• Journal of Ginseng Research
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• v.35 no.2
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• pp.176-190
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• 2011

There seems to be some controversy about the effect of total ginseng saponin (TGS) on the secretion of catecholamines (CA) from the adrenal gland. Therefore, the present study aimed to determine whether TGS can affect the CA release in the perfused model of the adrenal medulla isolated from spontaneously hypertensive rats (SHRs). TGS (15-150 ${\mu}g/mL$), perfused into an adrenal vein for 90 min, inhibited the CA secretory responses evoked by acetylcholine (ACh, 5.32 mM) and high $K^+$ (56 mM, a direct membrane depolarizer) in a dose- and time-dependent fashion. TGS (50 ${\mu}g/mL$) also time-dependently inhibited the CA secretion evoked by 1.1-dimethyl-4 -phenyl piperazinium iodide (DMPP; 100 ${\mu}M$, a selective neuronal nicotinic receptor agonist) and McN-A-343 (100 ${\mu}M$, a selective muscarinic M1 receptor agonist). TGS itself did not affect basal CA secretion (data not shown). Also, in the presence of TGS (50 ${\mu}g/mL$), the secretory responses of CA evoked by veratridine (a selective $Na^+$ channel activator (50 ${\mu}M$), Bay-K-8644 (an L-type dihydropyridine $Ca^{2+}$ channel activator, 10 ${\mu}M$), and cyclopiazonic acid (a cytoplasmic $Ca^{2+}$-ATPase inhibitor, 10 ${\mu}M$) were significantly reduced, respectively. Interestingly, in the simultaneous presence of TGS (50 ${\mu}g/mL$) and N${\omega}$-nitro-L-arginine methyl ester hydrochloride [an inhibitor of nitric oxide (NO) synthase, 30 ${\mu}M$], the inhibitory responses of TGS on the CA secretion evoked by ACh, high $K^+$, DMPP, McN-A-343, Bay-K-8644, cyclopiazonic acid, and veratridine were considerably recovered to the extent of the corresponding control secretion compared with the inhibitory effect of TGS-treatment alone. Practically, the level of NO released from adrenal medulla after the treatment of TGS (150 ${\mu}g/mL$) was greatly elevated compared to the corresponding basal released level. Taken together, these results demonstrate that TGS inhibits the CA secretory responses evoked by stimulation of cholinergic (both muscarinic and nicotinic) receptors as well as by direct membrane-depolarization from the isolated perfused adrenal medulla of the SHRs. It seems that this inhibitory effect of TGS is mediated by inhibiting both the influx of $Ca^{2+}$ and Na+ into the adrenomedullary chromaffin cells and also by suppressing the release of $Ca^{2+}$ from the cytoplasmic calcium store, at least partly through the increased NO production due to the activation of nitric oxide synthase, which is relevant to neuronal nicotinic receptor blockade, without the enhancement effect on the CA release. Based on these effects, it is also thought that there are some species differences in the adrenomedullary CA secretion between the rabbit and SHR.

• Archives of Pharmacal Research
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• v.28 no.7
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• pp.791-798
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• 2005

The hepatoprotective activity of flavonol glycosides rich fraction (F-2), prepared from 70% alcohol extract of the aerial parts of V calcarata Desf., was evaluated in a rat model with a liver injury induced by daily oral administration of $CCl_4$ (100 mg/kg, b.w) for four weeks. Treatment of the animals with F-2 using a dose of (25 mg/kg, b.w) during the induction of hepatic damage by $CCl_4$ significantly reduced the indices of liver injuries. The hepatoprotective effects of F-2 significantly reduced the elevated levels of the following serum enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including glutathione (GSH) content, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. In addition, it normalized liver malondialdehyde (MDA) levels and creatinine concentration. Chromatographic purification of F-2 resulted in the isolation of two flavonol glycosides that rarely occur in the plant kingdom, identified as quercetin-3,5-di-O-$\beta$-D-diglucoside (5) and kaempferol-3,5-di-O-$\beta$-D-diglucoside (4) in addition to the three known compounds identified as quercetin-3-O-$\alpha$-L-rhamnosyl- (${\rightarrow}6$)-$\beta$-D-glucoside [rutin, 3], quercetin-3-O-$\beta$-D-glucoside [isoquercitrin, 2] and kaempferol-3-O-$\beta$-D-glucoside [astragalin, 1]. These compounds were identified based on interpretation of their physical, chemical, and spectral data. Moreover, the spectrophotometric estimation of the flavonoids content revealed that the aerial parts of the plant contain an appreciable amount of flavonoids (0.89%) calculated as rutin. The data obtained from this study revealed that the flavonol glycosides of F-2 protect the rat liver from hepatic damage induced by $CCl_4$ through inhibition of lipid peroxidation caused by $CCl_4$ reactive free radicals.

• Journal of the Korean Geotechnical Society
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• v.28 no.12
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• pp.53-64
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• 2012

In this study, the modified cyclic triaxial tests with Joomunjin standard sand are performed for dynamic deformation characteristics, such as Young's moduli and damping ratio. The cyclic triaxial test is equipped with Local Displacement Transducer (LDT) on the outside of a cell which has a range from $10^{-4}$ to $10^{-1}$ of shear strains, ${\gamma}$ (%), instead of conventional cyclic triaxial test which has linear variable displacement transducer (LVDT) with low precision. With the small strain control, tests were carried out at various loading rates, void ratios, and effective confining pressures. Based on the test results, such as dynamic deformation characteristics, shear modulus, and damping ratio, it is found that the test can measure more range of medium strains (0.02-0.2%) than results obtained from conventional test (resonant column test). For the medium strain range, dynamic deformation characteristics investigated by the cyclic triaxial test are also different from those predicted by nonlinear model in conventional test.

• Journal of the Korea Concrete Institute
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• v.14 no.1
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• pp.118-125
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• 2002

Hydration is the main reason for the growth of the material properties. An exact parameter to control the chemical and physical process is not the time, but the degree of hydration. Therefore, it is reasonable that development of all material properties and the formation of microstructure should be formulated in terms of degree of hydration. Mathematical formulation of degree of hydration is based on combination of reaction rate functions. The effect of moisture conditions as well as temperature on the rate of reaction is considered in the degree of hydration model. This effect is subdivided into two contributions: water shortage and water distribution. The former is associated with the effect of W/C ratio on the progress of hydration. The water needed for progress of hydration do not exist and there is not enough space for the reaction products to form. The tatter is associated with the effect of free capillary water distribution in the pore system. Physically absorption layer does not contribute to progress of hydration and only free water is available for further hydration. In this study, the effects of chemical composition of cement, W/C ratio, temperature, and moisture conditions on the degree of hydration are considered. Parameters that can be used to indicate or approximate the real degree of hydration are liberated heat of hydration, amount of chemically bound water, and chemical shrinkage, etc. Thus, the degree of heat liberation and adiabatic temperature rise could be determined by prediction of degree of hydration.

• Journal of the Korea Convergence Society
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• v.9 no.3
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• pp.241-247
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• 2018

The purpose of this study is to investigate the relationship between the residential satisfaction and the residential satisfaction in the residential environment. For this study, we analyzed the main factors of occupancy satisfaction by integrating previous studies on brand and housing and purchase intention, developing a research model based on the theoretical study on occupancy satisfaction, and establishing a research hypothesis. The results of this study are as follows: First, the relationship between first brand image and occupancy satisfaction is statistically significant. Second, the relationship between residential satisfaction and residential satisfaction is significant. In addition, the relationship with prices acting as parameters is analyzed to be somewhat significant. Therefore, this study is expected to provide not only useful information in the relationship between apartment supplier and consumer, but also provide basic information on similar research. Therefore, this study is expected to provide not only useful information in the relationship between apartment supplier and consumer, but also provide basic information on similar research. However, due to limitations such as selection of control variables and analytical errors, future research should be conducted through development of more comprehensive and valid indicators.

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.938-942
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• 2007

The importance of process improvement under construction has arisen from recent issue, lower productivity in the construction site. The various 3D modeling program is utilized in the procedure of construction as an alternative solution. However, it's still shortage of the consideration about a specific technical application. The purpose of the study in this paper is helpful to improve the productivity of construction site using 3D realization of constructing place as one of extensive modeling technologies, which leads to not only efficient management of construction site allowing people to check the real time situation in the place but also the revitalization of information flow about building process control and prgress, Therefore, I research into modeling algorithm and extensive construction site realization technology. 3D realization of building place would reduce the safety concerns by providing the real time information about construction site, and it could help to access easily to similar project through collecting and appling the database of sites. Furthermore it can be an opportunity to develop the procedure of production in construction industry and to upgrade the image of this field.

• Proceedings of the Korea Database Society Conference
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• 1998.09a
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• pp.525-543
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• 1998

This paper proposes a conceptual taxonomy of architectures far workflow management systems. The systematic classification work is based on a framework for workflow architectures. The framework, consisting of generic-level, conceptual-level and implementation-level architectures, provides common architectural principles for designing a workflow management system. We define the taxonomy by considering the possibilities for centralization or distribution of data, control, and execution. That is, we take into account three criteria. How are the major components of a workflow model and system, like activities, roles, actors, and workcases, concretized in workflow architecture？ Which of the components is represented as software modules of the workflow architecture？ And how are they configured and operating in the architecture？ The workflow components might be embodied, as active (processes or threads) modules or as passive (data) modules, in the software architecture of a workflow management system. One or combinations of the components might become software modules in the software architecture. Finally, they might be centralized or distributed. The distribution of the components should be broken into three: Vertically, Horizontally and Fully distributed. Through the combination of these aspects, we can conceptually generate about 64 software Architectures for a workflow management system. That is, it should be possible to comprehend and characterize all kinds of software architectures for workflow management systems including the current existing systems as well as future systems. We believe that this taxonomy is a significant contribution because it adds clarity, completeness, and "global perspective" to workflow architectural discussions. The vocabulary suggested here includes workflow levels and aspects, allowing very different architectures to be discussed, compared, and contrasted. Added clarity is obtained because similar architectures from different vendors that used different terminology and techniques can now be seen to be identical at the higher level. Much of the complexity can be removed by thinking of workflow systems. Therefore, it is used to categorize existing workflow architectures and suggest a plethora of new workflow architectures. Finally, the taxonomy can be used for sorting out gems and stones amongst the architectures possibly generated. Thus, it might be a guideline not only for characterizing the existing workflow management systems, but also for solving the long-term and short-term architectural research issues, such as dynamic changes in workflow, transactional workflow, dynamically evolving workflow, large-scale workflow, etc., that have been proposed in the literature.

• The Journal of Information Technology and Database
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• v.5 no.1
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• pp.97-108
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• 1998

This paper proposes a conceptual taxonomy of architectures for workflow management systems. The systematic classification work is based on a framework for workflow architectures. The framework, consisting of generic-level, conceptual-level and implementation-level architectures, provides common architectural principles for designing a workflow management system. We define the taxonomy by considering the possibilities for centralization or distribution of data, control, and execution. That is, we take into account three criteria. How are the major components of a workflow model and system, like activities, roles, actors, and workcases, concretized in workflow architecture. Which of the components is represented as software modules of the workflow architecture\ulcorner And how are they configured and operating in the architecture\ulcorner The workflow components might be embodied, as active (processes or threads) modules or as passive (data) modules, in the software architecture of a workflow management system. One or combinations of the components might become software modules in the software architecture. Finally, they might be centralized or distributed. The distribution of the components should be broken into three: Vertically, Horizontally and Fully distributed. Through the combination of these aspects, we can conceptually generate about 64 software Architectures for a workflow management system. That is, it should be possible to comprehend and characterize all kinds of software architectures for workflow management systems including the current existing systems as well as future systems. We believe that this taxonomy is a significant contribution because it adds clarity, completeness, and global perspective to workflow architectural discussions. The vocabulary suggested here includes workflow levels and aspects, allowing very different architectures to be discussed, compared, and contrasted. Added clarity is obtained because similar architectures from different vendors that used different terminology and techniques can now be seen to be identical at the higher level. Much of the complexity can be removed by thinking of workflow systems. Therefore, it is used to categorize existing workflow architectures and suggest a plethora of new workflow architectures. Finally, the taxonomy can be used for sorting out gems and stones amongst the architectures possibly generated. Thus, it might be a guideline not only for characterizing the existing workflow management systems, but also for solving the long-term and short-term architectural research issues, such as dynamic changes in workflow, transactional workflow, dynamically evolving workflow, large-scale workflow, etc., that have been proposed in the literature.

• Journal of the Korean Society for Library and Information Science
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• v.13
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• pp.39-71
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• 1986

Interlibrary loan has been a very common library service in the developed countries but it is yet to be actualized formerly in Korea. As Korea is moving toward an information society where all the individual user's request in the library should be met, we need to understand, in detail, the theory and practice of interlibrary loan service. As various information technology has been applied to the libraries, the libraries became the open system. Thus, the libraries become more cooperative, form networks, and make interlibrary loan service available. This study is based on the following three hypothesis formulated from the systems theory. 1. If libraries cooperate each other and form some kind of networks by mail, computers or telecommunications, they become the open system. 2. If a library develops as the open system, interlibrary loan becomes available in the library. 3. If the interlibrary loan system works, the role of the librarians will be changed. The research was carried out by analyzing the various studies about interlibrary loan service and by examining the interlibrary loan systerns presently working in the U.S.. The conclusions are reached deductively from the data. Some of the terminology used are defined as follows: System: a network of interrelated procedures that are joined together to perform an activity or to accomplish a specific objective. It is, in effect, all the ingredient which make up the whole. Cooperation: Working together to benefit participant libraries. Network: a much more structured type of cooperation in which definite regions or areas are connected by electronic or other means to promote interlibrary loaning of materials, in-service traing & other sharing of resources. Interlibrary loan: the lending of books between libraries. The model of cooperation or networks was used to be (1) a star type, (2) a hieranchical type, (3) a distributed type or (4) the combination of aforementioned three. However, the development of the telecommunications and computers enables all kinds of libraires cooperate together. Interlibrary loan service starts with the needs of user's information. The information have to be logically accessed through bibliographies, computers, electronic mails and satellite communications. And the logical access requires the information technology and the libraries become cooperative. The physical access to the information follows next but only traditional method of mail and some commercial service are currently available for this purpose. Therefore, researches are needed to develop this physical access. If the libraries form networks, the microaspect of library changes accordingly as the macroaspect changes. If the libraries . cooperate to become one large world library, the librarians plan, organize, control library operations and report the results. And the librarians work inside and outside of the library to cooperate with other libraries. Only the cooperation of the libraries will enhance interlibrary loan and the Korean librarians have to be prepared to accept the new role of librarianship for the interlibrary loan service.

• The Journal of Information Technology
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• v.1 no.1
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• pp.85-101
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• 1998

Information system, organization structure, and business strategy have been major variables in MIS research. Most of research about these variables interested in the relationship of two variables. There were very few efforts to connect three variables. But relationship or fitness of these factors plays an important role to improve performance. Nowadays managers face new challenge. That is 'globalization' To cope with this turbulent environment, they have to know how to fit these Important factors(information system, organization structure, business strategy). It is the main purpose of this article to find out the fitness of these variables under global business environment. Based on literature review, I made research model which tells whether fitness of three variables affects performance under the control of headquarter. And I propose hypothesis. I define strategy as global innovator, integrated player, implementers role, local innovator and organization structure as multinational, global, international, trans-national and information system as independent IT operation, headquarter driven configuration, intellectual synergy configuration, global integrated IT configuration.