• Journal of Korean Library and Information Science Society
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• v.50 no.3
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• pp.191-216
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• 2019

This study is to suggest the revitalization plan of the medical school libraries in the future, on the basis of analysis for the overall operation situation of the medical school libraries among the medical libraries. So based on the website, it is divided into 1) whether independent homepage exists, 2) service target, 3) books, 4) classification system, 5) manpower, 6) facilities (area, number of seats available), 7) equipment (pc, printer, copy machine, etc.), 8) services, and then analyzed. Consequently, as the ways to revitalize the medical libraries, firstly, it is necessary to establish legal standards and develop guidelines for the medical school library's books, sizes, librarians, etc. Secondly, establishing a cooperative community network between medical school libraries is necessary. Thirdly, policies such as support at the national level, specialization education of librarians, development of operational guidelines, and activation of inter-library networks are needed to revitalize the medical school libraries. It is also expected that research on the actual situation of the medical libraries should be conducted at the national level or at the level of the association of medical libraries.

• KLA journal
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• v.32 no.6 s.271
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• pp.30-35
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• 1991

• KLA journal
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• v.32 no.6 s.271
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• pp.36-41
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• 1991

• Molecules and Cells
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• v.27 no.3
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• pp.313-319
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• 2009

The dual-vector system-II (DVS-II), which allows efficient display of Fab antibodies on phage, has been reported previously, but its practical applicability in a phage-displayed antibody library has not been verified. To resolve this issue, we created two small combinatorial human Fab antibody libraries using the DVS-II, and isolation of target-specific antibodies was attempted. Biopanning of one antibody library, termed DVFAB-1L library, which has a $1.3{\times}10^7$ combinatorial antibody complexity, against fluorescein-BSA resulted in successful isolation of human Fab clones specific for the antigen despite the presence of only a single light chain in the library. By using the unique feature of the DVS-II, an antibody library of a larger size, named DVFAB-131L, which has a $1.5{\times}10^9$ combinatorial antibody complexity, was also generated in a rapid manner by combining $1.3{\times}10^7$ heavy chains and 131 light chains and more diverse anti-fluorescein-BSA Fab antibody clones were successfully obtained. Our results demonstrate that the DVS-II can be applied readily in creating phage-displayed antibody libraries with much less effort, and target-specific antibody clones can be isolated reliably via light chain promiscuity of antibody molecules.

• 대한예방의학회:학술대회논문집
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• 1996.10a
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• pp.369-370
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• 1996

• Journal of the Korean Society for Library and Information Science
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• v.27
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• pp.183-214
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• 1994

The purpose of this study is to suggest the schemes to enhance information service functions by the utilization of CD-ROM in medical school libraries. The results of the study are summarized as follows : 1. The selection and evaluation of CD-ROM database are necessary steps in the planning of a CD-ROM. Before the CD-ROM is selected, therefore, medical libraries must make a practical evaluation criteria in important order of information services environment, characteristics of hardware/software, service requirements, price and cost, etc. 2. If possible, CD-ROM MEDLINE must be suited for the information services environment. 3. In case of the popular core journals, full-text CD-ROM should be gradually purchased. 4. In order to reduce the time required from search of bibliographic informations to receipt of original articles, CD-NET system and library holding administration program must be built up and developed. And channel of information search and order/receipt of original article should be varied. 5. Search education program for medical librarians and users should be enforced, and librarians must play an important role in CD-ROM retrieval consultant and intermediator.

• Journal of Information Science Theory and Practice
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• v.9 no.4
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• pp.63-74
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• 2021

Virtual Reality (VR) is one of the core components of the fourth industrial revolution as a technology that makes the virtual world feel as if it is real. VR is being used in various fields such as entertainment, advertisement, education, medical care, training, sports, and tourism, as well as providing contents for such things as games and videos. Libraries are already looking for ways to utilize VR from various angles, such as operating experiential programs. The purpose of this thesis is to develop and propose a VR-based library user education program. In order to achieve the purpose of the study, we analyzed previous studies from a theoretical perspective to find a way to construct a user education program, and also to derive possible implications based on examples of countries such as the United States and Korea that are already introducing and applying VR technology to library services. Therefore, the user education program proposed in this study can be used as a basic building block when many libraries want to develop VR-based programs in the future.

• Journal of Microbiology and Biotechnology
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• v.17 no.6
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• pp.993-1001
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• 2007

The technique of serological analysis of antigens by recombinant cDNA expression library (SEREX) uses autologous patient sera as a screening probe to isolate tumor-associated antigens for various tumor types. Isolation of tumor-associated antigens that are specifically reactive with patient sera, but not with normal sera, is important to avoid false-positive and autoimmunogenic antigens for the cancer immunotherapy. Here, we describe a selection methodology to isolate patient sera-specific antigens from a yeast surface-expressed cDNA library constructed from 15 patient lung tissues with non-small cell lung cancer (NSCLC). Several rounds of positive selection using patient sera alone as a screening probe isolated clones exhibiting comparable reactivity with both patient and normal sera. However, the combination of negative selection with allogeneic normal sera to remove antigens reactive with normal sera and subsequent positive selection with patient sera efficiently enriched patient sera-specific antigens. Using the selection methodology described here, we isolated 3 known and 5 unknown proteins, which have not been isolated previously, but and potentially associated with NSCLC.

• Korean Journal of Health Education and Promotion
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• v.30 no.4
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• pp.41-56
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• 2013

Objectives: This article reviewed researches on intersectoral partnership of school health programs to suggest importance, current status and development plan of those. Methods: Domestic research papers were screened though Research Information Sharing Service (RISS), Koreanstudies Information Service System (KISS), Medical Library Information System (MEDLIS), Korean Medical Database (KMbase), and digital national assembly library. International papers were searched mainly via Pubmed. Results: Since intersectoral partnership is effective, comprehensive and universal approach for school health programs, many collaborative programs are universally progressing in various domain including smoking, alcohol, mental health and sexual behavior. On the other hand, intersectoral partnership of school health programs in Korea is still in the beginning stage, and there are few intersectoral partnerships. Moreover, there are several limitations including top-down approach, passive participation and lack of studies on the effect of intersectoral partnership. However, intersectoral partnerships in school health program including tuberculosis control system in school or WEE project are in progress, so it is worth looking forward in the future. Conclusions: To achieve successful intersectoral partnership in school health programs, appropriate partnership guideline for Korean society, policy support, active participation and improvement of consciousness in community stakeholders are needed.

• BMB Reports
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• v.44 no.8
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• pp.517-522
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• 2011

Mitochondrial dynamics not only involves mitochondrial morphology but also mitochondrial biogenesis, mitochondrial distribution, and cell death. To identify specific regulators to mitochondria dynamics, we screened a chemical library and identified niclosamide as a potent inducer of mitochondria fission. Niclosamide promoted mitochondrial fragmentation but this was blocked by down-regulation of Drp1. Niclosamide treatment resulted in the disruption of mitochondria membrane potential and reduction of ATP levels. Moreover, niclosamide led to apoptotic cell death by caspase-3 activation. Interestingly, niclosamide also increased autophagic activity. Inhibition of autophagy suppressed niclosamide-induced cell death. Therefore, our findings suggest that niclosamide induces mitochondria fragmentation and may contribute to apoptotic and autophagic cell death.