• 대한기계학회논문집A
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• 제28권8호
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• pp.1183-1189
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• 2004

A novel cell count method, which can improve the count efficiency and reduce contamination problem, was presented using micro lattice engraved on culture dish. The micro lattice has feature of $50{\mu}m{\times}50{\mu}m$ rectangular shape, $2{\mu}m$ line width, and $2{\mu}m$ depth in $3mm{\times}3mm$ area. In this paper, nickel mold was fabricated with thickness of 3mm and diameter of 80 mm, and transcription of the micro lattice on a polystyrene cell culture dish was performed by hot embossing at $200\;^{\circ}C$. The tedious and error-prone harvest/load processes of conventional cell counts with a hemocytometer could be omitted, and these advantages became magnified during periodical counts involving long-term cultures. SupT1 cells and HeLa cells were cultivated with the dish for 7 days in $CO_2$ incubator and counted as $371.84/mm^2$ and $123.36/mm^2$, respectively, during the cultivation without harmful effects on the cells.

• 유체기계공업학회:학술대회논문집
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• 유체기계공업학회 2004년도 유체기계 연구개발 발표회 논문집
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• pp.743-747
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• 2004

In this study, micro blood separators capable of separating blood cell and blood plasma using microstructure are fabricated and their feasibility and separation performance are evaluated. Test results show the possibility of separating blood cell and blood plasma using microstructure. To improve separation performance and anti-clogging characteristic, technical points of tested micro blood separators are discussed and improved designs are presented.

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제53권4호
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• pp.218-224
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• 2004

We present a miniature Direct Methanol Fuel Cell (micro-DMFC) using platinum sputtered microcolumn electrodes with a limited amount of fuel. We use the microcolumn electrode in order to improve the power density of the micro-DMFC that consists of two electrodes and polymer electrolyte. We also design the built-in fuel chamber in the anode for the portable electronics applications. We design and fabricate both microcolumn and planar electrodes, having an identical projective area of 5mm${\times}$5mm. The diffusion current density of the microcolumn electrode is 1.73 times higher than that of the planar electrode at electrode potential of 1.1V in the half-cell test. The micro-DMFC based on the microcolumn electrodes shows the maximum power of 10.8$\pm$7.54㎼(43.23$\pm$0.16㎼/$\textrm{cm}^2$) at the projective area of 5mm${\times}$5mm, while the planar electrode micro-DMFC shows the maximum power of 0.81$\pm$0.42㎼(3.24$\pm$1.68㎼/$\textrm{cm}^2$) at the same projective area. The micro-DMFC based on the microcolumn electrodes shows 13 times higher power density that the micro-DMFC based on the planar electrodes does.

• 한국통신학회논문지
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• 제30권9B호
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• pp.602-609
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• 2005

본 연구에서는 HAPS 서비스 커버리지 내의 셀 구조로서 광역 서비스가 가능하고 동일 채널 간섭을 억제하면서 주파수 이용 효율을 높이기 위해 지상 이동 통신 시스템과 유사한 셀룰러를 가정하여 매크로 셀과 마이크로 셀이 혼재하는 계층적 셀 구조의 성능을 분석하였다. 이를 위해 기존 지상 이동 통신 시스템에서 사용되고 있는 인접 셀 간섭 계수를 도입하여 매크로 셀에 미치는 마이크로 셀의 간섭영향을 분석하였다. 그 결과 HAPS는 지상 이동 통신 시스템과는 다르게 셀 간의 간섭 영향은 셀 간의 거리에는 크게 영향이 없고 마이크로 셀의 유저의 수 및 전력제어 계수 퐁에 의해 지배적으로 영향을 받으므로 이 계수를 적절히 조절한다면 매크로 셀 간에 마이크로 셀 삽입에 의한 계층적 구조를 실현할 수가 있다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.829-834
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• 2013

Background: MicroRNAs are noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was to determine the role of microRNA-21 in cholangiocarcinomas and its relationship to cholangiocarcinoma RBE cell capacity for invasion and metastasis. Methods: MicroRNA-21 expression was investigated in 41 cases of cholangiocarcinoma samples by in situ hybridization and real-time PCR. Influence on cholangiocarcinoma cell line invasion and metastasis was analyzed with microRNA-21 transfected cells. In addition, regulation of reversion-inducing-cysteine-rich protein with kazal motifs (RECK) by microRNA-21 was elucidated to identify mechanisms. Results: In situ hybridization and real-time quantitative PCR results for patients with lymph node metastasis or perineural invasion showed significantly high expression of microRNA-21 (P<0.05). There was a dramatic decrease in cholangiocarcinoma cell line invasion and metastasis ability after microRNA-21 knockdown (P<0.05). However, overexpression significantly increased invasion and metastasis (P<0.05). Real-time PCR and Western-blot analysis showed that microRNA-21 could potentially inhibit RECK expression in RBE cells. Survival analysis showed that patients with higher expression levels of microRNA-21 more often had a poor prognosis (P<0.05). Conclusions: MicroRNA-21 may play an important role in cholangiocarcinoma invasion and metastasis, suggesting that MicroRNA-21 should be further evaluated as a biomarker for predicting cholangiocarcinoma prognosis.

• 대한전자공학회:학술대회논문집
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• 대한전자공학회 2005년도 추계종합학술대회
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• pp.1235-1240
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• 2005

This paper supposes the perfect power control at micro-cell and macro-cell. Under this supposition, we calculate SIR and decide the call admission by SIR. When we calculate SIR, we use the ratio of the power received the base station of micro-cell and the power received the base station of macro-cell. We analysis the performance of the system by the computer simulation while changing the ratio of power.

• Journal of Yeungnam Medical Science
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• 제38권2호
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• pp.107-117
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• 2021

MicroRNAs (miRNAs) are a class of noncoding RNAs that negatively regulate target messenger RNAs. In multicellular eukaryotes, numerous miRNAs perform basic cellular functions, including cell proliferation, differentiation, and death. Abnormal expression of miRNAs weakens or modifies various apoptosis pathways, leading to the development of human cancer. Cell death occurs in an active manner that maintains tissue homeostasis and eliminates potentially harmful cells through regulated cell death processes, including apoptosis, autophagic cell death, and necroptosis. In this review, we discuss the involvement of miRNAs in regulating cell death pathways in cancers and the potential therapeutic functions of miRNAs in cancer treatment.

• BMB Reports
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• 제46권11호
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• pp.550-554
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• 2013

The platelet-derived growth factor (PDGF) signaling pathway is essential for inducing a dedifferentiated state of vascular smooth muscle cells (VSMCs). Activation of PDGF inhibits smooth muscle cell (SMC)-specific gene expression and increases the rate of proliferation and migration, leading to dedifferentiation of VSMCs. Recently, microRNAs have been shown to play a critical role in the modulation of the VSMC phenotype in response to extracellular signals. However, little is known about microRNAs regulated by PDGF in VSMCs. Herein, we identify microRNA- 15b (miR-15b) as a mediator of VSMC phenotype regulation upon PDGF signaling. We demonstrate that miR-15b is induced by PDGF in pulmonary artery smooth muscle cells and is critical for PDGF-mediated repression of SMC-specific genes. In addition, we show that miR-15b promotes cell proliferation. These results indicate that PDGF signaling regulates SMC-specific gene expression and cell proliferation by modulating the expression of miR-15b to induce a dedifferentiated state in the VSMCs.

• 전기학회논문지
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• 제63권2호
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• pp.205-210
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• 2014

The micro grid considered in this paper consists of a diesel generator, a photovoltaic array, a wind turbine, a fuel cell, and a energy storage system. This paper explains and simulates the micro grid components in terms of accuracy and efficiency of having a system model based on the costs of fuel as well as operation and maintenance. For operational efficiency, the objective function in a diesel generator consists of the fuel cost function similar to the cost functions used for the conventional fossil-fuel generating plants. The wind turbine generator is modeled by the characteristics of variable output. The optimization is aimed at minimizing the cost function of the system while constraining it to meet the customer demand and safety of micro grid. The operating cost in fuel-cell system includes the fuel costs and the efficiency for fuel to generate electric power. To develop the overall system model gives a possibility to minimize of the total cost of micro grid. The application of optimal operation can save the interruption costs as well as the operating costs, and improve reliability index in micro grid.

• 한국태양에너지학회:학술대회논문집
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• 한국태양에너지학회 2009년도 추계학술발표대회 논문집
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• pp.104-109
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• 2009

If the Photovoltaic(PV) Module should get physical load, the PV module will be warped according to elongation of the front glass and then micro-crack will be occurred in the heat sealed Solar Cell. This micro-crack drops output of the short circuit current and the open circuit voltage of the PV Module. This is because of increase of resistance component by micro-crack. Micro-crack at specific Solar Cell in the module reduces the durability of PV Module such as less output, Hot-Spot in the PV module caused by Solar Cell output mismatch, heat generating as resistance component caused by micro-crack. In this study, among some factors which effect to the output of crystalline PV Module, we will see how the micro-crack caused by mechanical stress effects to the electrical output of PV Module.