• Journal of Korea Water Resources Association
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• v.42 no.8
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• pp.643-657
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• 2009

The major reason to construct large dams is to store surplus water during rainy seasons and utilize it for water supply in dry seasons. Reservoir storage has to meet a pre-defined target to satisfy water demands and cope with a dry season when the availability of water resources are limited temporally as well as spatially. In this study, a Hedging rule that reduces total reservoir outflow as drought starts is applied to alleviate severe water shortages. Five stages for reducing outflow based on the current reservoir storage are proposed as the Hedging rule. The objective function is to minimize the total discrepancies between the target and actual reservoir storage, water supply and demand, and required minimum river discharge and actual river flow. Mixed Integer Linear Programming (MILP) is used to develop a multi-reservoir operation system with the Hedging rule. The developed system is applied for the Han River basin that includes four multi-purpose dams and one water supplying reservoir. One of the fours dams is primarily for power generation. Ten-day-based runoff from subbasins and water demand in 2003 and water supply plan to water users from the reservoirs are used from "Long Term Comprehensive Plan for Water Resources in Korea" and "Practical Handbook of Dam Operation in Korea", respectively. The model was optimized by GAMS/CPLEX which is LP/MIP solver using a branch-and-cut algorithm. As results, 99.99% of municipal demand, 99.91% of agricultural demand and 100.00% of minimum river discharge were satisfied and, at the same time, dam storage compared to the storage efficiency increased 10.04% which is a real operation data in 2003.

• Journal of the Korea Concrete Institute
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• v.22 no.3
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• pp.389-397
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• 2010

Concrete has excellent mechanical properties, high durability, and economical advantages over other construction materials. Nevertheless, it is not an easy task to apply concrete to long span bridges. That's because concrete has a low strength to weight ratio. Ultra high performance concrete (UHPC) has a very high strength and hence it allows use of relatively small section for the same design load. Thus UHPC is a promising material to be utilized in the construction of long span bridges. However, there is a possibility of crack generation during the curing process due to the high binder ratio of UHPC and a consequent large amount of hydration heat. In this study, adiabatic temperature rise and mechanical properties were modeled for the stress analysis due to hydration heat. Adiabatic temperature rise curve of UHPC was modeled superposing 2-parameter model and S-shaped function, and the Arrhenius constant was determined using the concept of equivalent time. The results are verified by the mock-up test measuring the temperature development due to the hydration of UHPC. In addition, models for mechanical properties such as elastic modulus, tensile strength and compressive strength were developed based on the test results from conventional load test and ultrasonic pulse velocity measurement.

• Journal of Korea Water Resources Association
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• v.36 no.3 s.134
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• pp.345-363
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• 2003

From the General Circulation Models(GCMs), it is known that the increases of concentrations of greenhouse gases will have significant implications for climate change in global and regional scales. The GCM has an uncertainty in analyzing the meteorologic processes at individual sites and so the 'downscaling' techniques are used to bridge the spatial and temporal resolution gaps between what, at present, climate modellers can provide and what impact assessors require. This paper describes a method for assessing local climate change impacts using a robust statistical downscaling technique. The method facilitates the rapid development of multiple, low-cost, single-site scenarios of daily surface weather variables under current and future regional climate forcing. The construction of climate change scenarios based on spatial regression(transfer function) downscaling and on the use of a local stochastic weather generator is described. Regression downscaling translates the GCM grid-box predictions with coarse resolution of climate change to site-specific values and the values were then used to perturb the parameters of the stochastic weather generator in order to simulate site-specific daily weather values. In this study, the global climate change scenarios are constructed using the YONU GCM control run and transient experiments.

• KSBB Journal
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• v.19 no.4
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• pp.274-283
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• 2004

Six lumbrokinase (LK) fractions from Lumbricus rubellus lysates were purified by a series of column chromatographies. The molecular weights of the six LK fractions appeared to range from 24.6 to 33.1 kDa. In the experimental model of rat venous thrombosis, the thrombus weight and PAI activity decreased significantly when the LK was administered orally. However, the activities of APTT, PT and plasmin showed a significant increase. The aggregation of rat platelets pretreated with various LK doses was inhibited by thrombin, and the MDA generation decreased. The rat thoracic aorta and mesentric arteries contracted with phenylephrine relaxed due to the treatment of the LK fractions. These results suggest that the fibrinolytic effects of LK were mediated not only by proteolytic activity, but also by the inhibition of platelet agregation and the relaxation of blood vessels. It is concluded that the LK may be useful as a hemolytic agent for treatment of fibrin clot.

• BMB Reports
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• v.51 no.11
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• pp.584-589
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• 2018

Secondary prevention via earlier detection would afford the greatest chance for a cure in premalignant lesions. We investigated the exomic profiles of non-malignant and malignant changes in head and neck squamous cell carcinoma (HNSCC) and the genomic blueprint of human papillomavirus (HPV)-driven carcinogenesis in oropharyngeal squamous cell carcinoma (OPSCC). Whole-exome (WES) and whole-genome (WGS) sequencing were performed on peripheral blood and adjacent non-tumor and tumor specimens obtained from eight Korean HNSCC patients from 2013 to 2015. Next-generation sequencing yielded an average coverage of $94.3{\times}$ for WES and $35.3{\times}$ for WGS. In comparative genomic analysis of non-tumor and tumor tissue pairs, we were unable to identify common cancer-associated early mutations and copy number alterations (CNA) except in one pair. Interestingly, in this case, we observed that non-tumor tonsillar crypts adjacent to HPV-positive OPSCC appeared normal under a microscope; however, this tissue also showed weak p16 expression. WGS revealed the infection and integration of high-risk type HPV16 in this tissue as well as in the matched tumor. Furthermore, WES identified shared and tumor-specific genomic alterations for this pair. Clonal analysis enabled us to infer the process by which this transitional crypt epithelium (TrCE) evolved into a tumor; this evolution was accompanied by the subsequent accumulation of genomic alterations, including an ERBB3 mutation and large-scale CNAs, such as 3q27-qter amplification and 9p deletion. We suggest that HPV16-driven OPSCC carcinogenesis is a stepwise evolutionary process that is consistent with a multistep carcinogenesis model. Our results highlight the carcinogenic changes driven by HPV16 infection and provide a basis for the secondary prevention of OPSCC.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.28 no.2
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• pp.73-80
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• 2016

To reduce the mechanical energy loss and to get the high energy efficiency, an apparatus of wave power generation inducing a consistent one way rotating motion from the wave reciprocation motions was developed and the hydraulic experiments for the real electric power production were conducted and the results were discussed. In the experiments for the shape of the buoyant tank, the efficiency of the fixed 9 cm diameter type enduring the wave plate weight was 14.6% and this was the best result for all shapes. But although the free sliding type was expected to represent a high efficiency, the experiments did not show a good result as 8.5% efficiency. Therefore, the shape of buoyant tank was decided as the fixed 9 cm diameter type in the next all tests. In the experiments for the various incident waves, when the water depth was 90 cm, the average efficiencies were measured as 3.9% in the 2nd gear, 4.9% in the 3rd gear, 4.9% in the 4th gear, 12.0% in the 5th gear, 10.0% in the 6th gear, 3.1% in the 7th gear, and 3.0% in the 8th gear. Also, when the water depth was 80 cm, the average efficiency was shown as 15.0% with 5th gear condition. Therefore the high average efficiency as 13.5% was given with 80~90 cm water depth and the 5th gear in the model.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.35 no.1
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• pp.53-60
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• 2011

In this study, an organic Rankine-cycle system using HFC-134a, which is a power cycle corresponding to a low-temperature heat source, such as that for geothermal power generation, was investigated from the view point of power optimization. In contrast to conventional approaches, the heat transfer and pressure drop characteristics of the working fluid within the heat exchangers were taken into account by using a discretized heat exchanger model. The inlet flow rates and temperatures of both the heat source and the heat sink were fixed. The total heat transfer area was fixed, whereas the heat-exchanger areas of the evaporator and the condenser were allocated to maximize the power output. The power was optimized on the basis of three design parameters. The optimal combination of parameters that can maximize power output was determined on the basis of the results of the study. The results also indicate that the evaporation process has to be optimized to increase the power output.

• Journal of Engineering Education Research
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• v.10 no.2
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• pp.44-61
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• 2007

The present investigation is concerned chiefly with new curriculum development at the Department of Mechanical System & Design Engineering at Hongik University with the aim of enhancing creativity, team working and communication capability which modern engineering education is emphasizing on. 'Mechanical System & Design Engineering' department equipped with new curriculum emphasizing engineering design is new name for mechanical engineering department in Hongik University. To meet radically changing environment and demands of industries toward engineering education, the department has shifted its focus from analog-based and machine-centered hard approach to digital-based and human-centered soft approach. Three new programs of Introduction to Mechanical System & Design Engineering, Creative Engineering Design and Product Design emphasize hands-on experiences through project-based team working. Sketch model and prototype making process is strongly emphasized and cardboard, poly styrene foam and foam core plate are provided as working material instead of traditional hard engineering material such as metals material because these three programs focus more on creative idea generation and dynamic communication among team members rather than the end results. With generative, visual and concrete experiences that can compensate existing engineering classes with traditional focus on analytic, mathematical and reasoning, hands-on experiences can play a significant role for engineering students to develop creative thinking and engineering sense needed to face ill-defined real-world design problems they are expected to encounter upon graduation.

• Information Systems Review
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• v.8 no.1
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• pp.81-99
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• 2006

Recently, the area of ubiquitous has gained a great attention both in academics and in business organizations as we are entering an ubiquitous society where people can interact at "anytime" and "anywhere". To preoccupy the leading status for the next generation of IT technology, many countries such as Korea, Japan, and US are concerned the ubiquitous. In this tendency, companies want to identify what factors make people use ubiquitous in order to develop the effective ubiquitous service and to supply the higher quality service. However, prior researches on ubiquitous are focused on technical area such as higher data delivery, efficient compression of images, so they do not have given companies beneficial materials for making fascinating ubiquitous services. To offer the service materials for development, from the viewpoint of the customer, important factors to use ubiquitous services are investigated in this study. Moreover, the study was progressed up to the new area of investigation how much these factors influenced ubiquitous service actual usage. To achieve these goals, Ubiquitous service adopting reflected in ubiquitous service characteristics was suggested in this study. The results of this study are as follows. First, contextual offer, ubiquity, invisibility are positively related to perceived value. Second, perceived value is positively related to usage intention but perceived risk is negatively related to usage intention. Third, usage intention is positively related to usage frequency. Based on these results, managerial implications for ubiquitous service vitalization are discussed. Lastly, the limitation of this research and further research issues are suggested.

• Journal of Plant Biotechnology
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• v.42 no.4
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• pp.312-325
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• 2015

In this review, we summarized the trends of genomics and transcriptomics research on peach, a model species of Rosaceae. Peach genome maps have been developed from various progeny groups with many next-generation sequencing (NGS) based single nucleotide polymorphism markers. Molecular markers of qualitative traits and quantitative trait loci (QTL) such as fruit characteristics, blooming date, and disease resistance have been analyzed. Among many characteristics, markers related to flesh softening and flesh adhesion are useful for marker assisted selection. Through comparative genomics, peach genome has been compared to the genome of Arabidopsis, Populus, Malus, and Fragaria species. Through transcriptomics and proteomics, fruit growth and development, and flavonoid synthesis, postharvest related transcriptomes and disease resistance related proteins have been reported. Recently, development of NGS based markers, construction of core collection of germplasm, and genotyping of various progenies have been preceded. In the near future, accurate QTL analysis and identification of useful genes are expected to establish a foundation for effective molecular breeding.