• 한국보육지원학회지
• /
• 제19권4호
• /
• pp.53-72
• /
• 2023

Objective: This study examined the effects of cooking activities related to seasonal customs on the language expression ability and pro-social behaviors of young children. Methods: Participants consisted of thirty-four 5-year-old children who were attending S preschool in Jeollanamdo. Seventeen children belonged to the experimental group and seventeen children to the comparative group. The experimental group participated in cooking activities related to seasonal customs, and the comparative group in cooking activities according to life themes of Nuri curriculum. Results: The results of this study revealed a significant improvement in the language expression ability and pro-social behaviors of young children in the experimental group. That is to say, the scores of the language expression ability and pro-social behaviors of the experimental group were significantly higher than those of the comparative group. Conclusion/Implications: This study carries significant implications for the early childhood field as it provides valuable insight into teaching-learning activities that effectively enhance the language expression ability and pro-social behaviors of young children.

• Asian Pacific Journal of Cancer Prevention
• /
• 제13권5호
• /
• pp.2379-2383
• /
• 2012

Objective: To investigate possible signal pathway involvement in multi-drug resistant P-glycoprotein (P-gp) expression induced by cyclooxygenase-2 (COX-2) in a human gastric adenocarcinoma cell line stimulated with pacliaxel (TAX). Methods: The effects of TAX on SGC7901 cell growth with different doses was assessed by MTT assay, along with the effects of the COX-2 selective inhibitor NS-398 and the nuclear factor-KB (NF-KB) pathway inhibitor pyrrolidine dithiocarbamate (PDTC). Influence on COX-2, NF-KB p65 and P-gp expression was determined by Western blotting. Results: TAX, NS-398 and PDTC all reduced SGC7901 growth, with dosedependence. With increasing dose of TAX, the expression of COX-2, p65 and P-gp showed rising trends, this being reversed by NS-398. PDTC also caused decrease in expression of p65 and P-gp over time. Conclusion: COX-2 may induce the expression of P-gp in SGC7901 cell line via the NF-kappa B pathway with pacliaxel stimulation.

• 대한한의학회지
• /
• 제30권6호
• /
• pp.69-79
• /
• 2009

Objective: In this study, the immunomodulatory activity of a mixture of wild Panax ginseng and red-mold rice extracts (MPR) on RAW 264.7 macrophage cells in the presence and absence of methotrexate (MTX), an anti-cancer drug, was investigated. Methods and Results: In the cell viability, MPR showed a significant cell proliferation and inhibited cell regression by red-mold rice (RMR) alone or MTX alone. MPR induced moderate increase in nitric oxide (NO) production. NO production and inducible nitric oxide synthase (iNOS) mRNA expression by LPS decreased after MPR treatment. In addition, MPR slightly induced COX-2 mRNA expression, but it did not affect the expression of COX-2 mRNA by LPS treatment. In RT-PCR analyses, MPR induced IL-$1{\alpha}$, IL-$1{\beta}$, IL-6, and TNF-$\alpha$ mRNA expression, but had no effect on IL-10 and TGF-$\beta$, regardless of MTX treatment. Furthermore, MPR did not interfere with the cytotoxicity of MTX against MCF-7 human breast carcinoma cells. Conclusions: MPR is efficacious in protecting against MTX-induced cell regression as a result of macrophage activation, resulting in induction of cytokine expression, implying that MPR could be considered an adjuvant in MTX-chemotherapy.

• 대한한방내과학회지
• /
• 제31권1호
• /
• pp.25-39
• /
• 2010

Background : At high glucose levels in $\beta$-cells, cell viability and insulin secretion are decreased by glucotoxicity. Sopyung-tang(SPT) had an effect on blood glucose level decrease and antioxidant enzyme activities in streptozotocin-induced diabetic rats. Objectives : This study performed a series of experiment to verify the effects of SPT extract on the cell viability, antioxidant enzyme activities, insulin secretion and insulin mRNA expression at hyperglycemic states of RIN-m5F. Methods : After treatment at various concentrations of SPT added to the RIN-m5F cells, cell viability by MTT assay, free radical-scavenging activity, SOD activity and insulin secretion were measured. Additionally, insulin-related gene expression was measured using real-time RT-PCR. Results : Compared to the control group, SPT extract showed considerable effects on RIN-m5F cell viability, DPPH radical-scavenging activity, superoxide dismutase (SOD) activity, insulin secretion and insulin-related gene expression. Conclusions : This study showed that SPT extract has an effect on $\beta$-cell cell viability, insulin secretion and insulin-related gene expression. Thus, SPT extract may be used for treatment of diabetes and its complications. Further mechanism studies of SPT seem to be necessary on the glucotoxicity and oxidative stress.

• ETRI Journal
• /
• 제32권5호
• /
• pp.784-794
• /
• 2010

Automatic facial expression recognition has many potential applications in different areas of human computer interaction. However, they are not yet fully realized due to the lack of an effective facial feature descriptor. In this paper, we present a new appearance-based feature descriptor, the local directional pattern (LDP), to represent facial geometry and analyze its performance in expression recognition. An LDP feature is obtained by computing the edge response values in 8 directions at each pixel and encoding them into an 8 bit binary number using the relative strength of these edge responses. The LDP descriptor, a distribution of LDP codes within an image or image patch, is used to describe each expression image. The effectiveness of dimensionality reduction techniques, such as principal component analysis and AdaBoost, is also analyzed in terms of computational cost saving and classification accuracy. Two well-known machine learning methods, template matching and support vector machine, are used for classification using the Cohn-Kanade and Japanese female facial expression databases. Better classification accuracy shows the superiority of LDP descriptor against other appearance-based feature descriptors.

• 한국보육지원학회지
• /
• 제14권6호
• /
• pp.241-255
• /
• 2018

Objective: The purpose of this research was to examine the moderating effect of children's negative emotionality on the relationship between maternal attitude toward children's emotional expression based on the differential susceptibility model. Methods: Participants were 216 preschool children including 116 boys and 100 girls from day care centers and preschools located in Chungchung province and Seoul. EAS was used to measure the children's negative emotionality. The children's empathy quotient was used to measure empathy. Mothers reported their attitude toward children's emotional expression. Results: The results revealed that the association between empathy and maternal suppression of children's emotional expression was significant only for the children with high levels of negative emotionality. Moreover, the magnitude of association between empathy and maternal acceptance of children's emotional expression was greater for high levels of negative emotionality. Conclusion/Implications: It was concluded that these findings supported the differential susceptibility model.

• 한국컴퓨터정보학회논문지
• /
• 제27권9호
• /
• pp.41-47
• /
• 2022

본 논문에서는 자동표정인식을 위하여 얼굴 이미지 배열의 가운데 이미지를 예측하는 새롭고 간단한 자기주도학습 방법을 제안한다. 자동표정인식은 딥러닝 모델을 통해 높은 성능을 달성할 수 있으나 일반적으로 큰 비용과 시간이 투자된 대용량의 데이터 세트가 필요하고, 데이터 세트의 크기와 알고리즘의 성능이 비례한다. 제안하는 방법은 추가적인 데이터 세트 구축 없이 기존의 데이터 세트를 활용하여 자기주도학습을 통해 얼굴의 잠재적인 심층표현방법을 학습하고 학습된 파라미터를 전이시켜 자동표정인식의 성능을 향상한다. 제안한 방법은 CK+와 AFEW 8.0 두가지 데이터 세트에 대하여 높은 성능 향상을 보여주었고, 간단한 방법으로 큰 효과를 얻을 수 있음을 보여주었다.

• 가정∙방문간호학회지
• /
• 제21권2호
• /
• pp.101-109
• /
• 2014

Purpose: The purpose of this study was to identify the difference in health behavior according to the anger expression styles in patients with coronary arteries disease. Methods: Participants included 99 patients with coronary artery disease who were treated with a percutaneous coronary intervention in K University Hospital in Seoul, from January to March 2012. The survey data were collected using the Anger Expression Inventory Korea Version and the Health Promoting Lifestyle Profile Version 2. The data were analyzed using descriptive statistics, acluster analysis, chi-square test,and ANOVA with the PASW 19.0program. Results: The anger expression styles identified from the cluster analysis were anger-control type(43.3%), anger-in/out type(42.4%), and high anger expression type(14.4%). The total score of the Health Promoting Life style Profile for the anger-control type was significantly higher than the other two types. Additionally, anger-control type showed significantly higher scores than the other two types in all domains of the Health Promoting Life style Profile. Conclusion: These results indicated that higher levels of anger-in and anger-out increased the risk of adverse health behavior and that anger control strategies could have some benefit in reinforcing healthy behavior in patients with coronary artery disease.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권23호
• /
• pp.10401-10405
• /
• 2015

Background: Molecular prognostic markers have been under investigation for the last decade and no validated marker to date has been proven to be used in daily clinical practice for urinary bladder cancers. The aim of the present study is to evaluate the significance of HYAL-1 expression in prediction of recurrence and progression in pT1 urothelial carcinomas. Materials and Methods: Eighty-nine urothelial carcinoma cases staged as T1 according to 2004 WHO classification were studied. Representative sections from every case were stained immunohistochemically for HYAL-1 and scored between 0 and +3, according to staining density, and graded as low and high for the scores 0-1 and 2-3, respectively. Results: Of the 89 pT1 bladder cancer patients, HYAL-1 expression was high in 92.1% (82 patients; 72 patients +3 and 10 patients +2) and low in 7.9% (only 7 patients; 6 patients +1 and 1 patient 0) of the cases. Of the 89 patients, 38 (42.7%) had recurrence and 22 (24.7%) showed progression. HYAL-1 staining did not show significant characteristics for tumor grade, accompanying CIS, multiplicity, tumor size, age and sex. HYAL-1 expression did not have any prognostic value in estimating recurrence or progression. Conclusions: HYAL-1 expression was found to be high, but did not have any prognostic importance in T1 bladder urothelial carcinomas.

• Asian Pacific Journal of Cancer Prevention
• /
• 제14권11호
• /
• pp.6415-6418
• /
• 2013

Background: The aim of this study was to assess EGFR and p53 expression in head and neck tumors among Sudanese patients using immunohistochemistry. Materials and Methods: A retrospective descriptive study was performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benign head and neck tumors. EGFR and p53 expression was assessed using immunohistochemistry (IHC). Results: EGFR was expressed in 126/150 (84%) of HNCS and 6/50 (12%) benign head and neck tumors where as p53 was expressed in 29/150 (19.3%) of HNCs and 2/50 (4%) of benign head and neck tumors, with significance at p values of 0.001 and 0.009 respectively. Conclusions: There is a significant association between EGFR, P53 expression and head and neck cancers among Sudanese patients.