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http://dx.doi.org/10.4062/biomolther.2014.058

Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice  

Jung, Yang-Hee (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Hong, Sa-Ik (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Ma, Shi-Xun (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Hwang, Ji-Young (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Kim, Jun-Sup (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Lee, Ju-Hyun (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Seo, Jee-Yeon (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Lee, Seok-Yong (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Jang, Choon-Gon (Department of Pharmacology, School of Pharmacy, Sungkyunkwan University)
Publication Information
Biomolecules & Therapeutics / v.22, no.5, 2014 , pp. 453-459 More about this Journal
Abstract
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a chronic mild stress animal model of depression and anxiety to examine the responses of two strains of mice that have different behavioral responsiveness. An outbred ICR and an inbred C57BL/6 strain of mice were selected because they are widely used strains in behavioral tests. The results showed that the inbred C57BL/6 and outbred ICR mice were similarly responsive to CMS treatment in sucrose intake test (SIT) and open field test (OFT). However, the two strains showed quite different responses in forced swimming test (FST) and novelty-suppressed feeding (NSF) test after 3 weeks of CMS treatment. Only C57BL/6 mice displayed the depression- and anxiety-like behavioral effects in response to CMS treatment in FST and NSF test. Our results suggest that there are differences in responsiveness to CMS according to the different types of strain of mice and behavioral tests. Therefore, these results provide useful information for the selection of appropriate behavioral methods to test depression- and anxiety-like behaviors using CMS in ICR and C57BL/6 mice.
Keywords
Chronic mild stress; Depression; Anxiety; Behavior; Mice;
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1 Bekris, S., Antoniou, K., Daskas, S. and Papadopoulou-Daifoti, Z. (2005) Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav. Brain Res. 161, 45-59.   DOI   ScienceOn
2 Bessa, J. M., Mesquita, A. R., Oliveira, M., Pego, J. M. Cerqueira, J. J., Palha, J. A., Almeida, O. F. and Sousa, N. (2009) A transdimensional approach to the behavioral aspects of depression. Front. Behav. Neurosci. 3, 1.
3 Bodnoff, S. R., Suranyi-Cadotte, B., Aitken, D. H., Quirion, R., Meaney and M. J. (1988) The effects of chronic antidepressant treatment in an animal model of anxiety. Psychopharmacology 95, 298-302.
4 Briones, A., Gagno, S., Martisova, E., Dobarro, M., Aisa, B., Solas, M., Tordera, R. and Ramirez, M. (2012) Stress-induced anhedonia is associated with an increase in Alzheimer's disease-related markers. Br. J. Pharmacol. 165, 897-907.   DOI
5 Elizalde, N., Garcia-Garcia, A. L., Totterdell, S., Gendive, N., Venzala, E., Ramirez, M. J., Del Rio, J. and Tordera, R. M. (2010) Sustained stress-induced changes in mice as a model for chronic depression. Psychopharmacology 210, 393-406.   DOI
6 Grivas, V., Markou, A. and Pitsikas, N. (2013) The metabotropic glutamate 2/3 receptor agonist LY379268 induces anxiety-like behavior at the highest dose tested in two rat models of anxiety. Eur. J. Pharmacol. 715, 105-110.   DOI
7 Gronli, J., Murison, R., Fiske, E., Bjorvatn, B., Sorensen, E., Portas, C.M. and Ursin, R. (2005) Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions. Physiol. Behav. 84, 571-577.   DOI
8 Jang, C. G., Whitfield, T., Schulteis, G., Koob, G. F. and Wee, S. (2013) A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology 225, 753-763.   DOI
9 Kaufman, J. and Charney, D. (2000) Comorbidity of mood and anxiety disorders. Depress Anxiety 12, 69-76.   DOI
10 Kendler, K. S., Karkowski, L. M. and Prescott, C. A. (1999) Causal relationship between stressful life events and the onset of major depression. Am. J. Psychiatry 156, 837-841.   DOI   ScienceOn
11 Kessler, R. C. (1997) The effects of stressful life events on depression. Annu. Rev. Psychol. 48, 191-214   DOI   ScienceOn
12 Kim, S. J., Lee, M. S., Kim, J. H., Lee, T. H. and Shim, I. (2013) Antidepressant-like effects of Lycii Radicis Cortex and betaine in the forced swimming test in rats. Biomol. Ther. 21, 79-83.   DOI   ScienceOn
13 Ma, X. C., Jiang, D., Jiang, W. H., Wang, F., Jia, M., Wu, J., Hashimoto, K., Dang, Y. H. and Gao, Cg. (2011) Social isolation-induced aggression potentiates anxiety and depressive-like behavior in male mice subjected to unpredictable chronic mild stress. PLoS ONE 6, e20955   DOI
14 Lee, B., Sur, B., Kwon, S., Yeom, M., Shim, I., Lee, H. and Hahm, D. H. (2013) Chronic administration of catechin decreases depression and anxiety-like behaviors in a rat model using chronic corticosterone injections. Biomol. Ther. 21, 313-322.   DOI
15 Li, S., Wang, C., Wang, W., Dong, H., Hou, P. and Tang, Y. (2008) Chronic mild stress impairs cognition in mice: From brain homeostasis to behavior. Life Sci. 82, 934-942.   DOI   ScienceOn
16 Lucki, I., Dalvi, A. and Mayorga, A. J. (2001) Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology 155, 315-322.   DOI
17 Matthews, K., Forbes, N. and Reid, I. C. (1995) Sucrose consumption as an hedonic measure following chronic unpredictable mild stress. Physiol. Behav. 57, 241-248.   DOI
18 Mayorga, A. J. and Lucki, I. (2001) Limitations on the use of the C57BL/6 mouse in the tail suspension test. Psychopharmacology 155, 110-112.   DOI   ScienceOn
19 Mineur, Y. S., Belzung, C. and Crusio, W. E. (2006) Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice. Behav. Brain Res. 175, 43-50.   DOI
20 Mineur, Y. S., Prasol, D. J., Belzung, C. and Crusio, W. E. (2003) Agonistic behavior and unpredictable chronic mild stress in mice. Behav. Genet. 33, 513-519.   DOI   ScienceOn
21 Porsolt, R. D., Le Pichon, M. and Jalfre, M. (1977) Depression: a new animal model sensitive to antidepressant treatments. Nature 266, 730-732.   DOI   ScienceOn
22 Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C. and Hen, R. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809.   DOI   ScienceOn
23 Pothion, S., Bizot, J. C., Trovero, F. and Belzung, C. (2004) Strain differences in sucrose preference and in the consequences of unpredictable chronic mild stress. Behav. Brain Res. 155, 135-146.   DOI
24 Prut, L. and Belzung, C. (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review. Eur. J. Pharmacol. 463, 3-33.   DOI   ScienceOn
25 Sakata, K., Jin, L. and Jha, S. (2010) Lack of promoter IV-driven BDNF transcription results in depression-like behavior. Genes Brain Behav. 9, 712-721.   DOI
26 Schweizer, M. C., Henniger, M. S. H. and Sillaber, I. (2009) Chronic mild stress (CMS) in mice: Of anhedonia, 'anomalous anxiolysis' and activity. PLoS ONE 4, e4326   DOI
27 Stedenfeld, K. A., Clinton, S. M., Kerman, I. A., Akil, H., Watson, S. J. and Sved, A. F. (2011) Novelty-seeking behavior predicts vulnerability in a rodent model of depression. Physiol. Behav. 103, 210-216.   DOI
28 Strekalova, T., Spanagel, R., Bartsch, D., Henn, F. A. and Gass, P. (2004) Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology 29, 2007-2017.   DOI
29 Willner, P. (1997) Validity, reliability and utility of the chronic mild stress model of depression: A 10-year review and evaluation. Psychopharmacology 134, 319-329.   DOI
30 Willner, P. (2005) Chronic mild stress (CMS) revisited: Consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52, 90-110.   DOI   ScienceOn
31 Willner, P., Muscat, R. and Papp, M. (1992) Chronic mild stress-induced anhedonia: A realistic animal model of depression. Neurosci. Biobehav. Rev. 16, 525-534.   DOI   ScienceOn
32 Wu, H. H. and Wang, S. (2010) Strain differences in the chronic mild stress animal model of depression. Behav. Brain Res. 213, 94-102.   DOI   ScienceOn
33 Yalcin, I., Belzung, C. and Surget, A. (2008) Mouse strain differences in the unpredictable chronic mild stress: a four-antidepressant survey. Behav. Brain Res. 193, 140-143.   DOI
34 Zhang, K., Song, X., Xu, Y., Li, X., Liu, P., Sun, N., Zhao, X., Liu, Z., Xie, Z. and Peng, J. (2013) Continuous GSK-3${\beta}$ overexpression in the hippocampal dentate gyrus induces prodepressant-like effects and increases sensitivity to chronic mild stress in mice. J. Affect. Disord. 146, 45-52.   DOI   ScienceOn
35 Zhu, X. H., Yan, H. C., Zhang, J., Qu, H. D., Qiu, X. S., Chen, L., Li, S. J., Cao, X., Bean, J. C., Chen, L. H., Qin, X. H., Liu, J. H., Bai, X. C., Mei, L. and Gao, T. M. (2010) Intermittent hypoxia promotes hippocampal neurogenesis and produces antidepressant-like effects in adult rats. J. Neurosci. 30, 12653-12663.   DOI
36 Liu, X. and Gershenfeld, H. K. (2001) Genetic differences in the tailsuspension test and its relationship to imipramine response among 11 inbred strains of mice. Biol. Psychiatry 49, 575-581.   DOI