• 생명과학회지
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• 제25권5호
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• pp.515-522
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• 2015

Treculia africana Decne는 빵나무종으로 뽕나무과, Treculia 속에 속하는 식물로서, 이 식물의 다양한 부위에서 추출한 물질은 항염증, 항균등의 효과를 가지고 있어 백일해의 치료등 다양한 질환에서 민간요법으로 사용되어 왔다. 하지만 정확한 생리활성에 관한 연구는 보고된 바가 없다. 따라서 본 연구에서는 T. africana Decne 메탄올추출물(META)을 사용하여 항산화능 및 인체 대장암 세포주인 HT29에 대한 항암활성에 관하여 분석하였다. DPPH radical scavenging activity를 통해 분석한 결과, META의 IC₅₀가 4.53 μg/ml로 강력한 항산화능을 보유하 였음을 확인하였다. 또한 META 처리에 의해 HT29의 생존율이 감소함과 더불어 IC₅₀가 66.41 μg/ml로 강력한 세포사멸효과를 나타냈다. META 처리에 의해 HT29의 subG1 세포비율 및 Annexin V⁺ 세포의 비율이 증가하고, DAPI로 염색된 apoptotic body가 증가하였다. 또한 apoptosis 관련 단백질인 Fas, Bax, cytochrome c의 발현이 증가하였으며, 이는 caspase 3, 8, 9를 활성화 시켜 최종적으로 PARP가 분해되어 apoptosis가 유도되었음을 확인하였다. 이러한 결과들을 통해 META는 강한 항산화 활성과, 대장암세포에서 apoptosis 유도에 의한 높은 항암활성을 보유한 물질임을 확인하였다.

• 한국교육학연구
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• 제22권3호
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• pp.67-87
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• 2016

교육활동의 성격과 교육이론의 실행성을 규명하고자 메타 프락시스의 의미를 검토하였다. 메타 프락시스의 중층구조는 다시 메타 프락시스의 되먹임구조를 드러낸다. 교육논의에서 메타 프락시스의 성격을 배제할 수 없는 것은 이 되먹임구조가 교육현장에서 아이러니를 야기하고, 실행 지침 자체가 실행성과 관련되기 때문이다. 인간 활동의 영역에서 교육은 단순히 포이에시스로 파악되어서 안 되며, 프락시스로 파악되어야 한다. 하지만 교육이 이론화하는 과정에서 메타 프락시스의 속성을 지닌다. 그 결과 교육학의 독자성 확보를 정당화해 준다. 특히 메타 프락시스의 중층구조는 교육활동과 교사의 존재와 역할 등에 시사하는 바가 매우 크다는 점을 확인할 수 있다. 이와 관련하여 교육에서 되먹임구조를 상즉(相卽), 상입(相入), 원증(圓證)과 관련하여 파악하였으며, 교사의 존재의의를 할아버지론(論)에 비추어 파악하였다.

• International journal of advanced smart convergence
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• 제11권3호
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• pp.102-118
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• 2022

With the development of digital content software production technology and the technological progress of related hardware, the social status quo in the post-epidemic era, the popularization and application of 5G networks, the market and consumers' increasing demand for digital content products, artificial intelligence, virtual digital human, virtual Idols, virtual live, self-media content and metaverse-related content industries are all developing rapidly. Virtual idols, virtual digital human, etc. are not only accelerating innovation in production technology. The economic cost, technical difficulty and time requirements of production are also greatly reduced. With the arrival and development of the Metaverse, the author believes that the content industry with virtual digital humans as the core will continue to develop in the direction of refinement, specialization, facilitation and customization. In this article, we will analyze and study the production of virtual digital human based on Photoscan technology and Unreal Engine 5 Metahuman software, and discuss the application status and future development of related content.

• ETRI Journal
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• 제46권1호
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• pp.59-70
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• 2024

We introduce a high-performance named entity recognition (NER) model for written and spoken language. To overcome challenges related to labeled data scarcity and domain shifts, we use transfer learning to leverage our previously developed KorBERT as the base model. We also adopt a meta-pseudo-label method using a teacher/student framework with labeled and unlabeled data. Our model presents two modifications. First, the student model is updated with an average loss from both human- and pseudo-labeled data. Second, the influence of noisy pseudo-labeled data is mitigated by considering feedback scores and updating the teacher model only when below a threshold (0.0005). We achieve the target NER performance in the spoken language domain and improve that in the written language domain by proposing a straightforward rollback method that reverts to the best model based on scarce human-labeled data. Further improvement is achieved by adjusting the label vector weights in the named entity dictionary.

• 한국의류학회지
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• 제48권1호
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• pp.50-65
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• 2024

By analyzing the style of creator avatars in the world of Metaverse, which is emerging as a fourth-generation social media platform, this study aims to identify the meta-fashion tastes of Generation Z (Gen Z) creators (born in the late 2010s and early 2020s) and to analyze the extent to which current trends in the fashion market are influencing meta-fashion. The research method uses a case study to compare meta-fashion and current fashion trends. First, five Gen Z fashion creators on ZEPETO were selected to analyze the meta-fashion styles presented by this group. In the end, a total of 100 fashion styles were analyzed by combining 50 items each from the current meta-fashion and real fashion trends. The fashion styles were found to be hip-hop, easy-casual, punk, lovely feminine, and sexy, and the main fashion items were analyzed as jeans, hip-hop style pants, sneakers, tight crop tops, dresses, tattoos, chain accessories, and dyeing. Meta-fashion is the emergence of items similar in shape to those popular in the current fashion market, but are more exaggerated or show off the human body than actual fashion items.

• 한국생활과학회지
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• 제17권4호
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• pp.785-796
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• 2008

The Open-Market internet shopping malls has rapidly been growing over the past few years. Thus, this study compares Meta-Mall and Open-Market, as well as evaluates image factors of the internet shopping mall in order to verify different levels of influence on customer satisfaction and revisit intentions. The subject of stud was made for students enrolled in colleges in the Busan area, using this Data collection method. Data were gathered using a questionnaire and through personal interviews from a sampling made from May 1 to May 8, 2008. The final 337 accomplished questionnaire forms were used for the subsequent analysis. The results of the substantial analysis are as follows. First, the following factors affect the image of internet shopping malls: assortment of goods and information service, site design, convenience, reliability of goods and information, and customer service. In Meta-Mall, these same factors, except customer service, were found to influence customer satisfaction, while in Open-Market, all the five factors were found to influence customer satisfaction. In Open-Market, convenience and reliability of goods and information had especially high levels of influence on customer satisfaction. Second, customer satisfaction with Internet shopping malls was found to influence the intentions of the customers to make a revisit. The result of the study shows that the factors of shopping mall image between Meta-Mall and Open-Market are perceived differently by their customers, and differences were found in the levels of their influence on customer satisfaction.

• 한국운동역학회지
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• 제31권4호
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• pp.259-269
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• 2021

Objective: The purpose of this systematic review and meta-analysis was to investigate age-related bimanual coordination functions in older adults. Method: Thirteen studies that compared bimanual coordination functions in older adults with those in healthy young adults qualified for this meta-analysis. We additionally categorized 21 total comparisons from the 13 qualified studies into two types of task-related moderator variables: (1) kinematic versus kinetic movements and (2) symmetry versus asymmetry movements. Results: Random effects model meta-analysis found that older adults revealed significant bimanual coordination impairments as compared with young adults (Hedges's g = -0.771; p < .0001; I² = 74.437%). We additionally confirmed specific bimanual coordination deficits using two moderator variables: 1) kinematic (Hedges's g = -0.884; p < .0001; I² = 0.000%) and kinetic (Hedges's g = -0.666; p = .023; I² = 86.170%). 2) symmetry (Hedges's g = -0.712; p = .001; I² = 74.291%) and asymmetry (Hedges's g = -0.817; p < .0001; I² = 76.322%). The moderator variable analysis indicated older adults indicated bimanual coordination deficits in the upper extremities than healthy young adults while performing kinematic bimanual coordination tasks and asymmetry coordination tasks. Conclusion: These findings suggest that developing motor rehabilitation programs based on asymmetric bimanual movement task for enhancing interlimb coordination functions of older adults may be crucial for increasing their independence in everyday activities. Given that elderly revealed the deficits in lower extremities coordination when older adults perform gait, posture, and balance, future studies should estimate lower limb coordination functions in elderly people.

• Asian Pacific Journal of Cancer Prevention
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• 제15권22호
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• pp.9725-9730
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• 2014

Background: Sister chromatid exchange (SCE) in human peripheral blood lymphocytes is one of the most extensively studied biomarkers employed to evaluate genetic damage subsequent to pesticide exposure. Objective: To estimate the pooled levels of SCE in human peripheral blood lymphocytes among population exposed to pesticide. Materials and Methods: Meta-analysis on the association between SCE frequency and pesticide exposure was performed with STATA 10.0 software package and Review Manager 5.0.24 in this study. Results: The overall means of SCE were 7.88 [95% confidence intervals (95%CI): 6.71-9.04] for exposure group and 6.05 (95%CI: 5.13-6.95) for controls, respectively. There was statistically significant difference in the SCE frequency in human peripheral blood lymphocytes between pesticide-exposed groups and control groups, and the summary estimate of weighted mean difference was 1.69 (95%CI: 1.01-2.38). We also observed that pesticide-exposed population had significantly higher SCE frequency than control groups among smokers, nonsmokers, pesticide applicator, pesticide producer, other exposure population and Asian population in stratified analyses. Conclusions: Data indicate that the SCE frequency in human peripheral blood lymphocytes might be an indicator of early genetic esffects for pesticide-exposed populations.

• 한국환경보건학회지
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• 제37권5호
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• pp.358-368
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• 2011

Objectives: In order to evaluate the association between occupational exposure to chloroethylene (TCE) and risk of non-Hodgkin lymphoma (NHL), we conducted a meta-analysis of retrospective cohort studies and casecontrol studies and attempted to summarize the evidence of the association from molecular-epidemiological studies and experiments with human cells. Methods: In the meta-analysis, we restricted the analysis to those studies with data for chlorinated solvents, degreasers, or TCE. Studies involving dry cleaners or launderers were excluded from the analysis because use of TCE as a dry cleaning fluid has been rare since the 1960s. The data were combined using a random-effects model to estimate the summary risks (OR and RR) and 95% confidence intervals (CIs). Molecular evidence of the effect of TCE on human immune system were also reviewed and summarized. Results: Occupational exposure to TCE was strongly associated with NHL among cohort studies (number of studies=13, summary RR=1.33, 95% CI=1.04-1.70) whereas the association was not statistically significant among case-control studies (number of studies=15, summary OR=1.10, 0.98-1.23). When exposure level was considered, it became statistically significant for the highest exposure level (number of studies=5, summary OR=1.70, 1.25-2.32). Molecular evidences showed that TCE exposure in human or cultured human cells may cause a significant decrease immune cell subsets and changes in hormone levels related to immune response. Conclusions: Our results from meta-analysis and additional molecular evidence suggest that occupational exposure to TCE may cause NHL. However, unmeasured potential confounding and unclear dose-response relationships warrant further study on the role of TCE exposure in NHL carcinogenesis.

• 한국생활과학회지
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• 제19권5호
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• pp.835-844
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• 2010

This study used meta-analysis to compare analyze data regarding the effects of music therapy on children and adolescent. The study examined 96 ESs using means and standard deviations from 77 Korean degree dissertations conducted between2000 and 2010. Results were as follows: The overall effect size (ES) of the therapy program was found to be 0.14, which, according to Cohen's ES interpretation criteria, is small. The mean ES was influenced by the subjects (children/ adolescents), ES of children(0.50) was bigger than ES of adolescents(-0.23). When results were sorted by the variables of therapy part: social, emotional and behavior development), the ES of social development was the biggest (1.11), followed by behavior development (-1.07) and emotional development (-0.01). However, other variables (total number of procedures, number of treatments per week, the average treatment time, therapist characteristics) made no statistically significant differences to the efficacy of the therapy. Finally, limitations of this study and potential future research are discussed.