• Annals of Occupational and Environmental Medicine
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• v.34
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• pp.32.1-32.12
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• 2022

Background: This study was conducted to examine the relationship between chronotype and depressive symptoms to provide grounded knowledge in establishing nurses' health promotion strategies. Methods: The subjects of this study were 493 newly hired nurses working in 2 general hospitals within the university from September 2018 to September 2020. Sociodemographic and work-related characteristics were collected from a medical examination database and a self-reported questionnaire. These included sex, age, marital status, living situation, education level, alcohol consumption, physical activity, prior work experience before 3 months, workplace, and departments. To analyze the associations between the chronotype and depressive symptoms, multiple logistic regression analyses were performed to calculate odds ratios (ORs). Results: Among participants, 9.1% had depressive symptoms and 16.4% had insomnia. The subjects are divided into morningness (30.2%), intermediate (48.7%), and eveningness (21.1%). The multiple logistic regression analysis controlling for age, living status, education level, alcohol consumption, physical activity, workplace, prior work experience before 3 months, and insomnia, revealed that the OR of depressive symptoms in the eveningness group was 3.71 (95% confidence interval [CI]: 1.50-9.18) compared to the morningness group, and the R² value was 0.151. It also can be confirmed that insomnia symptoms have a statistically significant effect on depressive symptoms (OR: 2.16, 95% CI: 1.03-4.52). Conclusions: Our findings suggest that evening-type nurses are more likely to have depression than morning-type nurses. We should consider interventions in a high-risk group such as the evening type nurses to reduce depressive symptoms in nurses.

• Journal of Society of Preventive Korean Medicine
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• v.28 no.2
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• pp.1-18
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• 2024

Objectives : This study aimed to analyze the College of Korean Medicine's education related to vaccination to examine the feasibility of Korean medical doctors administering vaccines. Methods : We conducted a comprehensive review of the guidelines from the Korea Disease Control and Prevention Agency (KDCP) and the U.S. Advisory Committee on Immunization Practices (ACIP), along with the educational standards of Korean medical colleges. From these sources, key knowledge areas essential for vaccination were identified and distilled into 12 core items, creating a checklist used to evaluate the vaccination-related education. The curricula of Korean medical colleges and online continuing education courses for Korean medical doctors were analyzed using this checklist. Additionally, we reviewed the compulsory education course for vaccination providers for comparative purposes. Results : The analysis of common textbooks from colleges of Korean medicine revealed that while basic concepts of vaccination are widely covered, practical guidance on vaccine administration is less comprehensive. Continuing education for Korean medical doctors emphasizes basic epidemiological knowledge, vaccination contraindications and treating adverse reactions, but lacks details on patient education and the vaccination process. Compulsory education for vaccination providers covers extensive administrative content and comprehensively addresses essential vaccination knowledge, including patient education and practical vaccination procedures. Conclusion : The College of Korean Medicine's curriculum covers basic vaccination theories but lacks specific training in vaccine management. Additional training can improve Korean medical doctors' vaccination skills, enhancing the healthcare system's emergency response.

• Korean Journal of Agricultural Science
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• v.49 no.4
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• pp.749-758
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• 2022

The effect of varied light intensities on the growth of daughter plants during propagation and after transplant to raised beds were examined in 'Sulhyang' strawberry. To this end, four treatments in controlling solar radiation inside a plastic house were made: 55% retractable shading and 35, 55, and 75% fixed shading. The plastic house was shaded only from 11:00 to 16:00 in June and 10:00 to 16:00 in July to September for the treatment of 55% retractable shading. The mean solar radiation inside the plastic house in the retractable 55% shading treatment was 317 W·m^-2 and those in the 35, 55, and 75% fixed shading treatments were 183, 165, and 116 W·m^-2, respectively, at 10 o'clock in the morning. The 55% and 75% fixed shading resulted in taller daughter plants with wider leaf areas than 55% retractable shading. The retractable shading also showed higher leaf numbers, crown diameters, root weights, and fresh weights compared to fixed shading treatments. Regarding the inorganic element contents, daughter plants grown under 75% fixed shading had 1.35% total nitrogen content followed by 1.19% in 35% fixed shading, 1.14% in 55% fixed shading, 1.14% in open culture, and 1.10% in 55% fixed shading. After 54 days following the transplant of daughter plants to a raised bed, the fresh weight of the aboveground part was the heaviest in the 55% retractable shading and non-shading treatments. The 75% fixed shading treatment had the lowest fresh weight of the aboveground plant parts. The results of this study could be used for the production of high-quality daughter strawberry plants.

• Korean Journal of Agricultural Science
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• v.49 no.4
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• pp.979-988
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• 2022

The effects of seasonal differences and crating densities on the preslaughter losses, breast meat quality, and physiological indices of broilers were determined. A total of 600 broilers aged 35 days were divided into 10 treatment groups based on five crating densities (10.3, 11.5, 12.8, 14.1, 15.4 birds·m^-2) with two seasons (i.e., summer and winter) to give six replicates and were placed at various locations in the truck. The birds were transported in crates having dimensions of 1.0 m × 0.78 m × 0.26 m. The transportation distance was 20 km for 40 minutes (average 30 - 50 km·h^-1) during the early morning. The results revealed that broilers transported at densities of 14.1 and 15.4 birds·m^-2 recorded lower (p < 0.05) pH, water-holding capacity (WHC), and muscle redness compared to those at densities of 11.5 birds·m^-2. Furthermore, higher (p < 0.05) cooking loss was found in birds stocked at more than 14.1 birds·m^-2 compared to the other treatments. However, no effect (p > 0.05) with different crating densities on body weight loss, carcass traits, glucose, lactate, or muscle yellowness was observed. Crating density of 14.1 birds·m^-2 showed lower (p < 0.05) cortisol contents compared with birds at 10.3 and 15.4 birds·m^-2. Winter transportation had higher (p < 0.05) relative breast meat weight, cooking loss, muscle redness, and cortisol contents whereas summer transportation had higher (p < 0.05) glucose and lactate contents in the blood plasma of broilers. In conclusion, the stocking of 12.8 birds·m^-2 is recommended to minimize stress responses and undesirable changes that could negatively affect muscle quality.

• The Korean Journal of Nuclear Medicine Technology
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• v.15 no.2
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• pp.94-98
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• 2011

Purpose: The radiation exposure from radioisotope at the hands and foots of radiation workers who works in PET/CT part at the department of nuclear medicine was investigated in this study. Materials and Methods: From 4th August 2010 to 14th January 2011, 6 radio-technologists' radiation on hands and feet were measured. All radio-technologist have been examined around 8; morning, 12; afternoon, and 16 o'clock; evening, respectively. SPSS version 17 was used for statistical analysis. Results: The statistical significances were calculated in several ways. The radiation from both hands and feet in the Morning was lower than Afternoon and Evening. In some cases, the detected radiation showed extremely high values in data. In order to find the effect of the ${\gamma}$-ray on the hand, the estimated doses were presumably calculated, however, the exposure dose on feet were unmeasured. Conclusion: Even if the radiation exposure from the radioisotope at the hands and feet were under the limitations, it is definitely needs to prevent the radiation-contamination. Therefore, the radio-technologists need to have a proper radiation-dealing-procedure of their own, and must try to prevent a radiation exposure by themselves.

• Environmental Mutagens and Carcinogens
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• v.24 no.1
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• pp.15-18
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• 2004

There are significant differences in the extent of drug interactions between subjects. The influence of the genetic make up of drug metabolizing enzyme activities (CYP3A5, CYP2C19 and UDP-glucuronosyl transferase) on the pharmacokinetic drug interaction potential were studied in vivo. Nineteen healthy volunteers were grouped with regard to the $CYP3A5^{*}3$ allele, into homozygous wild-type (CYP3A5^{*}1/1^{*}1$, n=6), heterozygous $(CYP3A5^{*}1/^{*}3$, n=6), and homozygous variant-type $(CYP3A5^{*}3/^{*}3$, n=7) subject groups. The pharmacokinetic profile of intravenous midazolam was characterized before and after itraconazole administration (200 mg once daily for 4 days), and also following rifampin pretreatment (600 mg once daily for 10 days), with a washout period of 2 weeks in between. For omeprazole and moclobemide pharmacokinetic interaction study 16 healthy volunteers were recruited. The volunteer group comprised 8 extensive metabolizers and 8 poor metabolizers of CYP2C19, which was confirmed by genotyping. Subjects were randomly allocated into two sequence groups, and a single-blind, placebo-controlled, two-period crossover study was performed. In study I, a placebo was orally administered for 7 days. On the eighth morning, 300 mg of moclobemide and 40 mg of placebo were coadministered with 200 mL of water, and a pharmacokinetic study was performed. During study n, 40 mg of omeprazole was given each morning instead of placebo, and pharmacokinetic studies were performed on the first and eighth day with 300 mg of moclobemide coadministration. In the UGT study pharmacokinetics and dynamics of 2 mg intravenous lorazepam were evaluated before and after rifampin pretreatment (600 mg once daily for 10 days), with a washout period of 2 weeks in between. The subjective and objective pharmacodynamic tests were done before and 1, 2, 4, 6, 8, and 12 hrs after lorazepam administration. The pharmacokinetic profiles of midazolam and of its hydroxy metabolites did not show differences between the genotype groups under basal and induced metabolic conditions. However, during the inhibited metabolic state, the $CYP3A5^{*}3/^{*}3$ group showed a greater decrease in systemic clearance than the $CYP3A5^{*}1/^{*}1$ group $(8.5\pm3.8$ L/h/70 kg vs. $13.5\pm2.7$ L/h/70 kg, P=0.027). The 1'-hydroxymidazolam to midazolam AUC ratio was also significantly lower in the $CYP3A5^{*}3/^{*}3$,/TEX> group $(0.58\pm0.35,$ vs. $1.09\pm0.37$ for the homozygous wild-type group, P=0.026). The inhibition of moclo-bemide metabolism was significant in extensive metabolizers even after a single dose of omeprazole. After daily administration of omeprazole for 1 week, the pharmacokinetic parameters of moclobemide and its metabolites in extensive metabolizers changed to values similar to those in poor metabolizers. In poor meta-bolizers, no remarkable changes in the pharmacokinetic parameters were observed. The area under the time-effect curves of visual analog scale(VAS), choice reaction time, and continuous line tracking test results of lorazepam was reduced by 20%, 7%, 23% respectively in induced state, and in spite of large interindividual variablity, significant statistical difference was shown in VAS(repeated measures ANOVA, p=0.0027).

• Korean Journal of Animal Reproduction
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• v.27 no.3
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• pp.241-248
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• 2003

This study was conducted to determine the effects of progestagen (Synchromate-B, Veramix, CIDR) and hormone (PMSG, FSH, hCG) treatments on superovulation and estrous synchronization in Korean native goats. Goats were initially superovulated by using progestagens (Synchromate-B, Veramix, CIDR) and hormones (FSH, PMSG, hCG). The progestagens were removed after 15 days of insertion and 0.88 mg of FSH was injected intramuscularly twice a day from day 12 to day 15. In addition, 150 IU of PMSG and 200 IU hCG were injected intramuscularly in the morning of day 12 and in the afternoon of day 15, respectively. Estrous synchronization was induced by the progestagen releasing devices for 13 days and intramuscular injection of 400 IU PMSG in the morning of day 11. The results were summarized as follows: 1. The responses of superovulation treated with three types (Synchromate-B, Veramix, CIDR) of progestagen were 98.6, 99.4 and 98.8%, respectively. The average ovulation rates with Synchromate-B, Veramix and CIDR were 12.58 $\pm$ 6.52, 12.91 $\pm$ 7.27 and 11.28 $\pm$ 6.33, respectively. The average ovulation rates of Synchromate-B and Veramix treatments were significantly higher than that of the CIDR treatment (P<0.05). 2. The responses of estrus synchronization treated with Synchromate-B, Veramix and CIDR were 52.9, 72.9 and 75.7%, respectively. Veramix and CIDR treatments on estrous synchronization were significantly higher than the Synchromate-B treatment (P<0.05). Among the estrous synchronized goats, the estrous ovulation rates with Synchromate-B, Veramix and CIDR were 2.11 $\pm$ 1.89, 1.35 $\pm$ 0.87 and 1.43 $\pm$ 0.96, respectively. The estrous ovulation rates of the Synchromate-B treatment were significantly higher than those of the other treatments (P<0.05). 3. The average superovulation rates were 11.76 $\pm$ 6.00 and 11.07 $\pm$ 6.46 for the PMSG treatment and control groups, showing that there was no PMSG effects for the superovulation treated with CIDR.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.2
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• pp.331-338
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• 2004

Folate nutrition in early pregnancy is crucial in order to prevent neural tube defects (NTDs) in the fetus and maternal folate deficiency in late pregnancy If the influencing factors on maternal folate status are identified we may be able to detect the women at most risk of folate deficiency. This study intends to determine folate intakes, assess the levels of serum folate, erythrocyte folate, and plasma homocysteine, and reveal theinfluencing factors on maternal folate status in early pregnancy. A total of 151 healthy women in their first trimester volunteered for this study. The average length of gestation period was 9.1$\pm$ 2.3 weeks and seventy subjects were primipara. They consumed 1599$\pm$589 ㎉/day of energy and 230.8$\pm$145.2 $\mu\textrm{g}$/day of folate. This represented 72.5％ and 46.2％ of the Korean RDA respectively for pregnant women in the first half of Pregnancy. Results show that they consume less folate and energy due to morning sickness. Morning sickness correlated negatively with the intakes of energy, folate, ana Kimchi also. Their levels of serum folate, erythrocyte folate, and plasma homocysteine were 5.5$\pm$1.9 ng/mL, 266.6$\pm$75.0 ng/mL, and 7.0$\pm$1.8 $\mu$mol/L, respectively. Results indicate that 7.8% were deficient and 60.3% were borderline deficient in serum folate, 4.3% were deficient in erythrocyte folate, however, all had normal levels of plasma homocysteine. Results indicate that the folate status was not poor Contributing factors influencing serum folate concentrations ($R^2$= 0.724, p = 0.0001) were self-reported health status (+), folate intake (+), age (-), length of gestation (-), and homocysteine levels (-). Factors influencing erythrocyte folate concentrations ($R^2$ = 0.570, p = 0.0029) were the infant birth height of the last pregnancy (+), energy intake (+), age (-), plasma homocysteine concentration (-), and education level (-). Factors influencing plasma homocysteine concentrations ($R^2$= 0.450, p = 0.0051) were income level (+), prepregnancy weight (+), serum folate concentration (-), and the infant birth weight of the last pregnancy (-). These results indicate that pregnant women are likely to have a folate deficiency if they are in poor health status, having a history of delivering small infant and low energy and/or folate intake, and/or are older. And folate status is likely to decline as pregnancy progresses.

• Journal of Animal Science and Technology
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• v.46 no.1
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• pp.97-106
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• 2004

The study was conducted to investigate the effects of practical variations in feed restriction, pre-slaughter handing and chilling regime on pork quality during ageing. A total of twenty male landraces were allocated into three treatments(i.e., pre-slaughter feeding, stress and chilling regime) in a factorial arrangement. pH, temperature, free calcium ions, WB-shear force, sarcomere length, cooking loss, drip loss and objective color were determined during rigor development and/or 1, 3, 7 d postmortem. Pre-slaughter chasing stress for approximately 15 min had no effects on pH/temperature profile and objective meat quality. There was an interaction(P < 0.05) between the fasting treatment and chi1ling regime for muscle temperature at pH 6.2. Sarcomere length indicated that the current experiment conditions did not induce muscle shortening, with 1.7 to 1.8 ${\mu}m$, in spite of a significant effect of the fasting treatment (P<0.01). Pigs fed until the morning of slaughter showed a low WB-shear force(P < 0.05) until 3 d at I "C. The treatment also resulted in a higher Hunter L* and a*(P < 0.05) at 24 h and 7 d. Fasted pigs showed a significantly(P < 0.05) reduced cooking loss. The current results indicated that feeding upon the morning of slaughter became detrimental on meat color and the negative effect on cooking loss were linearly elevated with increased ageing time. On the other hand, WB-shear force did not distinguishable after 3 d. Collectively, it appeared that feed restriction from a day before slaughter could produce more a desirable meat quality at the time of consuming. However, the limited effect of animal handling and chilling rate on meat quality is not necessarily to extend to that these do not affect pork quality, as that largely depends on experimental design.

• Korean Journal of Clinical Laboratory Science
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• v.47 no.4
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• pp.216-224
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• 2015

This study aims to identify the prevalence of sleep related disease in those who experienced car accidents caused by drowsy driving. To this end, a survey of usual sleep habits, polysomnography, and multiple sleep latency tests were conducted in 34 persons who experienced an accident after normal sleep (Group 1), 22 persons who experienced an accident after abnormal sleep (Group 2), and 17 persons who was proven to be normal as a result of polysomnography and had no accident (Group 3). In all, 192 persons responded to the preliminary survey and the results were compared and analyzed. Crossover analysis was conducted to test the homogeneity of statistical characteristics, and the physical characteristics by age were analyzed. In the survey of sleeping habits, there was a significance between groups in how often they woke up while asleep (p<0.01), how difficult it was to go back to sleep again after waking up from sleep (p<0.05), how early they woke up in the morning (p<0.05), how difficult it was to get up in the morning (p<0.05), how sleepy they felt in the daytime (p<0.01), and how tired they felt in the daytime (p<0.01). Furthermore, among 56 subjects who had an accident during drowsy driving, 94.6% (53 persons) were found to have sleep related diseases. This suggests that car accidents during drowsy driving is not simply caused by temporary lack of sleep but by sleep related diseases even when sleep is adequate, leading to car accidents. Therefore, this study is significant identifying the association between car accidents during drowsy driving and sleep related disorders. Furthermore, the data would be considered basic to prepare social measures against drowsy driving related to such sleep related disorders.