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Purification of p-Dioxanone from p-Dioxanone and Diethylene Glycol Mixture by a Layer Melt Crystallization  

Kim, Sung-Il (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Kim, Chul-Ung (Chemical Process and Engineering Center, Korea Research Institute of Chemical Technology)
Park, So-Jin (Department of Chemical Engineering, Chungnam National University)
Publication Information
Korean Chemical Engineering Research / v.43, no.5, 2005 , pp. 595-602 More about this Journal
Abstract
In order to purify diethylene glycol as main impurity included in p-dioxanone, SLE (solid-liquid equilibria) and mixture density on two components system of p-dioxanone and diethylene glycol were measured and a layered melt crystallization with seed has been applied. The SLE of p-dioxanone and diethylene glycol were a simple eutectic system and the temperature and PDX concentration at eutectic point were 0.08 and 246 K, respectively. Densities of their binary mixtures were well fitted by the best correlation equation, ${\rho}_l=0.405+1.361x+0.002T-0.004xT$. In the melt crystallization, the growth rate (G) was proportional to the 1.5th power of the subcooling degree. The effective distribution coefficient ($K_{eff}$) as the degree of impurity removal was observed to increase with increasing the growth rate and initial p-dioxanone concentration. And also, $K_{eff}$ was correlated with Z function using Wintermantel's model such as $K_{eef}=-0.0604+6.392{\times}Z$. Finally, PDX purity through the optimization of this process can be obtained over 99%.
Keywords
Layer Melt Crystallization; Purification; p-Dioxanone; Diethylene Glycol; Growth Rate; Effective Distribution Coefficient; Wintermantel's Model;
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