• Journal of Life Science
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• v.32 no.5
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• pp.355-361
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• 2022

Melanin pigments are the main cause of skin color. They are produced in melanocytes and then transferred to keratinocytes, which eventually gives the skin surface a variety of colors. Although many skin-lightening or depigmenting agents have been developed, the demand for materials to reduce pig- mentation is still increasing. Here, we tried to find materials for skin-lightening or depigmentation using natural compounds and found that mistletoe (Viscum album var. coloratum) extracts (ME) had an inhibitory effect on tyrosinase activity. As a result, ME significantly reduced pigmentation in human primary melanocytes. In addition, a promoter reporter assay revealed that ME inhibited the transcription of microphthalmia-associated transcription factor (MITF), melanophilin (MLPH), tyrosinase-related protein-2 (TRP-2), and tyrosinase (TYR) genes in HM3KO melanoma cells. In addition, ME decreased the protein level for pigmentation-related molecules, such as TYR and TRP-1. Furthermore, it markedly inhibited the melanogenesis of zebrafish embryos, an in vivo evaluation model for pigmentation. To elucidate the action mechanism of ME, we investigated its effects on intracellular signaling. Eventually, the ME dramatically decreased the phosphorylation of the cAMP responsive element binding protein (CREB), AKT, and ERK. The data suggest that ME may inhibit the melanogenesis pathway by regulating the signaling pathway related to pigmentation. Taken together, these data propose that ME can be developed as a depigmenting or skin-lightening agent.

• Journal of Space Technology and Applications
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• v.3 no.1
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• pp.44-57
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• 2023

In order for a latecomer in deep-space exploration such as Korea to quickly keep pace with advanced deep-space exploration countries in the mutually-beneficial space exploration market, it is essential to derive a deep-space probe reference model that can reduce development period and cost. In this paper, concept and configuration for the deep-space probe reference model consisting of basic, lightweight, and expansion types are newly presented, which are based on commonly required designs for various deep-space probes. The proposed configuration adopts modular design so that the expandability and design/implementation efficiency are improved. In addition, the electrical system design pursuing lightweight and expandability is also described, which is applicable to the proposed three-types of deep-space probe reference model.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.261-264
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• 1997

A contactless eddy current type braking system is developed to take advantages of the recent brake system which uses hydraulic force can show high efficiency in a certain velocity region, but not in a high velocity region, and has initial response delay time and pressure build-up time which make stopping distance longer. These are the limits of mechanical brake system of a contact type, which makes a concept brake system required. So, in this paper, the contactless brake system .of a inductive current type is chosen instead of hydraulic brake system. This brake system can be used almost forever for being no wear and contributed to lightening weight of a vehicle. Besides, the contactless brake system can be used as that of electric or solar car with anti-lock brake system. The analysis of induced electromotive force and braking torque obtained with theoretical approximate model, the design of a braking system and a nonlinear controller, and the results of simulation of the ABS, experiment are included.

• Journal of Aerospace System Engineering
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• v.10 no.1
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• pp.118-126
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• 2016

North Korea has continued developing ballistic missiles with various ranges. Even through the recent launch long-range missiles, it can be inferred that North Korea's Missile technology has reached a level where it can even threaten the US. moreover, through the three times nuclear tests, North Korea is known to have succeeded at gaining 10~20KT of explosive power as well as the minimization and lightening of nuclear warhead. Considering the short length of war zone in Korean peninsula and the possibility of nuclear equipment, if be the most severe threat across the whole peninsula. Since the midcourse phase flight takes the longest time, ROK should establish the ability to intercept at this middle phase. From this perspective, this paper describes mission effect of a sea-based BMD system through empirical threat and flight characteristic analysis using MIT model that was not suggested in original research.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.28 no.8 s.227
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• pp.1174-1182
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• 2004

Recently, Self Piercing Rivet(SPR) has been spotlighted in the automotive industry as a substitutive resort of spot welding and has also been watched by the designer as lightening a car body due to their superior assembly processes. Fatigue behavior of SPR joint needs to be investigated experimentally and numerically to predict its structural stiffness and fatigue life. Testing of lap-shear specimens with various material combinations is performed to obtain the joining strength and the fatigue life of SPR connections. The simulation of SPR lap-shear specimens is also conducted to obtain the structural stiffness of SPR connections under different material combinations. A Finite element model of the SPR lap-shear specimen is developed using a FEMFAT SPR pre-processor. The fatigue lift of SPR specimen is predicted using a FEMFAT 4.4e based on the liner finite element analysis.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2017.05a
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• pp.764-765
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• 2017

A trajectory analysis program was developed using a 3 DOF model to analyze KSLV-II performance with the reducing weight. The program estimates the injection performance on the SSO orbit, which is determined as payload weight for the orbit, with various vehicle structural ratios. The KSLV-II can transport 2.58 ton to the target orbit with a reduced structural ratio similar to the Angara rockets.

• Proceedings of the Korean Society of Computer Information Conference
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• 2021.07a
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• pp.629-631
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• 2021

본 논문에서는 웹 기반 서비스 플랫폼 환경에서 3D 모델의 경량화 및 품질 유지를 위한 후처리 방법을 제안한다. 3D 모델을 산업 현장에서 다양한 용도로 활용되기 위해 웹 기반 환경에서의 3D 모델 시각화 서비스가 제공되고 있으며, 최적화된 서비스 제공을 위해 대용량 3D 모델의 경량화 및 품질 유지가 필수적이다. 제안하는 3D 모델의 후처리 방법은 간편한 사용자 조작뿐만 아니라 면의 경량화 가능 및 시각 품질을 유지할 수 있다. 이는 웹 기반 환경에서의 활용을 위한 대용량 3D 모델을 효율적으로 최적화하는 방안이 될 것으로 기대한다.

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.343-348
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• 2013

We investigated the inhibitory effects of hesperidin on melanogenesis. To find melanosome transport inhibitor from natural products, we collected the structural information of natural products from Korea Food and Drug Administration (KFDA) and performed pharmacophore-based in silico screening for Rab27A and melanophilin (MLPH). Hesperidin did not inhibit melanin production in B16F10 murine melanoma cells stimulated with ${\alpha}$-melanocyte stimulating hormone (${\alpha}$-MSH), and also did not affect the catalytic activity of tyrosinase. But, hesperidin inhibited melanosome transport in melanocyte and showed skin lightening effect in pigmented reconstructed epidermis model. Therefore, we suggest that hesperidin is a useful inhibitor of melanosome transport and it might be applied to whitening agent.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.24 no.5 s.176
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• pp.1103-1114
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• 2000

Recent attempt to enhance the safety against collision reshaped the simple shell structures into the integrated complex shell structures. Moreover, due to various regulations continuously tightened for environment protection, weight reduction of automobiles becomes an increasingly important issue. Auto parts lightening is mainly accomplished by more reasonable design, adoption of lighter materials and miniaturization of the auto bodies. Focusing on the locally enhanced design approach among the above three ways, we here attempt to develop a patching optimization method, and also to determine the thicknesses of an integrated shell structure, both bringing a specified amount of stress relaxation. We first select a cross member as a patching optimization model. Based on the finite element stress calculations, we relieve the stress of cross member by patching in two ways-nonuniform thickness patching and optimized uniform thickness patching, the latter of which is more effective in a practical point of view for the preset amount of stress relaxation. Selecting a box type subframe as another finite element analysis model, we then determine the thickness of each part by axiomatic design approach for a preset amount of stress relaxation. The patching methodology and the axiomatic approach adopted in this work can be applied to the other complex shell structures such as center member and lower control arm.

• Journal of computational fluids engineering
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• v.18 no.3
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• pp.8-13
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• 2013

Drag reduction of a running vehicle is very important issue for the energy savings and emission reduction of its power train. Especially for a solar powered electric vehicle, the drag reduction and weight lightening are two serious problems to be solved to extend its driving distance under the given energy condition. In this study, the ground effect of an airfoil shaped road vehicle was studied for an optimum body design of an ultra-light solar powered electric vehicle. Clark-Y airfoil type was adopted to the body shape of the model vehicle to reduce aerodynamic drag. From the study, it was found that the drag of the model vehicle was reduced as the height(h) between ground and the lower surface of the model vehicle was decreased. It is due to the reduction of the down-wash decreasing the induced drag of the vehicle. The lift was also decreased as the height decreased. It is due to the turbulent boundary layer developed beneath the vehicle body. The drag is classified into two types; the form and friction drag. The fraction of form drag to friction one is 76 to 24 on the model vehicle. As the height(h) of the model vehicle from the ground surface increases the form drag also increases but the friction drag is in reverse.