• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.11
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• pp.271-284
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• 2016

This study was carried out to evaluate the efficacy of CBT for perinatal depression through systematic literature review and meta-analysis. The following databases were used to search the literature: CINAHL, PubMed, EMBASE, Koreamed, Library of Korean Congress, KISS, and Korean Academic Publication Database. Keywords included 'perinatal depression,' 'pregnant women,' and 'cognitive behavioral therapy,' and the evaluated articles were published up to May 2016. Using the R program, the effect size of perinatal depression and anxiety were calculated by random-effects model. The heterogeneity of the effect size was analyzed by data moderator analysis using the meta-ANOVA. Furthermore, the funnel plot, Egger's regression test, fail-safe N, trim-and-fill test, and publication bias analysis were conducted and used to verify the results. Out of the 180 selected articles, 16 clinical trial studies were meta-analyzed. Each articles were evaluated for the risk of bias by the checklist of SIGN; the overall risk of bias was low. The effect size of CBT for perinatal depression was Hedges' g=-0.55 (95% CI: -0.76~-0.33), which was a moderate level, while for anxiety reduction, Hedges' g=-0.20 (95% CI: -0.48~-0.08) and it was not statistically significant. Heterogeneity or risk of publication bias were low. This meta-analytic study found that CBT is moderately effective in reducing perinatal depression in pregnant women.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.7
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• pp.3165-3172
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• 2012

Objective: Genetic polymorphisms in metabolic enzymes are associated with numerous cancers. A large number of single nucleotide polymorphisms (SNPs) in the CYP2D6 gene have been reported to associate with cancer susceptibility. However, the results are controversial. The aim of this Human Genome Epidemiology (HuGE) review and meta-analysis was to summarize the evidence for associations. Methods: Studies focusing on the relationship between CYP2D6 gene polymorphisms and susceptibility to cancer were selected from the Pubmed, Cochrane library, Embase, Web of Science, Springerlink, CNKI and CBM databases. Data were extracted by two independent reviewers and the meta-analysis was performed with Review Manager Version 5.1.6 and STATA Version 12.0 software. Odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated. Results: According to the inclusion criteria, forty-three studies with a total of 7,009 cancer cases and 9,646 healthy controls, were included in the meta-analysis. The results showed that there was a positive association between heterozygote (GC) of rs1135840 and cancer risk (OR=1.92, 95%CI: 1.14-3.21, P=0.01). In addition, we found that homozygote (CC) of rs1135840 might be a protective factor for cancer (OR=0.58, 95%CI: 0.34-0.97, P=0.04). Similarly, the G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 had negative associations with cancer risk (OR=0.69, 95%CI: 0.48-0.99, P=0.04; OR=0.60, 95%CI: 0.38-0.94, P=0.03; OR=0.50, 95%CI: 0.26-0.95, P=0.03; respectively). Conclusion: This meta-analysis suggests that CYP2D6 gene polymorphisms are involved in the pathogenesis of various cancers. The heterozygote (GC) of rs1135840 in CYP2D6 gene might increase the risk while the homozygote (CC) of rs1135840, G allele and G carrier (AG + GG) of rs16947 and heterozygote (A/del) of rs35742686 might be protective factors.

• Journal of Preventive Medicine and Public Health
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• v.30 no.3 s.58
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• pp.643-664
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• 1997

This study is to provide evidence-based recommendations for the most-effective treatments of benign prostatic hyperplasia based on patient preference or clinical need, and to meta-analyze the Korean literatures for the development of BPH treatment guidelines. For these analyses, extensive literature searches (208 articles), with priority given to the Korean Journal of Urology, were conducted from 1960 to August, 1996. Meta-analysis, like all statistical analysis, has two main functions: data summarization (qualitative meta-analysis) and smoothing o. pattern recognition (quantitative meta-analysis). As well, critical reviews and syntheses with the mean and 90-percent confidence intervals for the likelihood were used to evaluate empirical evidence and significant outcomes of the BPH treatment literatures (106 articles). For this task, the Methodologic Panel for BPH Guidelines was composed of multidisciplinary experts in the field. The results of the study were summarized as follows: For all that watchful waiting is an appropriate treatment strategy for the majority of patients with prostatism, we couldn't find the Korean literatures which carried this article. The literatures on alpha-1-adrenergic receptor blockers provide no evidence to suggest that any one alpha blocker is more effective than another. The finasteride reduces the size of the prostate, on average, and leads to a small yet perceptible reduction in sysptoms. Of all treatment options, prostate surgery with transurethral resection of the prostate (TURP), transurethral incision of the prostate (TUIP), and so on, offers the best chance for symptom improvement. However, surgery also has the highest rates of significant complications. Therefore, surgery need not always be a treatment of last resort. Balloon dilation of the prostatic urethra is clearly less effective than surgery in relieving symptoms, but it is associated with fewer complications. Emerging technologies for treating BPH include lasers, coils, stents, thermal therapy and hyperthermia. Established technologies will also be reanalyzed as results of new trials are reported. Although this study has some limitations due to lacking for good quality literatures, ' it provides a cornerstone for our medical research. It represents the most current scientific knowledge regarding the clinical epidemiology including treatment of BPH. It will be revised and updated as needed.

• Smart Media Journal
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• v.10 no.2
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• pp.61-69
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• 2021

Wayfinding is a 'Process solving problem to find destination', and it is important to select spatial data for optimal way. Recently, due to the complexity of space and the expansion of the medium of the wayfinding service, it is necessary to the approach on the information design for them. Therefore, the purpose of this study is to propose a meta guideline on the information design for the design of orientation sign, which is an important cognitive clue in the wayfinding. It was conducted in 3 stages, First, a design process was proposed and design elements were derived for each step by literature research related to information and sign design, and analysis of manual for signage design. Second, a meta guideline for information organization and visualization in the three-stage design process was proposed by FGI and analysis. Third, the meta guideline was applied to the sign design on an area for user evaluation to inspect the applicability of the meta guideline. Through the user questionnaire, the possibility of applying the guideline for visualization of directions and spaces, information hierarchy according to spatial characteristics and information priority was identified. It is meaningful in that necessary element for signage design are systematized centering on the process and that it presents a macroscopic methodology according to spatial characteristics.

• The Journal of the Korea Contents Association
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• v.22 no.8
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• pp.660-670
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• 2022

This study was analyzed by applying AMSTAR-2, a methodological quality evaluation tool, to evaluate the quality of domestic meta-analysis papers on rehabilitation interventions for stroke patients. The purpose of this study is to provide guidelines for qualitative improvement of evidence-based practice and meta-analysis research by analyzing the qualitative level of the analyzed research. The literature search was conducted using the Research Information Sharing Service, Korean Medical database, and Korean studies Information Service System. Two authors searched, extracted, and reviewed literature using the keywords 'stroke' and 'meta-analysis'. As a result of the AMSTAR-2 quality evaluation of the final 18 studies, 3 studies (16.67%) were 'Moderate', 8 studies (44.44%) were 'Low', and 7 studies (38.89%) were 'Critically Low'. In future research, scientific and objective data selection and extraction process should be performed. It is expected that interest and efforts to improve the quality of meta-analysis research will continue by referring to the contents analyzed in this study as a way to improve the quality of literature.

• Proceedings of the Korea Contents Association Conference
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• 2006.05a
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• pp.503-506
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• 2006

In this paper, we suggest the Agent System for management and service of science and technology information that performs the collection, analyzing, processing and managing the information. Generally, any system can process the collection and service the information as usual method, but that mean can't be clear because of the data process method on different systems of hardware and software. So, it's very important point that the design and development of S&T information flow framework that can accept the various data, and we expect that the agent system adapted in framework guarantee the reduction of man power and process time and the enlarged system. Agent System consists of five multi agents, Resource Format Register Agent, Data Collector Agent, Data Analyzer Agent, Data Processor Agent and MetaDB Creator Agent. We describe the main roles and elements of agent systems.

• The Korean Journal of Applied Statistics
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• v.26 no.2
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• pp.307-319
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• 2013

With the rapid accumulation of microarray data, it is a significant challenge to integrate available data sets addressing the same biological questions that can provide more samples and better experimental results. Sometimes, different microarray platforms make it difficult to effectively integrate data from several studies and there is no consensus on which method is the best to produce a single and unified data set. Methods using median rank score, quantile discretization and standardization (which directly combine rescaled gene expression values) and meta-analysis (which combine the results of individual studies at the interpretative level) are reviewed. Real data examples downloaded from GEO are used to compare the performance of these methods and to evaluate if the combined data set detects more reliable information from the separated data sets or not.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.10
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• pp.1957-1967
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• 2007

User can be offered various information form internet and reserve. However this operation is hard to be satisfied with user's requirement. Because it offer the alternative by self-mediation and the place where offer the information is distributed and a form or stored f[nm of data would be different. These cases occurred in change of enterprise recently. In a process of M&A, outsourcing or cooperation. necessity of new strategy become a pressing issue for ensuring interoperability on application, database of each enterprise and integration information management. Thus, interoperability of distributed data is a base condition for cooperation of legacy system, it will solve a problem such as available or clarity of data, problem of cooperation system. This paper use a XMDR for integration of distributed system and ensuring interoperability. By using XMDR, integrate a traveling information system and it will be solve the problem of interoperability and variety data problem that be occurred in integration of data by suggesting a technique of transaction management.

• Journal of the Korea Society of Computer and Information
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• v.14 no.10
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• pp.31-41
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• 2009

In the Semantic Web, it is possible to provide intelligent information retrieval and automated web services by defining a concept of information resource and representing a semantic relation between resources with meta data and ontology. It is very important to manage semantic data such as ontology and meta data efficiently for implementing essential functions of the Semantic Web. Thus we propose an index structure to support more accurate search results and efficient query processing by considering semantic and structural features of the semantic data. Especially we use a graph data model to express semantic and structural features of the semantic data and process various type of queries by using graph model based path expressions. In this paper the proposed index aims to distinguish our approach from earlier studies and involve the concept of the Semantic Web in its entirety by querying on primarily extracted structural path information and secondary extracted one through semantic inferences with ontology. In the experiments, we show that our approach is more accurate and efficient than the previous approaches and can be applicable to various applications in the Semantic Web.

• Korean Journal of Adult Nursing
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• v.25 no.4
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• pp.377-388
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• 2013

Purpose: The purpose of this study was to assess the effects of cognitive behavioral therapy (CBT) on depression, anxiety, self care behavior and quality of life in cancer patients. Methods: Two thousand and eighty three abstracts were identified through six electronic databases (1980 to June 2012) in Korea. Seventeen studies involving 679 participants met the inclusion criteria for meta analysis. Two authors independently assessed trial quality by Cochrane's Risk of Bias and Methodological Items for Non Randomized Studies and extracted data. The data were analyzed by the RevMan 5.2 program of Cochrane library. Results: Overall, study quality was moderate to high. CBT was conducted for a mean of 4.2 weeks, 7 sessions and an average of 36.1-minutes per session. CBT was effective for depression (d=-0.85; 95% CI=-1.09, -0.61), anxiety (d=-0.52; 95% CI=-0.75, -0.29), self care behavior (d=-1.34; 95% CI=-1.93, -0.74), and quality of life (d=-0.42; 95% CI=-0.80, -0.04). Publication bias was not detected as evaluated by funnel plot and Egger's test. Conclusion: CBT has small to large effects on depression, anxiety, self care and quality of life. These finding suggests that various CBT interventions can assist cancer patients in reducing emotional distress and improving self care and quality of life.