• 한국미생물·생명공학회지
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• 제50권1호
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• pp.89-94
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• 2022

Triclosan (TCS) is an antimicrobial agent used in various human personal care products against both gram-positive and gram-negative bacteria. The purpose of this study was to evaluate the presence of TCS-resistant bacteria in sewage water in Peshawar, Khyber Pakhtunkhwa (KPK), Pakistan, for the first time. TCS-supplemented Luria Bertani (LB) agar was used to isolate TCS-tolerant bacteria. A total of 17 TCS-resistant isolates were randomly selected from a large pool of bacteria that showed growth on TCS-supplemented LB agar. Based on gram staining and physiochemical characteristics, the isolated strains were identified as Salmonella typhi (n = 6), Escherichia coli (n = 4), Citrobacter freundii (n = 4), Proteus mirabilis (n = 1), Enterobacter cloacae (n = 1), and Pseudomonas aeruginosa (n = 1). The Triclosan mean minimum inhibitory concentrations (MICs) for the isolates of Salmonella typhi, Escherichia coli, Citrobacter freundii, Proteus mirabilis, Enterobacter cloacae, and Pseudomonas aeruginosa were 23.66 ㎍ ml^-1, 18.75 ㎍ ml^-1, 42 ㎍ ml^-1, 32 ㎍ ml^-1, 64 ㎍ ml^-1, and 128 ㎍ ml^-1, respectively. The antibiogram revealed that all isolates were resistant to penicillin G (100%) and linezolid (100%), followed by ampicillin (94%), tetracycline (76%), tazobactam (76%), sulbactam/cefoperazone (64%), polymyxin PB (58%), amikacin (29.41%), aztreonam (29.41%), imipenem (5%), and gentamicin (5%). This is the first known study regarding the isolation of TCS-tolerant bacteria from sewage water in Peshawar, KPK, Pakistan. It was concluded that all the TCS-resistant isolates were multidrug resistant (MDR) gram-negative rod-shaped bacteria, mostly belonging to the Enterobacteriaceae family.

• 대한임상독성학회지
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• 제19권2호
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• pp.127-132
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• 2021

Purpose: It is known that the most common cause of gas poisoning in Korea is suicide attempts by burning ignition coals. Ignition coals are made from waste wood, and studies have been reported that heavy metals are emitted when this coal is burned. However, there was no study on how much heavy metal poisoning occurs in the human body through this, so this study was planned to find out whether the concentration of heavy metals in the blood increased in patients exposed to ignition coal combustion. Methods: From April 2020 to April 2021, blood lead, mercury, and cadmium concentrations were investigated in carbon monoxide poisoning patients who visited one regional emergency medical center in Seoul, and their association with exposure time, source of poisoning, and rhabdomyolysis were investigated. Results: During the study period, a total of 136 carbon monoxide poisoning patients were tested for heavy metals, and 81 cases of poisoning by ignition coal were reported. When comparing poisoning caused by combustion of ignition coal and other substances, there was no difference in the concentrations of lead, mercury, and cadmium in the blood, and there was no difference in the number of patients above the reference range. However, the patients exposed to more than 5 hours of ignition coal gas exposure are more frequent than those in the group less than 5 hours in lead (51.4% vs. 23.9%, p=0.012). Conclusion: Compared to poisoning with other combustible substances, the blood concentration of lead, mercury, and cadmium does not increase further in patients with gas poisoning by ignition coal. However, prolonged exposure may result in elevated levels of lead.

• Journal of Ginseng Research
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• 제47권3호
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• pp.366-375
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• 2023

Background: Ginseng contains three active components: ginsenosides, gintonin, and polysaccharides. After the separation of 1 of the 3 ingredient fractions, other fractions are usually discarded as waste. In this study, we developed a simple and effective method, called the ginpolin protocol, to separate gintonin-enriched fraction (GEF), ginseng polysaccharide fraction (GPF), and crude ginseng saponin fraction (cGSF). Methods: Dried ginseng (1 kg) was extracted using 70% ethanol (EtOH). The extract was water fractionated to obtain a water-insoluble precipitate (GEF). The upper layer after GEF separation was precipitated with 80% EtOH for GPF preparation, and the remaining upper layer was vacuum dried to obtain cGSF. Results: The yields of GEF, GPF, and cGSF were 14.8, 54.2, and 185.3 g, respectively, from 333 g EtOH extract. We quantified the active ingredients of 3 fractions: L-arginine, galacturonic acid, ginsenosides, glucuronic acid, lysophosphatidic acid (LPA), phosphatidic acid (PA), and polyphenols. The order of the LPA, PA, and polyphenol content was GEF > cGSF > GPF. The order of L-arginine and galacturonic acid was GPF >> GEF = cGSF. Interestingly, GEF contained a high amount of ginsenoside Rb1, whereas cGSF contained more ginsenoside Rg1. GEF and cGSF, but not GPF, induced intracellular [Ca²⁺]_i transient with antiplatelet activity. The order of antioxidant activity was GPF > GEF = cGSF. Immunological activities (related to nitric oxide production, phagocytosis, and IL-6 and TNF-α release) were, in order, GPF > GEF = cGSF. The neuroprotective ability (against reactive oxygen species) order was GEF > cGSP > GPF. Conclusion: We developed a novel ginpolin protocol to isolate 3 fractions in batches and determined that each fraction has distinct biological effects.

• 대한영상의학회지
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• 제83권3호
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• pp.538-558
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• 2022

혈관주위공간(perivascular space; 이하 PVS)는 뇌 실질을 관통하는 세동맥 둘러싸고 있는 공간으로, 최근에는 별아교세포의 종족(astrocyte endfoot)에 의해 가장 바깥쪽이 경계지워지는, 체액, 세포, 결합조직으로 구성된 혈관벽내, 혈관벽 주위의 구획을 모두 아우르는 개념으로 이해하고 있다. 정상적으로는 현미경적 해부학 구조물이지만 이 구조물이 늘어나게 되면 MRI T1 혹은 T2 이미지에서 확인할 수 있게 된다. PVS의 명확한 실체나 임상적인 의의에 대해서는 아직 분명치 않은 부분이 많이 있지만 PVS의 확장(enlarged PVS; 이하 EPVS)은 다양한 퇴행성 뇌질환 뿐만 아니라 뇌출혈 및 외상성 뇌손상, 당뇨성 신질환 같은 다양한 질병과의 연관성이 있다는 연구 결과들이 발표되고 있다. 이번 종설에서는 PVS와 EPVS가 가지는 임상적 의의와 병태 생리에 대한 최근 문헌을 고찰하고, MRI를 이용한 정성적 평가 및 최적화에 대해 논의해 보고자 한다.

• 방사선산업학회지
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• 제17권1호
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• pp.61-67
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• 2023

A Study on the Introduction of Dose Constraints for Occupational Exposures: Focusing on Experts' Opinions by Field of Radiation Industry. The International Commission on Radiological Protection suggests Justification, Optimization, and Dose Limits as the three principles of radiological protection, among which, as a means of protection optimization, ICRP 103 recommends to set dose constraints. In this study, opinions are collected from experts in each category of radiation industries for stakeholder participation to qualify dose constraints. A guidance and questionnaire for analyzing the dose constraints have been developed for their collection, and opinions were collected from radiation protection experts in selected categories. 20 out of 22 experts, consisted with 91%, have assessed the dose constraints setting is necessary, and 2 experts, consisted with 9%, assessed it is unnecessary. The average of dose constraint presented by experts for RI production institutions is to be the highest level of 15.3 mSv, and light-water reactors (14.6 mSv), non-destructive inspection (14.4 mSv), heavy-water reactor and medical institutes (13.9mSv) is to be above the overall average dose constraint. In case of public institutions, the average dose constraint is to be 8.6mSv, and research institutions (8.8mSv), educational institutions (9.6 mSv), waste disposal sites (9.7 mSv), and general industries (10.6 mSv) are resulted to below the overall average dose constraint. As for the means of setting dose constraints, 8 experts out of 22 suggested setting dose constraints for each specific industry or task. And, 5 experts especially suggest setting dose constraints for the specific groups with relatively high exposure, such as workers with above the record levels. As a countermeasure for workers who exceed the dose constraints, 15 experts out of 22 expressed that the cause analyses for them and preparation for a plan of reducing them are necessary.

• 대한간호학회지
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• 제1권1호
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• pp.85-94
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• 1970

This is a study of 21 tuberculosis patients receiving medical treatment at the Public Health Center in Kyongi Do, Pu Chun Gun and at the General Hospital. The results cover the findings of the period from May, 1969 to November 1970. The information obtained is based on personal interviews with the patients, and symptomatic diagnosis made from observations. The following statistics when not equalling 100% contain only the responses of the two extremes in each case. The findings of the research are as follows: 1. 52.3% of the patients in the study are males and 47.7% are females. 28.6% of the subjects are between 20 and 29 years of age and an equal percent are between 30 and 39 years. 2. 47.5% of the subjects had graduated from primary school, while only 4.8% had graduated from high school. 3. 57.1% of the patients said they had no religions beliefs, while 4.8% professed to being Buddhists or believing in superstition. 4. 47.3% of the people said they were unemployed, while 4.8% classified themselves as labourers. 5. In response to how tuberculosis was first detected in their respective cases, 52.6% became aware of their disease through X-ray results, while 4.8% were discovered to have tuberculosis when being treated for other diseases at the hospital. 6. When asked how many of the patients knew anything about their disease when treated, 57.1% knew nothing about tuberculosis when they received treatment, while 42.9% had some knowledge of the disease. 7. Of those who knew something about tuberculosis, 61.9% learned about from doctors and nurses, while 4.8% learned from other people. 8. 57.1% of the patients knew that tuberculosis is a communicable disease, while 42.9% did not know. 9. 52.4% of the patients did not know the cause of tuberculosis while 4.9% believed the disease was caused by a curse. 10. When asked about the extent of treatment, 52.4% responded that they had undergone continuous treatment, while 4.8% had not received treatment. 11.The reasons given for not continuing treatment were the following: economic factors 55.6%; side reactions to the treatment, lack of knowledge of how to get treatment, of the need for treatment, or of the positive effects of treatment 11.1%. 12. 61.9% of the subjects usually took the medical treatment at home, 9.5% took it in the mountains or at the beach. 13. 42.9% of the patients received drugs for treatment at the local public health center, while 4.8% received them at the hospital 14. 33.3% of the patients received P.A.S＋I.N.H.＋S.M. for treatment of tuberculosis, while 4.8% received P.A.S.＋S.M.. and some secondary drug. 15. Of the patients who took some extra medicine for tuberculosis, 38.1% took a Chinese drug, while 9.5% took herb medicine. 16. 38.1% of the patients had continued treatment for three years, 4.8% had interrupted the treatment. 17. When asked about the development of the disease after treatment, the patients gave the following information: after one month, 90.5% thought the treatment helped, while 9.5% weren't sure; after one year, 55.6% thought it was good, while 5.5% thought it was not; after three years, 63.6% had a very bad condition. while 4.8% didn't know. 18. 61.9% of the patients were unconcerned about covering their mouths when they coughed, while 38.1% covered their mouths. 19. 57.2% were unconcerned they spit, while 23.8% spit into a waste basket. 20. 66.7% were unconcerned about sterilizing tableware, while 9.5% handled it separately. 21. 66.7% were unconcerned about ventilating their room, while 9.5% ventilated the room twice a week.

• 간호행정학회지
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• 제3권1호
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• pp.93-106
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• 1997

By the increase of the rate of existence of the hemodialyzing patients, they were required the long run treatment. Regardless of medical insurance expansion, hemodialyzing cost much expenses so that hospital has been considering the reuse of hemodialyzer and flowing euqipments along with the diverse study and progress of the ways of hemodialyzing and medical instruments. This study was aimed to provide the basic materials regarding the reuse of hemodialyzer which is used for the patients of chronic renal disease. The reusing program in the artificial kidney center of K hospital has been used for this study from 50 patients aften one year result from Sep. 1995 through Aug. 1996. Automatic equipment of DRS-4 made by Seratronic Co., was used as the equipment and it was retreated with the function test simultaneously. Compliaction and confirmation of the infection were by the records of the hemodialysis of the patients. SPSS was used for the analysis of the materials by computerization. The character of the patients and the rate of removal was by mistake and percentage, function test and rate of complication by Ftest(ANOVA) and the rate of complication per items by ${\chi}^2$ and Ftest. As the post test the Duncan's test was used for the statistically significant different variables in the standard of p<.05 after Ftest. The followings are the summary of the result : 1) In the function test of the new hemodialyzer and the reused one, and in all of CA110 and CF15.11, the dialyzer ultrafiltration coeffient(KUf) was appeared to have been higher in the reusing groups than the first use ones. This has been the normal limit showing no troubles with them. 2) In the function test of the new and reused hemodialyzer, in all of CA110 and CF15.11, the total blood volume was appeared to have been the less value in the reuse groups than the new ones. This was the price within 80% of the first price that both showed possible for use. 3) The result of reuse hemodialyzer of CA110 was $29.48{\pm}7.83$ in average in the test of leak test while $17.3{\pm}7.96$ in reuse of CF15.11. The normal limit of <60 was the leak test result. So both of the hemodialyzer was normal for reuse. 4) The rate of removal of Blood Urea Nitrogen(BUN) was 72.25% in CA110 hemodialyzer by reusing 16-20 times as the highest rate showing the better result in the reuse hemodialyzer, while in CF15.11 hemodialyzer showed 71.16% by highest rate in the first use by the highest rate with no difference from the reuse. 5) The rate of removal of serum creatinine of CA110 was 64.08% by highest rate in reuse of 1-5 times by showing better result in reuse hemodialyzer. While in CF15.11 66.47% the highest by reuse of 16-20 times showing no difference from each other. 6) No patients were admitted or precribed by antibiotics in relation with reuse dialyzer and no reports were shown about hepatitis $B{\cdot}C$. AIDS in fection. 7) Of the total 248 episods of complication due to the hemodialyzing, 86 by first use, 73 by 1-5 times, 35 by 6-10 times, 35 by 11-15 times and 19 by 16-20 times have been shown which have had no significant difference between the groups. 8) In the comparison of the expense for the hemodialyzer, there was the effect of saving 11,597.6 Won between the first and reuse hemodialyzer. And by decreasing the extracted materials, they did the great role of disposing the waste matters.

• The Journal of Korean Physical Therapy
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• 제3권1호
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• pp.109-121
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• 1991

농촌지역 성인의 요통 유병율과 요통 치료형태를 조사하기 위하여 1991년 4월 1일부터 20일 까지 경상북도 안동군 서후면에 거주하고 있는 만 20세에서 59세 사이 남${\cdot}$여 주민 총 2,024명을 대상으로 가정방문하여 면담이 완료된 1,106명을 대상으로 분석하였다. 면담된 1,l06명 중 530명이 요통을 경험하여 기간 유병율이 $47.9\%$였는데 연령교정한 남자의 유병율은 $43.7\%$, 여자는 $52.3\%$로 남여간에 통계적으로 유의한 차이를 보였다(p<0.005). 요통환자들의 요통 경과양상은 재발성이 남여 각각 $57.0\%,\;55.2\%$로 가장 높았고, 만성이 $28.9\%,\;35.8\%$, 급성미 $14.1\%,\;9.0\%$였다. 요통원인은 '원인은 잘 모르겠으나 나이가 들면서' $48.1\%$, '일을많이 해서' $15.1\%$, '외부의 물리적 충격'이 $11.3\%$ 등이었다. 요통환자 가운데 요통으로 일상생활을 제대로 못하거나 누워서 생활하는 사람이 $2.5\%$, 1시간 이상서 있거나 걸을 수 없는 사람이 $12.5\%$나 되었다. 요통환자의 $56.6\%$는 요통진단을 받기 위해 의료기관을 이용한 적이 없었고 $31.3\%$ 는 병${\cdot}$의원을 이용하였다. 아무 진단을 받지 않은 이유는 '별로 심하지 않고 견딜만 해서'가 $75.7\%$였다. 요통 치료양상은 첫번째 치료로 약물치료와 물리치료를 받은 경우가 남여 각각 $34.1\%,\;36.3\%$였고, 두 번째 치료로는 한약을 제일 많이 이용했고, 세번째 치료로는 침술을 제일 많이 이용했다. 요통환자들의 $15.5\%$가 민속요법을 사용한 경험이 있는데 그 내용을 '익모초를 삶아서 즙을 마셨다'. '닭 삶은, 국물에 소주를 섞어 마셨다'는 등 35가지로 다양하였다. 본 연구결과로 요통이 농촌주민들에게 중요한 보건문제임을 알 수 있었고, 요통이 발생하여도 병${\cdot}$의원을 이용한 사람은 3분의 1밖에 되지 않았고, 비과학적인 치료법을 많이 사용하고 있음을 알 수 있었다. 따라서 합리적인 요통치료법에 관한 보건교육 실시와 비과학적인 민속요법의 모용과 남용으로 인한 부작용과 의료비의 낭비를 막기 위한 홍보활동이 요구된다.

• 대한간호학회지
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• 제4권3호
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• pp.63-79
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• 1974

1. The purpose of this study. The purpose of this study is to plan and investigate short-term nursing education of two-years associate degree program to produce middle-level professional nurses which are needed by-society and nation. Current nursing education in Korea is divided into four years degree program, three years diploma program Even (though) there are differences in the aims of their education, the curriculums are not much different between the education for producing leaders which is its basic purpose and training middle-level professional nurses. Therefore the purpose of associate degree program lies in minimizing the waste of time and finance which are invested for long-term education for middle-level professional nurses. And also this coincide with the policy of national technical training and definite supply of nurse manpower according to health policy for effective role and ability of nurse. 2. The method of study. This is based on the study of literature, research on the actual condition and investigation of opinion- through questionnaire. L) The study of literature: Domestic and foreign literatures for two years associate degree program were studied and investigated. 2) Research on the actual condition : Current three years nursing education program was collected and analysed. 3) Investigation of opinion. The problem of curried nursing education system and the possibility of two years associate degree program were investigated through questionnaire. 3. The result of the study. 1) The trend of recent nursing education. a. The aims of nursing in past chiefly taking care of physical disease of patient has recently changed to nursing of character including physical, mental, socio-economic, educational and psychological condition. b. For the performing systematic and effective nurse's duty according to her role, the-change of educational system which is classified as a range of education the period of education and certificate after graduation has been enforced or fulfilled. c. Nursing education also has a trend to become a collage or two years associate degree program which can get same legal protection as other educational institutions whose basic purpose is education. Attached nursing school to hospital is getting disappeared because of disadvantage of educational system. 2) Problems. Depending upon research on actual condition of current 3 years nursing education program. a. There are too many subjects. b. Contents of education could be doubled because major subjects are subdivided in detail. c. The credits for graduation are too heavy comparing to the period of study or the ability of students. (The necessary credits are 150.8 for three years according to actual investigation 4. There is no certain standard in organizing curriculum therefore there are too much differences between schools. 4. Basic Plan. The plan for two years associate degree program in nursing education depending on demand of professional nursing field of society is based on following items. 1) Training middle-level professional nurse lay emphasis on liberal arts and basic major field. 2) Liberal arts are divided into required and optional subjects and students could take courses by choice. 3) Major subjects are compound together by fields and they become the sciences of nursing Ⅰ,Ⅱ,Ⅲ,Ⅳ and every items has its educational purposes and contents major study includes laboratory practice and clinical experience. 4) The required credits for graduation are to which means 17-18 credits a semester. The above has been planned to solve the problems of current three years nursing education program. In conclusion for the achievement of this system, following items are needed. 1) It is necessary to change educational administration and system such as amendment of educational law or order of educational application of law. 2) Qualified professors should be available to understand and develope the idea or purpose of this educational system. 3) Local medical institutions should be opened widely and educational for clinical training. 4) The job after graduation should he secured positively.

• 지능정보연구
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• 제26권1호
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• pp.23-45
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• 2020

기업의 경쟁력 확보를 위해 판별 알고리즘을 활용한 의사결정 역량제고가 필요하다. 하지만 대부분 특정 문제영역에는 적합한 판별 알고리즘이 어떤 것인지에 대한 지식은 많지 않아 대부분 시행착오 형식으로 최적 알고리즘을 탐색한다. 즉, 데이터셋의 특성에 따라 어떠한 분류알고리즘을 채택하는 것이 적합한지를 판단하는 것은 전문성과 노력이 소요되는 과업이었다. 이는 메타특징(Meta-Feature)으로 불리는 데이터셋의 특성과 판별 알고리즘 성능과의 연관성에 대한 연구가 아직 충분히 이루어지지 않았기 때문이며, 더구나 다중 클래스(Multi-Class)의 특성을 반영하는 메타특징에 대한 연구 또한 거의 이루어진 바 없다. 이에 본 연구의 목적은 다중 클래스 데이터셋의 메타특징이 판별 알고리즘의 성능에 유의한 영향을 미치는지에 대한 실증 분석을 하는 것이다. 이를 위해 본 연구에서는 다중 클래스 데이터셋의 메타특징을 데이터셋의 구조와 데이터셋의 복잡도라는 두 요인으로 분류하고, 그 안에서 총 7가지 대표 메타특징을 선택하였다. 또한, 본 연구에서는 기존 연구에서 사용하던 IR(Imbalanced Ratio) 대신 시장집중도 측정 지표인 허핀달-허쉬만 지수(Herfindahl-Hirschman Index, HHI)를 메타특징에 포함하였으며, 역ReLU 실루엣 점수(Reverse ReLU Silhouette Score)도 새롭게 제안하였다. UCI Machine Learning Repository에서 제공하는 복수의 벤치마크 데이터셋으로 다양한 변환 데이터셋을 생성한 후에 대표적인 여러 판별 알고리즘에 적용하여 성능 비교 및 가설 검증을 수행하였다. 그 결과 대부분의 메타특징과 판별 성능 사이의 유의한 관련성이 확인되었으며, 일부 예외적인 부분에 대한 고찰을 하였다. 본 연구의 실험 결과는 향후 메타특징에 따른 분류알고리즘 추천 시스템에 활용할 것이다.