• The Korean Journal of Pharmacology
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• v.29 no.2
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• pp.253-261
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• 1993

Possible changes in the role of insulin-sensitive cyclic nucleotide phosphodiesterase(PDE) in mediating the antilipolytic action of insulin were investigated in adipocytes from streptozotocin-induced diabetic rats. Isolated adipocytes prepared from epididymal adipose tissue were incubated, with or without insulin, at $37^{\circ}C$ for 15 min following pretreatment with various drugs or toxins, and three (plasma membranes, microsomal membranes, and cytosol) fractions prepared by differential centrifugation were then assayed for cAMP phosphodiesterase activity. The PDE activities only in the crude microsomal (P2) fractions were activated by insulin both in diabetic and control rats. The basal PDE activities in P2 fractions of adipocytes from diabetic rats were higher than those from control rats, although the maximal effects observed at 2 nM of insulin, $100\;{\mu}M$ of isoproterenol or the combination of both were not significantly different from each other. The insulin-stimulated PDE activities in P2 fractions of adipocytes from diabetic rats were not changed by PIA, a $A_{1}$ adenosine receptor agonist, whereas they were decreased to the basal PDE activities in those from control rats. In addition, the adipocytes from diabetic rats showed an increased sensitivity to pertussis toxin compared to those from controls. There were no differences between diabetic and control rats in the sensitivity of adipocytes to cholera toxin. These data indicate that the impaired signalling through inhibitory receptors such as adenosine receptors in adipocytes from streptozotocin-induced diabetes relates to the loss or the decreased function of $G_i$ proteins, and leads to the increased activity of the insulin-dependent PDE at the basal states.

• Korean Journal of Construction Engineering and Management
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• v.19 no.6
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• pp.103-114
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• 2018

Public-Private-Partnership(PPP) is becoming a popular form of projects in construction industry worldwide. Normally, the management team of PPP project consists of various experts from different disciplines such as construction engineer, bank financier, contract manager, investors, etc. The diversity of team members causes difficulties in managing the team efficiently and furthermore for the smooth execution of the project itself. One of the solutions to this issue might be the application of citizenship behavior by the team members. This study conducts an empirical investigation of the effect of project citizenship behavior on the project performance. We have collected data by using a questionnaire from those with PPP project experiences in the domestic construction industry. The results show that project citizenship behavior has full mediating effects between PM's leadership and the project performance. This study has an academic significance in that it is the first attempt to apply the concept and to show the effect of citizenship behavior in project management discipline, particularly in construction industry, in Korea. We also expect that the project management teams for PPP projects would benefit from the findings of this study.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.170-185
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• 2016

The purpose of this study was to investigate the relationship among instructor's non-verbal communication, emotional reaction, and self-efficacy. By using convenience sampling method of non-provability sampling, 258 student athletes from S and D cities were selected for a questionnaire survey. The 184 returned surveys were analyzed with structural equation modeling through SPSS 22.0 and AMOS 22.0 statics program. The study results are summarized as follows. First, instructor's non-verbal communication has a positive influence on emotional reaction of high school student athletes. Second, high school student athletes experiencing emotional reactions by instructor have a positive influence on self-efficacy. Third, instructor's non-verbal communication does not influence self-efficacy of high school student athletes directly. Fourth, emotional reactions of high school student athletes experienced by instructor's non-verbal communication have a mediating effect on self-efficacy. Fifth, neither gender nor exercise period has a moderating effect on the relationship between non-verbal communication, emotional reactions, and self-efficacy.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.12
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• pp.582-593
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• 2016

The purpose of this study is to (evaluate) the effectiveness of neurofeedback training (NFT) and systematically search for the related factors by conducting a meta-analysis of theses and journal articles published in (the Korean language/Korea). This study analyzed 21 articles selected through a database search from 2001 to 2015. The quality evaluation result of the research, as research method characteristic, was low. It was found that, first, the effect size of the neurofeedback program training was .683 above the (median). Second, the effect size as the (moderator) variable played a statistically significant role in moderating the effect of the the subject characteristics, including the presence or not of disabilities and school level (elementary, junior high school, high school), on the effectiveness of the neurofeedback training program. Third, (the effect size) played a statistically significant role in mediating the effect of the research method (training method), number of sessions per week, total number of sessions and training time on the effectiveness of the neurofeedback training program. This study provides (comprehensive) data on the effect of the interventions and selection of the neuro-feedback training program subjects.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.5
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• pp.226-236
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• 2017

This study was conducted to investigate the relationship between contingencies of self-worth(superiority and others' approval), college adjustment and expectancy for future success and the mediating role of cognitive flexibility in these relationships. For this study, data from 460 college students were analyzed. The results were as follows. Contingencies of self-worth(superiority) were positively associated with college adjustment and expectancy for future success, while contingencies of self-worth(others' approval) were negatively associated with college adjustment and expectancy for future success. Second, the results of structural equation modeling indicated that cognitive flexibility fully mediated the relationship of contingencies of self-worth (superiority and others' approval) with college adjustment and expectancy for future success. Third, even the contingencies of self-worth(other's approval) were negatively associated with cognitive flexibility, and if the latter was high, it influenced college adjustment and expectancy for future success. Finally, the meanings and limitations of this research and implicationsfor counseling strategies and interventions were discussed in detail.

• Journal of Global Scholars of Marketing Science
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• v.16 no.3
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• pp.61-86
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• 2006

The main purpose of this study is to conceptualize and investigate the relationships between the antecedents and outcomes of customer satisfaction and the linking variables of brand preference and repurchase intention in service industries. To achieve this objective, the study tries to validate the structural equation model and causal relationships among the model's elements involving antecedents to customer satisfaction(perceived quality, value, equity), consequences(brand preference, repurchase intention), and moderating variable/switching cost, customer loyalty). Empirical findings are as follows: First, the effect of two antecedents/perceived quality and value) on customer. satisfaction was accepted but perceived equity was rejected. Second, I found out that there were direct or indirect relationships between the mediating variables/switching cost, customer loyalty, brand preference) and repurchase intention. This means that the proper management concerned with indirect path is probably more important for the success of services industries. Third, the direct effects of customer satisfaction and switching cost on repurchase intention were not significant against the existing studies excepting brand preference. This implies that repurchase intention was mainly intensified by the indirect path, 'customer loyalty${\rightarrow}$brand preference${\rightarrow}$repurchase intention' and 'switching cost${\rightarrow}$brand preference${\rightarrow}$repurchase intention.' The service marketers make efforts not only to strengthen the direct casual linkage but also to consolidate the indirect connections leading to create repurchase intention. Finally, the proper management of these structural relationships will help clarify the role of service marketer resulting in increasing sustainable competitive advantage in service industries.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.18
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• pp.8503-8512
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• 2016

The purpose of this study was to provide a detailed explanation of the mechanism of bisanthracycline, WP 631 in comparison to doxorubicin (DOX), a first generation anthracycline, currently the most widely used pharmaceutical in clinical oncology. Experiments were performed in SKOV-3 ovarian cancer cells which are otherwise resistant to standard drugs such as cis-platinum and adriamycin. As attention was focused on the ability of WP 631 to induce apoptosis, this was examined using a double staining method with Annexin V and propidium iodide probes, with measurement of the level of intracellular calcium ions and cytosolic cytochrome c. The western blotting technique was performed to confirm PARP cleavage. We also investigated the involvement of caspase activation and DNA degradation (comet assay and immunocytochemical detection of phosphorylated H2AX histones) in the development of apoptotic events. WP 631 demonstrated significantly higher effectiveness as a pro-apoptotic drug than DOX. This was evident in the higher levels of markers of apoptosis, such as the externalization of phosphatidylserine and the elevated level of cytochrome c. An extension of incubation time led to an increase in intracellular calcium levels after treatment with DOX. Lower changes in the calcium content were associated with the influence of WP 631. DOX led to the activation of all tested caspases, 8, 9 and 3, whereas WP 631 only induced an increase in caspase 8 activity after 24h of treatment and consequently led to the cleavage of PARP. The lack of active caspase 3 had no outcome on the single and double-stranded DNA breaks. The obtained results show that WP 631 was considerably more genotoxic towards the investigated cell line than DOX. This effect was especially visible after longer times of incubation. The above detailed studies indicate that WP 631 generates early apoptosis and cell death independent of caspase-3, detected at relatively late time points. The observed differences in the mechanisms of the action of WP631 and DOX suggest that this bisanthracycline can be an effective alternative in ovarian cancer treatment.

• Korean Journal of Childcare and Education
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• v.11 no.6
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• pp.199-219
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• 2015

The purpose of this study was to identify the relationship among beginning early childhood teachers' role performance and self leadership, and childcare teachers's supports. The subjects in this study were 491 beginning early childhood teachers working in kindergartens and child care centers across the country. Childcare teachers' support questionnaire(Jae-Young Lee, 2012) role performance questionnaire(Bog-Mae Park, 2011), and self-leadership questionnaire(Dong-Hyen Park,2014) were used for this study. For the research analysis, frequency, Cronbach's ${\alpha}$ coefficient, ANOVA test, $Scheff{\acute{e}}$ post-hoc analysis and Pearson's correlation were calculated and regression analysis were conducted. The results are as follows. Firstly, it was revealed that there are statistically meaningful differences in beginning early childhood teachers 'role performance and self leadership, and childcare teachers's support which were related to early childhood teachers' salary, education background, and age. Also, there are statistically meaningful differences in beginning early childhood teachers' role performance and childcare teachers's support, which were related to type of child-care center role performance, but there were no differences in beginning early childhood teachers' self leadership. Secondly, childcare teachers's support have statistically meaningful positive influences on beginning early childhood teachers' role performance through the mediation of self leadership. Through this study, it is possible to provide basic information to seek ways to enhance beginning early childhood teachers' role performance and self leadership under the considerations of their individual background characteristics, and to promote the practical support for the director or colleagues.

• Journal of Digital Convergence
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• v.16 no.3
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• pp.395-405
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• 2018

The purpose of this study is to investigate the effects of parental rearing attitudes on smartphone addiction and mediation effect of children's aggression and impulse between them. The randomly chosen 390 subjects of the 4th and 5th elementary school students (boy: 199, girl: 191) of J City participated in this research. The main scales were EMBU-Shot, Smartphone Addiction Scale and NEO-PAS. Spss 22.0 was used for its statistical analysis, that is correlation analysis and regression analysis. The main results are as follows. First, parental rearing attitude, smartphone addiction, and aggression and impulse were statistically significantly correlated. Second, it is testified that rejective parental rearing attitudes statistically significantly increasingly influenced smartphone addiction with partial mediation of aggression and impulse. Also overprotective parental rearing attitudes statistically significantly increasingly influenced smartphone addiction with full mediation of them. It suggested the importance of intervention for aggression and impulse of the children with smartphone addiction as well as parental rearing attitude changes in intervening and counseling them. This study tried to supply evidence-based and basic data for the developing preventive education and counseling programs for them. The limit and future tasks were discussed.

• Management & Information Systems Review
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• v.37 no.1
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• pp.55-74
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• 2018

China joined the WTO in 2001, and the Chinese market are growing at a rapid pace in the M&A Market. This Research is an Empirical analysis of China's leadership that subdivides leadership style and is an study on the effects of globalization on leadership and job satisfaction in the globalization as moderation variable. The significance of this study is to Refer to the direction of Chinese investments. This paper places emphasis on the change in Chinese organizational culture as a result of globalization and explores the influence of leadership on job satisfaction and turnover intention by using data from MBA students data of Wuhan City, 178 observations. And all of the data were analyzed using both the multiple regression analysis and the moderated regression analysis as well. Results of the empirical test are suggested as follow. First, transactional, transformational and servant leadership have a positive influence on job satisfaction. But it can't find the significant relationship between leadership and turnover intention. Second, there has a significant result that globalization on leadership is partially via the influence of job satisfaction. The result of the moderated regression analysis through the globalization as moderation variable is that globalization strengthens a positive influence on between transformational, emotional leadership and job satisfaction. On the other hand, In the case of this hypothesis that globalization will have mediating effect in the pathway between leadership and turnover intention, I expect that globalization strengthens a negative influence on turnover intention as dependent variable. But The result of the moderated regression analysis through the globalization as moderation variable is that globalization strengthens a positive influence on transactional, transformational, emotional and servant leadership.