• Applied Microscopy
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• 제25권1호
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• pp.122-129
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• 1995

Pancreatic endocrine cells of the native Korean goat were investigated immunocytochemically at electron microscopic level. All glucagon-, insulin-, somatostatin- and pancreatic polypeptide(PP)-immunoreactive cells were showed chromogranin(CG) immunoreactivity in the secretory granules of each cells. In addition, bovine pancreatic polypeptide immunoreactivity was found to be colocalized in the secretory granules of the glucagon and insulin cells. These observations support that chromogranin is available as the marker of pancreatic endocrine cells on the native Korean goat and BPP colocalized in the secretory granules of glucagon and insulin cells.

• 대한화학회지
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• 제56권6호
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• pp.731-738
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• 2012

이 연구의 목적은 과학고등학교 학생들을 대상으로 설문지 조사와 면담을 통해 화학 전지에 대한 개념 이해를 분자적 수준의 미시적 관점에서 화학 평형과 연계하여 분석하는 것이다. 과학고등학교 학생들은 전극을 전해질에 담그자마자 전극의 금속이 산화되는 반응과 금속 이온이 환원되는 반응이 동시에 일어난다는 것과 화학 전지의 화학 평형 상태를 고르는 것에 대한 이해는 높았다. 그러나 전극과 전해질 사이에서 일어나는 상호작용을 미시적 관점으로 이해하는 데는 어려움을 겪고 있어, 화학 전지에서의 전위차 발생, 전자의 흐름, 반쪽 전지의 전위 측정, 산화전극과 환원전극 사이의 전지 전위값 계산하기 등에서는 어려움을 겪었다.

• Clinical and Experimental Reproductive Medicine
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• 제27권1호
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• pp.99-105
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• 2000

Objective: The objective of this study was to compare results of the macroscopic one-layer vasovasostomy with those of microscopic one-layer vasovasostomy and to analyze the change of semen parameters according to the interval of vasal obstruction. Method and Materials: Between March 1987 and December 1997, we performed 121 vasovasostomies using modified one-layer technique with loupe magnification (macroscopic vasovasostomy) or microscope. Among the 68 could be followed post-operatively, 37 patients were treated by macroscopic technique with loupe, and 31 patients by microscopic technique. We compared rates of anatomical patency (sperm count above than $10{\times}10^{6}$/ml) and pregnancy of macroscopic vasovasotomy with those of microscopic vasovasostomy. Patency and pregnancy rates according to vasal obstructive interval were also examined. Results: The patency rates of macroscopic and microscopic technique were 86.5% and 87.1%, and pregnancy rates of macroscopic and microscopic technique were 64.9% and 67.7%. There was no statistical significance between these two methods (p>0.05). The pregnancy rates and sperm motility were decreased if more than 10 years had elapsed following vasectomy (p<0.05). Conclusion: We found little difference in success rates resulting from macroscopic and microscopic vasovasostomy and the former had the advantage of reduced cost and a lower operator skill level. In post-operative semen analysis, the sperm motility was the most probable factor associated with vasal obstructive interval.

• 대한화학회지
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• 제67권4호
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• pp.241-252
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• 2023

이 연구는 학생들이 어려워하는 화학의 여러 개념 중 하나인 동적 평형에 대한 학생의 이해를 높이는 것을 목적으로 한다. 동적 평형은 입자들의 끊임없는 움직임과 상호 작용을 미시적으로 이해하고, 이를 통해 발현되는 거시적인 특성을 이해할 수 있도록 실제와 표상이 겹친 준미시적 수준으로 다루어야 한다. 하지만 9종의 화학 I 교과서를 분석한 결과 평형에 대한 표현 방식은 다소 한계가 있었다. 준미시적 표상 접근을 통해 평형을 이해할 수 있는 전략으로 스크래치를 활용한 수업을 4차시로 구안 하였고, 56명 학생을 대상으로 실행하였다. 4차시 수업은 6단계로 구성이 되며, 단계적으로 평형을 이해하도록 설계하였다. 사전 검사와 사후 검사를 비교한 결과, 학생들이 화학 평형에 대해 미시적 설명과 거시적 설명을 모두 옳게 하는 학생이 크게 증가하였다. 이를 통해 준미시적 표상의 접근 방식으로 스크래치를 활용한 수업의 적용 가능성을 엿볼 수 있었다.

• Interaction and multiscale mechanics
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• 제2권2호
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• pp.129-151
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• 2009

This paper presents a meshfree procedure using a convex generalized meshfree (GMF) approximation for the large deformation analysis of particle-reinforced rubber compounds on microscopic level. The convex GMF approximation possesses the weak-Kronecker-delta property that guarantees the continuity of displacement across the material interface in the rubber compounds. The convex approximation also ensures the positive mass in the discrete system and is less sensitive to the meshfree nodal support size and integration order effects. In this study, the convex approximation is generated in the GMF method by choosing the positive and monotonic increasing basis function. In order to impose the periodic boundary condition in the unit cell method for the microscopic analysis, a singular kernel is introduced on the periodic boundary nodes in the construction of GMF approximation. The periodic boundary condition is solved by the transformation method in both explicit and implicit analyses. To simulate the interface de-bonding phenomena in the rubber compound, the cohesive interface element method is employed in corporation with meshfree method in this study. Several numerical examples are presented to demonstrate the effectiveness of the proposed numerical procedure in the large deformation analysis.

• 대한교통학회지
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• 제34권6호
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• pp.499-509
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• 2016

보행교통류의 통행은 다른 교통수단과 비교하여 더 미시적인 움직임을 보인다. 정해진 차선의 구분 없이 통행하므로 2차원적인 움직임을 보일 수 있으며, 자유로운 방향전환 능력을 통해 이동할 수 있다. 이러한 이유로 보행교통류의 편의성을 평가하는 방법에 있어서도 보행교통류의 미시적인 특성이 반영되어야 한다고 할 수 있다. 만일 보행자만의 행태를 반영하여 편의성을 평가할 수 있다면 보행교통류의 통행 특성을 더 원활히 파악할 수 있을 것이다. 이에 본 연구에서는 보행교통류의 특성을 반영하여 편의성을 판단할 수 있는 지표들을 시뮬레이션을 통해 제시하였다. 본 연구에서는 경로이탈도, 속도의 변화 크기, 그리고 충돌 횟수라는 세 편의성 지표를 통해 보행교통류의 편의성을 평가할 수 있음을 보였다. 각각의 지표들은 보행교통류의 고유한 통행 특성을 해석할 수 있으면서도, 교통류율의 변화에 따라 서로 다른 함수 형태를 보였다. 결과적으로 기존의 교통유율이나 속도와 더불어서 LOS를 판단할 수 있는 보조 지표로 활용될 수 있음을 알 수 있었다.

• 한국주거학회논문집
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• 제24권4호
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• pp.39-52
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• 2013

This study examined the key factors that significantly improved the demand of multi-habitation. It determined the factors at the macroscopic level (or push factors) and the microscopic level (or pull factors). Focusing on a microscopic viewpoint, this study looked at the process of settlement through investigating 78 MH residents in the Seoul metropolitan area. The survey included the questions, such as who they are, how they prepared for moving, and how much they enjoyed their rural lives. In addition, any differences in this process were analyzed depending on respondents' characteristics. Major findings are as follows: First, general macro-level circumstances seemed supportive for the MH lifestyles. Second, six keywords were determined to represent the recent MH trends. They are "semi-sedentism, clustering, young people, female, money, and policy". Third, the distances between the original towns for native residents and new second-home towns for MH residents affected the interactions among them. However, these two groups had better relationships when the second-home towns were apart from the original towns. I then considered the need of a buffer zone between the two residential areas for MH residents. The conceptual difference between MH residents (i.e., semi-sedentism) and original rural residents (i.e., sedentism) might require certain types of buffer zones to continue good relationships among them.

• 대한의용생체공학회:의공학회지
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• 제44권3호
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• pp.176-181
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• 2023

During cancer treatment, the patient's response to drugs appears differently at the cellular level. In this paper, an image-based cell phenotypic feature quantification and key feature selection method are presented to predict the response of patient-derived cancer cells to a specific drug. In order to analyze the viability characteristics of cancer cells, high-definition microscope images in which cell nuclei are fluorescently stained are used, and individual-level cell analysis is performed. To this end, first, image stitching is performed for analysis of the same environment in units of the well plates, and uneven brightness due to the effects of illumination is adjusted based on the histogram. In order to automatically segment only the cell nucleus region, which is the region of interest, from the improved image, a superpixel-based segmentation technique is applied using the fluorescence expression level and morphological information. After extracting 242 types of features from the image through the segmented cell region information, only the features related to cell viability are selected through the ReliefF algorithm. The proposed method can be applied to cell image-based phenotypic screening to determine a patient's response to a drug.

• Advanced Composite Materials
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• 제17권4호
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• pp.373-407
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• 2008

This paper will examine the possibilities of the virtual tests of composite structures by simulating mechanical behaviors by using supercomputing technologies, which have now become easily available and powerful but relatively inexpensive. We will describe mainly the applications of large-scale finite element analysis using the direct numerical simulation (DNS), which describes composite material properties considering individual constituent properties. DNS approach is based on the full microscopic concepts, which can provide detailed information about the local interaction between the constituents and micro-failure mechanisms by separate modeling of each constituent. Various composite materials such as metal matrix composites (MMCs), active fiber composites (AFCs), boron/epoxy cross-ply laminates and 3-D orthogonal woven composites are selected as verification examples of DNS. The effective elastic moduli and impact structural characteristics of the composites are determined using the DNS models. These DNS models can also give the global and local information about deformations and influences of high local in-plane and interlaminar stresses induced by transverse impact loading at a microscopic level inside the materials. Furthermore, the multi-scale models based on DNS concepts considering microscopic and macroscopic structures simultaneously are also developed and a numerical low-velocity impact simulation is performed using these multi-scale DNS models. Through these various applications of DNS models, it can be shown that the DNS approach can provide insights of various structural behaviors of composite structures.

• 한국축산시설환경학회지
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• 제7권2호
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• pp.103-110
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• 2001

This study conducted to monitor decomposition process of the charomatophore pollution solution of an animal slurry by using a CCD camera. After the solution was put into test tube, the images(R, G, B, H, L, S) values of the solution were measured by the imgae processing system, and those of it\`s optical density were measured for three hours to be decomposed by microscopic organism. The values of measured for three hours to be decomposed by microscopic organism. The values of measured images(R, G, B, H, L, S) were analysed and compared with those of the optical density. Some of the results are as follows. 1. High correlation coefficients, which analyzed by using data on linear equations, were 0.9557 and 0.9672. They were decreased regularly in this R-value experiment of RGB level. The microscopic organism in this experiment was effective for decomposition of the red charomatophore pollution solution. 2. The values of all correlation coefficients from relationship between RGB-value and optical density were more than 0.95 except H-values. RGB-values, which were average values of summed R, G, B values, had correlation coefficients of 0.9863, 0.9937. These results showed so good relationship that decomposition process of charomatophore pollution solution could be monitored by a image processing system.