• Korean Journal of Clinical Pharmacy
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• v.33 no.4
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• pp.278-289
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• 2023

Background: Linezolid has been widely used in the treatment for multidrug-resistant tuberculosis. However, there are limitations to use it such as long treatment, because of related side effects, even adequate treatment period has been needed for remission of multidrug-resistant tuberculosis (MDR-TB). Method: The meta-analysis was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. To choose literatures, systematic literature reviews were conducted with databases of PubMed, Web of Science, and EMBASE. Results: Efficacy and safety of Linezolid were determined by 85% (95% CI=79~89%, p<0.05) in the sputum culture conversion and 55% (95% CI=45~64%, p<0.01) in side effects related to linezolid, respectively. In addition, I² was estimated by 72%. In the subgroup analysis, efficacy and safety by dose and region were analyzed. In the subgroup analysis, compared with the linezolid dose in groups greater than 600 mg/day and less than 600 mg/day, this study showed 85% (95% CI 79~90%, p>0.05) in 206 patients and 82% (95% CI 73~89%, p<0.05) in 297 patients, respectively. Also, in the subgroup analysis, adverse effects caused by linezolid occurred more than 50% of treated patients. Conclusion: Therapeutic efficacy of linezolid for MDR-TB patients was confirmed regardless of the initial dose of linezolid, especially for sputum culture conversion and it was recommended that the dose of linezolid has been more effective below 600 mg/day. However, it should be necessary to closely monitored for safety issues since serious side effects possibly occurred by administration of long period treatment.

• The Journal of Internal Korean Medicine
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• v.45 no.3
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• pp.396-414
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• 2024

Objective: This study assessed the effectiveness of Gammaekdaejo-tang for post-stroke depression through a systematic review and meta-analysis of randomized controlled trials (RCTs). Methods: A search was conducted using keywords such as "Post-stroke Depression", "PSD", "Gammaekdaejo", and "Ganmai-dazao" on April 30, 2024. A meta-analysis was conducted according to outcome measurements, such as total effective rate (TER), HDRS (Hamilton Depression Rating Scale), and NIHSS (National Institute of Health Stroke Scale), using the Review Manager website. Results: A total of 10 RCTs was selected. The treatment group ((Gammaekdaejo-tang) or (Gammaekdaejo-tang combined with other ingredients or decoction)+Western medicine) showed significant improvement effects in terms of TER, HDRS, and NIHSS compared to the control group (Western medicine). [TER] RR: 1.19, 95% CI: 1.11 to 1.27, P<0.00001, RR: 1.24, 95% CI: 1.11 to 1.38, P<0.00001; [HDRS] MD: -2.29, 95% CI: -2.58 to -2.00, P<0.00001), MD: -3.28, 95% CI: -4.21 to -2.35, P<0.00001) [NIHSS] MD: -7.70, 95% CI: -8.52 to -6.89, P<0.00001. Conclusion: This study suggests that Gammaekdaejo-tang is effective in treating PSD. However, there are limitations, such as the small number of included studies, inability to clearly determine the effect of Gammaekdaejo-tang, inability to use various evaluation tools, and risk of bias. This research must be supplemented through systematic research design and implementation.

• Journal of Korea Multimedia Society
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• v.9 no.10
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• pp.1332-1343
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• 2006

This paper proposes an educational community service system that manages information of good quality intensively without overlapping, and that provides an effective searching function by using a personal community with many user layers. This system raises the efficiency of searching and management by using Metadata and Category. It is a self-leading educational community system that brings merits into relief and improves weak points. We constructed an autogenous Blog chain service as a tool which verifies this system, which is called 'EduLOG(Educational Blog) service' Especially we extracted Metadata suitable for this service, which is on the basis of worldfamous Dublin Core Metadata. And we made a new category on the basis of categories which were proposed by some educational community sites and public educational authorities, and we applied it to this system. To ascertain whether this service system provide adequate function or not, we made a questionnaire on the basis of the appraisal table in websites, and evaluated it at the request of experts. In view of the results so far achieved, it returned good scores (above 3.5/5.0) in accuracy of evaluation, low-end reappearance ratio, easiness of registering and approaching information, and intensive management of a categorical information, confirming the efficiency of the ECSS system. Therefore we believe firmly that the ECSS system will play a efficient information storing and searching roles in the near future.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.10
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• pp.158-167
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• 2016

This study was conducted to evaluate the quality of meta-analysis of social work in South Korea using the Assessment of Multiple Systematic Review (AMSTAR). Electronic databases including the Korean Studies Information Service System (KISS), DBpia, and RISS4U were searched for 'meta-analysis', 'social work', and 'social welfare' from 2000 to December 2015, and 42 meta-analysis studies were included. Data were analyzed using descriptive statistics, t-tests, and ANOVA. The mean score for AMSTAR evaluation was $4.766{\pm}1.66$, while 19 studies (45.2%) were classified at the low-quality level, and 22 (52.4%) were at the moderate-quality level. The scores of quality assessment were analyzed by publication year, participants, number of studies included, number of DB, reporting study quality, extraction diagram and topics. The findings indicated that the following changes should be implemented to improve the quality and reliability of meta-analysis results in social work research: 1) common reporting guidelines should be provided for the social work field, 2) quality analyses of each study should be conducted to achieve a high level of evidence of effectiveness of social work interventions, 3) the characteristics of the included studies should be provided, and 4) a consensus and procedure based on at least two independent data extractors should be reported.

• Smart Media Journal
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• v.10 no.2
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• pp.61-69
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• 2021

Wayfinding is a 'Process solving problem to find destination', and it is important to select spatial data for optimal way. Recently, due to the complexity of space and the expansion of the medium of the wayfinding service, it is necessary to the approach on the information design for them. Therefore, the purpose of this study is to propose a meta guideline on the information design for the design of orientation sign, which is an important cognitive clue in the wayfinding. It was conducted in 3 stages, First, a design process was proposed and design elements were derived for each step by literature research related to information and sign design, and analysis of manual for signage design. Second, a meta guideline for information organization and visualization in the three-stage design process was proposed by FGI and analysis. Third, the meta guideline was applied to the sign design on an area for user evaluation to inspect the applicability of the meta guideline. Through the user questionnaire, the possibility of applying the guideline for visualization of directions and spaces, information hierarchy according to spatial characteristics and information priority was identified. It is meaningful in that necessary element for signage design are systematized centering on the process and that it presents a macroscopic methodology according to spatial characteristics.

• The Journal of Internal Korean Medicine
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• v.39 no.1
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• pp.22-43
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• 2018

Objective: The purpose of this study is to investigate the effect of Cheonmagudeung-eum (CGE) for essential hypertension by systematic review and meta-analysis. Methods: The period of literature search was until October 30, 2016, and 14 electronic databases were utilized as search engines. The evaluation for the risk of bias (RoB) was conducted by using the Cochrane Risk of Bias Tool. The meta-analysis was performed by synthesizing outcome data, including total effective rate (TER), systolic blood pressure (SBP), diastolic blood pressure (DBP), and the incidence of adverse events. Result: There were a total of 64 RCTs using CGE on adult essential hypertension. In the RoB evaluation, most of the items were unclear, and the qualities of studies were rated low. The concurrent treatment of CGE and antihypertensive drug (AHD) showed a significant hypotensive effect since the risk ratio (RR) of TER was 1.17 times (95% CI 1.14, 1.20, p<0.01) higher than that of AHD alone. In addition, the mean difference (MD) appeared low as 8.73 mm/Hg in SBP (95% CI -11.36, -6.09, p<0.01) and 5.81 mm/Hg in DBP (95% CI -7.50, -4.12, p<0.01). Conclusion: Through this study, it was identified that the combined treatment of CGE and AHD on hypertension would be more effective than that of AHD treatment alone. However, due to the low quality of the selected original articles, the significance of this conclusion is somewhat limited, and we hope that this would be complemented through more rigorous RCTs in the future.

• Journal of Preventive Medicine and Public Health
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• v.33 no.3
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• pp.343-348
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• 2000

Objectives : This study was conducted to integrate the results of studies assessing the association between chronic noise exposure and blood pressure. Methods : Using a MEDLINE search with noise exposure, blood pressure and hypertension as key words, we retrieved articles from the literature that were published from 1980 to December 1999. The criteria for quality evaluation were as follows: 1) the study subjects must have been workers employed at a high noise level area 2) The paper should use average and cumulative noise exposure as method for exposure evaluation. 3) Blood pressure in each article should be reported in a continuous scale Among the 77 retrieved articles, six studies were selected for quantitative meta-analysis. Before the integration of the regression coefficients for the association between blood pressure and noise level, homogeneity tests were conducted. Results : All studies were a cross-sectional design and the study subjects were industrial workers. Five papers used a time-weighted average for noise exposure and only one paper calculated the cumulative noise exposure level. The measurement of blood pressure in the majority of studios were accomplished in a resting stale, and used an average of two or more readings. The homogeneity of studies was rejected in a fixed effect model, so we used the results in a random effect model. The results of the quantitative meta-analysis, the weighted regression coefficient of noise associated with systolic blood pressure and diastolic blood pressure were 0.05 (95% confidence interval [CI]: -0.03, 0.13) and 0.06 (95% CI: -0.01, 0.13), respectively. Conclusions : Our results suggested that chronic exposure to industrial noise does not cause elevated blood pressure.

• Journal of the Korea Convergence Society
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• v.13 no.1
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• pp.109-118
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• 2022

The purpose of this study is to identify trends in the application of artificial intelligence by analyzing upper extremity movement assessment and artificial intelligence convergence research using a systematic literature review method. The research was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Among the 380 articles searched in three databases, 8 articles were finally selected according to the selection and exclusion criteria. For the evaluation of upper extremity movement, motion performance evaluation, FMA, and ARAT were used. For quantification, data were extracted using various tools, and upper extremity movement classification, recovery prognosis prediction, and evaluation tool score were predicted using artificial intelligence. This study is meaningful in that it systematically reviewed studies that objectively evaluated upper extremity movement using artificial intelligence and identified the direction in which artificial intelligence is being applied. Based on this, the introduction of artificial intelligence technology in the assessment of upper extremity movements is expected to help objectively identify the intervention effect and the patient's recovery.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.32 no.3
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• pp.71-77
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• 2009

Using the results of the expected busy periods for the dyadic Min(N, D) and Max(N, D) operating policies in a controllable M/G/1 queueing model, an important relation between them is derived. The derived relation represents the complementary property between two operating policies. This implies that it could be possible to obtained desired system characteristics for one of the two operating policies from the corresponding known system characteristics for the other policy. Then, upper and lower bounds of expected busy periods for both dyadic operating policies are also derived.

• Economic and Environmental Geology
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• v.24 no.3
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• pp.309-318
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• 1991

Analysis for landslides was studied in framework of Chungju dam right abutment, 6.5km northeast of Chungju city. $5.5{\times}10^6m^3$ landslide materials were excavated during dam construction for safety of the Chungju dam. Geology of study area is composed mainly of meta sediments such as dolomitic limestone, quartzite and schist which are dipping toward the Nam Han river. Scanline survey of discontinuities was performed for slope stability, resistivity exploration was performed for the evaluation of potential failure plane, and direct shear strength test of rocks and soils was performed for the effect on landslide. Monitoring systems of tiltmeter, tensiometer, ground water observation hole and level monument were installed during dam construction and interpreted for the evaluation of slope instability. Kinematic solution of the geological structure and evaluation using safety factor for slope may prove the failure of the slope.