• The Journal of Korean Medicine
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• v.26 no.1 s.61
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• pp.161-173
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• 2005

Objective : The water extract of Seokchangpowonji-san (SWS) has traditionally been used for treatment of dementia in oriental medicine. However, little is known about the mechanism by which the water extract of SWS rescues cells from neurodegenerative disease such as Alzheimer's disease. Methods & Results: This study was designed to investigate the protective mechanisms of SWS on $\beta-amyloid$ or $H_2O_2$-induced$ cytotoxicity in neuro 2A cells. $H_2O_2$ markedly decreased the viability of neuro 2A cells, which was characterized by apparent apoptotic features such as membrane blebbing as well as fragmentation of genomic DNA and nuclei. However, the water extract of SWS significantly reduced $H_2O_2-induced$ cell death and apoptotic characteristics through reduction of intracellular peroxide generation. Also, the. extract prevented the mitochondrial dysfunction including the disruption of mitochondria membrane permeability transition (MPT) and the modulation in expression of Bcl-2 family proteins in $H_2O_2­treated$ neuro 2A cells. Furthermore, pretreatment with SWS inhibited the activation of caspase-3, and in turn, degradation of ICAD/DFF45 was completely abolished in $H_2O_2-treated$ cells. Conclusion: Taken together, the data suggest that the protective effects of the water extract of SWS against $\beta-amyloid$ induced oxidative injuries may be achieved through modulation of mitochondrial dysfunction.

• The Korean Journal of Pain
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• v.27 no.3
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• pp.239-245
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• 2014

Background: Neuropathic pain induced by spinal or peripheral nerve injury is very resistant to common pain killers, nerve block, and other pain management approaches. Recently, several studies using stem cells suggested a new way to control the neuropatic pain. In this study, we used the spinal nerve L5 ligation (SNL) model to investigate whether intrathecal rat mesenchymal stem cells (rMSCs) were able to decrease pain behavior, as well as the relationship between rMSCs and reactive oxygen species (ROS). Methods: Neuropathic pain of the left hind paw was induced by unilateral SNL in Sprague-Dawley rats (n = 10 in each group). Mechanical sensitivity was assessed using Von Frey filaments at 3, 7, 10, 12, 14, 17, and 24 days post-ligation. rMSCs ($10{\mu}l$, $1{\times}10^5$) or phosphate buffer saline (PBS, $10{\mu}l$) was injected intrathecally at 7 days post-ligation. Dihydroethidium (DHE), an oxidative fluorescent dye, was used to detect ROS at 24 days post-ligation. Results: Tight ligation of the L5 spinal nerve induced allodynia in the left hind paw after 3 days post-ligation. ROS expression was increased significantly (P < 0.05) in spinal dorsal horn of L5. Intrathecal rMSCs significantly (P < 0.01) alleviated the allodynia at 10 days after intrathecal injection (17 days post-ligation). Intrathecal rMSCs administration significantly (P < 0.05) reduced ROS expression in the spinal dorsal horn. Conclusions: These results suggest that rMSCs may modulate neuropathic pain generation through ROS expression after spinal nerve ligation.

• Journal of The Korean Society of Agricultural Engineers
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• v.56 no.5
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• pp.89-99
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• 2014

The goal of this study was to evaluate sediment reduction effects of VFS (vegetative filter strip) applied for Iksan area in Saemangeum watershed. This study simulated runoff and sediment load from different types of uplands using VFSMOD-W. The general upland characteristics of the study area was investigated to build reasonable scenarios of the simulation. The simulation scenarios were designed by various areas, shapes, and slopes of uplands. Grass mixture was selected as VFS vegetation and the size of VFS was fixed as 10 % of uplands area. Additionally 50mm, 100mm, 150mm of daily rainfall were applied for the runoff and sediment simulation. As results, the calculated runoff and sediment loads were obtained $20.7{\sim}1,030.6m^3$ and 568.4~675,731.4 kg for the range of 0.1~1.0 ha of uplands with 7 % and 15 % slopes. The reduction effects on runoff and sediment were obtained 5~10 % and 21.0~47.7 % respectively from VFS applications. The VFSMOD-W simulations showed that runoff tended to increase as upland area and amount of rainfall increased while sediment increased when slope, length and area of uplands and amount of rainfall increased. These results indicated that rainfall amount and upland size are the critical factors for the generation of runoff and sediment load. In order to support this conclusion, further studies such as, long term monitoring, field experiments, and to calibrate and evaluate the model are necessary.

• Journal of Korea Technology Innovation Society
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• v.13 no.4
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• pp.700-716
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• 2010

This paper examines the development of smelting reduction process in POSCO from 1990 to 2007 with the perspective of post catch-up technological innovation. POSCO paid attention to smelting reduction process as a sort of next-generation iron and steel technology, and implemented COREX (coal ore reduction) by the cooperation with V$\"{o}$oest. In addition to this, POSCO started to develop FINEX (fine iron ore reduction) which can use abundant powder ore, and FINEX was developed through model plant, pilot plant, demo plant, and commercial facility. POSCO came up to innovation leader beyond fast follower by securing almost technologies concerning FINEX. The case of smelting reduction process shows various characteristics including appropriate technological choice, successive scale-up, spiral development system, complementary technological cooperation, long-tenn investment, the existence of top management's leadership, and Korean government's support in early stage. This case can be interpreted as a path-revealing innovation in the middle of technological paradigm change.

• Journal of the Korean Institute of Intelligent Systems
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• v.24 no.5
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• pp.457-461
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• 2014

Using $0.18{\mu}m$ CMOS process silicon neuron circuit of the pulse type for modeling biological neurons, were designed in the semiconductor integrated circuit. Neuron circuiSt providing is formed by MOS switch for initializing the input terminal of the capacitor to the input current signal, a pulse signal and an amplifier stage for generating an output voltage signal. Synapse circuit that can convert the current signal output of the input voltage signal, using a bump circuit consisting of NMOS transistors and PMOS few. Configure a chain of neurons for verification of the neuron model that provides synaptic neurons and two are connected in series, were performed SPICE simulation. Result of simulation, it was confirmed the normal operation of the synaptic transmission characteristics of the signal generation of nerve cells.

• 한국지형공간정보학회:학술대회논문집
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• 2002.11a
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• pp.73-80
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• 2002

RFM is believed to be universally applicable to any type of the sensor. Most of researches carried out lately are concentrated on terrain-independent method, but the researches about approvement of accuracy by way of terrain-dependent method are required to increase a practical use of satellite imagery in nonprofessional groups. This research focused on a means to improve RFM solution, a matching technique, and a generation of DEM through a correlation analysis, with terrain-dependent solution. The result shows that accuracy problem which is caused by over-parameterization on RFCs was removed through correlation analysis, and it was possible to generate a accurate DEM with terrain-dependent solution. And also, the application of RFM with different satellite images show sensor independent characteristics of RFM

• 한국지형공간정보학회:학술대회논문집
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• 2002.11a
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• pp.58-65
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• 2002

The most widespread techniques for DEM generation are stereoscopy for optical sensor images and interfereometry for SAR images. These techniques suffer from certain sensor and processing limitations, which can be overcome by the synergetic use of both sensors and DEMs respectively. In this paper, different strategies for fusing SAR and optical data are combined to derive high quality DEM products. The multiresolution wavelet transform, which take advantage of the complementary properties of SAR and stereo optical DEMs, will be applied for the fusion process. By taking advantage of the fact that errors of the DEMs are of different nature using the multiresolution wavelet transform, affected part are filtered and replaced by those of the counterpart and is tested with two sets of SPOT and ERS DEM, resulting in a remarkable improvement in DEM. For the analysis of results, the reference DEM is generated from digital base map(1:5000).

• Journal of Korean Society of Industrial and Systems Engineering
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• v.26 no.4
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• pp.82-90
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• 2003

The Systems Engineering, as a methodology for engineering and management of today's ever-growing complex system, is a comprehensive and iterative problem-solving process. The process centers on the analysis and management of the stakeholders' needs throughout the entire life-cycle of a system and searches for an optimized system architecture. There are many essential needs and requirements to be met when a system development task is carried out. Systems Engineering Management Plan(SEMP), as a specification for system development process, must be established to satisfy constraints and requirements of stakeholders successfully and to prevent cost overrun and schedule delay. SEMP defines technical management functions and comprehensive plans for managing and controlling the entire system development process, specialty engineering processes, etc. Especially. in the case of a large-scale complex system development program where various disciplinary engineering such as mechanical; electrical; electronics; control; telecommunication; material; civil engineering etc. must be synthesized, it Is essential to develop SEMP to ensure systematic and continuous process improvements for quality and to prevent cost/schedule overruns. This study will enable the process knowledge management on the subject of SEMP as a core systems engineering management effort, that is, definitely defining and continuously managing specification of development process about requirements, functions, and process realization of it using a computer-aided systems engineering software. The paper suggests a systematic SEMP development process and demonstrates a data model and schema for computer-aided systems engineering software, RDD-100, for use in the development and management of SEMP. These are being applied to the systems engineering technology development task for the next-generation high-speed railway systems in progress.

• Bulletin of the Society of Naval Architects of Korea
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• v.14 no.1
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• pp.1-10
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• 1977

The major objects of this report are to supplement data of natural frequencies of thin elastic rectangular plates to the available data, and to give an experimental verification for natural frequencies obtained by Rayleigh-Ritz method, the generation set of which are eigenfunctions of Euler beams. For the first object the following five models, for which data only for the fundamental mode or data only for square plates are available, are adopted; (1) two opposed edges are clamped and the other two opposed edges simply supported (C-C, S-S), (2) one edge is simply supported and the other three edges clamped (C-C, C-S), (3) one edge is free and the other three edges clamped (C-C, C-F), (4) two adjacent edges are clamped and the other two adjacent edges free (C-F, C-F). For the (C-C, S-S) model the frequency equation obtained with the mode shapes assumed as of a single trigonometric series is solved. And for the other four models Rayleigh-Ritz method taking eigenfunctions of Euler beams as the generating set is applied. The numerical examples are obtained up to the fourth, the fifth or the sixth order depending on the range of the aspect ratio (0.1-10.0). The number of terms in the generating set for Rayleigh-Ritz method is fifteen for all models. For the experiment three models made of 3.2mm thickness mild steel plate for general structure use were prepared in following size; $300mm{\times}600mm,\;600mm{\times}600mm\;and\;900mm{\times}600mm$. Their boundary conditions are made to fit (C-C, C-F) condition. From the experiment mechanical impedance curves based on the frequency response method were obtained together with phase relation diagrams. The experimental data are resulted in good conformity to calculated values.

• Journal of Digital Convergence
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• v.14 no.9
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• pp.89-97
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• 2016

Intellectual property rights play a key role in employment creation and income generation plays an important role, especially in the creative economy. Many companies are ultimately increasing efforts to boost the company's financial performance, such as maximizing profits by building a strong brand assets amid committed to brand management in this paradigm. Reasonable evaluation and commercialization of technology transactions, financial assistance, investment decisions, trademark brand value for the reactivation (revitalizing) for the purposes of M & A, litigation, brand strategy will be said to be very important. In spite of the importance, the awareness of the property and the capabilities to assess are hardly sufficient. Thus, this study, targeting companies with valid trademarks for value assessment, conducted case analysis by cost method and income approach; the analysis presented the result from 2.05 million by the cost method to 2.7 million by the income approach applied to a variable discount rate and adjustment contribution. However, now that the implication was drawn from a single company, further studies covering case study and application plan according to scale and type of diverse company groups should be continued.