Korean Journal of Clinical Pharmacy (한국임상약학회지)

Korean College Of Clinical Pharmacy (한국임상약학회)
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Evaluation of the Efficacy and Safety of Linezolid by Meta-analysis for Multidrug-resistant Tuberculosis Patients

다제내성결핵 환자에서 메타분석을 통한 Linezolid의 효능 및 안전성 평가

  • Woojin Jung (College of Pharmacy, Chungnam National University) ;
  • Taewook Sung (College of Pharmacy, Chungnam National University) ;
  • Ae Jin Kim (College of Pharmacy, Chungnam National University) ;
  • Jung-woo Chae (College of Pharmacy, Chungnam National University) ;
  • Hwi-yeol Yun (College of Pharmacy, Chungnam National University)
  • Received : 2023.10.12
  • Accepted : 2023.12.19
  • Published : 2023.12.31
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Abstract

Background: Linezolid has been widely used in the treatment for multidrug-resistant tuberculosis. However, there are limitations to use it such as long treatment, because of related side effects, even adequate treatment period has been needed for remission of multidrug-resistant tuberculosis (MDR-TB). Method: The meta-analysis was performed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria. To choose literatures, systematic literature reviews were conducted with databases of PubMed, Web of Science, and EMBASE. Results: Efficacy and safety of Linezolid were determined by 85% (95% CI=79~89%, p<0.05) in the sputum culture conversion and 55% (95% CI=45~64%, p<0.01) in side effects related to linezolid, respectively. In addition, I2 was estimated by 72%. In the subgroup analysis, efficacy and safety by dose and region were analyzed. In the subgroup analysis, compared with the linezolid dose in groups greater than 600 mg/day and less than 600 mg/day, this study showed 85% (95% CI 79~90%, p>0.05) in 206 patients and 82% (95% CI 73~89%, p<0.05) in 297 patients, respectively. Also, in the subgroup analysis, adverse effects caused by linezolid occurred more than 50% of treated patients. Conclusion: Therapeutic efficacy of linezolid for MDR-TB patients was confirmed regardless of the initial dose of linezolid, especially for sputum culture conversion and it was recommended that the dose of linezolid has been more effective below 600 mg/day. However, it should be necessary to closely monitored for safety issues since serious side effects possibly occurred by administration of long period treatment.

Keywords

Acknowledgement

이 연구는 충남대학교 학술연구비, 2022년도 정부(과학기술정보통신부) 재원 정보통신기획평가원(No.RS-2022-00155857, 인공지능융합혁신인재양성사업 ( 충남대학교 )), 한국연구재단(No. NRF-2022R1A5A7085156, NRF-2022R1A2C1010929과 RS-2023-00278597)에 의해 지원을 받아 수행된 연구임.

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