• BMB Reports
• /
• 제55권4호
• /
• pp.187-191
• /
• 2022

Obesity is caused by an imbalance between energy intake and energy expenditure. Exercise is attracting attention as one of the ways to treat obesity. Exercise induces 'beige adipogenesis' in white adipose tissue, increasing total energy expenditure via energy dissipation in the form of heat. Also, beige adipogenesis can be induced by treatment with a beta-adrenergic receptor agonist. We developed a Cidea-dual reporter mouse (Cidea-P2A-Luc2-T2A-tdTomato, Luciferase/tdTomato) model to trace and measure beige adipogenesis in vivo. As a result, both exercise and injection of beta-adrenergic receptor agonist induced beige adipogenesis and was detected through fluorescence and luminescence. We confirmed that exercise and beta-adrenergic receptor agonist induce beige adipogenesis in Cidea-dual reporter mouse, which will be widely used for detecting beige adipogenesis in vivo.

• 대한한방소아과학회지
• /
• 제16권2호
• /
• pp.187-197
• /
• 2002

Objective: This study was proceeded to determine to what extent the decoction recipes and distillation recipes extracted from the infusion of the apricot seed and other herbs respectively would produce an effect on the proliferation and the differentiation of Preadipocyte 3T3-L1 Model separated from C57BL/6 mouse. Method: Preadipocyte 3T3-L1 Model was formed from the fat tissue of the epididymis organ, which was removed from 4-week-old C57BL/6 mouse and then was treated with collagenase. Results: 1. Concerning the restraint effect of proliferation on Preadipocyte 3T3-L1 Model, the decoction recipes, in the state of low consistency, were proved to be more effective than the distillation recipes. 2. Concerning the restraint effect of differentiation on Preadipocyte 3T3-L1 Model, the decoction recipes were shown to be more effective.

• Animal cells and systems
• /
• 제16권2호
• /
• pp.121-126
• /
• 2012

In this study, a neural network (NN) modeling approach has been used to predict the mechanical and geometrical behaviors of mouse embryo cells. Two NN models have been implemented. In the first NN model dimple depth (w), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were used as inputs of the model while indentation force (f) was considered as output. In the second NN model, indentation force (f), dimple radius (a) and radius of the semi-circular curved surface of the cell (R) were considered as inputs of the model and dimple depth was predicted as the output of the model. In addition, sensitivity analysis has been carried out to investigate the influence of the significance of input parameters on the mechanical behavior of mouse embryos. Experimental data deduced by Fl$\ddot{u}$ckiger (2004) were collected to obtain training and test data for the NN. The results of these investigations show that the correlation values of the test and training data sets are between 0.9988 and 1.0000, and are in good agreement with the experimental observations.

• 정보과학회 컴퓨팅의 실제 논문지
• /
• 제21권8호
• /
• pp.531-536
• /
• 2015

음성인식은 HCI(Human Computer Interface)분야에서 가장 활발히 연구되고 있는 분야로 음성을 이용하여 디지털 디바이스를 제어하는 것을 목적으로 하고 있으며 마우스는 GUI 컴퓨터 환경에서 가장 널리 사용하는 장치로서 높은 보급률을 자랑하는 컴퓨터 주변기기 중의 하나이다. 본 논문은 스마트폰 환경에서 실시간 모음 음성 인식을 이용한 마우스 제어 방법에 관하여 제안한다. 구현 방법은 스마트폰에서 실시간으로 일정크기의 음성 신호를 입력 받아 핵심 음성 신호를 추출하고 MFCC(Mel Frequency Cepstral Coefficient)를 이용하여 특징을 추출하여 학습되어 있는 코드 북을 이용하여 양자화를 진행하고 HMM(Hidden Markov Model)을 이용하여 해당 모음 단어를 인식한다. 그리고 각 모음에 해당하는 마우스 명령어로 변환하여 화면상의 가상의 마우스를 제어한다. 최종적으로, 우리는 구현된 스마트폰의 앱을 가지고 데스크톱 PC의 화면상에서 다양한 마우스의 동작을 보여준다.

• Clinical and Experimental Reproductive Medicine
• /
• 제43권1호
• /
• pp.1-8
• /
• 2016

Granulosa cell tumors (GCTs) are rare sex cord-stromal tumors that have been studied for decades. However, their infrequency has delayed efforts to research their etiology. Recently, mutations in human GCTs have been discovered, which has led to further research aimed at determining the molecular mechanisms underlying the disease. Mouse models have been important tools for studying GCTs, and have provided means to develop and improve diagnostics and therapeutics. Thus far, several genetically modified mouse models, along with one spontaneous mouse model, have been reported. This review summarizes the phenotypes of these mouse models and their applicability in elucidating the mechanisms of granulosa cell tumor development.

• 한국컴퓨터정보학회논문지
• /
• 제21권12호
• /
• pp.81-89
• /
• 2016

In this paper, we design and implement a mouse movement measurement system using an infrared sensor called MAMS (Mouse Activity Measurement System). Unlike existing systems, MAMS can measure movements between IREDs. MAMS is removable allowing convenient portability and is also low cost. MAMS automatically measures mouse activity during a pre-set time interval. Since the measured data can be easily stored in a computer system, it is much simpler and more efficient than the Ugo 47420 model. Moreover, MAMS can be used in medical and veterinary field to eliminate manual observations.

• Biomolecules & Therapeutics
• /
• 제10권4호
• /
• pp.218-223
• /
• 2002

This study compared the blood-brain barrier permeability of [$^3H$] taurine in senescence-accelerated mouse (SAM) and normal mouse with common carotid artery perfusion (CCAP) method and intravenous injection technique to establish a possible relation between aging and changes in tissue levels of taurine. The SAM strains show senescence acceleration and age-associated pathological phenotypes similar to geriatric disorders seen in humans. In the result of this experiments, the plasma clearance of [$^3H$]taurine in SAM was almost comparable with that of normal mice by intravenous injection technique, but the brain volume of distribution ($V_{D brain}$) of [$^3H$]taurine in SAM by CCAP method reduced by 85% compared with that in normal mice. These results suggest that aging may have an effect on the brain transport activity of taurine in disease state model animal.

• 한국방재학회 논문집
• /
• 제7권4호
• /
• pp.75-83
• /
• 2007

도시화된 유역은 복잡한 지형으로 인해 많은 유출경로를 갖게되며, 대부분 불투수 면적이 차지하고 있어 강우시 배수관거를 통해 우수가 배제되는데, 용량을 초과한 관거에서는 범람이 발생하여 다시 지표수를 형성하게 된다. 이처럼 도시유역에서 배수관망과 지표면 유출은 서로 연계되어 있으므로 침수해석 시 이를 고려해야 한다. 본 논문에서는 전형적인 도시지역의 특징을 보이는 인천교 부근의 매립된 유역을 대상으로 1차원-2차원 통합모델인 MIKE FLOOD 모델을 이용하여 수치해석하고, 그 해석결과를 기존의 1차원 모델인 MOUSE의 배수관망 해석결과와 비교 분석하였다. 분석 결과 1차원-2차원 통합모델은 1차원 배수관망에 2차원 지형도를 적용시킴으로서 지표면 저류현상 및 지체현상 등 지형적 특성을 반영한 유출해석결과를 나타내었으며, 기존의 1차원 해석시 파악 불가능한 유량상승 및 수위상승 등의 현실적인 모의가 가능함을 알 수 있었다.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-1
• /
• pp.64-65
• /
• 2003

Investigation of immunomodulating activities of the Agastache rugosa (Bae-cho-hyang) extract and its components was preformed through screening in vitro assays and evaluating anti-inflammatory activity and anti-atherosclerotic activity of the extract and tilianin in vivo. The extract showed strong anti-inflammatory activity in carrageenan-induced acute edema mouse model and anti-atherogenic activity in LDLR (low density lipoprotein receptor) deficient mouse model. (omitted)

• 제어로봇시스템학회논문지
• /
• 제13권8호
• /
• pp.743-748
• /
• 2007

Recently, various types of camera mouse are developed using the image processing. The camera mouse showed limited performance compared to the traditional optical mouse in terms of the response time and the usability. These problems are caused by the mismatch between the size of the monitor and that of the active pixel area of the CMOS Image Sensor. To overcome these limitations, we designed a new input device that uses the face recognition as well as the speech recognition simultaneously. In the proposed system, the area of the monitor is partitioned into 'n' zones. The face recognition is performed using the web-camera, so that the mouse pointer follows the movement of the face of the user in a particular zone. The user can switch the zone by speaking the name of the zone. The multimodal mouse is analyzed using the Keystroke Level Model and the initial experiments was performed to evaluate the feasibility and the performance of the proposed system.