• BMB Reports
• /
• 제45권2호
• /
• pp.114-119
• /
• 2012

Salsolinol (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline) is a compound derived from dopamine metabolism and is capable of causing dopaminergic neurodegeneration. Oxidative modification of neurofilament proteins has been implicated in the pathogenesis of neurodegenerative disorders. In this study, oxidative modification of neurofilament-L (NF-L) by salsolinol and the inhibitory effects of histidyl dipeptides on NF-L modification were investigated. When NF-L was incubated with 0.5 mM salsolinol, the aggregation of protein was increased in a time-dependent manner. We also found that the generation of hydroxyl radicals (${\bullet}OH$) was linear with respect to the concentrations of salsolinol as a function of incubation time. NF-L exposure to salsolinol produced losses of glutamate, lysine and proline residues. These results suggest that the aggregation of NF-L by salsolinol may be due to oxidative damage resulting from free radicals. Carnosine, histidyl dipeptide, is involved in many cellular defense processes, including free radical detoxification. Carnosine, and anserine were shown to significantly prevent salsolinol-mediated NF-L aggregation. Both compounds also inhibited the generation of ${\bullet}OH$ induced by salsolinol. The results indicated that carnosine and related compounds may prevent salsolinol-mediated NF-L modification via free radical scavenging.

• 한국항해학회지
• /
• 제25권1호
• /
• pp.45-52
• /
• 2001

본 논문은 선체구조에 많이 이용되고 있는 보강판 구조물의 동적 특성을 최적 변경하는데 그 목적이 있다. 유한요소법(FEM), 동적 감도해석법, 최적구조 변경법을 이용하여 보강판의 동적 특성을 최적화한다. 먼저, FEM을 이용하여 보강판 구조물의 동적 특성을 해석한다. 다음으로 설계변수의 변화에 따른 동적 특성의 변화율을 동적 감도해석법으로 해석한다. 감도해석법으로 구한 감도값과 최적구조 변경법을 이용하여 설계변수들의 변경 량을 계산한다. 보강판 구조물의 고유진동수의 변경을 목적함수로 하고, 보강판의 두께와 보강재의 단면2차 모우멘트를 설계 변수로 한다. 본 논문에서 이용한 최적구조 변경법이 보강판 구조물의 동특성을 최적화하는데 유용함을 보여준다.

• 융합보안논문지
• /
• 제18권2호
• /
• pp.77-88
• /
• 2018

본 연구의 목적은 기상조절기술의 군사적 활용방안을 연구하고, 한반도 환경 및 기술수준 등을 고려하여 연구의 우선순위를 과학적인 기법으로 도출하는데 있다. 이를 위해 각 기술들을 군사적으로 이용할 경우 장점과 단점을 살펴보고, 전문가 집단을 구성하여 델파이 기법을 통해 우선순위 평가를 위한 지표를 도출하였으며, 분석적계층분석 기법을 통해 평가지표의 가중치와 각 평가지표 내에서의 기술들의 가중치를 유도하여 최종적인 연구 우선순위를 정하였다. 분석결과 전리층 변조 기술이 무기체계로서의 효과성과 한반도 환경에서의 적합성 측면에서 가장 큰 우선순위가 있는 것으로 나타났다. 현재 북한의 전자전 및 미사일 위협 등을 고려할 때 전리층 변조 기술은 기상전의 일부로써 우선적인 확보가 필요하며, 통일 이후의 잠재적 주변국 위협에 대응하기 위해서는 전리층 변조뿐만 아니라 군사 과학기술 선진국들과의 기술적 격차가 있는 인공강우(설), 낙뢰유도, 안개 소산 기술도 민간기술의 적극적인 활용(Spin-On)을 통해 기반을 구축해야 할 시기이다.

• International Journal of Fuzzy Logic and Intelligent Systems
• /
• 제1권1호
• /
• pp.1-5
• /
• 2001

In this paper, we propose a fuzzy traffic controller that is able to cope with traffic congestion appropriately. In order to consider such situation as loss of green time caused by spillback of upper crossroad, it imports a degree of traffic congestion of upper roads which vehicles on a crossroad are to proceed to. We constructed the equal-partitioned fuzzy traffic controller that uses the membership functions of the same size and shape, and modified the size and shape, and modified the size and shape of its membership functions by the membership function modification algorithm. In experiment, we compared and analyzed the fixed signal controller, the fuzzy traffic controller with the membership of the same size and shape, and the modified fuzzy traffic controller by using the delay time, the proportion of entered vehicles to occurred vehicles and the proportion of passed vehicles to entered vehicles. As a result of experiment, the modified fuzzy controller showed more enhanced performance than others.

• 정보처리학회논문지B
• /
• 제8B권2호
• /
• pp.123-129
• /
• 2001

본 연구에서는 전문가와 운전자의 제어 지식을 더 정확하게 표현하여 퍼지 논리 제어기의 성능을 향상시킬 수 있는 소속함수 수정 알고리즘을 제안한다. 제안된 알고리즘은 제어지식을 더 정확히 표현할 수 있도록 직관적인 지식과 경험으로부터 유추된 대략적인 제어지식을 평가기준으로 하고 입출력 데이터 클러스터링에 의해 소속함수의 형태와 위치를 수정한다. 제안된 방법을 수위 조절 모델과 교통신호 제어 모델에 적용한 실험을 통해서, 제안된 알고리즘이 기존 제어기의 성능을 향상시킬 수 있고, 퍼지 제어기에서 언어적 변수에 대한 구간 설정의 어려움을 해결할 수 있음을 알 수 있었다.

• Journal of Advanced Marine Engineering and Technology
• /
• 제24권3호
• /
• pp.99-105
• /
• 2000

For multi-body dynamic problems. especially coalescent eigenvalue problems with multiobjective optimization, the design sensitivity analysis is too much complicated mathematically and numerically. Therefore, this article proposes a new technique for structural dynamic modification using a mode modification and homologous structures design method with Genetic Algorithm(GA). In this work, the homologous structure of the resiliently mounted multi-body for marine diesel generator systems is studied and the problem is treated as a combinational optimization problem using the GA. In GA formulation, fitness is defined based on penalty function approach. That include homology, allowable stress and minimum weight of common plate.

• 한국정밀공학회지
• /
• 제17권5호
• /
• pp.93-99
• /
• 2000

In many dynamic structural optimization problems, the goal is to reduce the total weight of the structure without causing the resonance. Up to now, gradient informations(i.e., design sensitivity) have been used to achieve the goal. For some class of dynamic problems, especially coalescent eigenvalue Problems with multiobjective optimization, the design sensitivity analysis is too much complicated mathematically and numerically. Therefore, this article proposes a new technique fur structural dynamic modification using a mode modification method with Genetic Algorithm(GA). In GA formulation, fitness is defined based on penalty function approach. Design variables are iteratively improved by using genetic algorithm. Two numerical examples are shown, (ⅰ) a cantilevered plate, and (ⅱ) H-shaped structure. The results demonstrate that the proposed method is highly efficient.

• 대한조선학회논문집
• /
• 제44권6호
• /
• pp.564-571
• /
• 2007

In the present study, stern form optimization has been carried out using computational fluid dynamics (CFD) techniques. The viscous pressure drag has been minimized to optimize stern shape. Parametric modification function has been used to modify the shape of the hull. By the use of the parametric modification function and algebraic scheme to grid manipulation, the initial ship geometry was easily deformed according to change of design parameters. For purpose of illustration, KRISO 319K VLCC (KVLCC) is chosen for example ship to demonstrate stern form optimization. The numerical results indicate that the optimized hull yields a reduction in viscous resistance.

• Journal of Electrical Engineering and Technology
• /
• 제7권3호
• /
• pp.330-335
• /
• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.

• Journal of Electrical Engineering and Technology
• /
• 제7권1호
• /
• pp.58-63
• /
• 2012

The shape optimization of a Thomson coil actuator used in an arc eliminator is done for fast response by adopting topology modification method. The displacement of the plate in a fixed calculation time is taken as the objective function. The objective function and contribution factor are calculated by using an adaptive equivalent circuit method which has been proved accurate and efficient. Both shape optimization and performance analysis are accomplished based on the segmentation of plate. Through the refinement of the sensitive segments a precise optimal plate shape can be obtained. The effectiveness of the proposed method is proved by the comparison of results before and after the shape optimization.