• Bulletin of the Korean Chemical Society
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• v.26 no.8
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• pp.1209-1213
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• 2005

Nuclear membrane is one of the main barriers in intracellular delivery of genetic materials. The previous report showed that glucocorticoid receptor dilated the nuclear pore to 60 nm in the presence of a ligand. It was also suggested that the transport of genetic material to nucleus might be facilitated by glucocorticoid. In this study, the effect of glucocorticoid preincubation in the polymeric gene delivery was investigated. The cells were preincubated with dexamethasone, a potent glucocorticoid, and transfection assays were performed with polyethylenimine (PEI) and polyamidoamine (PAMAM) dendrimer. As a result, the transfection efficiency of PEI or PAMAM to the cells in the presence of dexamethasone was enhanced, compared to the cells without dexamethasone. This effect was not observed in the cells preincubated with cholesterol. The polymer/DNA complex was stable in the presence of dexamethasone. In addition, the cytotoxicities of the polymeric carriers to the cells were observed in the presence of dexamethasone. In conclusion, dexamethasone enhances the transfection efficiency of polymeric carriers and may be useful in the development of polymeric gene carriers.

• Electrical & Electronic Materials
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• v.30 no.5
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• pp.3-8
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• 2017

• Proceedings of the Korean Institute Of Construction Engineering and Management
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• 2007.11a
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• pp.553-557
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• 2007

In general, material cost of a construction project is more than 30$^{\sim}$40% of total construction cost, thus on site material control is very important. The factthat buildings have recently become higher and bigger also increases the importance of on site material control. However, on site material control has not been considered as an important management issue. This study classifies building construction materials considering the material delivery characteristics such as ETO, ATO, MTO and MTS and the unique characteristics of each materials. Using the classification, this study examine the requirements for on site material control of each materials. Finally, this study suggests on site material control systems for each construction material.

• Journal of the Korean Society for Library and Information Science
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• v.51 no.2
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• pp.237-253
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• 2017

There are many systematic approaches to manage Interlibrary loan (ILL) efficiently. In this paper, we propose an operating method reducing user-waiting in ILL. Users are usually informed to wait around two to three days in a regional ILL service. The reason of the waiting is that there is inefficiency in running material-delivery vehicles. A mixed integer programming is employed to resolve this issue. It provides an optimal vehicle-route maximizing material-deliveries subject to time availability. We used an actual data of a regional ILL system to provide optimal vehicle routes under different time settings.

• Journal of the Society of Naval Architects of Korea
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• v.55 no.2
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• pp.124-135
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• 2018

In order to secure manufacturing competitiveness of offshore plants, piping process is one of the most important processes. This study is about the design of management system for piping materials manufacturing of the offshore plant. As a result of the study, we analyzed the system and algorithms needed for the processing of piping material products and designed the structure of the entire management system. We conducted a process analysis of the design, manufacturing and installation processes. And also we proposed a system structure to improve the various problems that have come out. We also proposed an algorithm to determine the delivery order of the pipe spools, and proposed a raw material management system for the manufacturing of the pipe spools. And we designed a manufacturing process management system to manage the risk of pipe materials delivery. And finally we proposed a data structure for the installation process management system. The data structures and algorithms were actually implemented, and applied the actual process data to verify the effect of the system.

• Journal of Veterinary Clinics
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• v.36 no.4
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• pp.212-218
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• 2019

This study evaluates the drug delivery and biocompatibility of latanoprost imbedded disk in rabbit eye by assessing pharmacokinetics (PK), clinical signs, and histopathologic findings. During 84 days of experimental period, 48 New Zealand Rabbit (NZW) eyes were divided into control group which received no treatment and test material group which latanoprost were implanted intrasclerally. Pharmacokinetic assessment was performed to evaluate the drug delivery for 3 months. For biocompatibility, clinical signs were observed and histopathological analysis was done at 3 months post-operatively. The concentration of latanoprost in the iris tissue was maintained during the experimental period and the highest level of latanoprost was found at 4 weeks. However, the latanoprost was not found in the aqueous humor. Macroscopically, there was no evidence of clinical signs except for temporary hyperemia, neovascularization and edema immediately after surgery. On histopathological examination, there were no abnormal findings such as hyperemia, neovascularization, and edema in the eye tissues. The latanoprost imbedded disks has effectively released the drug into the adjacent tissue with high compatibility. Therefore, this study suggests that the drug delivery system with intrascleral latanoprost imbedded implants might be a novel approach as a treatment option for glaucoma.

• IE interfaces
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• v.13 no.3
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• pp.455-461
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• 2000

Logistics systems can be evaluated by how productively distribution center operates, how promptly transportation vehicle dispatches, how efficiently facility layout is, and so on. In this paper, a practical vehicle routing scheme with fixed delivery time and fixed vehicle routes is introduced. The method helps the distribution center reduce logistics cost with respect to dispatching vehicles, and satisfy the customer with pre-determined delivery time window constraints. A case study has shown that the proposed scheme not only generates a feasible schedule with time windows, but also balances material flow in warehouse.

• Proceedings of the PSK Conference
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• 2003.10b
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• pp.230.1-230.1
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• 2003

In case of oral application of quinupramine, antidepressants, it may cause adverse effects such as diarrhea, nausea due to transient high blood concentration. Ethylene vinyl acetate (EVA) which is heat-processible, flexible, inexpensive material was used for transdermal drug delivery. The purpose of this study was to develop the new transdermal delivery system of quinupramine using EVA polymer matrix that can provide sustained release and avoid the side effects. The EVA matrix containing quinupramine was prepared by solvent-evaporation method. (omitted)

• IE interfaces
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• v.9 no.2
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• pp.159-171
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• 1996

In recent, most'of automobile industries adopt the concept of JIT production. According to the concept, the paternal manufacturers require their suppliers to supply parts just in time, so it is very important for a subcontractor to produce the parts in the appointed time of delivery. This study develops a production information system for Woosin Industry, which is one of such subcontractors of Hyundai Motors Company(HMC). The system is developed for use in Client/Server environment. In this study, the following three modules are developed, i. e., the production scheduling module, the sales management module to deal with the information about orders of HMC, delivery of parts, and bill collecting, and the module for supporting material requirements planning and purchase of material.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 1996.04a
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• pp.190-193
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• 1996

In recent, most of automobile industries adopt the concept of Just In Time production. The paternal manufacturers require their suppliers to supply parts just in time. It is very important for a subcontractor to produce the parts in the appointed time of delivery. This study develops a production information system for Woosin Industry, which is one of such subcontractor of Hundai Motors Company(HNC). The system is developed on Client/Server system. Firstly, three modules are developed, i.e., scheduling module to make a schedule, the subsystem of sales management to deal with the information about order of HMC, delivery of parts, and bill collecting, and the module for supporting material requirement planning and purchace of material.