• Archives of Pharmacal Research
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• v.20 no.4
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• pp.358-362
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• 1997

Metabolite identification and urinary and biliary excretion of the new fluoroquinolone antibacterial agent DW116 [1-(5-fluoro-2-pyridyl)-6-fluoro-7-(4-methyl-1 -piperazinyl)-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid, hydrochloride] after oral administration have been studied in Sprague-Dawley rats. The excretion kinetics were monoexponential. Most of the drug was eliminated via the hepatic and renal routes. Mean renal clearance of DW116 was 73.4 ml/hr/kg and mean biliary clearance was 83.8 ml/hr/kg. The major metabolite excreted in the bile was identified as the glucuronide ester of the parent drug using base-hydrolysis of the conjugate metabolite followed by co-HPLC with standard compound, $^{19}$ F-NMR and LC-MS methods. The glucuronide conjugate was also found in urine. The mean urinary recoveries of free and total (free plus glucuronide ester) DW116 were $28.6{\pm}2.7% $and $36.4{\pm}1.8%$ of the administered dose and the corresponding biliary recoveries were $14.4{\pm} 5.5%$ and $37.0{\pm}7.6%$, respectively.

• Journal of the Earthquake Engineering Society of Korea
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• v.7 no.4
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• pp.89-95
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• 2003

In this paper, an algorithm to locate and size damage in a complex truss structure using the time domain response is presented. Sampled response data for specific time interval is spatially expanded over the structure to obtain the mean train energy for each element of the structure. The mean strain energy for each element is, in turn, used to build a damage index that represents the ratio of the stiffness parameter of the pre-damaged to the post-damaged structure. The validity of the methodology is demonstrated using data from a numerical example of a space truss structure with simulated damage. Also in the example, the effects of noisy data on the proposed algorithm are examined by adding random noised to the response data.

• Journal of Sasang Constitutional Medicine
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• v.25 no.4
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• pp.320-329
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• 2013

Objectives We carried out this study to know that there is any differences on the health condition of the middle aged women between Sasang coustitution. We used Diagnosis System of Oriental Medicine(DSOM) for diagnosis and determining pattern identification. Methods This research was approved by the Dongeui University Oriental Hospital Institutional Review Board (certificate no. 2011-06). From March 2012 to October 2012, we examined Kupperman's index, the MENQOL, DSOM, and Sasang Constitution of 291 women from the general population, with ages ranging from 40 to 60 years. And we compared the results statistically by the chi-square test and F-test. Results and Conclusions We excluded 4 Taeyangin to analyze because they were few, and analyzed 287 subjects which were 53 Soyangin, 131 Taeeumin, and 103 Soeumin. 1. The pathogenic factors that showed significant differences were deficiency of qi, insufficiency of Yin, heat on the frequency of the output and deficiency of qi, heat, phlegm on the mean of pathogenic factor score. Deficiency of qi was higher in Soeumin, insufficiency of Yin and heat were higher in Taeeumin, and phlegm was higher in Taeeumin and Soeumin. Overall, Soyangin tended to be lower than others on both the frequency of the output and the mean of pathogenic factor score. 2. The middle aged women with ages ranging from 40 to 60 years tended to be dryness, kidney, damp and became to be blood-deficiency, stagnation of qi, heart easily. Soyangin was more health than others, Taeeumin tended to be heat, phlegm, insufficiency of Yang, and Soeumin tended to be deficiency of qi.

• Journal of Korean Society of Environmental Engineers
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• v.33 no.12
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• pp.900-906
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• 2011

To investigate concentration and sources of PCDD/Fs and Co-PCBs in sediments, total 52 sediment samples were measured at 17 sites in Geum River. As a result of analysis, total concentrations of PCDD/Fs and Co-PCBs were ranged from not detected (N.D.)~193.47 pg/g-d.w. (mean value: 84.52 pg/g-d.w) and 0.34~359.19 pg/g-d.w (mean value: 114.65 pg/g-d.w.) respectively. Also, toxic equivalent (TEQ) concentration of PCDD/Fs and Co-PCBs were ranged from N.D.~5.12 (mean value: 0.88) pg I-TEQ/g-d.w and N.D.~0.58 (mean value: 0.09) $WHO_{2005}$-TEQ pg/g-d.w. respectively. The upstream indicate the highest concentration and as it goes to the downstream, it has tendency to decrease. Higher chlorinated compounds were dominant in most of site which detected PCDD/Fs. Occurrence of Co-PCBs isomer patterns appear similar to each sampling site was found. The isomer patterns showed similar between sediment and PCB products. The principal component analysis also showed that the samples contained the characteristics of PCBs products.

• Korean Chemical Engineering Research
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• v.46 no.3
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• pp.486-491
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• 2008

This paper describes a model identification method that has been applied to a commercial 12-inch RTP (rapid thermal processing) equipment with an ultimate aim to develop a high-performance advanced controller. Seven thermocouples are attached on the wafer surface and twelve tungsten-halogen lamp groups are used to heat up the wafer. To obtain a MIMO balanced state space model, multiple SIMO (single-input multiple-output) identification with highorder ARX models have been conducted and the resulting models have been combined, transformed and reduced to a MIMO balanced state space model through a balanced truncation technique. The identification experiments were designed to minimize the wafer warpage and an output linearization block has been proposed for compensation of the nonlinearity from the radiation-dominant heat transfer. As a result from the identification at around 600, 700, and $800^{\circ}C$, respectively, it was found that $y=T(K)^2$ and the state dimension of 80-100 are most desirable. With this choice the root-mean-square value of the one-step-ahead temperature prediction error was found to be in the range of 0.125-0.135 K.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1993.04a
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• pp.140-146
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• 1993

Active noise control uses the intentional superposition of acoustic waves to create a destructive interference pattern such that a reduction of the unwanted sound occurs. In active noise control system the choice of a control structure and design of the controller are the main issues of concern. In real acoustic fields there are a vast number of noise sources with time-varying nature and the characteristics of transducers and the geometric set-up of control system are subject to change. Accordingly the control system should be designed to adapt such circumstances so that required level of performance is maintained. In this paper, the adaptive control algorithm for self-tuning adaptive controller is presented for the application in active noise control system. Self-tuning is a direct integration of identification and controller design algorithm in such a manner that the two processes proceed sequentially. The least mean square algorithm was used for the identification schemes and adaptive weighted minimum variance control algorithm was applied for self-tuning controller. Computer simulation results for self-tuning feedback controller are presented. And simulation results was shown to be useful for the situation in which the periodic noise sources act on the acoustic field.

• Plant Resources
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• v.1 no.2
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• pp.81-91
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• 1998

Fifty-nine Korean soybean (Glycine max L. Merr.) landrace accessions were tested for genotype fingerprinting, differentiation and association between morphological traits and SSR profile. Using 8 SSR loci, 59 varieties were divided into 55 groups, and only 4 pairs of varieties were not uniquely identified. The resolving power of SSR for soybean genotyping was much higher than that of the morphological traits that were studied. Identification efficiency also differed among SSR loci. Those loci with higher numbers of alleles distinguished varieties more effectively. Genetic differentiation values of the soybean landraces varied from 0.57 to 0.82 with a mean of 0.68. The number of alleles detected by the 8 loci ranged from 3 to 8. and the effective number of alleles ranged from 2.3 to 5.1. In a study of the association of SSR alleles with morphological traits, some alleles seemed to be related with some specific morphological traits. Comparison of two kinds of dendrograms which were derived from SSR markers and quantitative traits indicated that the dendrograms were not consistent. Considering the correlation between single SSR locus and qualitative traits governed by major genes, the data suggest that alleles of microsatellite loci be more closely related to some traits determined by major genes than those determined by minor genes.

• Wind and Structures
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• v.17 no.6
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• pp.609-627
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• 2013

The Yingxian wooden tower in China is currently the tallest wooden tower in the world. It was built in 1056 AD and is 65.86 m high. Field measurements of wind speed and wind-induced response of this tower are conducted. The wind characteristics, including the average wind speed, wind direction, turbulence intensity, gust factor, turbulence integral length scale and velocity spectrum are investigated. The power spectral density and the root-mean-square wind-induced acceleration are analyzed. The structural modal parameters of this tower are identified with two different methods, including the Empirical Mode Decomposition (EMD) combined with the Random Decrement Technique (RDT) and Hilbert transform technique, and the stochastic subspace identification (SSI) method. Results show that strong wind is coming predominantly from the West-South of the tower which is in the same direction as the inclination of the structure. The Von Karman spectrum can describe the spectrum of wind speed well. Wind-induced torsional vibration obviously occurs in this tower. The natural frequencies identified by EMD, RDT and Hilbert Transform are close to those identified by SSI method, but there is obvious difference between the identified damping ratios for the first two modes.

• Journal of Korean Medical classics
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• v.23 no.3
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• pp.69-80
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• 2010

The four taboos in using Baekhotang as explained by Odang(吳瑭), are identical to the standard symptoms of Severe Exterior Heat Syndrome[表熱重證]. There are similarities between Sanghan and Onbyeong in using Baekhotang(白虎湯). But there are significant differences between Sanghan and Onbyeong in explaining the pathogenesis of human body. In pattern identification by the Wi-Gi-Yoeng-Hyeol(衛氣營血) system, body fluid[津液] is the key feature, whereas in that of the Yuk-Gyeong(六經) system, Yanggi(陽氣) is the point. Therefore, we can understand that the standard symptoms of pattern identification are slightly different. However, that Sanghan and Onbyeong present different explanations does not mean that the disease itself strictly 'belong' to one category. They are different approaches, not explanations for two different subjects. Therefore, Sanghan and Onbyeong should be studied in line with this concept.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.19 no.8
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• pp.1528-1535
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• 1994

In this paper, a filtered-X LMS algorithm by new error path identification method is proposed for active noise control system. The proposed algorithm identifies accurately the error path transfer function using three microphones and the control of error signal through double loop scheme with on-line. In the computer simulation using the sinusoidal and the practical duct noise, the proposed algorithm reduces noise level about 29.1dB and 10.4dB, respectively. We can observe the improvement of about 0.5dB and 2.5dB in noise level compared with that obtained using the filtered-X LMS algorithm of Eriksson model.