Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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The Blood-brain Barrier Permeability of Taurine in Senescence-accelerated Mouse and Normal Mouse (ICR)

노화촉진모델마우스(SAM)와 정상 마우스(ICR)에서 타우린의 혈액-뇌 관문 투과성의 비교

  • 황인원 (숙명여자대학교 약학대학) ;
  • 이나영 (숙명여자대학교 약학대학) ;
  • 강영숙 (숙명여자대학교 약학대학)
  • Published : 2002.12.01
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Abstract

This study compared the blood-brain barrier permeability of [$^3H$] taurine in senescence-accelerated mouse (SAM) and normal mouse with common carotid artery perfusion (CCAP) method and intravenous injection technique to establish a possible relation between aging and changes in tissue levels of taurine. The SAM strains show senescence acceleration and age-associated pathological phenotypes similar to geriatric disorders seen in humans. In the result of this experiments, the plasma clearance of [$^3H$]taurine in SAM was almost comparable with that of normal mice by intravenous injection technique, but the brain volume of distribution ($V_{D brain}$) of [$^3H$]taurine in SAM by CCAP method reduced by 85% compared with that in normal mice. These results suggest that aging may have an effect on the brain transport activity of taurine in disease state model animal.

Keywords

References

  1. Alom J. Mahy J.N. and Tolosa E. (1991). Cerebrospinal fluid taurine in Alzheimer's disease. Ann. Neurol., 30, 735
  2. Benedetti M.S., Russo A., Mairrari P., Dostert P. (1991). Effects of ageing on the content in sulfur-containing amino acids in rat brain. J. Neural Transm. Gen. Sect., 86, 191-203 https://doi.org/10.1007/BF01250705
  3. Chung S.J., Ranianathan V, Giacomini K.M., Brett C.M. (1994). Characterization of a sodium-dependent taurine transporter in rabbit choroid plexus. Biochim. Biophys. Acta, 1193, 10-16
  4. Dawson R. Jr., Wallace D.R. (1990). Taurine content in tissues from aged Fischci 344 rats. Age, 15, 73-81
  5. Dawson R. Jr., Eppler B., Patterson T.A., Shih D. and Liu S. (1996). The effects of taurine in a rodent model of ageing. Adv. Exp. Med. Biol., 403, 37-50
  6. Gul N.S. and Arshag D.M. (1997). Age-related changes in the blood-brain barrier. Exp. Gerontol., 32, 501-519
  7. Huxtable R.J. (1989). Taurine in the central nervous system and the mammalian action of tauhne. Pros. Neurobiol, 32, 471-533
  8. Huxtable R.J. (1992). Physiological actions of taurine. Physiol. Rev., 72, 101-163
  9. Kang Y.S., OhtsuJki S., Takanaga H., Tomi M., Hosoya K.J. and Terasaki T (2002). Regulation of taurine transport at the blood-brain barrier by TNF-$\alpha$, taurine and hypertonicity. J. Neurochem. in press
  10. Kuriyarna K., Ida S,, Nishimura C. and Ohkuma S. (1983) Distribution and function of taurine in nervous tissues: an introductory review. Prog. Clin. Biol. Res., 125, 127-140
  11. Muramatsu M., Kakita K., Nakagawa K. and Kuriyama K. (1978). A modulating role of taurine on release of acetylcholine and norepinephrine from neuronal tissues. Jpn. J. Pharmacol, 28, 259-268
  12. Pardridge W.M., Kang Y.S., Yang J. and Buciak J.L. (1995). Enhanced cellular uptake and in vivo biodistribution of a monoclonal antibody following cationization. J. Pharm. Sci., 84, 943-948 https://doi.org/10.1002/jps.2600840808
  13. Saransaari P. and Oja S.S. (1997). Enhanced taurine release in cell-damaging conditions in the developing and ageing mouse hippocampus. Neuroscience, 79, 847-854 https://doi.org/10.1016/S0306-4522(97)00038-9
  14. Solis J.M., Herranz A.S., Henrrenas O., Lerma J. and Mairtin del Rio R. (1998). Does taurine acts as osrnoregulatory substance in the rat brain? Neurosci. Lett., 91, 53-58 https://doi.org/10.1016/0304-3940(88)90248-0
  15. Takasato Y, Rapoport S.I. and Smith Q.T. (1984). An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am. J. Physiol., 247, H484
  16. Takeda T., Hosokawa M., and Higuchi K. (1997). Senescenceaccelerated mouse (SAM): a novel murine model of senescence. Exp. Gerontol., 32, 105-109 https://doi.org/10.1016/S0531-5565(96)00036-8
  17. Takeda T. (1999). Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiol. Aging., 20, 105-110 https://doi.org/10.1016/S0197-4580(99)00008-1
  18. Tamai I., Senmaru M., Terasaki T. and Tsuji A. (1995). $Na^{+}$-and $Cl^{-}$- dependent transport of taurine at the blood-brain. barrier. Biochem. Pharmacol., 50, 1783-1793
  19. Tappaz M,, Almarghini K., Legay F. and Remy A. (1992). Taurine biosynthesis enzyme cysteine sulfinate decarboxylase CSD -from brain: the long and tricky trail to identification. Neurochem. Res., 17, 849-859 https://doi.org/10.1007/BF00993260
  20. Tappaz M., Alnarghini K. and Do K. (1994). Cysteinc sulfinate decarboxylase in brain: identification, characterization and immunocytochemical localization in astrocytes. Adv. Exp. Med. Biol, 359, 257-268
  21. Wiight C.E., Tallan H.H., Lin Y.Y., and Gaull G.E. (1986). Taurine; Biological update. Annu. Rev. Biochem., 55, 427-453 https://doi.org/10.1146/annurev.bi.55.070186.002235
  22. Wu J.Y. (1984). GABA and tauiine enzymes in mammalian brain. Curr. Top Cell Regul., 24, 119-128
  23. 강영숙, 김유정 (2000). 생쥐에 있어서 약물의 혈액-뇌 관문 투과성 평가를 위한 간편한 in vivo 방법. 약제학회지. 30, 99-105
  24. 강영숙, 이나영 (2002). 조건적 불사화 흰쥐 뇌 모세혈관 내피세포주에서 taurine의 수송특성 . 응용악물학회지. 10, 99-103