• The Journal of Korean Obstetrics and Gynecology
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• v.26 no.4
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• pp.191-203
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• 2013

Purpose: This review is to figure out evidence that suggest effectiveness of Korean Medicine treatments against cervical dysplasia. Methods: Studies on cervical cancer and cervical dysplasia were searched through 6 databases: Korean Studies Information Service System(KISS), National Discovery for Science Leaders (NDSL), Korea Institute of Science and Technology Information (Korean TK), Oriental Medicine Advanced Searching Integrated System (OASIS), the Journal of Korean Medicine, and the Journal of Korean Obstetrics & Gynecology. After that, the articles were extracted with reference point of Korean Traditional Medicine. Results: 37 articles were included lastly according to selection criteria. 3 of them were case reports on cervical dysplasia, and 34 were in-vitro studies on Human Papilloma Virus (HPV) positive cancer cell. In case reports, acupuncture, moxibustion, medical herbs and pharmacoacupuncture were used for treatments of cervical dysplasia with about 3 months. Experimental studies on cervical cancer cell showed that several herbs function with clear heat, eliminate stasis (淸熱解毒, 化瘀消腫) have anti-cancer effects inducing apoptosis. Conclusions: The results of articles are not enough to use in practice. Therefore, we indicates more advanced research methodology as follows: development of Korean Medicine treatment protocol with oral and external, in-vivo experimental study, and evaluation immunity index.

• Journal of Acupuncture Research
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• v.22 no.2
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• pp.163-170
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• 2005

Background : Over the last thirty years, majority of researches on clinical effectiveness of acupuncture have been explanatory (or experimental) randomized controlled trial. The benefits of acupuncture in clinical trials are still controversial and most studies concluded that further control studies were required. Standardized combinations of acupuncture points for all the experimental subjects in various past studies have been criticized because such treatments do not reflect current routine clinical treatment. Objective : This paper aims to review pragmatic clinical trials on the effect of acupuncture treatment and to develop the ideal clinical research methodology of acupuncture study. Method : Clinical studies of acupuncture relevant with pragmatic or individualized trials were searched mainly in Pubmed and Science direct databases. All articles were fully reviewed by researchers, and data were evaluated by usage of a standardized form. Results & Suggestion : Pragmatic acupuncture researches were tried for various symptoms (eg. low back pain, hypertension, depression during pregnancy, sleep quality in HIV disease, chronic poststroke leg spasticity, headache, etc). Individualized acupuncture treatments based on oriental disease pattern diagnosis reflexes practical treatments which is more effective than unified and fixed acupuncture treatments without any theoretical basis of oriental medical philosophy. Conclusion : To overcome the controversies and limitations of past explanatory acupuncture trials, more individualized and tailored acupuncture trials with the theoretical basis of oriental medical diagnosis is highly recommended. Also clear definition and categorization of pattern identification should be established for further active clinical researches and applications of acupuncture.

• Journal of Haehwa Medicine
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• v.12 no.2
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• pp.199-225
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• 2004

For the purpose of experimental and clinical studies on the 14 channels and collaterals, we performed an inquiry on the anatomical mapping of neronal, circulatory and muscular networks in the human body which possibly correspond to the major pathway of Du channel and Ren channel known to be critical for overall controlling and mediating 12 regular channel connections. The theoretical background of this analysis was based on the oriental medicinal treatises which described acu-points and related anatomical informations. We suggest that rearrangement methodology for the 12 regular channels as described here may be applied to other 12 regular channels and to develop the new concept on the elucidation of the medical efficacy based on precise anatomical localization of channels and collaterals as well as the meridian points. It is proposed that interdisciplinary studies between oriental and western medicine are critical for more efficient achievement.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.28 no.3
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• pp.30-47
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• 2015

Objective : Melanoma is a very critical and devastating disease. Although many people have depended on surgical operation in melanoma treatment, they have placed importance on non-invasive methods constantly. So we planned to establish a research methodology by analysing existing articles containing conservative melanoma treatments in Journals of Korean Medicine published in Korea.Methods : Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as following;Using search words of anti-cancer, B16, cancer, lung metastasis, melanoma, metastasis, S-100, SK-MEL, tumor, tyrosinase, we collected 26 articles by searching internet portal sites as followinghttp://oasis.kiom.re.kr,http://www.koreantk.com,http://www.riss.kr,http://www.dbpia.co.kr,http://www.ndsl.kr,http://kiss.kstudy.com,http://www.naver.com,http://www.google.com.Result : The number of articles is 26 and in the year of 2003, 2004 is ranked the highest number in publication. The journal of acupuncture & moxibustion society ranked the highest(30.8%). 2 and 4 authors ranked the highest(26.9%) in number of authors. T-test ranked the highest(58.1%) in statistics methods. P.O. med indicated in 11 articles and Pharmacopuncture in 15 articles. B16 murine melanoma cell was indicated in 25 articles by cancer-induced methods. In measurement, T cell activity was indicated in 14 articles, NK activity in 4 articles, IL-2 in 6 articles, apoptosis in 1 article, lung metastasis in 14 articles.Conclusion : Considering overall results, it is necessary to diversify cancer-induced methods and measurement methods in experimental melanoma research.

• Journal of Korean Society for Quality Management
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• v.39 no.3
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• pp.365-376
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• 2011

Robust design (RD) has emerged as a key feature in process design and development for more than twenty years. Many researchers and industrial engineers around the world have invested their intensive efforts to develop and apply RD in many fields in order to improve quality of output products. However, there is also room for improvement. The primary objective of this research is to determine "robust formulation" of a medicine by checking its gelation index. In order to achieve this target, based on the nature of problem, at first, a customized experimental format is designed for obtaining data. Second, time-depended responses based models are developed by the proposed inverse problem (IP) methodology. Third, an RD model based on mean square error (MSE) concept is introduced for time-depended responses. Finally, the proposed approach is illustrated by a case study while comparing obtained results to the response surface methodology (RSM) approach.

• Food Science of Animal Resources
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• v.39 no.2
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• pp.222-228
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• 2019

This research was motivated by our encounter with the situation where an optimization was done based on statistically non-significant models having poor fits. Such a situation took place in a research to optimize manufacturing conditions for improving storage stability of coffee-supplemented milk beverage by using response surface methodology, where two responses are $Y_1$=particle size and $Y_2$=zeta-potential, two factors are $F_1$=speed of primary homogenization (rpm) and $F_2$=concentration of emulsifier (%), and the optimization objective is to simultaneously minimize $Y_1$ and maximize $Y_2$. For response surface analysis, practically, the second-order polynomial model is almost solely used. But, there exists the cases in which the second-order model fails to provide a good fit, to which remedies are seldom known to researchers. Thus, as an alternative to a failed second-order model, we present the heterogeneous third-order model, which can be used when the experimental plan is a two-factor central composite design having -1, 0, and 1 as the coded levels of factors. And, for multi-response optimization, we suggest a modified desirability function technique. Using these two methods, we have obtained statistical models with improved fits and multi-response optimization results with the predictions better than those in the previous research. Our predicted optimum combination of conditions is ($F_1$, $F_2$)=(5,000, 0.295), which is different from the previous combination. This research is expected to help improve the quality of response surface analysis in experimental sciences including food science of animal resources.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.5 no.1
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• pp.81-93
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• 1998

The effectiveness of medication video tapes in teaching fundamental nursing skills was investigated using experimental research methodology. Data was collected from 153 students attending fundamental nursing practice classes of two junior colleges and two universities. The subjects were randomly assigned to two groups, one was an experimental group of 74 subjects and the other was a control group of 79 subjects. The independent variable was learning type and the dependent variables were the degree of knowledge achievement and nursing skills achievement regarding medication. The research hypotheses of this study were as follows : 1) There will be a significant difference between the experimental group and the control group in the degree of knowledge achievement about medication. 2) There will be a significant difference between the experimental group and the control group in the nursing skills achievement about medication. The data was analyzed with the SPSSWIN program and the t-test, number of subjects and percentiles were then examined. The findings of this study are as follows : 1) There was a significant difference between the experimental group and the control group in the knowledge achievement about medication using P<.05. 2) There was no significant difference between the experimental group and the control group in the nursing skill achievement about medication using P<.05. 3) This study suggests that medication video tapes in the education of fundamental nursing skills are effective for knowledge achievement. As a result, medication video tapes can be effectively utilized for the education of nursing skills regarding medication.

• The Journal of Korean Academic Society of Nursing Education
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• v.5 no.1
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• pp.86-96
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• 1999

Effectiveness of the videotaped-record learning method in teaching intramuscular injection skill was investigated using an experimental research methodology. Data was collected from 57 female students attending Fundamental nursing class from two depts. of nursing in Chung-ju and Seoul. The subjects were assigned to two groups, the experimental group of 30 and the control group of 27. The independent variable was videotaped-record learning method and the dependent variable were the degree of knowledge achivement, nursing skill achivement, competence on practicing intramuscular injection skill and satisfaction about the learning method. Data was analyzed using descriptive statistics, chi-square test, t-test and Pearson's correlation coefficient with SPSS-PC program. The results were summarized as follows ; 1. There was statistically significant difference between the experimental group and control group in knowledge achievement about intramuscular injections (t=4.721, P=.000). 2. There was statistically significant difference between the experimental group and control group in nursing skill achievement(t=3.542, P=.001). 3. There was no statistically significant difference between the experimental group and control group in competence on practicing intramuscular injection skill (t=.627, P=.533). 4. There was statistically significant difference between the experimental group and control group in satisfaction about learning method(t=4.708, P=.000). 5. There was significant correlation between nursing skill achievement and knowledge achievement(r=.233, p<.05). In conclusion, this study suggests that videotaped-record learning method is an effective learning method for achieving intramuscular injection skill as a basic nursing skills. Therefore, further study with more developed research design and other fundamental nursing skill practice will be needed to investigate the effectiveness of videotaped-recored learning method.

• Herbal Formula Science
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• v.17 no.1
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• pp.75-83
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• 2009

Objective : The purpose of this study is to indicate of problems in statistical analysis method of "The Korean Journal of oriental Medical Prescription" and we will be proposed the useful application of the statistical analysis method. Methods : In this paper, we were analysed statistical analysis methodology from published journal articles "The Korean Journal of Oriental Medical Prescription" December, year 2000 to December, year 2008. We were investigated of problems in application of structured analysis methods those journal articles that including statistical analysis techniques and analysis methods. Results : 1. A random allocation of the experimental group and control groups are important factors in the planning process of statistical analysis. However, there are less explanation those journal articles. 2. There are no consideration in specimen size that there will be considerate by the level of significance and statistical test. 3. Many article authors were confused between parametric methods and non-parametric methods that they were applied parametric statistical analysis methods although inapplicable sample size. 4. There were applied the parametric methods consists of t-test instead non-parametric methods in the comparison of average intergroup relations. 5. There were less understanding posterior analysis and were confused with t-test. Conclusion : Our goal was to outline the key methods with a brief discussion of problems(statistical analysis methods), avenues for solutions. we recommend authors to use an appropriate statistical analysis methods for obtaining a more cautions results.

• The Journal of Internal Korean Medicine
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• v.44 no.3
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• pp.387-401
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• 2023

Objective: This study was conducted to investigate the preventive effect of herbal medicines on restenosis after percutaneous coronary intervention (PCI) by reviewing randomized controlled trials (RCTs). Methods: RCTs were searched for herbal medicine treatment after PCI using eight online databases (PubMed, CNKI, Wanfang, J-STAGE, OASIS, ScienceON, KTKP, and KISS). Studies that confirmed restenosis through coronary angiography at follow-up were selected according to the inclusion and exclusion criteria. The primary outcome was the restenosis rate, and the secondary outcome was the angina recurrence rate. Data were extracted from the final selected studies according to the research methodology and then analyzed with Review Manager 5.4.1. Study quality was assessed using Cochrane's risk-of-bias (RoB) tool. Results: Of the 252 papers obtained through the primary search, nine studies that met the selection criteria were finally selected. In these nine studies, herbal medicine combined with western medicine was used for the experimental group, and western medicine treatment was used alone for the control group. The meta-analysis result revealed that the restenosis rate and angina recurrence rate were significantly lower in the experimental group than in the control group (RR=0.34, 95% CI: 0.22-0.53, p<0.00001, I²=0% and RR=0.47, 95% CI: 0.29-0.78, p=0.004, I²=0%, respectively). Furthermore, the quality of studies assessed by Cochrane's RoB was low. Conclusions: This study showed that the combined treatment of herbal medicine and western medicine was effective in preventing restenosis and angina after PCI. As the number of papers included in this study was small, a large number of high-quality clinical studies should be considered in the future.