication whereas normal human adult stem cells do not have expressed or functional gap junctional intercellular communication. On the other hand, their normal differentiated, non-stem cell derivatives do express connexins and express gap junctional intercellular communication during their differentiation. Examination of the roles of chemical tumor promoters, oncogenes, connexin knock-out mice and roles of genetically-engineered tumor and normal cells with connexin and anti-sense connexin genes, respectively, seems to provide evidence which is consistent with the roles of both stem cells and gap junctional communication playing a major role in carcinogenesis. The integrative hypothesis provides new strategies for chemoprevention and chemotherapy which focuses on modulating connexin gene expression or gap junctional intercellular communication in the premalignant and malignant cells, respectively.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2619-2623
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• 2014

Aim: To investigate signaling pathways for reversal of EGF-mediated multi-drug resistance (MDR) in hepatocellular carcinoma (HCC) models. Materials and Methods: HCC MDR cell strain HepG2/adriamycin (ADM) and SMMC7721/ADM models were established using a method of exposure to medium with ADM between low and high concentration with gradually increasing concentration. Drug sensitivity and reversal of multi-drug resistance by EGF were determined and the cell cycle distribution and apoptosis were analyzed by flow cytometry. Phosphorylation of ERK1, ERK2, ERK5 and expression of Bim were detected by Western blotting. Results: The results showed that HepG2/ADM and SMMC7721/ADM cells were resistant not only to ADM, but also to multiple anticancer drugs. When used alone, EGF had no anti-tumor activity in HepG2/ADM and SMMC7721/ADM cells in vitro, while it increased the cytotoxicity of ADM. EGF induced cell apoptosis and G0/G1 phase cell cycle arrest in HepG2/ADM And SMMC7721/ADM cells, while enhancing activity of p-ERKs and up-regulated expression of BimEL. Conclusions: EGF might enhance the chemosensitivity of HepG2/ADM and SMMC7721/ADM cells via up-regulating p-ERKs and BimEL protein.

• 한국정보통신학회논문지
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• 제19권5호
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• pp.1063-1070
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• 2015

본 논문은 다중 셀 기반의 다중 안테나 상향링크 네트워크에서 사용자가 인접 셀 기지국에 미치는 간섭의 양을 기반으로 송신 전력을 제어하고 사용자를 분산적으로 스케쥴링 방식을 제안한다. 시분할 시스템의 상호 호환성 특성을 이용하여 각 사용자는 인접 기지국으로부터 받은 파일럿 신호를 통하여 간섭 채널을 습득하고 데이터 전송 시 인접 셀 기지국들에 미칠 간섭을 각자 계산할 수 있다고 가정한다. 각 사용자는 특이값 분해를 통해서 송신 빔포밍 벡터를 생성하고 인접 셀 기지국으로 미칠 간섭의 양을 계산하여 미리 결정된 임계값보다 클 경우 자신의 송신 전력을 낮춘다. 각 기지국에서는 사용자들 중 전력 제어된 채널 이득 값이 가장 큰 사용자를 선택한다. 제안된 기법의 상향링크 데이터 전송률은 기존의 사용자 스케쥴링 알고리즘들에 비하여 월등히 좋은 성능을 보인다.

• 전력전자학회논문지
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• 제8권6호
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• pp.478-487
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• 2003

본 논문에서는 고압 대용량 전동기 구동용 멀티레벨 인버터의 종류 및 특징을 간략히 살펴보고, 특히 입출력 전력품질이 우수하고 전압별 시리즈화가 용이한 H-브릿지 멀티레벨 인버터의 구조적 특징 및 장점을 기술하였다. 연구 개발된 3,300V lMVA 용량의 Cascaded H-브릿지 멀티레벨 인버터의 구체적인 전력회로 구조 및 설계방법, 제어기 구성 그리고 PWM 기법을 제시하였다. 또한, 실용량의 시험을 통해 H-브릿지 멀티레벨 인버터는 출력 전압 Step이 여러 단계이고 dv/dt가 적으며 입력단 THD를 크게 낮출 수 있어 성능 면에서도 여타 방식보다 우수함을 입증하였다. 또한 생산적인 측면에서도 저압 소자를 사용하여 설계하므로 기존의 생산/시험 기술과 설비를 이용할 수 있어 매우 경제적이며 Power Cell 단위 결합 구조이므로 신뢰성 측면이나 보수/유지 측면에서도 유리하다는 결론을 얻었다.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2001년도 하계종합학술대회 논문집(2)
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• pp.281-284
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• 2001

This paper describes an analog multi-phase delay-locked loop (DLL) to solve the harmonic lock problem using current-starved inverter and shunt-capacitor delay cell. The DLL can be used not only as an internal clock buffer of microprocessors and memory It's but also as a multi-phase clock generator for gigabit serial interfaces. The proposed circuit was simulated in a 0.25${\mu}{\textrm}{m}$ CMOS technology to solve harmonic lock problem and to realize fast lock-on time and low-jitter we verified time interval less than 40 ps as the simulation results.

• 조명전기설비학회논문지
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• 제25권8호
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• pp.70-81
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• 2011

In this paper, a multi-agent control system for DC-coupled photovoltaic (PV), fuel cell (FC), ultracapacitor(UC) and battery hybrid power system is studied for commercial buildings & apartment buildings microgrid. In this proposed system, the PV system provides electric energy to the electrolyzer to produce hydrogen for future use and transfer to the load side, if possible. Whenever the PV system cannot completely meet load demands, the FC system provides power to meet the remaining load. A multi-agent system based-power management and control algorithm is proposed for the hybrid power system by taking into account the characteristics of each power source. The main works of this paper are hybridization of alternate energy sources with FC systems using long and short storage strategies to build the multi-agent control system with pragmatic design, and a dynamic model proposed for a PV/FC/UC/battery bank hybrid power generation system. A dynamic simulation model for the hybrid power system has been developed using Matlab/Simulink, SimPowerSystems and Stateflow. Simulation results are also presented to demonstrate the effectiveness of the proposed multi-agent control and management system for building microgrid.