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The Blood-brain Barrier Permeability of Taurine in Senescence-accelerated Mouse and Normal Mouse (ICR)  

황인원 (숙명여자대학교 약학대학)
이나영 (숙명여자대학교 약학대학)
강영숙 (숙명여자대학교 약학대학)
Publication Information
Biomolecules & Therapeutics / v.10, no.4, 2002 , pp. 218-223 More about this Journal
Abstract
This study compared the blood-brain barrier permeability of [$^3H$] taurine in senescence-accelerated mouse (SAM) and normal mouse with common carotid artery perfusion (CCAP) method and intravenous injection technique to establish a possible relation between aging and changes in tissue levels of taurine. The SAM strains show senescence acceleration and age-associated pathological phenotypes similar to geriatric disorders seen in humans. In the result of this experiments, the plasma clearance of [$^3H$]taurine in SAM was almost comparable with that of normal mice by intravenous injection technique, but the brain volume of distribution ($V_{D brain}$) of [$^3H$]taurine in SAM by CCAP method reduced by 85% compared with that in normal mice. These results suggest that aging may have an effect on the brain transport activity of taurine in disease state model animal.
Keywords
senescence-accelerated mouse (SAM); blood-brain barrier permeability; taurine;
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