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Anti-inflammatory Effect of Houttuyniae Herba Water Extract on LPS-induced RAW 264.7 Mouse Macrophages (마우스 대식세포를 이용한 어성초(魚腥草) 물추출물의 항염효능연구)

  • Hwang, In Seung;Kim, Young Jin;Park, Yun Soo;Kim, Hyun Ju;Kim, Do Hoon;Park, Wan Su
    • The Korea Journal of Herbology
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    • v.29 no.4
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    • pp.83-89
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    • 2014
  • Objectives : The purpose of this study was to investigate effects of Houttuyniae Herba water extract (HC) on calcium release and production of various inflammatory mediators such as nitric oxide (NO), interferon-inducible protein (IP)-10, platelet derived growth factor (PDGF)-BB, keratinocyte-derived chemokine (KC), vascular endothelial growth factor (VEGF), interleukin (IL)-4, and IL-5 in lipopolysaccharide (LPS)-induced RAW 264.7 mouse macrophages. Methods : NO production was measured by Griess reagent assay. Intracellular calcium level was measured with Fluo-4 assay. Levels of cytokines were measured by High-throughput multiplex bead array cytokine assay based on xMAP (multi-analyte profiling beads) technology. Results : HC significantly decreased NO production for 24 hrs incubation at the concentrations of 10, 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC significantly decreased production of IP-10, KC, VEGF, and PDGF-BB for 24 hrs incubation at the concentrations of 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). HC also significantly decreased intracellular calcium release for 24 hrs incubation at the concentrations of 25, 50, 100, and $200{\mu}/mL$ in LPS-induced RAW 264.7 (P < 0.05). But HC did not show any significant effect on production of IL-4 and IL-5 in LPS-induced RAW 264.7. Conclusions : The results suggested that HC has anti-inflammatory property related with its inhibition on the production of NO, IP-10, KC, VEGF, and PDGF-BB in LPS-induced macrophages via calcium pathway.

An Analysis for the Effect of ESP/gas Lift Hybrid System on Oil Productivity (전기공저펌프/가스리프트 혼합시스템이 오일 생산성에 미치는 영향 분석)

  • Lee, Hyesoo;Iranzi, Joseph;Wang, Jihoon;Son, Hanam
    • Journal of the Korean Institute of Gas
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    • v.26 no.5
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    • pp.1-9
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    • 2022
  • Selection of a suitable artificial lift is important in terms of efficient operation and economics for oil production. In general, process of well design includes the selection of artificial lift, but the oil recovery could be enhanced by use of hybrid system combined with two types of artificial lift method according to reservoir condition for oil production. Electric submersible pump (ESP), as a presentative artificial lift method, is a manner for supplying the pressure in the lower part of oil well by using of a multi-stage centrifugal pump with an electric energy. However, there is a disadvantage that has a limit to the application period because of mechanical defection on ESP. Accordingly, it is possible to reduce the shutdown time of production well by applying the ESP/Gas lift hybrid system, which is to switch to a gas lift when an ESP is defective. This study describes the effect of ESP/gas lift hybrid system compared with ESP method for a onshore horizontal well locating in the of Permian basin, USA. As a result of study, ESP/gas lift hybrid system could make more effective productivity than ESP method. Also, we quantitatively predicted how much economic benefit would be obtained when the hybrid system was applied in the production well.

An effect of Internal Audit of IATF 16949 Automotive Quality Management System on the Performance of Organization (IATF 16949 자동차 품질경영시스템 내부심사가 조직의 성과에 미치는 영향)

  • Joo, Daesung;Lee, Moonsu
    • Journal of Practical Engineering Education
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    • v.14 no.1
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    • pp.37-48
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    • 2022
  • This study analyzed the effect of internal audit on the performance of the IATF 16949 automotive quality management system to understand the internal audit of companies and propose measures to activate the company's internal audit process. It was identified with the empirical analysis that 'The internal auditor competence, internal audit planning, internal audit implementation, infrastructure, culture/environment, and CEO support' to characterize IATF 16949 internal audit of automotive quality management system affects the internal performance and business performance of the company. In addition, I checked the size of the company and the period of certification period as moderating variables according to the sales based on the presented as factors that can improve the performance of the company, and how the moderating effects are seen in the relationship with the performance of the organization. I did analysis of technical statistics, exploratory factors, reliability, and multi-regression analysis with SPSS program. I summarized the results of the study, as a result of that, it was found that the internal audit planning, internal audit implementation, culture/ environment, and CEO support of independent variables affected the parameter and dependent variables (the internal performance and management performance of companies).

The Relationship between Narcissism and Risk-taking: An Exploration of Intervening Variables (자기애와 위험감수의 관계: 중재변인 탐색)

  • Jung Sun Yun ;Sung Moon Lim
    • Korean Journal of Culture and Social Issue
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    • v.21 no.3
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    • pp.419-455
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    • 2015
  • In study I, Domain-Specific Risk Taking Scale(DOSPERT) was translated into Korean and was validated that it had 6 factors structure and showed adequate reliability and validity, using the data had been collected from 438 participants. In study 2, two research problems were examined using the data had been collected from 497 participants who were different from study I. First, the mediation effect of sensation seeking and perceived benefit on the relationship between narcissism and risk-taking were examined. Using path analysis, it found that sensation seeking and perceived benefit mediated the relationship between NPI narcissism and risk-taking fully, and between PNI narcissism and risk-taking partially. Seceond, the moderate effect of contingencies of self-worth(CSW) on the relationship between perceived benefit-risk and risk-taking was examined. Using multi-group analysis, it found that virtue CSW moderated the relationship between perceived benefit-risk and total risk-taking, various CSWs moderated the relationships between perceived benefit-risk and 6 sub domains of risk-taking. These results were compared with previous studies of risk-taking and discussed the relevance of the narcissistic type.

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A Study on Carbon Nano Materials as Conductive Oilers for Microwave Absorbers (전자파 흡수체를 위한 전도성 소재로서의 탄소나노소재의 특성에 대한 연구)

  • Lee, Sang-Kwan;Kim, Chun-Gon;Kim, Jin-Bong
    • Composites Research
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    • v.19 no.5
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    • pp.28-33
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    • 2006
  • In this paper, we have studied the complex permittivities and their influence on the design of microwave absorbers of E-glass fabric/epoxy composite laminates containing three different types of carbon-based nano conductive fillers such as carbon black (CB), carbon nano fiber (CNF) and multi-wall nano tube (MWNT). The measurements were performed fur permittivities at the frequency band of 0.5 GHz$\sim$18.0 GHz using a vector network analyzer with a 7 mm coaxial air line. The experimental results show that the complex permittivities of the composites depend strongly on the natures and concentrations of the conductive fillers. The real and imaginary parts of the complex permittivities of the composites were proportional to the filler concentrations. But, depending on the types of fillers and frequency band, the increasing rates of the real and imaginary parts with respect to the filler concentrations were all different. These different rates can have an effect on the thickness in designing the single layer microwave absorbers. The effect of the different rates at 10 GHz was examined by using Cole-Cole plot; the plot is composed of a single layer absorber solution line and measured permittivities from these three types of composites. Single layer absorbers of 3 different thicknesses using carbon nano materials were fabricated and the -10 dB band of absorbing performances were all about 3 GHz.

Factors Affecting Consumers' Acceptance of e-Commerce Consumer Credit Service: Multiple Group Path Analysis by Naver Shopping and Coupang (이커머스 후불결제(BNPL) 수용에 영향을 미치는 요인: 네이버쇼핑과 쿠팡 간 다중집단 비교)

  • Kim, Su Jin;Mo, Jeonghoon
    • The Journal of Society for e-Business Studies
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    • v.27 no.2
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    • pp.105-135
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    • 2022
  • As COVID-19 has led to a surge in e-commerce Buy Now Pay Later(BNPL) has become preferred choice among millennials. In Korea Coupang followed by Naver Pay offers a deferred payment, aiming to create customer lock-in effect, save credit card processing fee and lay the groundwork for entering into new financial services. However the literature related to the influential factors of customers' usage intention toward a deferred payment is scarce. For the study, a multi-group analysis was carried out to find differences between Naver shopping and Coupang. The results revealed that the important factors that affect a deferred payment adoption were compatibility, impulsive buying tendency in Naver shopping, whereas compatibility, relative advantage, additional value in Coupang(listed in order of most important). In addition, impulsive buying tendency had a positive effect on adoption intention in Naver shopping and on perceived risk in Coupang. The results imply that Naver shopping need to focus on managing delinquency while Coupang should provide sufficient information on how late fees and credit rating downgrade work and try not to make a deferred payment option stand out. In order to increase adoption rate it is recommendable to narrow down target segment of a deferred payment and expand it to a specialized vertical such as travel.

Effect of partially replacing soybean meal with sunflower meal with supplementation of multienzymes on growth performance, carcass characteristics, meat quality, ileal digestibility, digestive enzyme activity and caecal microbiota in broilers

  • Yaqoob, Muhammad Umar;Yousaf, Muhammad;Imran, Safdar;Hassan, Safdar;Iqbal, Waqar;Zahid, Muhammad Umer;Ahmad, Naveed;Wang, Minqi
    • Animal Bioscience
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    • v.35 no.10
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    • pp.1575-1584
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    • 2022
  • Objective: An experiment was conducted to evaluate the effects of partially replacing soybean meal (SBM) with sunflower meal (SFM) with added exogenous multienzymes (MEs) on various biological parameters in broilers. Methods: One week-old, 400 broiler chicks were randomly divided into four treatments (control, 3SFM, 6SFM, and 9SFM) with 5 replicates/treatment (20 chicks/replicate). Control diet was without SFM and MEs, while diets of 3SFM, 6SFM, and 9SFM treatments were prepared by replacing SBM with SFM at levels of 3%, 6%, and 9%, respectively, and were supplemented with MEs (100 mg/kg). Feeding trial was divided into grower (8 to 21 day) and finisher phases (22 to 35 day). External marker method was used to measure the nutrient digestibility. At the end of trial, twenty birds (one birds per replicate) with similar body weight were slaughtered for samples collection. Results: No significant effect of dietary treatments was found on all parameters of growth performance and carcass characteristics, except relative weight of bursa. Weight (25.0 g) and length (15.80 cm) of duodenum were significantly (p<0.05) higher in 3SFM than control. Lowest (p<0.05) villus height/crypt depth ratio was found in 3SFM and 9SFM than control. Most of meat quality parameters remained unaffected, however, highest pH of breast meat (6.16) and thigh meat (6.44) were observed in 9SFM and 3SFM, respectively. Lowest (p<0.05) cook loss of thigh meat was found in 6SFM (31.76%). Ileal digestibility of crude protein was significantly (p<0.05) higher in 3SFM (72.35%) than control (69.46%). In addition, amylase (16.87 U/mg) and protease (85.18 U/mg) activities were significantly (p<0.05) higher in 3SFM than control. However, cecal microbial count remained unaffected. Conclusion: Partial replacement (up to 9%) of SBM with SFM, with added MEs can help to improve the nutrient digestibility, intestinal morphology, and digestive enzyme activities without affecting cecal microbial count and growth performance in broilers.

Effect of Sensory Integration Therapy with Oral Activity on Drooling and Play in Children with Developmental Disorder: Single-Subject Research (감각통합치료가 발달지연 아동의 침 흘림과 놀이에 미치는 효과: 단일사례연구)

  • Park, Sohee;Hong, Eunkyoung
    • The Journal of Korean Academy of Sensory Integration
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    • v.21 no.3
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    • pp.54-64
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    • 2023
  • Objective : This study aims to ascertain the effect of oral activity and sensory integration therapy on drool and play using oral toys in children with developmental delays. Methods : The participants of the study were two children (2 years and 8 months) experiencing developmental delays with sensory modulation problems in their oral sensory faculties. The research design was multi-baseline design cross-subjects among single-subject research ABA. Target behaviors were measured by drooling and interest and concentration in play using oral toys through the Goal Attachment Scale (GAS). In the 10 sessions that the children underwent during the intervention period (B), oral activity and proprioception-vestibular sensory integration therapy were applied. Results : The GAS of drooling improved from 0.25 for child A and -0.5 for child B during the baseline to 1.88 for child A and 1.4 for child B during the intervention period. The follow-up was 3 for both child A and child B. Meanwhile, the GAS of play during the baseline was -0.75 for child A and 0.75 for child B, and 1.9 for child A and 1.1 for child B during the intervention period. The follow-up was 1.33 for child A and 2 for child B. Conclusion : Oral activity and proprioceptive-vestibular sensory integration therapy are effective in drooling and playing with oral toys in children with sensory modulation problems in their oral sensory faculties.

Study on the Factors Affecting the Richness Index of Bird Species in Environmental Impact Assessment (환경영향평가에서 조류 종풍부도 변화에 미치는 요인 고찰 연구)

  • Hyunbin Moon;Eunsub Kim;Dongkun Lee
    • Journal of Environmental Impact Assessment
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    • v.33 no.2
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    • pp.64-73
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    • 2024
  • As the seriousness of habitat destruction caused by development projects emerges, the importance of environmental impact assessment (EIA) is increasing to preserve biodiversity. In previous studies, research is being conducted to quantitatively evaluate the biodiversity impact of development factors and surrounding environmental factors on the landscape scale, but research on the factors affecting the reduction of biodiversity based on development projects is insufficient. This study examined whether independent variables (size of development project, type of the development, DEM, ecosystem and nature map, distance from the green land, distance from the protected area), which have been proven to effect biodiversity through the previous researches, have a significant effect on the change of richness index (RI) through multi-class logistic regression analysis, T-test, and analysis of the development type. As a result, only the size of development project and the first richness index in EIA showed p-value less than 0.05. And it was confirmed that the reduction in biodiversity was significantly changed in the following construction types: installation of sports facilities, energy development, and development of industrial location and industrial complex. Since the results of this study confirmed that the impact of the variables may be inconsistent depending on the analysis scale, additional study of necessary indicators at the development project is needed to analyze biodiversity changes in EIA accurately.

Compilation of 104 Experimental Theses on the Antitumor and Immuno-activating therapies of Oriental Medicine (한의학의 항종양 면역치료에 관한 연구 -1990년 이후 발표된 실험논문을 중심으로-)

  • Kang Yeon Yee;Kim Tai Im;Park Jong Ho;Kim Sung Hoon;Park Jong Dai;Kim Dong Hee
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.1-24
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    • 2003
  • This study was done to compile 104 experimental theses which are related to the antitumor and immuno-activating therapies between February 1990 through February 2002. Master's and doctoral theses were dassified by schools, degrees, materials, effects, experimental methods of antitumor and immunoactivity, and results. The following results were obtained from this study : 1. Classifying the theses by the school, 34.6% were presented by Daejeon University, 29.8% by Kyung-hee University and 11.5% by Won-kwang University. Of all theses, 51.0% were aimed for the doctoral degree and 43.3% were for the master's degree. All of three universities have their own cancer centers. 2. Classifying the theses by herb materials, complex prescription accounted for 60.3%, single herb accounted for 24.8% and herbal acupuncture accounted for 14.2%. Considering the key principles of the traditional medicine, complex prescription was much more thoroughly studied than single herb prescription. The results showed that the complex prescription had both antitumor activity and immuno-activating activity, which might reflects on multi-activation mechanisms by complex components. 3. Classifying the theses by the efficacy of herbs examined, in single herb, invigorating spleen and supplementing was 35.5%, expelling toxin and cooling was 29.0%, activating blood flow and removing blood stasis was 12.9%. In herbal acupuncture, invigorating spleen and supplementing was 52.9%, expelling toxin and cooling was 29.4%. In complex prescription, pathogen-free status was 41.9%, strengthening healthy qi to eliminate pathogen was 35.5%, strengthening healthy qi was 22.6%. It is presumed that the antitumor and immunoactivating therapy based on syndrome differentiation is the best way to develop oriental oncology. 4. Classifying the theses by antitumor experiments, cytotoxic effect was 48.1 %, survival time was 48.1 % and change of tumor size was 42.3%. Survival rate was not necessarily correlated with cytotoxicity. These data reflect the characteristic, wholistic nature of the oriental medicine which is based on BRM (biological response modifier). 5. Classifying the theses by immunoactivating experiments, hemolysin titer was 51.0%, hemagglutinin titer was 46.2% and NK cell's activity was 44.2%. In the future studies, an effort to elucidate specific molecular and cellular mechanisms of cytokine production in the body would be crucial. 6. Classifying the theses according to the data in terms of antitumor activity, 50% was evaluated good, 24.0% was excellent, and 15.5% have no effect. In an evaluation of immuno-activating activity, 35.9% was excellent and 18.0% showed a little effect. The index point, as described here, may helps to use experimental data for clinical trials. Changes in index points by varying dosage implicate the importance of oriental medical theory for prescription. 7. In 167 materials, IIP (immunoactivating index point, mean : 3.12±0.07) was significantly higher than AIP(antitumor index point, mean : 2.83±0.07). These data demonstrate that the effect of herb medicine on tumor activity depends more on immunoactivating activity than antitumor activity. This further implies that the development of herbal antitumor drugs must be preceded by the mechanistic understanding of immunoactivating effect. 8. After medline-searching tumor and herb-related articles from NCBI web site, we conclude that most of the studies are primarily focused on biomolecular mechanisms and/or pathways. Henceforth, we need to define the biomolecular mechanisms and/or pathways affected by herbs or complicated prescriptions. 9. Therefore, the most important point of oriental medical oncology is to conned between experimental results and clinical trials. For the public application of herbal therapy to cancer, it is critical to present the data to mass media. 10. To develop the relationship of experimental results and clinical trials, university's cancer clinic must have a long-range plan related to the university laboratories and, at the same time, a regular consortium for this relationship is imperative. 11. After all these efforts, a new type herbal medicine for cancer therapy which is to take care of the long-term administering and safety problem must be developed. Then, it would be expected that anti-tumor herbal acupuncture can improve clinical symptoms and quality of life (QOL) for cancer patients. 12. Finally, oriental medical cancer center must be constructed in NCC (National Cancer Center) or government agency for the development of oriental medical oncology which has international competitive power.