• Journal of Microbiology
• /
• 제44권5호
• /
• pp.502-507
• /
• 2006

In a previous study, an extract of Clavicorona pyxidata DGUM 29005 mycelia demonstrated an inhibitory effect against enzyme-associated perceptual disorders. We have attempted to determine whether this mycelial extract is also capable of inhibiting the activities of acetylcholinesterase (AChE) and ${\beta}$-secretase (BACE) activity. Butanol, ethanol, and water extracts of C. pyxidata DGUM 29005 mycelia were shown to inhibit AChE activity by 99.3%, 93.7%, and 91.7%, respectively. The inhibitory value of the butanol extract was more profound than that of tacrine (95.4%). The ethanol extract also exerted an inhibitory effect against BACE activity; this fraction may harbor the potential for development into a pharmocotherapeutic modality for the treatment of Alzheimer's disease (AD) patients. Rat pheochromocytoma PC12 cells in culture were not determined to be susceptible to the cytotoxic activity evidenced by the mycelial extract. The ethanol extract inhibited endogenous AChE activity in PC12 cellular homogenates, with an $IC_{50}\;of\;67.5{\mu}g/ml$, after incubation with intact cells, and also inhibited BACE activity in a dose-dependent fashion. These results suggest that the C. pyxidata mycelial extract has the potential to enhance cholinergic function and, therefore, may perform a function in the amelioration of the cholinergic deficit observed in cases of AD, as well as other types of age-associated memory impairment.

• The Journal of Korean Physical Therapy
• /
• 제17권3호
• /
• pp.377-390
• /
• 2005

The purpose of this study is to investigate the effect of neuromuscular re-education program and general intervention program. It is focused on difference between changes of experimental before and after on 20 stroke patient's motor control ability. The obtained results are as follows; In change in motor control ability, neuromuscular re-education program group about the motor control ability was a significant difference(p<.01). And traditional intervention program group, the motor control ability was a significant difference in all of items (p<.01; p<.05) but, were not a significant difference in bladder management, social interaction, problem solving and memory. And also comparison of change in motor control ability between the experimental group and control group, the between-subjects factors were a significant difference. Most of the functional items on the functional items on the functional measurement and neuromuscular function measurement are concerned with the physical autonomy of the hemiplegic patients. More in depth knowledge may be acquired about the distribution of physical and motor control patterns with respect to the degree of neurologic deficit for the enhencement of residual motor control function in hemiplegia. In conclusion, the neuromuscular re-education program was more effect then traditional intervention program in motor control ability.

• 동의생리병리학회지
• /
• 제35권3호
• /
• pp.97-103
• /
• 2021

Perilla frutescens (P. frutescens) is an important herb used for many purposes such as medicinal, aromatic, and functional food in Asian countries and has beneficial effects such as antioxidant activity, anti-inflammation activity, anti-depression activity, and anxiolytic activity. However, there have been no studies on the protective effect of P. frutescens extract (PFE) on amnesia in vivo. The present study aimed to investigate whether PFE protects memory deficit using a scopolamine-induced mice model and elucidate the underlying mechanisms involved. The protective effect of PFE against scopolamine-induced memory deficits was investigated using Y-maze, passive avoidance, and Morris water maze tests. Furthermore, the potential mechanisms of PFE in improving memory capabilities related to the cholinergic system and antioxidant activity were examined. PFE significantly increased spontaneous alternation in the Y-maze test, step-through latency in the passive avoidance test, and swimming time in the target quadrant in the probe test when compared to the scopolamine-treated group. Likewise, PFE significantly decreased escapes latency in the Morris water maze test. PFE could not regulate cholinergic function in acetylcholine level and acetylcholine esterase activity. However, PFE increased DPPH radical scavenging activity dose-dependently and total polyphenol content was 127.7±1.2 ㎍ GAE/mg. The results showed that the PFE could be a preventive and/or therapeutic candidate for memory and cognitive dysfunction in Alzheimer's disease.

• 산업융합연구
• /
• 제21권12호
• /
• pp.101-111
• /
• 2023

본 연구는 국내 경도인지장애 환자의 인지기능을 위한 이중과제 프로그램의 효과를 분석하기 위해 체계적 문헌고찰 및 메타분석을 시행하였다. 8개의 데이터베이스를 사용하여 검색하였으며, 검색어는 경도인지장애, 인지, 이중과제였다. 2013년 1월부터 2023년 7월까지 출간된 문헌 중 무작위 및 비무작위 대조군 실험설계를 분석하였다. 총 682편의 문헌이 검색되어 포함 및 배제 기준을 충족한 8편의 문헌을 최종 분석하였다. 문헌의 질 평가는 RoB와 RoBANS를 사용하였다. 메타분석은 CMA 4.0 ver.을 사용하였다. 분석 결과 이중과제 프로그램의 전체 효과 크기는 중간 효과 크기였다. 결과변수에 따른 효과 크기는 지남력, 실행기능은 큰 효과 크기이며, 전반적 인지기능, 시공간기능, 기억기능, 주의기능은 중간 효과 크기였다. 중재 기간에 따른 분석 결과 적용 기간은 4~8주 적용이 효과가 더 크게 나타났으며, 총 회기에서는 24~30회기 적용의 효과 크기가 더 크게 나타났다. 본 연구는 경도인지장애 환자의 인지기능 증진을 위해 적용된 이중과제 프로그램의 효과 및 적용 방법에 대한 임상적 근거를 제시하였다.

• 한국마이크로전자및패키징학회:학술대회논문집
• /
• 한국마이크로전자및패키징학회 2003년도 기술심포지움 논문집
• /
• pp.221-225
• /
• 2003

The MFIS-FET(Field Effect Transistor) devices using $BLT/Y_2O_3$ buffer layer on p-Si(100) substrates were fabricated by the Sol-Gel method and conventional memory processes. The crystal structure, morphologies and electrical properties of prepared devices were investigated by using various measuring techniques. From the C-V(capacitance-voltage) data at 5V, the memory window voltage of the $Pt/BLT/Y_2O_3/si$ structure decreased from 1.4V to 0.6V with increasing the annealing temperature from $700^{\circ}C\;to\;750^{\circ}C$. The drain current (Ic) as a function of gate voltages $(V_G)$ for the $MFIS(Pt/BLT/Y_2O_3/Si(100))-FET$ devices at gate voltages $(V_G)$ of 3V, 4V and 5V, the memory window voltages increased from 0.3V to 0.8V as $V_G$ increased from 3V to 5V.

• Preventive Nutrition and Food Science
• /
• 제20권2호
• /
• pp.126-132
• /
• 2015

This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.

• 사상체질의학회지
• /
• 제26권2호
• /
• pp.165-179
• /
• 2014

Objectives To evaluate the neuroprotective effects of Hyangsayangwi-tang (HY), a Korean traditional medicinal prescription in a Parkinson's disease mouse model. Methods Four groups(each of 10 mouse per group) were used in this study. The neuroprotective effect of HY was examined in a Parkinson's disease mouse model. C57BL/6 mouse treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP, 30mg/kg/day), intraperitoneal (i.p.) for 5 days. Slow behavioral responses and memory disorder is the major clinical symptoms of PD. In order to investigate the effect of HY on recovery of behavioral deficits and memory, we examined the motor function and memory by using Morris water maze and Forced swimming test. Ischemic mouse brain stained with TTC(2,3,5 triphenyl tetrazolium chloride) in the MPTP-induced Parkinson's disease to find out ischemia and tissue damage in mouse. The convenient, simple, and accurate high-performance liquid chromatography (HPLC) method was established for simultaneous determination of neurotransmitters in MPTP-HY group. To measure the amount of dopamine in mice brain, striatum-substantia nigra, was examined by Bradford assay. Immunohistochemistry was examined in the MPTP-induced Parkinson's disease (PD) mouse to evaluate the neuroprotective effects of Hyangsayangwi-tang on hippocampal lesion, ST and SNpc. Results and Conclusions Hyangsayangwi-tang (HY) prevents MPTP-induced loss of serotonin, hippocampus and TH-ir cell.

• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 1984년도 학술대회지
• /
• pp.215-223
• /
• 1984

인삼이 노령자의 피로 및 쇠약 치료효과에 미치는 영향을 연구하기 위해 런던의 성프란시스병원과 지방의 일반 개업 병인으로부터 50명의 노인들을 모집하였다. 매일 2g의 홍삼 분말을 이중맹검법에 의하여 10일간 투약하였으며. 위약과 홍삼 분말의 투여는 3주간의 간격을 두고 각기 투여하였다. 간호원이 10가지 정신측정 종합테스트와 심리측정 테스트를 하였고, 기분상태 및 일반적인 건강평가를 설문지로 측정하였다 이 측정을 홍삼 및 위약의 투여기간을 전후하여 실시하였다. 즉, 각각의 테스트를 모두 4번 실시하였다. 심리측정 테스트와 정신측정 종합테스트 결과 홍삼의 투여는 위약과는 달리, 미약하나마 일관성있는 증가를 가져왔다. 그러나 기분상태 및 일반적인 건강 평가는 별 변화가 없었다. 결론적으로 인삼은 강장효과를 갖는다 할 수 있다. 노인병 치료를 평가함에 있어 시도방법 및 기간 등에 의하여 약효의 평가가 모호해지는 경우가 종종 있다. 보다 적절한 임상시험법에 대하여 토론하고자 한다.

• 한국엔터테인먼트산업학회논문지
• /
• 제15권7호
• /
• pp.215-223
• /
• 2021

본 연구의 목적은 지역사회에 거주하고 있는 경도인지장애를 보이는 노인을 대상으로 한 컴퓨터 기반의 인지재활프로그램의 적용이 인지기능과 도구적 일상생활수행능력에 미치는 영향을 알아보고는 것이다. MCI 노인 22명을 실험군 11명, 대조군 11명으로 무작위 할당하여 진행하였으며, 총 10주간, 주 3회, 회기당 30분씩 실험군은 CoTras, 대조군은 전통적 인지 재활을 받았다. 중재 전후로 인지기능과 수단적 일상생활활동의 수행 능력애 대한 변화를 알아보기 위해 NCSE와 K-IADL을 사용하였다. 연구 결과, 실험군은 집중력과 기억력을 포함한 전반적인 인지기능과 수단적 일상생활활동의 수행능력의 향상을 보였다. 지역사회 경도인지장애 노인들을 대상으로 인지기능과 수단적 일상생활활동의 수행능력 증진을 위해 CoTras의 적용을 고려해 볼 수 있을 것이다.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1989년도 한국자동제어학술회의논문집; Seoul, Korea; 27-28 Oct. 1989
• /
• pp.653-662
• /
• 1989

Cerebellar Model Arithmetic Controller (CMAC) has been introduced as an adaptive control function generator. CMAC computes control functions referring to a distributed memory table storing functional values rather than by solving equations analytically or numerically. CMAC has a unique mapping structure as a coarse coding and supervisory delta-rule learning property. In this paper, learning aspects and a convergence of the CMAC were investigated. The efficient training algorithms were developed to overcome the limitations caused by the conventional maximum error correction training and to eliminate the accumulated learning error caused by a sequential node training. A nonlinear function generator and a motion generator for a two d.o.f. manipulator were simulated. The efficiency of the various learning algorithms was demonstrated through the cpu time used and the convergence of the rms and maximum errors accumulated during a learning process. A generalization property and a learning effect due to the various gains were simulated. A uniform quantizing method was applied to cope with various ranges of input variables efficiently.