• Asian Oncology Nursing
• /
• v.12 no.4
• /
• pp.274-279
• /
• 2012

Purpose: This study was conducted to test whether sleep disturbance mediates the effect of pain on fatigue, whether fatigue mediates the effect of pain on depression, and whether fatigue mediates the effect of sleep disturbance on depression. Methods: This study was conducted from September 12th to December 20th, 2011. One hundred eighty-eight breast cancer patients were recruited from D city and S city in Korea. The instruments used in this study were the pain, sleep disturbance, fatigue, and depression scales. Data were analyzed using descriptive statistics, Pearson correlation coefficients, and mediation pathway with the SPSS 12.0 and AMOS 20.0 programs. Results: There was correlation among pain, fatigue, sleep disturbance, and depression. Mediation analyses indicated that pain influences fatigue. sleep disturbance, and depression directly as well as indirectly. Sleep disturbance influences fatigue and depression directly, also fatigue influences depression directly. But sleep disturbance had no direct effect on depression. Conclusion: Significant correlations among the four symptoms supported the existence of the symptom cluster. Effects of pain on fatigue was partially mediated by sleep disturbance, also effects of pain on depression was partially mediated by fatigue. However, the effects of sleep disturbance on depression was fully mediated by fatigue.

• Korean Journal of Child Studies
• /
• v.35 no.1
• /
• pp.1-15
• /
• 2014

In this paper, the effects of parental neglect and abuse on school adjustment mediated by social withdrawal in adolescents were examined using a sample of 2,163 second grade middle school students(1,096 boys and 1,067 girls) from the Korean Child and Youth Panel Survey(KCYPS) data set. All research variables were measured using self-reported questionnaires. They were analyzed by means of Structural Equation Modeling. The results indicated that parents' abuse had no direct effect, but there was an indirect effect on adolescents' school adjustment mediated by adolescents' social withdrawal. Parental neglect had a direct effect on adolescents' school adjustment and also had an indirect effect on adolescents' school adjustment mediated by social withdrawal. The results indicate that parental neglect is a more significant contributor than adolescents' social withdrawal on adolescents' school adjustment. The results of this study show that parenting attitude, more specifically parental neglect, tend to be more important factors on school adjustment compared to adolescents' psychological problems, such as social withdrawal in adolescence. Taken together, these findings suggest that interventions aimed at improving parental neglect and adolescents' social withdrawal need to be emphasized if adolescents are to better adjust to school life.

• Journal of Distribution Science
• /
• v.20 no.7
• /
• pp.97-105
• /
• 2022

Purpose: This study aims to analyze and prove the effect of logistic capability and Total Quality Management practices on Micro, Small and Medium Enterprises (SME) performance directly or mediated by non-financial performance. Research design, data and methodology: This study tested the hypothesis using Hierarchical multiple regression analysis, the method of data collection in this study was using questionnaire, the sampling technique was purposive sampling technique, with SME that has been established for more than 5 years and manufacturing. The data analyzed were 180 respondents using SPSS 25. Results: The findings showed that logistic capability has direct and indirect effects on SME financial performance and has a positive effect on SME financial performance mediated by non-financial performance. While the total quality management practices have a positive effect on SME financial performance mediated by non-financial performance. Thus, companies can achieve maximum financial performance if they invest in developing employee knowledge and concerning on non-financial actions, such as employee satisfaction, innovation and proactively seeking market opportunities. Conclusions: In conclusion, one of the main factors that companies need to consider to improve financial performance is non-financial performance in mediating the effect of logistic capability and TQM practices on the financial performance of SMEs.

• Korean Journal of Pharmacognosy
• /
• v.34 no.2 s.133
• /
• pp.132-137
• /
• 2003

The effect of aqueous extract of Isodon japonicus Hara (Labiatae) (IJAE) on mast cell-mediated immediate-type allergic reactions was investigated. IJAE inhibited compound 48/80-induced systemic anaphylaxis and immunoglobulin E (IgE)-mediated local anaphylaxis. When IJAE was pretreated at the same concentration with systemic anaphylaxis, serum histamine levels were reduced in a dose-dependent manner. IJAE dose-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80. The level of cAMP in human mast cell line (HMC-1) cells, when IJAE was added, significantly was increased, compared with that of normal control. These results indicate that IJAE will beneficial in the treatment of immediate-type allergic reaction.

• Journal of the Korean Home Economics Association
• /
• v.41 no.8
• /
• pp.123-137
• /
• 2003

The purpose or this study was to examine the effect or maternal parenting experience, mediated by maternal depression, marital conflict, and parenting behavior, on school children's maladjustment. The theoretical model was specified and estimated. Subject of this study consisted of 637 mothers having elementary students(from 5th to 6th grade) drawn from 4 elementary schools in Cheong-ju city. Maternal parenting experience in childhood had an indirect effect on school children's maladjustment mediated by maternal depression. Maternal permissive parenting experience had more strong relationship with maternal depression rather than authoritative parenting behavior. Maternal depression, marital conflict, parenting behavior were directly effected on school children's maladjustment. Maternal depression were significantly effected on children's maladjustment indirectly mediated by marital conflict and parenting behavior Maternal depression was the most important factor predicting marital conflict, parenting behavior, and school children's Maladjustment.

• YAKHAK HOEJI
• /
• v.49 no.5
• /
• pp.386-391
• /
• 2005

The discovery of drugs for the treatment of mast cell-mediated allergic disease is a very important subject in human health. The Amomum xanthiodes (Zingiberaceae) has been used for centuries as a traditional medicine in Korea and is known to have an anti-inflammatory effect. However, its specific mechanism of action is still unknown. In this report, we investigated the effect of hot water extract from Amomum xanthiodes (EAX) on the mast cell-mediated allergic reaction and studied its possible mechanisms of action. EAX inhibited compound 48/80-induced systemic anaphylaxis and serum his­tamine release in mice. EAX decreased the passive cutaneous anaphylaxis reaction activated by anti-dinitrophenyl (DNP) IgE antibody. EAX dose-dependently reduced histamine release from rat peritoneal mast cells activated by compound 48/80 or anti-DNP IgE. EAX increased cAMP and decreased compound 48/80-induced intracellular $Ca^{2+}$ levels. Our findings provide evidence that EAX inhibits mast cell-derived allergic reactions, and also demonstrate the involvement of cAMP and intracellular $Ca^{2+}$ in these effects.

• Macromolecular Research
• /
• v.17 no.1
• /
• pp.14-18
• /
• 2009

The acceleration effect of various organic acids, such as methanesulfonic acid (MSA), ethanesulfonic acid (ESA), 4,4'-sulfonyldibenzoic acid (SDA), diphenylacetic acid (DPAA), and $\rho$-toluenesulfonic acid (TSA), on the rate of styrene bulk polymerization with 2,2,6,6-tetramethylpiperidinyloxy (TEMPO) and benzoyl peroxide (BPO) was investigated. The addition of organic acids significantly accelerated the rate. Among these organic acids, DPAA showed an efficient rate-accelerating effect with living nature of polymerization. When DPAA was used as a rate-accelerating additive for TEMPO-mediated living free radical polymerization (LFRP), the rate of polymerization was dramatically enhanced, the linearity of reaction kinetics was successfully maintained, and the polydispersity was effectively controlled.

• The Korean Journal of Physiology
• /
• v.27 no.1
• /
• pp.27-35
• /
• 1993

Effects of the endothelium on the contractile responses to norepinephrine (NE) were investigated in isolated helical strips of the proximal and distal coronaries artery of pigs. The helical strips were immersed in Tris-buffered Tyrode's solution equilibrated with 100% $O_2$ at $35^{\circ}C$ and its isometric tension was measured. NE relaxed the strips precontracted with acetylcholine from both the proximal and distal coronary artery. NE-induced relaxation, which might be induced mainly by $\beta$-adrenoceptor function was dominant in the distal coronary arteries. NE-induced relaxation was converted to a contraction after $\beta$-adrenoceptor blockade with propranolol $(3{\times}10^{-6}M)$. ${\alpha}$-adrenoceptor-mediated contraction by NE was greater in the proximal coronary artery than the distal coronary artery. Quantitatively, ${\alpha}_1$-adrenoceptor mediated contraction by NE was greater than ${\alpha}_2$-adrenoceptor mediated contraction by NE in both arteries. NE-induced relaxation was decreased by rubbing of endothelium in both arteries. ${\alpha}_1-and\;{\alpha}_2$-adrenoceptor mediated contraction by NE were potentiated by rubbing of endothelium in both arteries. Pretreatment with methylene blue, an inhibitor of soluble guanylate cyclase, increased ${\alpha}_1-\;and\;{\alpha}_2$-adrenoceptor mediated contraction by NE in both arteries with endothelium. From the above results, we suggest that the effect of activation of $\alpha$-adrenoceptors by NE may be modulated by endothelium in the proximal and distal coronary arteries of pigs. This effect may be mediated via endothelium derived relaxing factor.

• Journal of Microbiology and Biotechnology
• /
• v.24 no.8
• /
• pp.1051-1058
• /
• 2014

Platelet-activating factor receptor (PAFR) plays an important role in bacterial infection and inflammation. We examined the effect of the bacterial cell wall components lipopolysaccharide (LPS) and lipoteichoic acid (LTA) from Lactobacillus plantarum (pLTA) and Staphylococcus aureus (aLTA) on PAFR expression in THP-1, a monocyte-like cell line. LPS and aLTA, but not pLTA, significantly increased PAFR expression, whereas priming with pLTA inhibited LPS-mediated or aLTA-mediated PAFR expression. Expression of Toll-like receptor (TLR) 2 and 4, and CD14 increased with LPS and aLTA treatments, but was inhibited by pLTA pretreatment. Neutralizing antibodies against TLR2, TLR4, and CD14 showed that these receptors were important in LPS-mediated or aLTA-mediated PAFR expression. PAFR expression is mainly regulated by the nuclear factor kappa B signaling pathway. Blocking PAF binding to PAFR using a PAFR inhibitor indicated that LPS-mediated or aLTA-mediated PAF expression affected TNF-${\alpha}$ production. In the mouse small intestine, pLTA inhibited PAFR, TLR2, and TLR4 expression that was induced by heat-labile toxin. Our data suggested that pLTA has an anti-inflammatory effect by inhibiting the expression of PAFR that was induced by pathogenic ligands.

• Korean Journal of Human Ecology
• /
• v.21 no.5
• /
• pp.915-927
• /
• 2012

The purpose of this study was to examine the mediation effect of peer attachment on the relationship between children's depression and mother attachment. The respondents in this study were 697 school aged children attending elementary schools in Daegu and Gyeongbuk Province. Questionnaires, which required self-reporting by children, were used to investigate mother attachment, peer attachment and depression. The collected data were analyzed by Structural Equation Modeling(SEM) and Sobel test using AMOS 8.0, and SPSS 15.0. The results of the study were as follows. Structural Equation Modeling(SEM) revealed that peer attachment partially mediated the relationship between mother attachment and depression. First, mother attachment had a direct effect on peer attachment. Second, peer attachment had a direct effect on depression. Third, mother attachment had an indirect effect on depression as a mediated effect of peer attachment.