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http://dx.doi.org/10.7314/APJCP.2013.14.11.6415

Expression of EGFR and p53 in Head and Neck Tumors among Sudanese Patients  

Abusail, Mustafa Saadalnour (Department of Histopathology and Cytology, Faculty of Medical laboratory Sciences, Elneelain University)
Dirweesh, Ahmed Mohmed Ahmed (Medicine, University of Hail, Kingdom of Saudi Arabia)
Salih, Rashid Awad Abdalla (Medicine, University of Hail, Kingdom of Saudi Arabia)
Gadelkarim, Ahmed Hussain (Medicine, University of Hail, Kingdom of Saudi Arabia)
Publication Information
Asian Pacific Journal of Cancer Prevention / v.14, no.11, 2013 , pp. 6415-6418 More about this Journal
Abstract
Background: The aim of this study was to assess EGFR and p53 expression in head and neck tumors among Sudanese patients using immunohistochemistry. Materials and Methods: A retrospective descriptive study was performed on 150 samples from patients diagnosed with HNCs as well as 50 from individuals with benign head and neck tumors. EGFR and p53 expression was assessed using immunohistochemistry (IHC). Results: EGFR was expressed in 126/150 (84%) of HNCS and 6/50 (12%) benign head and neck tumors where as p53 was expressed in 29/150 (19.3%) of HNCs and 2/50 (4%) of benign head and neck tumors, with significance at p values of 0.001 and 0.009 respectively. Conclusions: There is a significant association between EGFR, P53 expression and head and neck cancers among Sudanese patients.
Keywords
Head and neck cancer; Sudanese; EGFR; p53;
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1 Ciardiello F, Tortora G (2003). Epidermal growth factor receptor (EGFR) as a target in cancer therapy: understanding the role of receptor expression and other molecular determinants that could influence the response to anti-EGFR drugs. Eur J Cancer, 39, 1348-54.   DOI   ScienceOn
2 Egloff AM, Grandis J (2006). Epidermal growth factor receptor-targeted molecular therapeutics for head and neck squamous cell carcinoma. Expert Opin Ther Targets. 10, 639-47.   DOI   ScienceOn
3 Fakhry C, Westra WH, Li S (2008). Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. J National Cancer Institute, 100, 261-9.   DOI   ScienceOn
4 Ferlay J, Shin HR, Bray F, et al (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127, 2893-917.   DOI   ScienceOn
5 Santarelli A, Lo Russo L, Bambini F, Campisi G, Lo Muzio L (2009). New perspectives in medical approach to therapy of head and neck squamous cell carcinoma. Minerva Stomatol, 58, 445-52.
6 Gallo O, Bianchi S, Giovannucci-Uzzielli ML, et al (1995). p53 oncoprotein overexpression correlates with mutagen-induced chromosome fragility in head and neck cancer patients with multiple malignancies. Br J Cancer, 71, 1008-12.   DOI
7 Gallo O, Bianchi S (1995). p53 expression: a potential biomarker for risk of multiple primary malignancies in the upper aerodigestive tract. Eur J Cancer B Oral Oncol, 31, 53-7.   DOI   ScienceOn
8 Gillison ML, Shah KV (2001). Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr Opin Oncol, 13, 183-8.   DOI   ScienceOn
9 Goon PK, Stanley MA, Ebmeyer J, et al (2009). HPV & head and neck cancer: a descriptive update. Head Neck Oncol, 1, 36.   DOI   ScienceOn
10 Grandis JR, Chakraborty A, Melhem MF(1997). Inhibition of epidermal growth factor receptor gene expression and function decreases proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. Oncogene, 15, 409-16.   DOI
11 Grandis JR, Chakraborty A, Zeng Q (1998). Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem, 69, 55-62.   DOI
12 Grandis JR, Chakraborty A, Zeng Q (1980). Downmodulation of TGF-alpha protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells. J Cell Biochem, 69, 55-62.
13 Grandis JR, Sok JC (2004). Signaling through the epidermal growth factor receptor during the development of malignancy. Pharmacol Ther, 102, 37-46.   DOI   ScienceOn
14 Grandis JR, Tweardy DJ (1993). Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res, 53, 3579-84.
15 Grandis JR, Zeng Q, Tweardy DJ (1996). Retinoic acid normalizes the increased gene transcription rate of TGF- alpha and EGFR in head and neck cancer cell lines. Nat Med, 2, 237-40.   DOI   ScienceOn
16 Helton ES, Chen X (2007). p53 modulation of the DNA damage response. J Cell Biochem, 100, 883-96.   DOI   ScienceOn
17 Andl T, Kahn T, Pfuhl A, et al (1998). Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res, 58, 5-13.
18 Benard J, Douc-Rasy S, Ahomadegbe JC (2003). TP53 family members and human cancers. Hum Mutat, 21, 182-91.   DOI   ScienceOn
19 Bonner JA, Harari PM, Giralt J, et al (2006). Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck. NEnglJ Med, 354, 567-578.   DOI   ScienceOn
20 Brachman DG, Graves D, Vokes E, et al (1992). Occurrence of p53 gene deletions and human papilloma virus infection in human head and neck cancer. Cancer Res, 52, 4832-3.
21 Calzolari A, Chiarelli I, Bianchi S, et al (1997). Immunohistochemical vs molecular biology methods. Complementary techniques for effective screening of p53 alterations in head and neck cancer. Am J Clin Pathol, 107, 7-11.   DOI
22 Chung CH, Gillison ML (2009) Human papillomavirus in head and neck cancer: its role in pathogenesis and clinical implications. Clin Cancer Res, 15, 6758-62.   DOI   ScienceOn
23 Chung CH, Ely K, McGavran L (2006). Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clinical Oncol, 24, 4170-6.   DOI   ScienceOn
24 Hoffmann TK, Schirlau K, Sonkoly E, et al (2009). A novel mechanism for anti-EGFR antibody action involves chemokine-mediated leukocyte infiltration. Int J Cancer, 124, 2589-96.   DOI   ScienceOn
25 Homann N, Nees M, Conradt C, et al (2001). Overexpression of p53 in tumor-distant epithelia of head and neck cancer patients is associated with an increased incidence of second primary carcinoma. Clin Cancer Res, 7, 290-6.
26 Knowles LM, Stabile LP, Egloff AM, et al (2009). HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin Cancer Res, 15, 3740-50.   DOI   ScienceOn
27 Kumar B, Cordell KG, Lee JS (2008). EGFR, p16, HPV titer, Bcl-xL and p53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer. J Clin Oncol, 26, 3128-37.   DOI   ScienceOn
28 Lassen P (2010). The role of Human papillomavirus in head and neck cancer and the impact on radiotherapy outcome. Radiother Oncol, 3, 371-80.
29 Lee JW, Soung YH, Kim SY (2005). Somatic mutations of EGFR gene in squamous cell carcinoma of the head and neck. Clin Cancer Res, 11, 2879-82.   DOI   ScienceOn
30 Lukas J, Lukas C, Bartek J (2004). Mammalian cell cycle checkpoints: signalling pathways and their organization in space and time. DNA Repair, 3, 997-1007.   DOI   ScienceOn
31 Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 2, 74-108.
32 Pu YS, Huang CY, Kuo YZ, et al (2009). Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma. J Biomed Sci, 16, 127-32.
33 Rischin D, Young R, Fisher R (2009). Prognostic significance of HPV and p16 status in patients with oropharyngeal cancer treated on a large international phase III trial. J Clin Oncol, 27, 6004.
34 Sarkis SA, Abdullah BH, Abdul Majeed BA, Talabani NG (2010). Immunohistochemical expression of epidermal growth factor receptor (EGFR) in oral squamous cell carcinoma in relation to proliferation, apoptosis, angiogenesis and lymphangiogenesis. Head Neck Oncol, 25, 13.
35 Sherr CJ, McCormick F (2002). The RB and p53 pathways in cancer. Cancer Cell, 2, 103-12.   DOI   ScienceOn
36 Smith EM, Rubenstein LM, Hoffman H, Haugen TH, Turek LP (2010). Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer. Infect Agent Cancer, 5, 4.   DOI   ScienceOn
37 Smith EM, Wang D, Kim Y, et al (2008). P16INK4a expression, human papillomavirus, and survival in head and neck cancer. Oral Oncol, 44, 133-42.   DOI   ScienceOn
38 Soulieres D, Senzer NN, Vokes EE, et al (2004). Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol, 22, 77-85.   DOI
39 Temam S, Kawaguchi H, El-Naggar AK, et al (2007). Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol, 25, 2164-70.   DOI   ScienceOn