• Bulletin of the Korean Chemical Society
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• 제26권8호
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• pp.1209-1213
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• 2005

Nuclear membrane is one of the main barriers in intracellular delivery of genetic materials. The previous report showed that glucocorticoid receptor dilated the nuclear pore to 60 nm in the presence of a ligand. It was also suggested that the transport of genetic material to nucleus might be facilitated by glucocorticoid. In this study, the effect of glucocorticoid preincubation in the polymeric gene delivery was investigated. The cells were preincubated with dexamethasone, a potent glucocorticoid, and transfection assays were performed with polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer. As a result, the transfection efficiency of PEI or PAMAM to the cells in the presence of dexamethasone was enhanced, compared to the cells without dexamethasone. This effect was not observed in the cells preincubated with cholesterol. The polymer/DNA complex was stable in the presence of dexamethasone. In addition, the cytotoxicities of the polymeric carriers to the cells were observed in the presence of dexamethasone. In conclusion, dexamethasone enhances the transfection efficiency of polymeric carriers and may be useful in the development of polymeric gene carriers.

• E2M - 전기 전자와 첨단 소재
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• 제30권5호
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• pp.3-8
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• 2017

• 한국건설관리학회:학술대회논문집
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• 한국건설관리학회 2007년도 정기학술발표대회 논문집
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• pp.553-557
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• 2007

건설산업에서 자재와 관련된 비용은 프로젝트 특성에 따라 다르지만 일반적으로 원가구성비 측면에서 40% 이상을 차지한다. 최근 대형화, 전문화, 복잡화 되어가는 건축 공사에서 자재의 반입, 이동 및 적재공간의 협소로 인해 자재관리가 매우 복잡하다. 하지만 대두분의 경우 자재관리는 현장 관리자의 경험에 의존해 관리되고 있으며 건설관리분야중 자재관리의 중요성에 대한 인식도 낮은 실정이다. 이에 대한 건설 산업에서 자재관리에 대한 연구도 활발히 진행되고 있다. 본 연구에서는 자재의 속성에 따른 ETO, ATO, MTO, MTS의 네가지 분류 방법과 자재 조달 특성 및 자재 고유특성을 통하여 현장 자재의 효율적인 공급관리를 위한 자재의 속성별 관리요소를 파악한다. 이를 이용하여 자재 속성별 자재관리 지표를 선정한다.

• 한국문헌정보학회지
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• 제51권2호
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• pp.237-253
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• 2017

상호대차 서비스 운영의 효율화를 위해서 시스템적 접근과 같은 다양한 방법이 모색되고 있다. 본 연구는 그 가운데 상호대차 대출 요청의 이용자 대기시간을 줄일 수 있는 운영관리 방법에 대해서 제시하였다. 지역 내 상호대차 대출의 이용자 대기 시간은 2~3일로 안내되고 있는데 이와 같은 대기가 발생하는 가장 큰 이유는 도서 배송 차량의 이동경로 및 도서 배송량 결정에 비효율성이 있기 때문이다. 이를 해결하기 위해 혼합정수계획모형이라는 수리적 모형을 통해 도서 배송량을 최대화할 수 있는 차량 경로이동 방법을 제시하였다. 그리고 실제 도서관의 상호대차 요구량 자료를 이용하여 하루 가용한 시간 별, 최적의 도서 이동 및 차량 경로 해법을 제안하였다.

• 대한조선학회논문집
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• 제55권2호
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• pp.124-135
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• 2018

In order to secure manufacturing competitiveness of offshore plants, piping process is one of the most important processes. This study is about the design of management system for piping materials manufacturing of the offshore plant. As a result of the study, we analyzed the system and algorithms needed for the processing of piping material products and designed the structure of the entire management system. We conducted a process analysis of the design, manufacturing and installation processes. And also we proposed a system structure to improve the various problems that have come out. We also proposed an algorithm to determine the delivery order of the pipe spools, and proposed a raw material management system for the manufacturing of the pipe spools. And we designed a manufacturing process management system to manage the risk of pipe materials delivery. And finally we proposed a data structure for the installation process management system. The data structures and algorithms were actually implemented, and applied the actual process data to verify the effect of the system.

• 한국임상수의학회지
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• 제36권4호
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• pp.212-218
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• 2019

This study evaluates the drug delivery and biocompatibility of latanoprost imbedded disk in rabbit eye by assessing pharmacokinetics (PK), clinical signs, and histopathologic findings. During 84 days of experimental period, 48 New Zealand Rabbit (NZW) eyes were divided into control group which received no treatment and test material group which latanoprost were implanted intrasclerally. Pharmacokinetic assessment was performed to evaluate the drug delivery for 3 months. For biocompatibility, clinical signs were observed and histopathological analysis was done at 3 months post-operatively. The concentration of latanoprost in the iris tissue was maintained during the experimental period and the highest level of latanoprost was found at 4 weeks. However, the latanoprost was not found in the aqueous humor. Macroscopically, there was no evidence of clinical signs except for temporary hyperemia, neovascularization and edema immediately after surgery. On histopathological examination, there were no abnormal findings such as hyperemia, neovascularization, and edema in the eye tissues. The latanoprost imbedded disks has effectively released the drug into the adjacent tissue with high compatibility. Therefore, this study suggests that the drug delivery system with intrascleral latanoprost imbedded implants might be a novel approach as a treatment option for glaucoma.

• 산업공학
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• 제13권3호
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• pp.455-461
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• 2000

Logistics systems can be evaluated by how productively distribution center operates, how promptly transportation vehicle dispatches, how efficiently facility layout is, and so on. In this paper, a practical vehicle routing scheme with fixed delivery time and fixed vehicle routes is introduced. The method helps the distribution center reduce logistics cost with respect to dispatching vehicles, and satisfy the customer with pre-determined delivery time window constraints. A case study has shown that the proposed scheme not only generates a feasible schedule with time windows, but also balances material flow in warehouse.

• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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• pp.230.1-230.1
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• 2003

In case of oral application of quinupramine, antidepressants, it may cause adverse effects such as diarrhea, nausea due to transient high blood concentration. Ethylene vinyl acetate (EVA) which is heat-processible, flexible, inexpensive material was used for transdermal drug delivery. The purpose of this study was to develop the new transdermal delivery system of quinupramine using EVA polymer matrix that can provide sustained release and avoid the side effects. The EVA matrix containing quinupramine was prepared by solvent-evaporation method. (omitted)

• 산업공학
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• 제9권2호
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• pp.159-171
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• 1996

In recent, most'of automobile industries adopt the concept of JIT production. According to the concept, the paternal manufacturers require their suppliers to supply parts just in time, so it is very important for a subcontractor to produce the parts in the appointed time of delivery. This study develops a production information system for Woosin Industry, which is one of such subcontractors of Hyundai Motors Company(HMC). The system is developed for use in Client/Server environment. In this study, the following three modules are developed, i. e., the production scheduling module, the sales management module to deal with the information about orders of HMC, delivery of parts, and bill collecting, and the module for supporting material requirements planning and purchase of material.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 1996년도 춘계공동학술대회논문집; 공군사관학교, 청주; 26-27 Apr. 1996
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• pp.190-193
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• 1996

In recent, most of automobile industries adopt the concept of Just In Time production. The paternal manufacturers require their suppliers to supply parts just in time. It is very important for a subcontractor to produce the parts in the appointed time of delivery. This study develops a production information system for Woosin Industry, which is one of such subcontractor of Hundai Motors Company(HNC). The system is developed on Client/Server system. Firstly, three modules are developed, i.e., scheduling module to make a schedule, the subsystem of sales management to deal with the information about order of HMC, delivery of parts, and bill collecting, and the module for supporting material requirement planning and purchace of material.