• 동의신경정신과학회지
• /
• 제12궈1호
• /
• pp.123-135
• /
• 2001

Objective: This study was designed to assess antidepressant effects of Quibitang on an Animal Model of Depression induced by Chronic Mild Stress. Method: The consumption of 1% sucrose solution and active avoidance learning test were used to evaluate antidepressant effect of Quibitang. The consumption of 1% sucrose solution was measured every week for 8 weeks, and active avoidance learning test was executed after 4 weeks treatment of saline or Quibitang. Result: 1. The consumption of 1% sucrose solution was significantly reversed in test group (Quibitang-treated group) at 5th, 7th, 8th weeks, but there was no significant change in control group. 2. Chronic Mild Stress was found to suppress the increase of body weight at 5th, 6th, 7th, 8th weeks. Treatment of Quibitang did not enhanced the body weigt, but it enhanced the consumption of sucrose solution. 3. In order to measure the learning ability of rat which drived to be depressed, we executed active avoidance test. The result revealed that depressed rat showed impaired acquisition than control group, and the treatment of Quibitang restored the learning activity. Conclusion: These results suggest that Quibitang may have antidepressant effects on depression induced by chronic mild stress.

• 가정간호학회지
• /
• 제17권1호
• /
• pp.5-11
• /
• 2010

Purpose: The study examined the psychometric properties of the Korean Geriatric Depression Scale Informant-15 (KGDSI-15), an instrument measuring geriatric depression through their primary caregivers. Methods: The participants were 370 Korean older adults $\geqq$65-years-of-age registered in a visiting health center in S city. The Korean version of Geriatric Depression Scale-Short Form (GDSSF-K) was used for comparison. Internal consistency measured tool reliability and Pearson correlation coefficient measured validity. One-way ANOVA was used to determine the clinical usability of the instrument: depression levels were classified as normal, mild depression, and severe using GDSSF-K, and the depression scores of these three groups were comparatively measured by KGDSI-15. Results: The Cronbach's alpha coefficient was .831. The correlation coefficient with GDSSF-K was r=.616 (p<.001). KGDSI-15 results showed the depression level of older adults with severe depression was highest followed by those with mild depression and normal. The group differences were also statistically significant, which indicated the clinical usability of the instrument. Conclusion: KGDSI-15 is suggested to be reliable and valid to measure the geriatric depression through the primary caregivers of older adult.

• Biomolecules & Therapeutics
• /
• 제22권5호
• /
• pp.453-459
• /
• 2014

Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a chronic mild stress animal model of depression and anxiety to examine the responses of two strains of mice that have different behavioral responsiveness. An outbred ICR and an inbred C57BL/6 strain of mice were selected because they are widely used strains in behavioral tests. The results showed that the inbred C57BL/6 and outbred ICR mice were similarly responsive to CMS treatment in sucrose intake test (SIT) and open field test (OFT). However, the two strains showed quite different responses in forced swimming test (FST) and novelty-suppressed feeding (NSF) test after 3 weeks of CMS treatment. Only C57BL/6 mice displayed the depression- and anxiety-like behavioral effects in response to CMS treatment in FST and NSF test. Our results suggest that there are differences in responsiveness to CMS according to the different types of strain of mice and behavioral tests. Therefore, these results provide useful information for the selection of appropriate behavioral methods to test depression- and anxiety-like behaviors using CMS in ICR and C57BL/6 mice.

• 생물정신의학
• /
• 제15권3호
• /
• pp.194-203
• /
• 2008

Objectives : This study was aimed at evaluating the relationship between somatic symptoms, depression, anxiety and cognitive function in the patients with Mild Traumatic Brain Injury(MTBI). Methods : Thirty seven patients with MTBI were selected from those patients who had visited the Department of Neuropsychiatry of Wonkwang University Hospital from 2003 to 2007. To assess and quantify the somatic symptoms, depression and anxiety, Personality Assessment Inventory(PAI) was used. Assessment of cognitive function was carried out by using Korean Wechsler Adult Intelligence Scale(K-WAIS), Rey-Kim Memory Test, and Kims Executive Function Test. The effects of somatic symptoms, depression, and anxiety on the cognitive function were evaluated by Pearson correlation test. Results : Somatic symptoms, depression, and anxiety, all showed inverse correlation to cognitive function. Specifically, 1) an increase in somatic symptoms was associated with a decrease in attention, verbal short term memory, verbal recall and recognition, and visual memory. 2) An increase in anxiety was associated with a decrease in verbal recall and recognition. 3) An increase in depression was associated with a decrease in cognitive function that requires high attention and verbal memory. Conclusion : The patients with MTBI displayed diverse symptoms ranging from cognitive impairment to somatic symptoms, depression, and anxiety. Somatic and emotional symptoms were correlated with cognitive function(especially executive function). Importantly, this study raises the possibility of treating the cognitive impairment associated with MTBI by treating somatic symptoms, depression, and anxiety.

• 한국보건간호학회지
• /
• 제29권2호
• /
• pp.219-230
• /
• 2015

Purpose: This research study not only examine the relationship between cognitive function, IADL, depression and quality of life, but also clarifies factors impacting quality of life for the elderly. The purpose of this study is to administer health promotion programs and to improve quality of life for the elderly. Methods: Data were collected from May 20, to June 10, 2014. The participants were 157 elderly persons with mild cognitive injury (MCI), who had under 23 points on MoCa-K from three different senior welfare centers in Daejeon. The questionnaires were conducted by four university students after receiving instruction from the researcher and consisted of general characteristics, cognitive function, depression and quality of life. SPSS WIN 19.0 program was used for data analysis. Results: Cognitive function showed positive correlation with quality of life (r=175, p=.028). IADL did not show correlation with quality of life (r=-.005, p=.947). However cognitive function(r=-.344, p<.001) and depression (r=-.623, p<.001) showed negative correlation with quality of life. In addition, the factors impacting quality of life were cognitive function (${\beta}=.14$, p=.29) and depression (${\beta}=-.61$, p<.001) which accounted for 39% of quality of life. Conclusion: These findings showed that the participants had depression and their cognitive function was low. As a result, the more participants' cognitive function decreased, the more their quality of life decreased. In addition, the more their depression decreased, the more their quality of life improved.

• 한국보건간호학회지
• /
• 제32권1호
• /
• pp.81-95
• /
• 2018

Purpose: This study was conducted to identify the effects of a group cognitive improvement program on cognitive function, depression and self-esteem in elderly individuals with mild cognitive impairment. Methods: This was an experimental study that employed a pre-post design of a non-equivalence control group. The subjects were 52 elderly people with mild cognitive impairment, 25 of whom were assigned to the experimental group and 27 to the control group. The program was conducted for a total of 12 sessions for 60 minutes each. Data were analyzed using the ${\chi}2-test$, Fisher's exact test, and Independent t-test with the SPSS 20.0 program. Results: After the intervention, the group who participated showed improvement in all areas of cognitive function based on MMSE-KC (F=26.37, p.<0.001), the Rey Complex Figure Test: copy (F=20.66, p.<0.001), Immediate memory of Seoul Verbal Learning Test-Elderly's version (F=29.68, p.<0.001), delayed memory (F=45.79 p.<0.001), memory recall (F=28.97, p.<0.001), Forward of Digit Span Test (F=9.25, p=.004), backward (F=8.33, p.=0.006), language comprehension (F=13.42, p.<0.001), and digit symbol coding (F=17.74, p.<0.001) relative to the control group. Moreover depression (F=24.09, p.<0.001) was decreased in program participants, whereas self-esteem (F=40.24, p.<0.001) was increased. Conclusion: The program could be a useful intervention because the results show that the group cognitive improvement program has a significant effect on cognitive function, depression and self-esteem in elderly with mild cognitive impairment.

• 문화기술의 융합
• /
• 제9권1호
• /
• pp.551-556
• /
• 2023

본 연구는 메타분석의 방법으로 경도인지장애 노인을 대상으로 한 컬러테라피 중재 연구에서 인지기능과 우울에 효과가 있었는가를 확인하고자 시도되었다. 본 연구에서는 2000년부터 2022년 10월까지 국내 데이터베이스를 통해 실험연구 최종 8편의 연구에 대한 인지기능과 우울의 효과 크기를 산출하였다. 그 결과 전체 연구의 통계적으로 유의한 평균 효과크기를 확인하였다. 집단 간 효과크기 차이 검정에서도 인지기능과 우울 모두 유의한 효과크기를 확인할 수 있었다. 본 연구를 통해 컬러테라피가 경도인지장애 노인의 인지기능을 향상시키고 우울을 완화시킬 수 있는 효과적인 중재임을 확인하였다. 이 연구결과를 근거로 칼러테라피를 활용한 경도인지장애 노인 대상 중재프로그램의개발이 필요하다고 본다.

• 한국농촌간호학회지
• /
• 제16권1호
• /
• pp.11-17
• /
• 2021

Purpose: The purpose of this study was to compare the quality of life and depression in nursing students between Korean and Cambodians. Methods: The subjects of this study were 223 students taking up a four-year nursing course in colleges located in Area A in Korea and Area B in Cambodia. The collected data were analyzed using SPSS 22.0. Results: The total score on quality of life among the Korean students was significantly higher than that of the Cambodian students (t=-4.596, p<.001), while the total score on depression was lower in the Korean students compared to that of the Cambodian students. There was a statistically significant difference in the scores (t=5.179, p<001). When the levels of depression were compared, the difference between the two groups was statistically significant - the Korean students had 92.7% normal and 7.3% mild depression, while the Cambodian students had 80.9% normal and 19.1% mild depression (x²=6.781, p=.009). As a result of analyzing the correlation between the total scores on depression and quality of life, a statistically significant correlation was found in both Korean (r=-.721, p<.001) and Cambodian (r=-.508, p<.001) students. Conclusion: Therefore, a nursing intervention that considers the cultural differences should be developed in order to improve emotional response and quality of life of cambodian students.

• 한국도서관정보학회지
• /
• 제41권4호
• /
• pp.383-402
• /
• 2010

본 연구는 독서요법이 경증 치매노인의 인지력, 우울, 자아존중감, 사회성 등에 미치는 효과를 알아보기 위해 경증치매를 가진 65세 이상 90세 이하의 남녀 노인 166명을 대상으로 실험집단과 통제집단으로 구분하고 6개월간 독서요법 프로그램을 실시하였다. 측정방법으로는 관찰지를 이용한 측정과 MMSE-K, 단축형 노인 우울척도, 자아존중감 검사척도, 대인관계척도를 이용한 양적측정을 동시에 사용하였다. 그 결과 독서요법 프로그램을 실시한 후 경증 치매노인들의 인지도는 향상되었으며, 우울증은 감소하였고, 자아존중감과 사회성이 증가하였다. 이로써 독서치료가 경증 치매노인의 증상을 완화시키는데 효과가 있다는 사실을 알 수 있었다.

• 농촌의학ㆍ지역보건
• /
• 제43권3호
• /
• pp.180-190
• /
• 2018

본 연구는 농촌지역 경증 치매노인의 삶의 질을 측정하고, 이들의 인구사회학적 특성, 주관적 건강인식, 동반질환, 의존성, 수면, 우울 등 대상자의 삶의 질에 관련된 요인들을 살펴본 상관연구로써, 대상자의 삶의 질 향상을 위한 여러 대안들을 위한 기초자료를 제공하고자 본 연구를 시행하였다. 본 연구의 대상자는 본 연구의 수행에 동의한 충청북도 ${\bigcirc}{\bigcirc}$군 보건소에 등록된 65세 이상의 경증 치매노인으로, 대상자로부터 동의서를 받은 후 설문지를 이용하여 자료 수집을 하였다. 본 연구결과 농촌지역 경증 치매노인의 주관적 건강인식과 의존성, 수면, 우울이 삶의 질과 상관성을 보이는 것으로 나타났고, 우울은 삶의 질의 변인으로써 54%를 설명하는 것으로 나타났다. 결론적으로 삶의 질에 유의한 예측변수는 우울이었다. 위의 결과로 다음과 같은 제언을 하고자 한다. 첫째, 대상자의 삶의 질에 영향을 미치는 우울의 원인을 파악하고, 그에 따른 지원정책을 분류하여 제공할 필요가 있다고 생각된다. 둘째, 대상자의 우울이 삶의 질에 영향을 주는 것으로 볼 때, 치매노인들의 정신적 건강상태에 따른 의료적 환경과 접근에 있어서 보다 더 용이한 환경이 되도록 보건소와 병원, 노인전문요양시설간의 지역사회내의 연계체계 구축을 통해 통합적 정신건강서비스를 제공할 필요가 있다고 생각된다. 특히 지역 간 보건의료자원의 불균형이 심한 농촌지역의 특성을 고려하여 보건소를 기점으로 보건지소나 보건진료소와 같은 공공보건의료체계를 포괄적이고 효율적으로 보강할 것을 제언한다. 셋째, 본 연구는 일개 농촌지역에 국한되어 선정 기준에 맞는 대상자들만 연구에 포함시켰기 때문에 연구결과를 우리나라 전체 경증 치매노인에게 일반화시키는데 제한적이므로 연구지역을 확대할 것을 제언한다. 또한 경증치매 노인을 위해 개발되는 간결한 검증된 도구의 사용이 필요하다고 본다. 넷째, 경증 치매노인이 평균적으로 어느 정도의 우울을 동반하는지에 대한 후속 연구를 통해 치매정도를 고려한 인지향상 프로그램 외에 우울의 정도에 따른 개별화된 예방 중재 프로그램이 개발되어 장기적인 효과를 확인할 것을 제언한다.