Journal of Oriental Neuropsychiatry (동의신경정신과학회지)

The Korean Society of Oriental Neuropsychiatry (대한한방신경정신과학회)
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The effects of Quibitang on an Animal Model of Depression induced by Chronic Mild Stress

Chronic Mild Stress로 유발(誘發)된 우울증(憂鬱症) 모델 흰쥐에 대한 귀비탕(歸脾湯)의 실험적(實驗的) 연구(硏究)

  • Kim Jong-Woo (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Whang Wei-Wan (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyunghee University) ;
  • Kwak So-Young (Dept. of Psychology, Korea University) ;
  • Kim Min-Jung (Dept. of Psychology, Korea University) ;
  • Park Eun-Hye (Dept. of Psychology, Korea University) ;
  • Lee Jeong-A (Dept. of Oriental Neuropsychiatry, College of Oriental Medicine, Kyunghee University)
  • 김종우 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 황의완 (경희대학교 한의과대학 한방신경정신과학교실) ;
  • 곽소영 (고려대학교 심리학과) ;
  • 김민정 (고려대학교 심리학과) ;
  • 박은혜 (고려대학교 심리학과) ;
  • 이정아 (경희대학교 한의과대학 한방신경정신과학교실)
  • Published : 2001.06.30
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Abstract

Objective: This study was designed to assess antidepressant effects of Quibitang on an Animal Model of Depression induced by Chronic Mild Stress. Method: The consumption of 1% sucrose solution and active avoidance learning test were used to evaluate antidepressant effect of Quibitang. The consumption of 1% sucrose solution was measured every week for 8 weeks, and active avoidance learning test was executed after 4 weeks treatment of saline or Quibitang. Result: 1. The consumption of 1% sucrose solution was significantly reversed in test group (Quibitang-treated group) at 5th, 7th, 8th weeks, but there was no significant change in control group. 2. Chronic Mild Stress was found to suppress the increase of body weight at 5th, 6th, 7th, 8th weeks. Treatment of Quibitang did not enhanced the body weigt, but it enhanced the consumption of sucrose solution. 3. In order to measure the learning ability of rat which drived to be depressed, we executed active avoidance test. The result revealed that depressed rat showed impaired acquisition than control group, and the treatment of Quibitang restored the learning activity. Conclusion: These results suggest that Quibitang may have antidepressant effects on depression induced by chronic mild stress.

Keywords

References

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