• Journal of Microbiology and Biotechnology
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• 제19권11호
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• pp.1319-1327
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• 2009

Marine red algae of genus Laurencia are becoming the most important resources to produce unique natural metabolites with wide bioactivities. However, reports related to Laurencia undulata, an edible species used as folk herb, are rarely found to date. In this research, 5-hydroxymethyl-2-furfural (5-HMF) was isolated and characterized by nuclear magnetic resonance (NMR) from Laurencia undulata as well as other marine algae. The following characteristics of 5-HMF were systematically evaluated: its antioxidant activities, such as typical free-radicals scavenging in vitro by electron spin resonance spectrometry (ESR) and intracellular reactive oxygen species (ROS) scavenging; membrane protein oxidation; oxidative enzyme myeloperoxidase (MPO) inhibition; as well as expressions of antioxidative enzymes glutathione (GSH) and superoxide dismutase (SOD) on the gene level using the polymerase chain reaction (PCR) method. The results demonstrated that 5-HMF could be developed as a novel marine natural antioxidant or potential precursor for practical applications in the food, cosmetic, and pharmaceutical fields.

• 한국양식학회:학술대회논문집
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• 한국양식학회 2004년도 수산관련학회 공동학술대회 발표요지집
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• pp.144-145
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• 2004

• 한국어업기술학회:학술대회논문집
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• 한국어업기술학회 1998년도 수산관련공동학술대회발표요지집
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• pp.355-356
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• 1998

• Bulletin of the Korean Chemical Society
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• 제9권4호
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• pp.264-266
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• 1988

• 한국수산과학회지
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• 제43권1호
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• pp.63-68
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• 2010

Ecological characteristics of Undariopsis peterseniana, an endangered brown alga, were investigated from January to December 2007 at Jeju Island, Korea. The U. peterseniana population formed dense patches at depths of 12~17 m depth. Growth in length of the alga reached a maximum of $168{\pm}36cm$ at June. Sorus were observed from May to August, and a maturation peak was detected in June, when bottom seawater temperatures were around $18^{\circ}C$. After zoospore release, the alga bleached and disappeared after August. Developmental initiation of sporophytes occurred at temperature above $15^{\circ}C$, and sorus formation required approximately 236 degree-days. This is the first study to examine a U. peterseniana population throughout the entire year in a natural habitat.

• ALGAE
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• 제26권1호
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• pp.3-20
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• 2011

The physiology of the unicellular green alga Dunaliella salina in response to abiotic stress has been studied for several decades. Early D. salina research focused on its remarkable salinity tolerance and ability, upon exposure to various abiotic stresses, to accumulate high concentrations of $\beta$-carotene and other carotenoid pigments valued highly as nutraceuticals. The simple life cycle and growth requirements of D. salina make this organism one of the large-scale commercially exploited microalgae for natural carotenoids. Recent advances in genomics and proteomics now allow investigation of abiotic stress responses at the molecular level. Detailed knowledge of isoprenoid biosynthesis mechanisms and the development of molecular tools and techniques for D. salina will allow the improvement of physiological characteristics of algal strains and the use of transgenic algae in bioreactors. Here we review D. salina isoprenoid and carotenoid biosynthesis regulation, and also the biotechnological and genetic transformation procedures developed for this alga that set the stage for its future use as a production system.

• 수산해양교육연구
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• 제27권3호
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• pp.747-756
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• 2015

Brown alga Undaria peterseniana has been interested in the commercial scale aquaculture for warm water species development in southern coastal area of Korea. However, this species was classified an endangered species caused by a decrease in habitat and natural population. In this study, inhabit characteristics of U. peterseniana was investigated in their natural habitat of Ulleung Island, Korea. The U. peterseniana population was occurred dense patches at 20~30m depth. Total length of the alga reached 1.0~2.0m and the largest width ranged 10.0~35.0cm during the study. In 2013, habitats of this species increased two sites compared with the previous year and their distribution extended to low depth (10m) of coastal area. In long-term data, seawater temperature revealed a continuous increment by strong going north of East Korea Warm Current or Ulleung Warm Eddy turning around the coast of Ulleung Island. It suggested that habitat extension of U. peterseniana may be caused by suitable settlement condition and increase of warm water around the coastal area. Current studies of this species may be continuously required in the possibility of fisheries resources as aquaculture species and index species of increment of water temperature at the fixed monitoring site in East Sea. This is the first study to research ecological feature U. peterseniana population at the natural habitat of Ulleung Island.

• KSBB Journal
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• 제18권1호
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• pp.19-24
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• 2003

해수 미세조류인 Chlorella capsulata를 배양하여 그로부터 기능성물질을 분리하여 면역활성측정 및 항암실험을 실시하였다. C. capsulata를 이용한 면역활성능 측정실험에서 일반적 인 담수종의 추출물이나 같은 종의 여러 추출용매를 이용한 추출물보다 물추출물의 분획층에 대한 면역활성이 높은 것으로 나타났다. 인간 T 세포, B 세포와 대식세포에 대해서 높은 면역활성을 나타내었으며, 정상세포에 대한 독성측정 실험에서도 약 10∼25%의 독성을 나타났으며, 유방암세포와 위암세포에 대한 성장저해 실험에서도 각각 80% 이상의 높은 저해능을 확인하였다. 앞서의 결과들로부터 Chloreila capsulata로부터 분리한 분획물은 면역세포들의 생육을 증강시켜 외부항원에 대한 면역기능을 강화시키는 것을 간접적으로 확인할 수 있었다

• ALGAE
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• 제29권4호
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• pp.333-341
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• 2014

In this study, four compounds isolated from the red alga Laurencia snackeyi were evaluated for their potential anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. These compounds were tested for their inhibitory effects on nitric oxide (NO) production in LPS-stimulated RAW 264.7 cells. Since $5{\beta}$-hydroxypalisadin B showed the best activity it was further tested for the production of prostaglandin-$E_2$ ($PGE_2$), expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), the release of pro-inflammatory cytokines tumor necrotic factor-alpha (TNF-${\alpha}$), interleukin-$1{\beta}$ (IL-$1{\beta}$), and interleukin-6 (IL-6). $5{\beta}$-Hydroxypalisadin B significantly reduced the $PGE_2$ release and suppressed the iNOS and COX-2 expression in LPS-stimulated RAW 264.7 cells. It also significantly reduced the release of pro-inflammatory cytokines TNF-${\alpha}$, IL-$1{\beta}$, and IL-6. These findings provide the first evidence of anti-inflammatory potential of $5{\beta}$-hydroxypalisadin B isolated from the red alga L. snackeyi and hence, it could be exploited as an active ingredient in pharmaceutical, nutraceutical and functional food applications.

• 한국영양학회:학술대회논문집
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• 한국영양학회 2003년도 연합학술대회
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• pp.302.2-302.2
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• 2003