• 농업과학연구
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• 제38권2호
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• pp.325-330
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• 2011

In order to revive the ecological function of degraded rivers, a total restoration plan for riverbeds and riparians needs to be developed. Previous evaluations for rivers were mainly focused on the river's physical structures. Therefore, this research has developed indicators to evaluate a riparian restoration considering biodiversity. Through literature and previous cases review, 4 fields and 13 indicators are selected for the evaluation. Four fields are biodiversity, habitat diversity, connectivity and habitat functionality. In the biodiversity field, 4 indicators of the exuberant extent of herbaceous vegetation and their diversity, the exuberant extent of shrub and woody plants and their diversity, the number of plant communities and naturalized plants are included. Habitat diversity are comprised of 4 indicators of the longitudinal continuity of vegetation, the mixture of plant communities, the extent of plant type color fruit abundance and the distribution of vegetation. Connectivity includes 3 indicators of target distribution, the shore slope of low water channels and the extent of artificial embankment materials. Habitat functionality has 2 indicators of the status of food supply plants and the habitat functionality. The value weighting for the fields and indicators has been calculated based on the AHP(Analytic Hierarchy Process) method. 50 experts were surveyed with quantifiable questionnaire, among them 43 experts have more than 10 yesrs experiences in the nature restoration field. The selected and weighted indicators have been tested to the 12 sections in Gap stream located in Daejeon. In conclusion, the indicators are feasible and the selected indicators could be used to establish the direction and objectives of riparian restoration.

• 대한토목학회논문집
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• 제33권5호
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• pp.1861-1870
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• 2013

최근 기후변화 영향으로 인해 수문변동성이 크게 증가되고 있으며 이러한 변동성을 고려하기 위한 방안으로서 강수량 모의발생 기법에 대한 중요성이 대두되고 있다. 본 연구에서는 복잡한 강수발생 패턴을 인지하고 강수량의 다양한 분포특성을 고려할 수 있는 혼합분포를 이용한 동질성 Hidden Markov Chain(HMM) 모형을 제안하였다. HMM 모형의 개선효과를 검증하기 위해서 기존 Markov Chain 모형과 비교 하였으며 서울관측소 및 전주관측소를 대상으로 연구를 진행하였다. 계절강수량 및 일강수량 등 다양한 시간규모에서 모형의 적합성을 평가하기 위해서 천이확률, 평균, 분산, 왜곡도 및 첨예도 등을 비교하였으며 HMM 모형이 기존 Markov Chain 모형에 비해서 개선된 모의능력을 확인할 수 있었다. 특히, HMM 모형은 극치강수량을 재현하는데 있어서 기존 Markov Chain 모형에 비해서 월등한 모의능력을 보여주었다. 이러한 점에서 장기유출량 및 확률홍수량 등을 산정하기 위한 입력자료로 활용이 충분히 가능할 것으로 판단된다.

• Geomechanics and Engineering
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• 제31권1호
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• pp.99-112
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• 2022

The present study examines the natural frequencies (NFs) of perfect/imperfect functionally graded sandwich beams (P/IP-FGSBs), which are composed of a porous core constructed of functionally graded materials (FGMs) and a homogenous isotropic metal and ceramic face sheets resting on elastic foundations. To accomplish this, the material properties of the FGSBs are assumed to vary continuously along the thickness direction as a function of the volume fraction of constituents expressed by the modified rule of the mixture, which includes porosity volume fraction represented using four distinct types of porosity distribution models. Additionally, to characterize the reaction of the two-parameter elastic foundation to the Perfect/Imperfect (P/IP) FGSBs, the medium is assumed to be linear, homogeneous, and isotropic, and it is described using the Winkler-Pasternak model. Furthermore, the kinematic relationship of the P/IP-FGSBs resting on the Winkler-Pasternak elastic foundations (WPEFs) is described using trigonometric shear deformation theory (TrSDT), and the equations of motion are constructed using Hamilton's principle. A closed-form solution is developed for the free vibration analysis of P/IP-FGSBs resting on the WPEFs under four distinct boundary conditions (BCs). To validate the new formulation, extensive comparisons with existing data are made. A detailed investigation is carried out for the effects of the foundation coefficients, mode numbers (MNs), porosity volume fraction, power-law index, span to depth ratio, porosity distribution patterns (PDPs), skin core skin thickness ratios (SCSTR), and BCs on the values of the NFs of the P/IP-FGSBs.

• Korean Chemical Engineering Research
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• 제43권5호
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• pp.595-602
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• 2005

파라디옥사논에 포함된 주요한 불순물인 디에틸렌글리콜을 제거하기 위해, 파라디옥사논과 디에틸렌글리콜과의 이성분계 고액 상평형 및 혼합물의 밀도를 측정하였으며, 종(seed)을 이용한 경막 용융결정화 실험을 하였다. 얻어진 2성분계 고액 상평형 결과는 단순 공융계를 형성하였는데, 공용점은 파라디옥사논의 0.08 몰농도에서 246 K였다. 또한, 혼합물의 밀도 데이터는 ${\rho}_l=k_1+k_2x+k_3T+k_4xT$ 식과 잘 연관되었으며, 각 파라메타인 $k_1$, $k_2$, $k_3$ 및 $k_4$의 값은 0.405, 1.361, 0.002, -0.004이었다. 용융결정화 실험에서 결정 성장속도(G)는 냉각속도가 감소하거나 파라디옥사논의 초기농도가 증가할수록 감소하는 경향을 나타내었으며, 결정 성장속도식은 과냉각 온도의 1.5승에 비례하였다. 또한, 불순물의 제거 정도를 나타내는 유효 분배계수($K_{eff}$)는 냉각속도 및 PDX 초기농도가 증가할수록 증가하는 경향을 나타내었으며, 유효분배계수는 Wintermantel 모델에 의해 $K_{eef}=-0.0604+6.392{\times}Z$ 관계로 표현되었다. 최종적으로 얻어진 PDX 순도는 결정화 조작변수를 최적화하여 99% 이상으로 조절할 수 있음을 알 수 있었다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9673-9678
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• 2014

Background: Breast cancer is a fatal disease and the most frequently diagnosed cancer in women with an increasing pattern worldwide. The burden is mostly attributed to metastatic cancers that occur in one-third of patients and the treatments are palliative. It is of great interest to determine factors affecting time from cancer diagnosis to secondary metastasis. Materials and Methods: Cure rate models assume a Poisson distribution for the number of unobservable metastatic-component cells that are completely deleted from the non-metastasis patient body but some may remain and result in metastasis. Time to metastasis is defined as a function of the number of these cells and the time for each cell to develop a detectable sign of metastasis. Covariates are introduced to the model via the rate of metastatic-component cells. We used non-mixture cure rate models with Weibull and log-logistic distributions in a Bayesian setting to assess the relationship between metastasis free survival and covariates. Results: The median of metastasis free survival was 76.9 months. Various models showed that from covariates in the study, lymph node involvement ratio and being progesterone receptor positive were significant, with an adverse and a beneficial effect on metastasis free survival, respectively. The estimated fraction of patients cured from metastasis was almost 48%. The Weibull model had a slightly better performance than log-logistic. Conclusions: Cure rate models are popular in survival studies and outperform other models under certain conditions. We explored the prognostic factors of metastatic breast cancer from a different viewpoint. In this study, metastasis sites were analyzed all together. Conducting similar studies in a larger sample of cancer patients as well as evaluating the prognostic value of covariates in metastasis to each site separately are recommended.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2001년도 추계학술대회 및 정기총회
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• pp.99-99
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• 2001

The acid-labile subunit (ALS) associates with insulin-like growth factor (IGF)-I or -II and IGF binding protein-3 (IGFBP-3) to form a 150-kD complex in the circulation. This complex is thought to regulate the serum IGFs by restricting them in the vascular system and promotes their endocrine actions. Little is known about how ALS binds to IGFBP3, which connects the IGFs to ALS. Xenopus oocyte was utilized to study the function of ALS in assembling IGFs into the ternary complexes. Xenopus oocyte was shown to correctly translate in vitro transcribed mRNAs of ALS and IGFBP3. IGFBP3 and ALS mRNAs were injected in mixture and their products were immunoprecipitated by antisera against ALS and IGFBP3. Contrary to the traditional reports that ALS interacts only with IGF-bound IGFBP3, this study shows that ALS is capable of forming a binary complex with IGFBP3 in the absence of IGF. When cross-linked by disuccinimidyl substrate, band representing ALS-IGFBP3 complex was evident on the PAGE. IGFBP3 movement was monitored according to the distribution between the hemispheres. Following a localized translation in the vegetal hemisphere, IGFBP3 was shown to remain in the vegetal half in the presence of ALS. Different from wild type IGFBP3, however, mutant IGFBP3 freely diffused into the animal half despite the presence of ALS. Taken together, this study suggests that ALS may play an important role in sequestering IGFBP3 polypeptides via the intermolecular aggregation. Studies using this heterologous model will lead to a better understanding of the IGFBP3 and ALS assembling into the ternary structure and circulating IGF system.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2000년도 추계학술대회 논문집
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• pp.457-460
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• 2000

Injection molding is the most widely used process for the industrial forming of plastic articles. During an injection molding process of composites, the fiber-matrix separation and fiber orientation are caused by the flow of molten polymer/fiber mixture. As a result, the product tends to be nonhomogeneous and anisotropic. Hence, it is very important to clarify the relations between separation·orientation and infection molding conditions. So far, there is no research on the measurement of fiber orientation using image processing. In this study, the effects of fiber content ratio and molding condition on the fiber orientation-angle distributions are studied experimentally. Using the image processing method, the fiber orientation distribution of welding parts in injection-molded products is assessed. And the effects of fiber content and injection mold shapes on the fiber orientation in case of fiber reinforced polymeric composites are studied. experimentally.

• 한국음향학회지
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• 제15권2호
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• pp.40-48
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• 1996

본 논문은 단음절 전구간에 대해 4프레임폭과 7프레임폭을 결합하여 만든 40차원의 세그먼트를 K-L전개와 신경망으로 각각 10, 14, 20차원으로 압축하여 연속분포 HMM의 음성인식 특징파라미터로 사용하였다. 그리고 이산지속시간, 희귀계수 그리고 혼합분포를 특징 파라미터로 추가한 경우와 비교검토하였다. 단음절 100개에 대한 인식실험결과 연속분포 HMM의 인식률 85.19%에 비해 희귀계수를 부가한 경우 1.4%, 혼합분포를 이용한 경우 2.36%, 이산 지속시간제어를 한 경우 2.78%의 인식률이 향상되었다. 그리고 K-L전개에 의한 압축파라미터만 이용한 경우는 멜켑스트럼 + 희귀계수의 경우보다 인식률이 낮았으나, K-L전개에 의한 압축파라미터에 멜켑스트럼과 희귀계수를 부가한 경우는 동등한 결과를 얻을 수 있었다. 신경망에 의한 압축파라미터를 이용한 경우에는 비선형 변환인 시그모이드 함수를 사용하므로 음성의 동적변화가 잘 반영되어 K-L전개 및 다른 방법에 비해 향상된 인식결과를 얻을 수 있었다.

• 폴리머
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• 제26권4호
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• pp.422-430
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• 2002

Antimony trioxide 촉매를 사용하여 241 - $260^{\circ}C$ 범위에서 bishydroxyethyl naphthalate (BHEN)의 축중합 반응에 관한 속도론적 연구를 수행하였다. 반응은 회분식 반응기에서 진행되었고 반응물의 농도는 high performance liquid chromatography (HPLC)를 사용하여 측정하였다. 분자종 모델을 적용하여 구한 반응속도상수의 정반응 및 역반응 활성화 에너지 값은 각각 19.7과 31.4 kcal/mole 이었으며, 평형상수는 1.4-2.0으로 PET 축중합 반응의 경우보다 큰 값을 가지며 온도에 따라 어느 정도 변하였다. 말단기인 hydroxyethyl기의 반응속도는 분자의 크기에 관계없이 일정함을 Flory, 모델식으로부터 확인할 수 있었다. 관능기 모델을 적용한 결과 정반응과 역반응 활성화 에너지 길기 큰 차이가 없었으며, 평형상수는 1.4정도의 값을 가졌다. 관능기 모델로부터 구한 속도상수 값은 분자종 모델로부터 구한 값의 3-4배로서 두 모델이 모두 반응계를 잘 설명하였다. 제안된 분자종 모델이 10개의 분자종을 모두 예측해야 하는 어려움에도 불구하고 실험 결과와 잘 맞음을 알 수 있었다.

• BMB Reports
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• 제35권2호
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• pp.186-193
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• 2002

The acid-bible subunit (ALS) associates with the insulinlike growth factor (IGF)-I or II, and the IGF binding protein-3 (IGFBP-3) in order to form a 150-kD complex in the circulation. This complex may regulate the serum IGFs by restricting them in the vascular system and promoting their endocrine actions. Little is known about how ALS binds to IGFBP3, which connects the IGFs to ALS. Xenopus oocyte was utilized to study the function of ALS in assembling IGFs into the ternary complexes. Xenopus oocyte was shown to correctly translate in vitro transcribed mRNAs of ALS and IGFBP3. IGFBP3 and ALS mRNAs were injected in a mixture, and their products were immunoprecipitated by antisera against ALS and IGFBP3. Contrary to traditional reports that ALS interacts only with IGF-bound IGFBP3, this study shows that ALS is capable of forming a binary complex with IGFBP3 in the absence of IGF When cross-linked by disuccinimidyl suberate, the band that represents the ALS-IGFBP3 complex was evident on the PAGE. IGFBP3 movement was monitored according to the distribution between the hemispheres. Following a localized translation in the vegetal hemisphere, IGFBP3 remained in the vegetal half in the presence of ALS. However, the mutant IGFBP3 freely diffused into the animal half, despite the presence of ALS, which is different from the wild type IGFBP3. This study, therefore, suggests that ALS may play an important role in sequestering IGFBP3 polypeptides via the intermolecular aggregation. Studies using this heterologous model will lead to a better understanding of the IGFBP3 and ALS that assemble into the ternary structure and circulate the IGF system.