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http://dx.doi.org/10.3746/pnf.2015.20.2.126

Anti-Amnesic Effect of Fermented Ganoderma lucidum Water Extracts by Lactic Acid Bacteria on Scopolamine-Induced Memory Impairment in Rats  

Choi, Yu Jin (Imsil Research Institute of Cheese Science)
Yang, Hee Sun (Imsil Research Institute of Cheese Science)
Jo, Jun Hee (Imsil Research Institute of Cheese Science)
Lee, Sang Cheon (Imsil Research Institute of Cheese Science)
Park, Tae Young (Janghung Research Institute for Mushroom Industry)
Choi, Bong Suk (Janghung Research Institute for Mushroom Industry)
Seo, Kyoung Sun (Janghung Research Institute for Mushroom Industry)
Huh, Chang Ki (Imsil Research Institute of Cheese Science)
Publication Information
Preventive Nutrition and Food Science / v.20, no.2, 2015 , pp. 126-132 More about this Journal
Abstract
This study investigated the anti-amnesic effect of fermented Ganoderma lucidum water extracts (GW) on scopolamine- induced memory impairment in rats. GW were fermented by the lactic acid bacterium Bifidobacterium bifidum (FGWB), followed by Lactobacillus sakei LI033 (FGWBL). To induce amnesia, scopolamine (1 mg/kg) was intraperitoneally injected into rats 30 min before the behavioral tests. Step-through latencies of rats treated with primary fermented extracts (300 mg/kg, FGWB) and secondary fermented extracts (300 mg/kg, FGWBL) were significantly longer than those of rats treated with GW (300 mg/kg) in the retention trial of the multiple trial passive avoidance test. In the Morris water maze task, FGWBL significantly shortened escape latencies in training trials. Furthermore, swimming times within the target zone during the probe trial with FGWBL were significantly higher than the GW and FGWB treatments. In addition, acetylcholinesterase activities were lower in the brains of scopolamine-treated rats treated with FGWBL. These results suggest that FGWBL could be useful to enhance learning memory and cognitive function via cholinergic dysfunction.
Keywords
Ganoderma lucidum; fermentation; scopolamine; passive avoidance test; Morris water maze test;
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