• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.31 no.2
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• pp.173-183
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• 2021

Objectives: This study evaluated the skin permeability of lawsone in henna hair dyes to understand the exposure characteristics of henna hair dyes in the human body. It examined the protective effects of protectants by applying protectants A, B, and C to test skin. Methods: Skin absorption tests were conducted using Franz diffusion cells according to OECD test guideline 428. After applying one kind of natural henna hair dye and chemical henna hair dye, respectively, to a standardized pig skin model, samples of receptor fluid were collected at 1h, 3h, 6h, and 24h. The skin permeation of lawsone was determined using HPLC. After the skin absorption experiment, the skin to which hair dye was applied was analyzed to determine the residual amount of lawsone in the skin. Results: The cumulative permeation of both natural and chemical henna hair dyes increased over time, and the natural henna hair dye had a flux value (t=3.194, p<.05) high both in the K_p value (t=3.207, p<.05) and the residual amount (t=22.701, p<.001). For skin treated with a protectant, the cumulative permeation of natural henna hair dye 24h control and the cumulative permeation of protectant A, B, and C increased over time. Flux and K_p values were in the order control > protectant A > protectant C > protectant B. The residual amount (F=4.469, p<.05) was in the order of protectant C > protectant A > protectant B > control. At 3h, the dye application time of natural henna hair dye, the lawsone flux value (F=4.454, p<.05) and K_p value (F=4.455, p<.05) were higher in the control group than in the protectant groups. The 24h cumulative permeation of the chemical henna hair dye increased with time in both the control and the protectant groups, and the flux and K_p values were in the order of protectant A > protectant C > protectant B > control. The residual amount (F=7.901, p<.01) was in the order of protectant B > protectant A> protectant C > control. Conclusions: Within the normal dyeing time for henna hair dye (three hours for natural henna hair dyes and 30 minutes for chemical henna hair dyes) lawsone skin penetration was not observed even when no protective agent was applied. After that time, however, evidence of skin penetration and retention of lawsone and the protective effect of protective agents were observed.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.49 no.9
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• pp.709-719
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• 2021

Recent progress in analysis and flight simulation methods enables wider use of a virtual certification and reduces number of certification flight tests. Aerodynamic database (AeroDB) is one of the most important components for the flight simulation. It is composed of aerodynamic coefficients at a range of flight conditions and control deflections. This paper proposes and efficient method for construction of AeroDB that combines Gaussian Process based Variable Fidelity Modeling with adaptive sampling algorithm. A case study of virtual certification of a F-16 fighter is presented. Four AeroDB were constructed using different number and distribution of high-fidelity data points. The constructed database is then used to simulate gliding, short pitch, and roll response. Compliance with certification regulations is then checked. The case study demonstrates that the proposed method can significantly reduce number of high-fidelity data points while maintaining high accuracy of the simulation.

• Smart Structures and Systems
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• v.24 no.6
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• pp.769-781
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• 2019

Dynamic displacement response of civil structures is an important index for in-construction and in-service structural condition assessment. However, accurately measuring the displacement of large-scale civil structures such as high-rise buildings still remains as a challenging task. In order to cope with this problem, a vision-based system with the use of industrial digital camera and image processing has been developed for long-distance, remote, and real-time monitoring of dynamic displacement of supertall structures. Instead of acquiring image signals, the proposed system traces only the coordinates of the target points, therefore enabling real-time monitoring and display of displacement responses in a relatively high sampling rate. This study addresses the in-situ experimental verification of the developed vision-based system on the Canton Tower of 600 m high. To facilitate the verification, a GPS system is used to calibrate/verify the structural displacement responses measured by the vision-based system. Meanwhile, an accelerometer deployed in the vicinity of the target point also provides frequency-domain information for comparison. Special attention has been given on understanding the influence of the surrounding light on the monitoring results. For this purpose, the experimental tests are conducted in daytime and nighttime through placing the vision-based system outside the tower (in a brilliant environment) and inside the tower (in a dark environment), respectively. The results indicate that the displacement response time histories monitored by the vision-based system not only match well with those acquired by the GPS receiver, but also have higher fidelity and are less noise-corrupted. In addition, the low-order modal frequencies of the building identified with use of the data obtained from the vision-based system are all in good agreement with those obtained from the accelerometer, the GPS receiver and an elaborate finite element model. Especially, the vision-based system placed at the bottom of the enclosed elevator shaft offers better monitoring data compared with the system placed outside the tower. Based on a wavelet filtering technique, the displacement response time histories obtained by the vision-based system are easily decomposed into two parts: a quasi-static ingredient primarily resulting from temperature variation and a dynamic component mainly caused by fluctuating wind load.

• Journal of Digital Convergence
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• v.17 no.11
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• pp.279-288
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• 2019

The aim of this study was to identify the factors related to the practice of patient safety management (PSM) in nursing college students. The participants comprised 139 students in a nursing college. Data collection was conducted for five days from November 26, 2018 to November 30, 2018. The data were analyzed using descriptive statistics, paired t-test, independent t-tests, one-way analysis of variance (ANOVA), Pearson's correlation coefficient, and a multiple regression analysis. The total score for practice of PSM was $4.25{\pm}0.48$ out of a maximum of 5. Practice of PSM had a statistically significant relationship with attitude (r=.39, p<.001), confidence (r=.43, p<.001), and perception of the importance (r=.54, p<.001). The factors affecting practice of PSM were perception of the importance (${\beta}=.43$, p<.001) and confidence (${\beta}=.26$, p=.001); the explanatory power of the model was 38%. Therefore, it is necessary to include the perception of importance of PSM and confidence in the practice of PSM by nursing college students.

• The Korean Journal of Franchise Management
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• v.10 no.2
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• pp.49-58
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• 2019

Purpose - As the growth potential of the cultural contents industry steadily grows, the cinemas industry is growing fast especially due to popularity and commerciality. The recent in the cinemas industry is evolving on multiplex cinemas that combine cultural facilities such as theaters, restaurants, and shopping centers. Due to the rapid growth of multiplex cinemas, many researchers have studied the characteristics of visiting customers in Korea. Among them, selection attribute of multiplex cinemas, including the service quality and physical environment, is important because it may examines the cause of customer 's behavior. Thus, this research focuses on the effects of the selection attributes of the multiplex cinemas on customer satisfaction and their loyalty. This research suggests the guidelines for how cinemas should manage their customers and build their customers satisfaction and loyalty that improve business performance. Research design, data, and methodology - This study tests the structural relationship between selection attributes of multiplex cinemas, customer satisfaction, and loyalty. selection attributes of multiplex cinemas divide into five sub-dimensions such as movies facility quality, services, cleanliness, accessibility, and snack bars quality. In order to examine the purposes of this research, research model and hypotheses were developed. All constructs were measured with multiple items developed and tested in the previous studies. The data were collected from 100 students in their 10-20s and were analyzed using SPSS 22.0, SmartPLS 3.0 and fsQCA program. Result - The findings of this research are as follows. First, all selection attributes except cleanliness have significant positive impacts on customer satisfaction and loyalty. Second, customer satisfaction has significant positive impact on loyalty. Third, as a result of fsQCA, high satisfaction and high accessibility were the necessary conditions on loyalty. Fourth, the necessary conditions for male and female groups were different. Conclusions - The implications of this study are as follows. Overall, multiplex cinemas should manage selection attributes basically regardless of the type of theater. Especially, cleanliness was not significant, but the customer probably consider it an essential and basic factors. Also, they are able to manage the selection attributes differently depending on the type of gender. For the male customers, it is effective that centralized strategy and for female customers, it is effective that emphasized the multiplex cinemas image.

• Journal of Ginseng Research
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• v.45 no.2
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• pp.325-333
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• 2021

Background: Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorders. Enhancing hippocampal neurogenesis by promoting proliferation and differentiation of neural stem cells (NSCs) is a promising therapeutic strategy for AD. 20(S)-protopanaxadiol (PPD) and oleanolic acid (OA) are small, bioactive compounds found in ginseng that can promote NSC proliferation and neural differentiation in vitro. However, it is currently unknown whether PPD or OA can attenuate cognitive deficits by enhancing hippocampal neurogenesis in vivo in a transgenic APP/PS1 AD mouse model. Here, we administered PPD or OA to APP/PS1 mice and monitored the effects on cognition and hippocampal neurogenesis. Methods: We used the Morris water maze, Y maze, and open field tests to compare the cognitive capacities of treated and untreated APP/PS1 mice. We investigated hippocampal neurogenesis using Nissl staining and BrdU/NeuN double labeling. NSC proliferation was quantified by Sox2 labeling of the hippocampal dentate gyrus. We used western blotting to determine the effects of PPD and OA on Wnt/GSK3β/β-catenin pathway activation in the hippocampus. Results: Both PPD and OA significantly ameliorated the cognitive impairments observed in untreated APP/PS1 mice. Furthermore, PPD and OA significantly promoted hippocampal neurogenesis and NSC proliferation. At the mechanistic level, PPD and OA treatments resulted in Wnt/GSK-3β/β-catenin pathway activation in the hippocampus. Conclusion: PPD and OA ameliorate cognitive deficits in APP/PS1 mice by enhancing hippocampal neurogenesis, achieved by stimulating the Wnt/GSK-3β/β-catenin pathway. As such, PPD and OA are promising novel therapeutic agents for the treatment of AD and other neurodegenerative diseases.

• Korean Journal of Metals and Materials
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• v.49 no.8
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• pp.628-634
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• 2011

SA508 Gr.4N Ni-Cr-Mo low alloy steel, in which Ni and Cr contents are higher than in commercial SA508 Gr.3 Mn-Mo-Ni low alloy steels, may be a candidate reactor pressure vessel (RPV) material with higher strength and toughness from its tempered martensitic microstructure. The inner surface of the RPV is weld-cladded with stainless steels to prevent corrosion. The goal of this study is to evaluate the microstructural properties of the clad interface between Ni-Cr-Mo low alloy steel and stainless weldment, and the effects of post weld heat treatment (PWHT) on the properties. The properties of the clad interface were compared with those of commercial Mn-Mo-Ni low alloy steel. Multi-layer welding of model alloys with ER308L and ER309L stainless steel by the SAW method was performed, and then PWHT was conducted at $610^{\circ}C$ for 30 h. The microstructural changes of the clad interface were analyzed using OM, SEM and TEM, and micro-Vickers hardness tests were performed. Before PWHT, the heat affected zone (HAZ) showed higher hardness than base and weld metals due to formation of martensite after welding in both steels. In addition, the hardness of the HAZ in Ni-Cr-Mo low alloy steel was higher than that in Mn-Mo-Ni low alloy steel due to a comparatively high martensite fraction. The hardness of the HAZ decreased after PWHT in both steels, but the dark region was formed near the fusion line in which the hardness was locally high. In the case of Mn-Mo-Ni low alloy steel, formation of fine Cr-carbides in the weld region near the fusion line by diffusion of C from the base metal resulted in locally high hardness in the dark region. However, the precipitates of the region in the Ni-Cr-Mo low alloy steel were similar to that in the base metal, and the hardness in the region was not greatly different from that in the base metal.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.3
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• pp.40-47
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• 2021

This study investigates the influence of hooked-end steel fiber volume fraction and aspect ratio on the mechanical properties, such as compressive and flexural performance, of concrete with specified compressive strength of 30MPa. Three types of hooked-end steel fibers with aspect ratios of 64, 67 and 80 were selected. The flexural tests of steel fiber reinforced concrete (SFRC) prismatic specimens were conducted according to EN 14651. The compressive performance of SFRC with different volume fractions (0.25, 0.50 and 0.75%) were evaluated through standard compressive strength test method (KS F 2405). Experimental results indicated that the flexural strength, flexural toughness, fracture energy of concrete were improved as steel fiber volume fraction increases but there is no unique relationship between steel fiber volume fraction and compressive performance. The flexural and compressive properties of concrete incorporating hooked-end steel fiber with aspect ratio of 64 and 80 are a little better than those of SFRC with aspect ratio of 67. For each SFRC mixture used in the study, the residual flexural tensile strength ratio defined in Model Code 2010 was more than the limit value to be able to substitute rebar or welded mesh in structural members with the fiber reinforcement.

• Journal of the Korea institute for structural maintenance and inspection
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• v.25 no.3
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• pp.100-109
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• 2021

This study was examined the tensile strength change of a circular tubular member with artificial sectional damage on its surface to consider surface sectional damage by corrosion. The tensile strength tests were conducted using circular tubular specimens with artificial sectional damage considering sectional damaged height and width on its surface according to the corrosion level. From the tensile strength test results, it is confirmed that tensile strength of the circular tubular specimens was affected by the damaged circumference (damaged width), not damaged length (damaged height) and their tensile failures were appeared at the minimum section of the artificial sectional damage part. Nonlinear finite-element analyses were conducted considering equivalent sectional damage effect on sectional damaged part in tensile specimens to examine the change in the tensile strength of tubular specimens with artificial sectional damage since it is difficult to estimate the sectional damaged surface condition of the specimens clearly. From the nonlinear finite element analysis results for the tensile test specimens, tensile strengths of test specimens with irregular sectional damaged surface were relatively evaluated to be highly decreased than these of FE analysis model with equivalent sectional damage. Therefore, residual tensile strengths of tensile members with irregular sectional damage as local corrosion can be evaluated and predicted using correlation coefficient between tensile test results and FE analysis results with equivalent sectional damage.

• Journal of the Korean Geosynthetics Society
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• v.19 no.4
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• pp.75-84
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• 2020

This paper described the analysis result on heaving of soft ground with DCM column type, based on the results of laboratory model tests on the soft ground with DCM column. The heave characteristics of the soft ground were evaluated according to the application of DCM column in soft ground. The results showed that the heaving of soft ground without DCM column occurred rapidly when the lateral deformation of soft ground increased significantly under the 4th load step condition. In addition, the heaving of soft ground in final load step caused tensile failure of the ground surface. The maximum heaving of the soft ground with the DCM column occurred in the final load step, and the heaving quantity decreased in the order of pile, wall, and grid type. Especially, the soft ground with DCM of grid type effectively resisted ground heaving, even if it was extremely failure in the bottom ground of embankment. The results of the maximum heaving according to the measurement point showed that the heaving of the soft ground with DCM of grid type was 3.1% and 1.6% compared to that of the pile and wall type at the location of LVDT-1, and the heaving of the LVDT-2 position was 1.0% and 2.1%, respectively.