• 농업과학연구
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• 제43권4호
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• pp.623-633
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• 2016

A total of 6,973 steer growth records of Hanwoo breeding bull's progeny test data collected from 1989 to 2015 were analyzed to identify the most appropriate growth curve among three growth curve models (Gompertz, Logistic and von Bertalanffy). The Gompertz growth curve model equation was $W_t=990.5e^{{-2.7479e}^{-0.00241t}}$, the Logistic growth curve model equation was $W_t=772(1+8.3314e^{-0.00475t})^{-1}$, and the von Bertalanffy growth curve model equation was $W_t=1,196.4(1-0.646e^{-0.00162t})^3$. The Gompertz model parameters A, b, and k were estimated to be $990.5{\pm}10.27$, $2.7479{\pm}0.0068$, and $0.00241{\pm}0.000028$, respectively. The inflection point age was estimated to be 421 days and the weight of inflection point was 365.3 kg. The Logistic model parameters A, b, and k were estimated to be $772.0{\pm}4.12$, $8.3314{\pm}0.0453$, and $0.00475{\pm}0.000033$, respectively. The inflection point age was estimated to be 445 days and the weight of inflection point was 385.0 kg. The von Bertalanffy model parameters A, b, and k were estimated to be $1196.4{\pm}18.39$, $0.646{\pm}0.0010$, and $0.00162{\pm}0.000027$, respectively. The inflection point age was estimated to be 405 days and the weight of inflection point was 352.0 kg. Mature body weight of the von Bertalanffy model was 1196.4 kg, the Gompertz model was 990.5 kg, and the Logistic model was 772.0 kg. The difference between actual and estimated weights was similar in the Logistic model and the von Bertalanffy model. The difference between market weight and estimated market weight was the lowest in the Gompertz model. The growth curve using the von Bertalanffy model showed the lowest mean square error.

• Nuclear Medicine and Molecular Imaging
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• 제42권1호
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• pp.1-7
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• 2008

PET allows non-invasive, quantitative and repetitive imaging of biological function in living animals. Small animal PET imaging with $[^{18}F]$FDG has been successfully applied to investigation of metabolism, receptor-ligand interactions, gene expression, adoptive cell therapy and somatic gene therapy. Experimental condition of animal handling impacts on the biodistribution of $[^{18}F]$FDG in small animal study. The small animal PET and CT images were registered using the hardware fiducial markers and small animal contour point. Tumor imaging in small animal with small animal $[^{18}F]$FDG PET should be considered fasting, warming, and isoflurane anesthesia level. Registered imaging with small animal PET and CT image could be useful for the detection of tumor. Small animal experimental condition of animal handling and registration method will be of most importance for small lesion detection of metastases tumor model.

• Reproductive and Developmental Biology
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• 제37권1호
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• pp.41-49
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• 2013

Ovarian cancer is the most lethal world-wide gynecological disease among women due to the lack of molecular biomarkers to diagnose the disease at an early stage. In addition, there are few well established relevant animal models for research on human ovarian cancer. For instance, rodent models have been established through highly specialized genetic manipulations, but they are not an excellent model for human ovarian cancer because histological features are not comparable to those of women, mice have a low incidence of tumorigenesis, and they experience a protracted period of tumor development. However, the laying hen is a unique and highly relevant animal model for research on human ovarian cancer because they spontaneously develop epithelial cell-derived ovarian cancer (EOC) as occurs in women. Our research group has identified common histological and physiological aspects of ovarian tumors from women and laying hens, and we have provided evidence for several potential biomarkers to detect, monitor and target for treatment of human ovarian cancers based on the use of both genetic and epigenetic factors. Therefore, this review focuses on ovarian cancer of laying hens and relevant regulatory mechanisms, based on genetic and epigenetic aspects of the disease in order to provide new information and to highlight the advantages of the laying hen model for research in ovarian carcinogenesis.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2008년도 춘계학술대회
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• pp.132-132
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• 2008

• 한국축산식품학회지
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• 제38권3호
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• pp.442-450
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• 2018

Liquid egg products can be contaminated with Salmonella spp. during processing. A predictive model for the growth of Salmonella spp. in unpasteurized liquid eggs was developed and validated. Liquid whole egg, liquid yolk, and liquid egg white samples were prepared and inoculated with Salmonella mixture (approximately 3 Log CFU/mL) containing five serovars (S. Bareilly, S. Richmond, S. Typhimurium monophasic, S. Enteritidis, and S. Gallinarum). Salmonella growth data at isothermal temperatures (5, 10, 15, 20, 25, 30, 35, and $40^{\circ}C$) was collected by 960 h. The population of Salmonella in liquid whole egg and egg yolk increased at above $10^{\circ}C$, while Salmonella in egg white did not proliferate at all temperature. These results demonstrate that there is a difference in the growth of Salmonella depending on the types of liquid eggs (egg yolk, egg white, liquid whole egg) and storage temperature. To fit the growth data of Salmonella in liquid whole egg and egg yolk, Baranyi model was used as the primary model and the maximum growth rate and lag phase duration for each temperature were determined. A secondary model was developed with maximum growth rate as a function of temperature. The model performance measures, bias factor ($B_f$, 0.96-0.99) and $r^2$ (0.96-0.99) indicated good fit for both primary and secondary models. In conclusion, it is thought that the growth model can be used usefully to predict Salmonella spp. growth in various types of unpasteurized liquid eggs when those are exposed to various temperature and time conditions during the processing.

• 한국축산시설환경학회지
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• 제16권1호
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• pp.29-40
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• 2010

본 연구에서는 동물복지형 축산물의 경제적 가치를 국내외의 선행연구를 통하여 알아보고자 하였다. 이 연구를 위하여 국내 외에서 발간된 다양한 연구결과를 참고하였다. 분석결과 국내 외 모두 이 분야에 대한 연구가 그리 활발하지 않다는 점을 발견하였다. 분석은 소고기, 돼지고기, 닭고기, 칠면조고기 등의 육류와 계란에 대한 소비자들의 의식조사가 주를 이루고 있었다. 여기에 사용된 데이터는 설문조사를 통한 데이터가 주를 이루고 있었으며, Lexis-Nexis databases, 소고기, 돼지고기, 가금육, 비육류 식품에 대한 분기별 소비량과 소비자가격, 그리고 경매실험을 통한 데이터 등이 사용되었다. 한편, 분석모형으로는 Random parameters logit and latent c1ass model, WTP 분석, Roterdam model, Pearson's Chi test, Mann-Whitney U-test, Kruskal-Wallis test, structural equation model, 회귀분석, Target-costing, 그리고 conjoint 분석 등이 사용되었다.

• 한국응용과학기술학회지
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• 제30권4호
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• pp.622-634
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• 2013

The multi-origin of obesity and its associated diseases made it's a complex area of biomedical science research and severe health disorder. From the 1970s to onwards this health problem turned to an epidemic without having any report of declining yet and it created a red alert to the health sector. Meanwhile, many animal models have been developed to study the lethal effect of obesity. In consequence, many drugs, therapies and strategies have already been adopted based on the findings of those animal models. However, many complicated things based on molecular and generic mechanism has not been clarified to the date. Thus, it is important to develop a need based animal model for the better understanding and strategic planning to eliminate/avoid the obesity disorder. Therefore, the present review would unveil the pros and cons of presently established animal models for obesity research. In addition, it would indicate the required turning direction for further obesity and obesity based disease research.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2007년도 추계국제학술대회 및 컨퍼런스
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• pp.624-624
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• 2007

• 대한한의학회지
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• 제20권4호
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• pp.82-92
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• 2000

The purpose of the present study was to explore the proper method for animal stroke model of Oriental medicine To this end, brain ischemia was induced by distal middle cerebral artery occlusion(dMCAO) and proximal middle cerebral artery occlusion(pMCAO) and evaluated with the method of Triphenyl Tetrazolium Chloride (TTC) staining and Swimming Behavior Test. Results demonstrated that first, infarct size and volume of pMCAO group were significantly bigger that those of dMCAO group. Second, analysis of swimming behavior test revealed that the percentage of left turning angles of pMCAO was significantly bigger than that of dMCAO. Third, during swimming behavior test, there were peculiar traces of small successive circles that represent motor dysfunction and conscious disturbance among dMCAO group. The results of the study thus indicate that non-invasive intraluminal method of pMCAO was the appropriate animal stroke model for Oriental medicine in the light of brain ischemia as hemiplesia and conscious disturbance.

• 한국초지조사료학회지
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• 제40권3호
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• pp.167-176
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• 2020

The objective of the present study was to determine the best model to describe and quantify the changes in live body weight, height at withers, height at rump, body length and chest girth of Holstein cows raised under Korean feeding conditions for 50 months. The five standard growth models namely polynomial linear regression models, regression of growth variables on the first and second-order of ages in days (model 1) and regression of growth variables on age covariates from first to the third-order (model 2) as well as non-linear models were fitted and evaluated for representing growth pattern of Holstein cows raised in Korean feeding circumstances. Nonlinear models fitted were three exponential growth curve models; Brody, Gompertz, and von Bertalanffy functional models. For this purpose, a total of 22 Holstein cows raised in Korea used in the period from April 2016 to May 2020. Each model fitted to monthly growth curve records of dairy cows by using PROC NLIN procedure in SAS program. On the basis of the results, nonlinear models showed the lower root mean square of error (RMSE) for live body weight, height at withers, height at rump, body length and chest girth (12.22, 1.95, 1.55, 4.04, 2.06) with higher correlation coefficiency (R²) values for live body weight, height at withers, height at rump, body length and chest girth (0.99, 0.99, 0.99, 1.00, 1.00). Overall, the evaluation of the different growth models indicated that the Gompertz model used in the study seemed to be the most appropriate one for standard growth of Holstein cows raised under Korean feeding system.